NCBI Conserved Domain Search

Conserved domains on [gi|52353953|ref|NP_001004490|]

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olfactory receptor 2AG2 [Homo sapiens]

Protein Classification

olfactory receptor family 2 protein( domain architecture ID 11607568)

olfactory receptor family 2 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

5.83e-153

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 429.28 E-value: 5.83e-153

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

5.83e-153

Pssm-ID: 320543 Cd Length: 277 Bit Score: 429.28 E-value: 5.83e-153

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-305

2.01e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 147.65 E-value: 2.01e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953    31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   191 DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH--SP 268
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52353953   269 KQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-301

5.83e-153

Pssm-ID: 320543 Cd Length: 277 Bit Score: 429.28 E-value: 5.83e-153

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-301

3.36e-128

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 366.78 E-value: 3.36e-128

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-294

1.38e-117

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 339.46 E-value: 1.38e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-294

3.89e-113

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 328.47 E-value: 3.89e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-294

2.48e-112

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 326.39 E-value: 2.48e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15230 242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-301

7.72e-108

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 315.32 E-value: 7.72e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

12-305

9.35e-107

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 313.15 E-value: 9.35e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  12 FILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENT 91
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  92 ISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVS 171
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 172 WEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF 251
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 252 YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-301

7.01e-105

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 307.65 E-value: 7.01e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15231 242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-303

5.66e-104

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 305.39 E-value: 5.66e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-294

1.08e-102

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 301.84 E-value: 1.08e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMyTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-294

1.87e-102

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 301.29 E-value: 1.87e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYAT-FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd15227   1 ILHFVlFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15227  81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15227 161 LKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15227 241 DSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-301

7.63e-102

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 300.01 E-value: 7.63e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-294

7.68e-102

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 299.53 E-value: 7.68e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-297

9.60e-102

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 300.01 E-value: 9.60e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  12 FILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  92 ISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 172 WEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 252 YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-294

1.14e-100

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 296.70 E-value: 1.14e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-294

1.37e-98

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 291.47 E-value: 1.37e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-301

1.30e-97

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 289.11 E-value: 1.30e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15229 242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-301

1.78e-97

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 288.89 E-value: 1.78e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-303

2.75e-97

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 288.39 E-value: 2.75e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-305

3.52e-97

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 288.79 E-value: 3.52e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  12 FILVGIlndSGSPEL---LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRR 88
Cdd:cd15410   1 FILLGF---TDYPELqvpLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  89 ENTISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPF 168
Cdd:cd15410  78 DKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSF 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 169 CVSWEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVV 248
Cdd:cd15410 158 CGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAI 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 249 GMFYGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:cd15410 238 TIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-294

5.81e-97

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 287.07 E-value: 5.81e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15911 162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15911 242 TSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

27-303

1.20e-96

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 286.91 E-value: 1.20e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15411   3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15411  83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15411 243 SLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-294

1.91e-96

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 286.06 E-value: 1.91e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-303

6.42e-96

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 285.48 E-value: 6.42e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  12 FILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  92 ISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 172 WEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 252 YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-294

3.89e-95

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 282.72 E-value: 3.89e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

24-305

1.19e-94

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 281.95 E-value: 1.19e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  24 PEL---LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQ 100
Cdd:cd15406   6 PELqlpLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQ 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 101 MFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCE 180
Cdd:cd15406  86 LFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 181 IPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV 260
Cdd:cd15406 166 ILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYL 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52353953 261 LPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:cd15406 246 KPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-301

2.54e-94

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 280.83 E-value: 2.54e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-303

4.78e-93

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 277.71 E-value: 4.78e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15416 243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-303

6.27e-92

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 274.67 E-value: 6.27e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15409 242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-301

2.26e-91

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 273.15 E-value: 2.26e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-305

3.84e-91

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 273.20 E-value: 3.84e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  12 FILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  92 ISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVS 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 172 WEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 252 YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-303

6.47e-91

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 272.27 E-value: 6.47e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-303

1.76e-90

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 271.22 E-value: 1.76e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15407 243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-294

3.40e-90

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 269.92 E-value: 3.40e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15224 242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-294

6.90e-88

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 264.07 E-value: 6.90e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELII-----YVTGVTFLLLpisaiVASYTLVLFTVlRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV 260
Cdd:cd15226 162 KLACTDTYVLELMVvansgLISLVCFLLL-----LISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYV 235

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 261 LPSSFHSpkQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15226 236 WPFSTFP--VDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-301

4.05e-87

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 262.51 E-value: 4.05e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

26-304

7.63e-86

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 259.33 E-value: 7.63e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRV 304
Cdd:cd15418 243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-307

1.28e-85

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 258.90 E-value: 1.28e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVLGK 307
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

27-303

1.90e-85

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 258.11 E-value: 1.90e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15415   3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15415  83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15415 243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-294

3.55e-85

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 257.24 E-value: 3.55e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-294

9.01e-85

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 256.25 E-value: 9.01e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

27-294

9.40e-85

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 256.08 E-value: 9.40e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVL-FTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIIsFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-303

1.07e-84

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 256.17 E-value: 1.07e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15412 242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-301

1.31e-84

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 255.87 E-value: 1.31e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

26-294

2.45e-84

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 254.83 E-value: 2.45e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTvLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSpkQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15939 241 FP--IDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-301

1.57e-82

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 250.86 E-value: 1.57e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15432  82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15432 162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15432 242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-301

2.16e-80

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 245.03 E-value: 2.16e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15228   2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYvTGVTFLLLP-ISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15228 162 KLACADTSIAETVSF-TNVGLVPLTcFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 265 fhSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15228 241 --SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-301

