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Conserved domains on  [gi|52138727|ref|NP_001004435|]
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phosphoinositide 3-kinase regulatory subunit 6 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PI3K_1B_p101 super family cl11126
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
34-749 3.09e-46

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


The actual alignment was detected with superfamily member pfam10486:

Pssm-ID: 431309  Cd Length: 860  Bit Score: 177.19  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727    34 MWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPED--LYHRAYTFCTRLLTLPAP 111
Cdd:pfam10486  35 MNRWSLEELVKRDPHNFLILLQQILRKTREVQEQCQYELVAPLALLFSSTLLQTPYCPPDsdLLEEAAEVFHRFLTWPEP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   112 YSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSAsvcsalllEIQAAQEQ-QTPEACMR 190
Cdd:pfam10486 115 YCSVCRELLSFIQQELKAPGISFQRLVREEQGLPTSSHCSKTITVLLLNPDEVPA--------EFLSVAEQlSNAEHSQR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   191 HV----VSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPS--RLGHLEKMEEIYCSLLGPATT 264
Cdd:pfam10486 187 DTyitlIKHAFQATLGTKYDLQSIHKALQSKTVEELEQIFSSVTEALETAAAMSDPLkaREHLIQGLERLREKLGIPASN 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   265 rrhcvGDLLQDRLPSIPLPSP--YiTFHLWTD-----QEQLWKELVLFLRPRSQLRLSAD-LDALDLQGFRLDRDLA--- 333
Cdd:pfam10486 267 -----GDASDGMLQTLPLPTAkcY-TYHWEKDnfdvlNEILEKESDLDSPVDSEDEEEEDeVDFDEEEDLEEDDELPerd 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   334 -------RVSTDSGIERD----------------LPLGSD-------ELPDPSSSEMERAALQRKGGIKK---------- 373
Cdd:pfam10486 341 slahrasTFSTASSLSKDsmfstlslssssltpsVSSLSSgvdsdycEDSDESSSSSPRAEKPREKSKKKsrsrlgqriy 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   374 RVWPP-------------DF----------------------FMPGSWDGPPGLHRRTG----RP--SGDGEllpgvSRV 412
Cdd:pfam10486 421 RLFKPksplvlrrakslgNPeakdlipvrskrsnslpqqvllRSLEPPPLPPLSTLRHVcvrrRPilSCDED-----TKA 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   413 HTARVLVLGDDRMLGRLAQAYYRLRKRETKkfCltPRLS----LQLYYIPV-------------------------LAPQ 463
Cdd:pfam10486 496 TTLRVVVFGADRIAGKVARAYSNLRRKEST--C--PRLTrafkLQFYFVPVkrsssaspggssspllqspsplgssLSSA 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   464 DPEASRKPE-LGELASFLGRVDPWYESTV--------NTLCPAILKlAEMPPYlDTSRTVDPFILDVITYYVRMGTQPIY 534
Cdd:pfam10486 572 DLNLSGVEDsTNDIAHYLGMLDPWYERNVlsllnlpsDVLCQQTSK-TESESL-ESSEERLPILADMVLYYCRHAARPVL 649
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   535 FQLYKVKIfTSLSHDPTEDIFLTELK---------VKIQDSKSPKEGSSPRRrgaaEGTGAELSMCYQKALLSHRPREVT 605
Cdd:pfam10486 650 LQLYQAEL-TLAGGERRTEVFIHSLElghtagtraIKAMGAASKRFGIDGDR----EAVPLTLEIVYNKVAISGRSQWSN 724
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   606 VSLRATGLVL-KAipagdtevsgffhCTSPNA-ASATDcsCLHVSVTEVVKSSN-LAGRSFTT--STNTFRTSSIQVQSQ 680
Cdd:pfam10486 725 EEKVCTSVNLiKA-------------CKNPEElDSKME--CLQLTMTEVLKRQNsKSKKGYNQqiSTSEVKVDKVQVIGA 789
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52138727   681 DQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALnSHGQETEKNMAKPNSLLMPINTFSG 749
Cdd:pfam10486 790 NNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPL-SSGQVQPLQPTFCSLLCLPITTFSG 857
 
Name Accession Description Interval E-value
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
34-749 3.09e-46

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 431309  Cd Length: 860  Bit Score: 177.19  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727    34 MWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPED--LYHRAYTFCTRLLTLPAP 111
Cdd:pfam10486  35 MNRWSLEELVKRDPHNFLILLQQILRKTREVQEQCQYELVAPLALLFSSTLLQTPYCPPDsdLLEEAAEVFHRFLTWPEP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   112 YSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSAsvcsalllEIQAAQEQ-QTPEACMR 190
Cdd:pfam10486 115 YCSVCRELLSFIQQELKAPGISFQRLVREEQGLPTSSHCSKTITVLLLNPDEVPA--------EFLSVAEQlSNAEHSQR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   191 HV----VSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPS--RLGHLEKMEEIYCSLLGPATT 264
Cdd:pfam10486 187 DTyitlIKHAFQATLGTKYDLQSIHKALQSKTVEELEQIFSSVTEALETAAAMSDPLkaREHLIQGLERLREKLGIPASN 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   265 rrhcvGDLLQDRLPSIPLPSP--YiTFHLWTD-----QEQLWKELVLFLRPRSQLRLSAD-LDALDLQGFRLDRDLA--- 333
Cdd:pfam10486 267 -----GDASDGMLQTLPLPTAkcY-TYHWEKDnfdvlNEILEKESDLDSPVDSEDEEEEDeVDFDEEEDLEEDDELPerd 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   334 -------RVSTDSGIERD----------------LPLGSD-------ELPDPSSSEMERAALQRKGGIKK---------- 373
Cdd:pfam10486 341 slahrasTFSTASSLSKDsmfstlslssssltpsVSSLSSgvdsdycEDSDESSSSSPRAEKPREKSKKKsrsrlgqriy 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   374 RVWPP-------------DF----------------------FMPGSWDGPPGLHRRTG----RP--SGDGEllpgvSRV 412
Cdd:pfam10486 421 RLFKPksplvlrrakslgNPeakdlipvrskrsnslpqqvllRSLEPPPLPPLSTLRHVcvrrRPilSCDED-----TKA 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   413 HTARVLVLGDDRMLGRLAQAYYRLRKRETKkfCltPRLS----LQLYYIPV-------------------------LAPQ 463
Cdd:pfam10486 496 TTLRVVVFGADRIAGKVARAYSNLRRKEST--C--PRLTrafkLQFYFVPVkrsssaspggssspllqspsplgssLSSA 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   464 DPEASRKPE-LGELASFLGRVDPWYESTV--------NTLCPAILKlAEMPPYlDTSRTVDPFILDVITYYVRMGTQPIY 534
Cdd:pfam10486 572 DLNLSGVEDsTNDIAHYLGMLDPWYERNVlsllnlpsDVLCQQTSK-TESESL-ESSEERLPILADMVLYYCRHAARPVL 649
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   535 FQLYKVKIfTSLSHDPTEDIFLTELK---------VKIQDSKSPKEGSSPRRrgaaEGTGAELSMCYQKALLSHRPREVT 605
Cdd:pfam10486 650 LQLYQAEL-TLAGGERRTEVFIHSLElghtagtraIKAMGAASKRFGIDGDR----EAVPLTLEIVYNKVAISGRSQWSN 724
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   606 VSLRATGLVL-KAipagdtevsgffhCTSPNA-ASATDcsCLHVSVTEVVKSSN-LAGRSFTT--STNTFRTSSIQVQSQ 680
Cdd:pfam10486 725 EEKVCTSVNLiKA-------------CKNPEElDSKME--CLQLTMTEVLKRQNsKSKKGYNQqiSTSEVKVDKVQVIGA 789
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52138727   681 DQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALnSHGQETEKNMAKPNSLLMPINTFSG 749
Cdd:pfam10486 790 NNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPL-SSGQVQPLQPTFCSLLCLPITTFSG 857
 