4.71e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 244.25 E-value: 4.71e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-301

3.04e-76

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 234.65 E-value: 3.04e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRE-NTISFGGCALQMFLA 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 265 fhSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15916 242 --KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-294

4.75e-76

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 233.87 E-value: 4.75e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMpSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSf 265
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST- 239

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 hSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15940 240 -SFSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-301

9.82e-76

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 233.51 E-value: 9.82e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-301

6.73e-75

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 231.22 E-value: 6.73e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSS 264
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-301

1.31e-74

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 230.40 E-value: 1.31e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52353953 267 SpkQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15942 243 P--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-294

9.70e-74

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 228.02 E-value: 9.70e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-301

1.88e-73

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 227.75 E-value: 1.88e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-294

7.39e-72

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 222.98 E-value: 7.39e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELII-----YVTGVTFLLLPIsaivaSYTLVLFTvLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV 260
Cdd:cd15936 162 KLACTDTFLLELLMvsnsgLVTLLIFFILLI-----SYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYA 235

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 261 LPssFHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15936 236 RP--FQTFPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-301

6.30e-70

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 218.56 E-value: 6.30e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLH-MPMYLLLGQLSLMDLLFTSVVTPKALADFLRRE-NTISFGGCALQMFL 103
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPP 183
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPS 263
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 264 SfhSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15941 242 S--SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-294

2.86e-68

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 213.97 E-value: 2.86e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15938   2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLftvLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPssF 265
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARP--F 236

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15938 237 STFPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-294

1.28e-64

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 204.59 E-value: 1.28e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTlVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPssF 265
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYA-FLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--F 238

                       250       260
                ....*....|....*....|....*....
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15937 239 RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-294

3.29e-64

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 203.46 E-value: 3.29e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARL-HMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTvLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPss 264
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRP-- 238

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15935 239 FSSSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-301

2.22e-62

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 199.06 E-value: 2.22e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLL 185
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV--LPS 263
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFG 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 264 SFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15223 242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-297

1.43e-55

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 181.72 E-value: 1.43e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYelIIYVTGVTFLLLPISA--IVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV-------L 261
Cdd:cd15221 167 DITVN--IWYGLTVALLTVGLDVvlIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthrfgrhI 244

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 262 PSSFHSpkqdnIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15221 245 PRHVHI-----LLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

31-297

2.28e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 180.95 E-value: 2.28e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPS-SFHSPK 269
Cdd:cd15917 167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRfGHHVPP 246

                       250       260
                ....*....|....*....|....*....
gi 52353953 270 QDNII-SVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15917 247 HVHILlANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-297

1.11e-53

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 176.84 E-value: 1.11e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTsRYELIIYVTGVTFLLLPISAIVA-SYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATF-MYVLPSSFHSP 268
Cdd:cd15950 167 DP-RPSSLYSITGSTLVVGTDSAFIAvSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQGVP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 269 KQDNI-ISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15950 246 PHTQVlLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-297

1.86e-50

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 168.33 E-value: 1.86e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTsRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV-------LPS 263
Cdd:cd15952 167 SI-RINIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrfghnIPR 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 264 SFHSpkqdnIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15952 246 YIHI-----LLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-297

2.18e-49

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 165.51 E-value: 2.18e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMS-PRVCWIMVATSwILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLAC 189
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGL-IRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 190 ADTSRYelIIYVTGVTFLL--LPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFHS 267
Cdd:cd15953 166 GDTTIN--RIYGLVVALLVvgLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQG 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 52353953 268 --PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15953 244 iaPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-297

3.92e-49

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 164.83 E-value: 3.92e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DT---SRYELI--IYVTGVTFLLlpisaIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSF 265
Cdd:cd15951 167 DTrvsRAYGLSvaFLVGGLDVIF-----IAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 266 HS-PKQDNI-ISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15951 242 HNvPPHVHIlIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

31-297

5.27e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 151.50 E-value: 5.27e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMT-LMSPRVCWIMVA-----TSWILASLIAIGhtmytmHLPFCVSWEIRHLLCEIPPL 184
Cdd:cd15222  87 ESSVLLAMAFDRFVAICNPLRYASiLTNSRIAKIGLAivlrsVLLLLPLPFLLK------RLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADT---SRYEL--IIYVTGVTFLLlpisaIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFY----GAA 255
Cdd:cd15222 161 MKLACSDTrvnSIYGLfvVLSTMGLDSLL-----ILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYvpmiGLS 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52353953 256 T---FMYVLPSSFHSpkqdnIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15222 236 MvhrFGKHASPLVHV-----LMANVYLLVPPVLNPIIYSVKTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-305

2.01e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 147.65 E-value: 2.01e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953    31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   191 DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH--SP 268
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52353953   269 KQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

31-297

4.10e-41

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 144.24 E-value: 4.10e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVcwimVATSWILASLIAIGHTMY----TMHLPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEV----VAKAGLLLALRGVAIVIPfpllVCRLSFCASHTIAHTYCEHMAVVK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15956 163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGH 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 52353953 267 S--PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15956 243 SvpSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-297

2.60e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 139.52 E-value: 2.60e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILAS-LIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLAC 189
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVvLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 190 ADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH--S 267
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHhvA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 268 PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

31-297

6.09e-39

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 138.50 E-value: 6.09e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAAtfmyVLPSSFH---- 266
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPV----VLSSTMHrfar 243

                       250       260       270
                ....*....|....*....|....*....|...
gi 52353953 267 --SPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15948 244 hvAPHVHILLANFYLLFPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

42-290

1.35e-37

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 134.35 E-value: 1.35e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953    42 NGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTMGSAEDLLLAFMAY 120
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   121 DRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWeirHLLCEIPPLLKLACadtsRYELIIY 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK----PVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953   201 VTGVTFlLLPISAIVASYTLVLFTVLRMPSNEGR-------KKALVTCSSHLIVVGMFYGAATFMYVLPSSFHSPKQDNI 273
Cdd:pfam00001 155 ISVLGF-LLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233

                         250       260
                  ....*....|....*....|...
gi 52353953   274 ISVFYTI------VTPALNPLIY 290
Cdd:pfam00001 234 LDKALSVtlwlayVNSCLNPIIY 256

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-297

2.10e-35

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 129.51 E-value: 2.10e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  10 SGFILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRE 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  90 NTISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 170 VSWEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVG 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52353953 250 MFYGAATFMYVLPSSFH--SPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15949 242 AFYVPIAVSSLIHRFGQnvPPPTHILLANFYLLIPPMLNPIVYGVRTKQI 291

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-297

9.48e-34

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 124.94 E-value: 9.48e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV---LPSSFHS 267
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahrFGGHHIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 268 PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

29-294

5.62e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 98.51 E-value: 5.62e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMG 108
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 109 SAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFCVSWEIRHllceIPPLLKLA 188
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDY----GGYCCCCL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 189 CADTSRYELIIYVTG-VTFLLLPISAIVASYTLVLFTVLR--------------MPSNEGRKKALVTCsshLIVVGMF-- 251
Cdd:cd00637 151 CWPDLTLSKAYTIFLfVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVVFll 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 52353953 252 ----YGAATFMYVL-PSSFHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd00637 228 cwlpYFILLLLDVFgPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-301

2.77e-19

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 85.31 E-value: 2.77e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWeirHLLCEIPPLL 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL---------PPLVGW---RDETQPSVVD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFllLPISAIVASYTLVLFTVLRmpsnegRKKALVTCSshlIVVGMFYGA-ATFMYVLPSS 264
Cdd:cd14967 149 CECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLLCwLPFFIIYLVS 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 52353953 265 FHSPKqDNIISVFYTIVT------PALNPLIYSLRNKEVMRAL 301
Cdd:cd14967 218 AFCPP-DCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-166

2.24e-14

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 71.89 E-value: 2.24e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGG--CALQMFL 103
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSV--ETCWYFGDlfCKIHSSF 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHL 166
Cdd:cd15314  80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNI 142

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

25-301

7.23e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 70.70 E-value: 7.23e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLA 104
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYmTLMSPRVCWIMVATSWILAsliaightmytmhlpfcvsweirhLLCEIPPL 184
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYG------------------------LFWALPPL 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 L----------KLACA-----DTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSH----- 244
Cdd:cd14969 136 FgwssyvpeggGTSCSvdwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaek 215

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 245 ------LIVVGMFYGAATfMYVLPSSFHSPKQDNIISVfYTIVTPAL--------NPLIYSLRNKEVMRAL 301
Cdd:cd14969 216 kvakmvLVMIVAFLIAWT-PYAVVSLYVSFGGESTIPP-LLATIPALfaksstiyNPIIYVFMNKQFRRAL 284

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-158

3.50e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 68.35 E-value: 3.50e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkalADFLRRENTISFGG---CALQMF 102
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP---FSMIRSIETCWYFGdtfCKLHSS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 103 LALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIG 158
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

31-301

4.09e-13

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 68.09 E-value: 4.09e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLL---------FTSVVTPKALADFLRRentisfggcALQM 101
Cdd:cd14972   5 AIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafvftfLSVLLVSLTPSPATWL---------LRKG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 102 FLALTMGSAEDLLLAfMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFCVSWEIrhlLCEI 181
Cdd:cd14972  76 SLVLSLLASAYSLLA-IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCV---LCDQ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 182 PPLLKLACADTSRYeliiYVTGVTFLLLPISAIVASYTLVLFTVLRM--------------PSNEGRKKALVTcsshLIV 247
Cdd:cd14972 144 ESCSPLGPGLPKSY----LVLILVFFFIALVIIVFLYVRIFWCLWRHanaiaarqeaavpaQPSTSRKLAKTV----VIV 215

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 248 VGMF-YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPAL-----NPLIYSLRNKEVMRAL 301
Cdd:cd14972 216 LGVFlVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

26-292

6.71e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 65.07 E-value: 6.71e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFL-RRENTISFGGCALQMFLA 104
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI--GHTMYTMHLPFCVSWEIRH-LLCEI 181
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIpiLFLMGIQYLNGPLPGPVPDsAVCTL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 182 PPllklacaDTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMP------------------SNEGRK---KALVT 240
Cdd:cd14979 162 VV-------DRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRnikkgtraqgtrnvelslSQQARRqvvKMLGA 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52353953 241 CSSHLIVVGMFYGAATFMYvlpssFHSPKQDNIISVFYTIVTP----------ALNPLIYSL 292
Cdd:cd14979 235 VVIAFFVCWLPFHAQRLMF-----SYASKEDTFLFDFYQYLYPisgilfylssAINPILYNL 291