Name Accession Description Interval E-value
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
34-749 3.09e-46

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 431309  Cd Length: 860  Bit Score: 177.19  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727    34 MWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPED--LYHRAYTFCTRLLTLPAP 111
Cdd:pfam10486  35 MNRWSLEELVKRDPHNFLILLQQILRKTREVQEQCQYELVAPLALLFSSTLLQTPYCPPDsdLLEEAAEVFHRFLTWPEP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   112 YSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSAsvcsalllEIQAAQEQ-QTPEACMR 190
Cdd:pfam10486 115 YCSVCRELLSFIQQELKAPGISFQRLVREEQGLPTSSHCSKTITVLLLNPDEVPA--------EFLSVAEQlSNAEHSQR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   191 HV----VSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPS--RLGHLEKMEEIYCSLLGPATT 264
Cdd:pfam10486 187 DTyitlIKHAFQATLGTKYDLQSIHKALQSKTVEELEQIFSSVTEALETAAAMSDPLkaREHLIQGLERLREKLGIPASN 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   265 rrhcvGDLLQDRLPSIPLPSP--YiTFHLWTD-----QEQLWKELVLFLRPRSQLRLSAD-LDALDLQGFRLDRDLA--- 333
Cdd:pfam10486 267 -----GDASDGMLQTLPLPTAkcY-TYHWEKDnfdvlNEILEKESDLDSPVDSEDEEEEDeVDFDEEEDLEEDDELPerd 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   334 -------RVSTDSGIERD----------------LPLGSD-------ELPDPSSSEMERAALQRKGGIKK---------- 373
Cdd:pfam10486 341 slahrasTFSTASSLSKDsmfstlslssssltpsVSSLSSgvdsdycEDSDESSSSSPRAEKPREKSKKKsrsrlgqriy 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   374 RVWPP-------------DF----------------------FMPGSWDGPPGLHRRTG----RP--SGDGEllpgvSRV 412
Cdd:pfam10486 421 RLFKPksplvlrrakslgNPeakdlipvrskrsnslpqqvllRSLEPPPLPPLSTLRHVcvrrRPilSCDED-----TKA 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   413 HTARVLVLGDDRMLGRLAQAYYRLRKRETKkfCltPRLS----LQLYYIPV-------------------------LAPQ 463
Cdd:pfam10486 496 TTLRVVVFGADRIAGKVARAYSNLRRKEST--C--PRLTrafkLQFYFVPVkrsssaspggssspllqspsplgssLSSA 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   464 DPEASRKPE-LGELASFLGRVDPWYESTV--------NTLCPAILKlAEMPPYlDTSRTVDPFILDVITYYVRMGTQPIY 534
Cdd:pfam10486 572 DLNLSGVEDsTNDIAHYLGMLDPWYERNVlsllnlpsDVLCQQTSK-TESESL-ESSEERLPILADMVLYYCRHAARPVL 649
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   535 FQLYKVKIfTSLSHDPTEDIFLTELK---------VKIQDSKSPKEGSSPRRrgaaEGTGAELSMCYQKALLSHRPREVT 605
Cdd:pfam10486 650 LQLYQAEL-TLAGGERRTEVFIHSLElghtagtraIKAMGAASKRFGIDGDR----EAVPLTLEIVYNKVAISGRSQWSN 724
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138727   606 VSLRATGLVL-KAipagdtevsgffhCTSPNA-ASATDcsCLHVSVTEVVKSSN-LAGRSFTT--STNTFRTSSIQVQSQ 680
Cdd:pfam10486 725 EEKVCTSVNLiKA-------------CKNPEElDSKME--CLQLTMTEVLKRQNsKSKKGYNQqiSTSEVKVDKVQVIGA 789
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52138727   681 DQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALnSHGQETEKNMAKPNSLLMPINTFSG 749
Cdd:pfam10486 790 NNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPL-SSGQVQPLQPTFCSLLCLPITTFSG 857
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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