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

26-301

1.10e-11

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 64.20 E-value: 1.10e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILY-MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaLADFLRRENTISFGGCALQMFLA 104
Cdd:cd14968   1 AVYIVLEVLIaVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFcVSWEIRHLLCEIPPL 184
Cdd:cd14968  79 LVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPM-FGWNNGAPLESGCGE 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTS--RYELIIYVTGVTFLLLPISAIVASYTLVlFTVLRmpsNEGRKKALVTCSSHL---------------IV 247
Cdd:cd14968 150 GGIQCLFEEviPMDYMVYFNFFACVLVPLLIMLVIYLRI-FRVIR---KQLRQIESLLRSRRSrstlqkevkaakslaII 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 248 VGMF-------YGAATFMYVLPSSfHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd14968 226 LFLFalcwlplHIINCITLFCPEC-KVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

29-227

5.51e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 61.87 E-value: 5.51e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSV-VTPKALADFlrrenTISFGG----CALQMFL 103
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDI-----TYRFYGgdllCRLVKYL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLmSPRVCWIMVATSWILASLIAIGHtMYTMHLPFCVSWEIRHLLCEIPP 183
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQ-LFIFSYQEVGSGVYDCWATFEPP 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 184 llklacadtsrYELIIYVTGVTFL--LLPISAIVASYTLVLFTVLR 227
Cdd:cd15196 158 -----------WGLRAYITWFTVAvfVVPLIILAFCYGRICYVVWR 192

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-157

3.01e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 59.65 E-value: 3.01e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGGCALQMFLAL 105
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELT--GRWILGQVLCDIWISL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 106 --TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15064  80 dvTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133

7tmA_GPR83

cd15389

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...

26-290

4.63e-10

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.

Pssm-ID: 320511 [Multi-domain] Cd Length: 285 Bit Score: 59.27 E-value: 4.63e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEipPLL 185
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCL--PSF 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYelIIYVTGVTFLLLPISAIVASYTLV------------LFTVLRMPSNEGRKKALvtcsSHLIVVGMFYG 253
Cdd:cd15389 158 PEPSDLFWKY--LDLATFILQYVLPLLIIGVAYTRVakklwlrnaigdVTTEQYVAQRRKKKKTI----KMLMLVVLLFA 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 52353953 254 AATF---MYVLPSSFHSPKQDNIISVFY---TIVTPALNPLIY 290
Cdd:cd15389 232 ICWLplnCYHVLLSSHPIRSNSALFFAFhwlAMSSTCYNPFIY 274

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

26-300

6.14e-10

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 58.91 E-value: 6.14e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRrENTISFGGCALQMFLAL 105
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMT-GGYWLFGRDWCDVWHSF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 -TMGSAEDLL-LAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAightmytmhLPFCVSWEIrhllCEIPP 183
Cdd:cd15067  80 dVLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS---------FPAIAWWRA----VDPGP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LLKLACADTSRYELIIYVTGVTFlLLPISAIVASYtlvlFTVLRMPSNEgrKKALVTCSshlIVVGMFYGAAT--FMYVL 261
Cdd:cd15067 147 SPPNQCLFTDDSGYLIFSSCVSF-YIPLVVMLFTY----YRIYRAAAKE--QKAAKTLG---IVMGVFILCWLpfFVTNI 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52353953 262 PSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNKEVMRA 300
Cdd:cd15067 217 LIGFCPSNCVSNPDILFPLVTwlgyinSGMNPIIYACSSRDFRRA 261

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

26-163

6.50e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 59.00 E-value: 6.50e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALadfLRRENTISFGG---CALQMF 102
Cdd:cd15317   2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSM---IRTVETCWYFGdlfCKFHTG 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 103 LALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGhTMYT 163
Cdd:cd15317  79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFG-LIYT 138

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-157

3.00e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 56.90 E-value: 3.00e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREntISFGGCALQMFLA- 104
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGY--WPFGEILCDVWISf 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 105 -LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15329  80 dVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

29-167

6.69e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 56.10 E-value: 6.69e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHM--PMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGGCALQMFLALT 106
Cdd:cd14981   5 APPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYAS--NFEWDGGQPLCDYFGFM 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953 107 M---GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTM----YTMHLP 167
Cdd:cd14981  83 MsffGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLglgsYVLQYP 150

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

33-227

7.16e-09

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 55.80 E-value: 7.16e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15083   9 IIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI----GHTMYTM-HLPFCVSWEIrhllceippllkL 187
Cdd:cd15083  89 NTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLpplfGWSRYVLeGLLTSCSFDY------------L 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 52353953 188 ACADTSRYELIIYVTGVtfLLLPISAIVASYTLVLFTVLR 227
Cdd:cd15083 157 SRDDANRSYVICLLIFG--FVLPLLIIIYCYSFIFRAVRR 194

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

30-295

7.43e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 55.68 E-value: 7.43e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILY----MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd14993   2 VLIVLYvvvfLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHL-LCEIPPL 184
Cdd:cd14993  82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIML---------PLLVVYELEEIiSSEPGTI 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACAD--TSRYELIIYVTGVTFLL--LPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSH------------LIVV 248
Cdd:cd14993 153 TIYICTEdwPSPELRKAYNVALFVVLyvLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVV 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953 249 GMFYGA-----ATFMYVLPSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNK 295
Cdd:cd14993 233 VLFALSwlpyyVLSILLDFGPLSSEESDENFLLILPFAQllgysnSAINPIIYCFMSK 290

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

33-301

1.20e-08

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 54.92 E-value: 1.20e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaLADFLRRENTISFGGCALQMFLALTM--GSA 110
Cdd:cd15327   9 IFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP--FSATLEVLGFWAFGRVFCDIWAAVDVlcCTA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMytmhlpfcvSWEirhllcEIPPLLKLACA 190
Cdd:cd15327  87 SILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL---------GWK------EPPPPDESICS 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRMPSNEGRKKALVtcsshlIVVGMFYGA-ATFMYVLPSSFHSPK 269
Cdd:cd15327 152 ITEEPGYALFSSLFSF-YLPLMVILVMYFRVYVVALKFSREKKAAKTLA------IVVGVFILCwFPFFFVLPLGSFFPA 224

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52353953 270 QDNIISVFYTI-----VTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15327 225 LKPSEMVFKVIfwlgyFNSCVNPIIYPCSSKEFKRAF 261

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

26-157

1.50e-08

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 54.57 E-value: 1.50e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15334   2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15334  82 TCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM 133

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-300

3.08e-08

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 53.52 E-value: 3.08e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGG--CALQMFL 103
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL--GYWPLGShlCDFWISL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIaightmytMHLP-FCVSWEIRHLLCEip 182
Cdd:cd15061  79 DVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLI--------TSPPlVGPSWHGRRGLGS-- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 183 pllklaCADTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRmpsnegRKKALVTCSshlIVVGMF---YGAATFMY 259
Cdd:cd15061 149 ------CYYTYDKGYRIYSSMGSF-FLPLLLMLFVYLRIFRVIAK------ERKTAKTLA---IVVGCFivcWLPFFIMY 212

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 260 VLPSSFHSPkqdnIISVFYTIVT------PALNPLIYSLRNKEVMRA 300
Cdd:cd15061 213 LIEPFCDCQ----FSEALSTAFTwlgyfnSVINPFIYAFYNKDFRRA 255

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

29-227

5.88e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 53.15 E-value: 5.88e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSV-VTPKALADFLRRENTISFGgCALQMFLALTM 107
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFtVLTQIIWEATGEWVAGDVL-CRIVKYLQVVG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAI-----------GHTMYTmhlpfCVSWEIrh 176
Cdd:cd14986  84 LFASTYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIpqlvifverelGDGVHQ-----CWSSFY-- 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 52353953 177 llceippllklacadtSRYELIIYVTGVTFLLL--PISAIVASYTLVLFTVLR 227
Cdd:cd14986 155 ----------------TPWQRKVYITWLATYVFviPLIILSYCYGRILRTIWI 191

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

31-157

7.30e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 52.74 E-value: 7.30e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15065   6 LSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15065  86 SILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISF 132

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

33-156

1.75e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 51.68 E-value: 1.75e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15058   9 LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15058  89 ETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVS 132

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

39-158

2.03e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 51.59 E-value: 2.03e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  39 LTSNGLLLLAITIE--ARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGG--CALQMFLALTMGSAEDLL 114
Cdd:cd15312  13 LTVFGNLMVIISIShfKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV--ESCWYFGDlfCKIHSSLDMMLSTTSIFH 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 115 LAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIG 158
Cdd:cd15312  91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFG 134

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

26-157

2.10e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 51.08 E-value: 2.10e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15335   2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISI 133

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

34-157

3.22e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 50.75 E-value: 3.22e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  34 LYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDL 113
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 114 LLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15330  90 HLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI 133

7tmA_NTSR

cd15130

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

63-214

3.24e-07

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320258 [Multi-domain] Cd Length: 281 Bit Score: 50.72 E-value: 3.24e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  63 LGQLSLMDLLFTSVVTPKALADFLRRENTISFG--GCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRV 140
Cdd:cd15130  42 LGSLALSDLLILLLAMPVELYNFIWVHHPWAFGdaGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSR 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 141 CWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHLLCEIPPLLKLACA---DTSRYELIIYVTGVTFLLLPISAI 214
Cdd:cd15130 122 TKKFISAIWLASALLAI---------PMLFTMGLQNESDDGTHPGGLVCTpivDTATLKVVIQVNTFMSFLFPMLVT 189

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

32-157

3.64e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 50.95 E-value: 3.64e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILyMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDL---LFTsvVTPKALADFLRRENTISFGGCALQMFLALTMG 108
Cdd:cd15386   9 AIL-VVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLvvaLFQ--VLPQLIWEITYRFQGPDLLCRAVKYLQVLSMF 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 52353953 109 SAEDLLLAfMAYDRYVAICHPLKymTLMSP-RVCWIMVATSWILASLIAI 157
Cdd:cd15386  86 ASTYMLIM-MTVDRYIAVCHPLR--TLQQPsRQAYLMIGATWLLSCILSL 132

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

26-157

4.31e-07

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 50.55 E-value: 4.31e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaladFLRRENTIS--FGG---CALQ 100
Cdd:cd15205   2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIP-----FTLLQNISSnwLGGafmCKMV 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 101 MFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15205  77 PFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGS 133

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-296

4.52e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 50.34 E-value: 4.52e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd14982   2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHLLCEIPPLL 185
Cdd:cd14982  82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV---------PLLLLRSTIAKENNSTTCF 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEG----RKKALVTCSSHLIV-VGMF--YGAATFM 258
Cdd:cd14982 153 EFLSEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVfLVCFlpYHVTRIL 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 259 YVL--PSSFHSPKQDNIISVFYTI------VTPALNPLIYSLRNKE 296
Cdd:cd14982 233 YLLvrLSFIADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKT 278

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

36-301

5.65e-07

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 49.89 E-value: 5.65e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  36 MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALAdfLRRENTISFGG--CALQMFLALTMGSAEDL 113
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSAT--LEILGYWVFGRifCDIWAAVDVLCCTASIL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 114 LLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMytmhlpfcvSWEirhllcEIPPLLKLACADTS 193
Cdd:cd15326  90 SLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL---------GWK------EPAPPDDKVCEITE 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 194 RYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRMpSNEgrKKALVTCSshlIVVGMFYGA-ATFMYVLP-----SSFHS 267
Cdd:cd15326 155 EPFYALFSSLGSF-YIPLIVILVMYCRVYIVALKF-SRE--KKAAKTLG---IVVGMFILCwLPFFIALPlgslfSHLKP 227

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 268 PKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15326 228 PETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

32-158

8.21e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 49.63 E-value: 8.21e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVT-P-KALADFLRRentISFG--GCALQMFLALTM 107
Cdd:cd15337   8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPlKTISSFNKK---WIWGkvACELYGFAGGIF 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIG 158
Cdd:cd15337  85 GFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP 135

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

34-300

1.13e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 49.02 E-value: 1.13e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  34 LYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALAdfLRRENTISFGGCALQMFLALTM--GSAE 111
Cdd:cd15062  10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSAT--LEVLGYWAFGRIFCDVWAAVDVlcCTAS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 112 DLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMytmhlpfcvSWEIRhllceIPPLLKlACAD 191
Cdd:cd15062  88 IMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL---------GWKEP-----APADEQ-ACGV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 192 TSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRMPSnegRKKALVTCSshlIVVGMFYGA-ATFMYVLP-----SSF 265
Cdd:cd15062 153 NEEPGYVLFSSLGSF-YLPLAIILVMYCRVYVVAFKFSR---EKKAAKTLG---IVVGAFVLCwFPFFVVLPlgslfSTL 225

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52353953 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRA 300
Cdd:cd15062 226 KPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRA 260

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

26-301

1.47e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 48.87 E-value: 1.47e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15051   2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFCVSWEIRHLLCEippll 185
Cdd:cd15051  82 MLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSF--------LPIHLGWNTPDGRVQ----- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYEL----IIYVTGVTFlLLPISAIVASYTLVLFTV---------LRMPSNEGRKKALVTCSSH------LI 246
Cdd:cd15051 149 NGDTPNQCRFELnppyVLLVAIGTF-YLPLLIMCGVYLRIFRIAreqakrinaLTPASTANSSKSAATAREHkatvtlAA 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 247 VVGMFYgAATFMYVLPSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNKEVMRAL 301
Cdd:cd15051 228 VLGAFI-ICWFPYFTYFTYRGLCGDNINETALSVVLwlgyanSALNPILYAFLNRDFRRAF 287

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

63-229

1.60e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 48.69 E-value: 1.60e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  63 LGQLSLMDLLFTSVVTPKALADFLRRENTISFG--GCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRV 140
Cdd:cd15355  42 LASLALSDLLILLLAMPVELYNFIWVHHPWAFGdaACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSR 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 141 CWIMVATSWILASLIAIgHTMYTMHLPFCVSWEIRHLLCEippllklACADTSRYELIIYVTGVTFLLLPISAIVASYTL 220
Cdd:cd15355 122 TKKFISAIWLASALLAI-PMLFTMGEQNRSGTHPGGLICT-------PIVDTSTLKVVIQVNAFLSFLFPMLVISVLNTL 193


                ....*....
gi 52353953 221 VLFTVLRMP 229
Cdd:cd15355 194 IANQLTVMV 202

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

26-168

1.67e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 48.58 E-value: 1.67e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALAdFLRRENTISFGG--CALQMFL 103
Cdd:cd15394   2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLA-YAFEPRGWVFGRfmCYFVFLM 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPF 168
Cdd:cd15394  81 QPVTVYVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF 143

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

32-300

1.69e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 48.46 E-value: 1.69e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKA-LADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15052   8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSiLTELFGGVWPLPLVLCLLWVTLDVLFCTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVsweirhllceippLLKLACA 190
Cdd:cd15052  88 SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNV-------------LNNGTCV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 DTSRYeLIIYVTGVTFlLLPISAIVASYTLvlftVLRMPSNEgRKKALVTCSSHLIVVGMF--YGAATFMYVLPSSFHSP 268
Cdd:cd15052 155 LFNPN-FVIYGSIVAF-FIPLLIMVVTYAL----TIRLLSNE-QKASKVLGIVFAVFVICWcpFFITNILTGLCEECNCR 227

                       250       260       270
                ....*....|....*....|....*....|....
gi 52353953 269 KQDNIISVFYTI--VTPALNPLIYSLRNKEVMRA 300
Cdd:cd15052 228 ISPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

26-163

2.24e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 48.32 E-value: 2.24e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGG--CALQMFL 103
Cdd:cd15316   2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSV--ESCWYFGEsfCTFHTCC 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILaSLIAIGHTMYT 163
Cdd:cd15316  80 DVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIF-SLTYSFSVFYT 138

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

26-244

2.47e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 48.37 E-value: 2.47e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTisFGGCALQMfLAL 105
Cdd:cd15203   2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWP--FGSILCKL-VPS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSA---EDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAightmytmhLPFCVSWEIRHLLCEIP 182
Cdd:cd15203  79 LQGVSifvSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLS---------LPLAIFQELSDVPIEIL 147

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 183 PLLKLACAD--TSRYELIIYVTGVTFL--LLPISAIVASYTLVLFtVLRMPSNEGRKKALVTCSSH 244
Cdd:cd15203 148 PYCGYFCTEswPSSSSRLIYTISVLVLqfVIPLLIISFCYFRISL-KLRKRVKKKRGKRTLSSRRR 212

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

26-157

2.91e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 47.87 E-value: 2.91e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGGCALQMFLA- 104
Cdd:cd15333   6 SLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTV--TGTWTLGQVVCDIWLSs 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 105 -LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15333  84 dITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISL 137

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

36-301

3.07e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 47.81 E-value: 3.07e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  36 MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDLLL 115
Cdd:cd15073  12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 116 AFMAYDRYVAICHPLKYMTlMSPRVCWIMVATSWILASLIAIghtmytmhLPF----CVSWEIRHLLCEIppllKLACAD 191
Cdd:cd15073  92 TVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAA--------MPLvgwaSYALDPTGATCTI----NWRKND 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 192 TSRYELIIYVTGVTFlLLPISAIVASY-----TLVLFTVLRMPSNEGRK---KALVTCSShLIVVGMFYGAAT--FMYVL 261
Cdd:cd15073 159 SSFVSYTMSVIVVNF-IVPLAVMFYCYynvsrFVKKVLASDCLESVNIDwtdQNDVTKMS-VIMIVMFLVAWSpySIVCL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 262 PSSFHSPKQdniISVFYTIVTPAL-------NPLIYSLRNKEVMRAL 301
Cdd:cd15073 237 WASFGEPKK---IPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

26-161

3.13e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 47.98 E-value: 3.13e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15959   2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTM 161
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIM 137

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-157

3.42e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 47.89 E-value: 3.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSV-VTPKALADFlrrenTISFGG----CALQMFL 103
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFqVLPQLIWDI-----TFRFYGpdflCRLVKYL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVcwiMVATSWILASLIAI 157
Cdd:cd15387  80 QVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRV---YVLFSWLLSLVFSI 130

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

33-157

3.64e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 47.42 E-value: 3.64e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15050   9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15050  89 FSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVI 133

7tmA_PAR4

cd15372

protease-activated receptor 4, member of the class A family of seven-transmembrane G ...

26-162

4.00e-06

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 320494 [Multi-domain] Cd Length: 274 Bit Score: 47.43 E-value: 4.00e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARlHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGGCALQMFLAL 105
Cdd:cd15372   2 LVPSLYTLVFLVGLPANGLALWVLATQVK-RLPSTIFLINLAVADLLLILVLPFKISYHFL--GNNWPFGEGLCRVVTAF 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 52353953 106 TMGS--AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMY 162
Cdd:cd15372  79 FYGNmyCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQ 137

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-157

4.07e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 47.42 E-value: 4.07e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  28 YATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLlFTSVVTpkALADFLRREnTISF----GGCALQMFL 103
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADL-CVGLIN--VLTDIIWRI-TVEWragdFACKVIRYL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTlmSPRVCWIMVATSWILASLIAI 157
Cdd:cd15197  80 QVVVTYASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSI 131

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

26-301

4.13e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 47.19 E-value: 4.13e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTP-KALADFLRRentISFGG--CALQMF 102
Cdd:cd15325   2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfSAIFEILGY---WAFGRvfCNIWAA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 103 LALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMytmhlpfcvSWEirhllcEIP 182
Cdd:cd15325  79 VDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLF---------GWK------EPA 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 183 PLLKLACADTSRYELIIYvTGVTFLLLPISAIVASYTLVLFTVLRMPSnegRKKALVTCSshlIVVGMFYGA-ATFMYVL 261
Cdd:cd15325 144 PEDETICQITEEPGYALF-SALGSFYLPLAIILVMYCRVYVVALKFSR---EKKAAKTLG---IVVGCFVLCwLPFFLVM 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52353953 262 P-----SSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15325 217 PigsifPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

26-301

4.29e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 47.46 E-value: 4.29e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKAL---ADFLRRENTISFGGCALqMF 102
Cdd:cd15102   2 ATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILlsgARTLRLSPAQWFLREGS-MF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 103 LALtmgSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVcWIMVATSWILASLIAIghtmytmhLPFcVSWEIRHLLCEIP 182
Cdd:cd15102  81 VAL---SASVFSLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLLLGG--------LPI-LGWNCLGALDACS 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 183 PLLKLacadTSRYELIIYVTGVTFLLLPISAI-VASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYG--AATFMY 259
Cdd:cd15102 148 TVLPL----YSKHYVLFCVTIFAGILAAIVALyARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIAcwGPLFIL 223

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 260 VLPSSFHSPKQDNIIS-----VFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15102 224 LLLDVACPVKTCPILYkadwfLALAVLNSALNPIIYTLRSRELRRAV 270

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

26-301

4.62e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 47.11 E-value: 4.62e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLiaightmyTMHLPFCVSW-----EIRHLLCE 180
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAAL--------ASFLPIELGWhelghERTLPNLT 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 181 IPPLLKlACADTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVlrmpsnegrKKALVTCSSHLIVVGMFYgaATFMYV 260
Cdd:cd15054 154 SGTVEG-QCRLLVSLPYALVASCLTF-FLPSGAICFTYCRILLAA---------RKALKASLTLGILLGMFF--VTWLPF 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 261 LPSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNKEVMRAL 301
Cdd:cd15054 221 FVANVVQAVCDCVSPGLFDVLTwlgycnSTMNPIIYPLFMRDFKRAL 267

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

31-237

5.36e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 47.29 E-value: 5.36e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15096   7 FGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHLLCEIPPLLKLACA 190
Cdd:cd15096  87 SVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANI---------PVLFLHGVVSYGFSSEAYSYCTFL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 52353953 191 DTSRYELIIYVTGVTFL--LLPISAIVASYTLVLFTVLRMPSNEGRKKA 237
Cdd:cd15096 158 TEVGTAAQTFFTSFFLFsyLIPLTLICVLYMLMLRRLRRQKSPGGRRSA 206

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

29-156

6.53e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 47.12 E-value: 6.53e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSV-VTPKALADFLRRENTISFGgCALQMFLALTM 107
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFqVLPQLCWDITYRFYGPDFL-CRIVKHLQVLG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRvCWIMVATSWILASLIA 156
Cdd:cd15385  84 MFASTYMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALSFILS 131

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-157

6.68e-06

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 46.57 E-value: 6.68e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREntISFGGCALQMFLAL 105
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGY--WYFGSVWCEIWLAL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 106 TM--GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15059  80 DVlfCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

26-238

7.06e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 46.82 E-value: 7.06e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARL-HMP-MYLLlgQLSLMDLLFtsVVTPKALADFLRRENTISFGGCALQMFL 103
Cdd:cd14984   2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLrSMTdVYLL--NLALADLLF--VLTLPFWAVYAADGWVFGSFLCKLVSAL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMhlpfcVSWEIRHLLCEipp 183
Cdd:cd14984  78 YTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQ-----VSEENGSSICS--- 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 184 llklacADTSRYELIIYVTGVTF------LLLPISAIVASYTLVLFTVLRMPsNEGRKKAL 238
Cdd:cd14984 150 ------YDYPEDTATTWKTLLRLlqnilgFLLPLLVMLFCYSRIIRTLLRAR-NHKKHRAL 203

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

30-173

8.46e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 46.65 E-value: 8.46e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILYMLALTSNGLLLLAITIEARLHMPM--YLLLgQLSLMDLLFTSVVTP-KALADFLrreNTISFGG-CALQMFLAL 105
Cdd:cd15057   6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKVtnYFIV-SLAVSDLLVAILVMPwAAVNEVA---GYWPFGSfCDVWVSFDI 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWE 173
Cdd:cd15057  82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHRADDTSEA 149

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

29-156

8.56e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 46.68 E-value: 8.56e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADfLRRENTISFG--GCALQMFLA-- 104
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAS-VRHGSGWIYGalSCKVIAFLAvl 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 105 LTMGSAedLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15005  84 FCFHSA--FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMA 133

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

36-156

8.95e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 46.39 E-value: 8.95e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  36 MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaLADFLRRENTISFGG--CALQMFLALTMGSAEDL 113
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP--FSTIRSVESCWYFGDsfCRLHTCLDTLFCLTSIF 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 52353953 114 LLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15318  90 HLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYT 132

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

37-150

1.07e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 45.91 E-value: 1.07e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  37 LALTSNGLLLL--AITIEARLHMPMYLLLgQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDLL 114
Cdd:cd15219  12 VSLLSNLLVLLcfLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLS 90

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 52353953 115 LAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWI 150
Cdd:cd15219  91 MAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWL 126

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

26-157

1.20e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 46.10 E-value: 1.20e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRreNTISFGGCALQMFLAL 105
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLM--NSWPFGDVLCKIVISI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 106 TMGS--AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15091  79 DYYNmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGI 132

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

29-223

1.22e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 46.13 E-value: 1.22e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRreNTISFGG--CALQMFLALT 106
Cdd:cd14970   5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLL--GYWPFGEvmCKIVLSVDAY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVswEIRHLLCEIPpllk 186
Cdd:cd14970  82 NMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEG--GTISCNLQWP---- 155

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 52353953 187 lACADTSRYELIIYVTGVTFlLLPISAIVASYTLVLF 223
Cdd:cd14970 156 -DPPDYWGRVFTIYTFVLGF-AVPLLVITVCYSLIIR 190

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

66-156

1.52e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 45.76 E-value: 1.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  66 LSLMDLLFTSVVTP-KALADFlrrENTISFGG-CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWI 143
Cdd:cd15320  44 LAVSDLLVAVLVMPwKAVAEI---AGFWPFGSfCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFI 120

                        90
                ....*....|...
gi 52353953 144 MVATSWILASLIA 156
Cdd:cd15320 121 MISVAWTLSVLIS 133

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

43-154

1.56e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 45.74 E-value: 1.56e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  43 GLLLLAITIEARLHM--PMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTIsFGG--CALQMFLALTMGSAEDLLLAFM 118
Cdd:cd14997  17 GNVLVGIVVWKNKDMrtPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEfmCKLVPFVELTVAHASVLTILAI 95

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 52353953 119 AYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASL 154
Cdd:cd14997  96 SFERYYAICHPLQAKYVCTKRRALVIIALIWLLALL 131

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-294

1.79e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 45.57 E-value: 1.79e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTlmSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIpplL 185
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLE---D 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVL--RMPSN-EGRKKALVTCSSHLIVVGMFYGAATF----- 257
Cdd:cd15202 157 WPERADLFWKYYDLALFILQY-FLPLLVISFAYARVGIKLWasNMPGDaTTERYFALRRKKKKVIKMLMVVVVLFalcwl 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 258 ----MYVLPSSFHSPKQDNIISVFYTIVTPAL-----NPLIYSLRN 294
Cdd:cd15202 236 pfniYVLLLSSKPDYLIKTINAVYFAFHWLAMsstcyNPFIYCWLN 281

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

31-215

1.91e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 45.32 E-value: 1.91e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITieaRLHM--PMYLLLGQLSLMDLLFTSVVTPKALADFLR-----RENTISFGGCALQMFL 103
Cdd:cd14978   7 LPVICIFGIIGNILNLVVLT---RKSMrsSTNVYLAALAVSDILVLLSALPLFLLPYIAdysssFLSYFYAYFLPYIYPL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIgHTMYTMHLPFCVSWEIRHLLCEIPP 183
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNL-PRFFEYEVVECENCNNNSYYYVIPT 162

                       170       180       190
                ....*....|....*....|....*....|..
gi 52353953 184 LLKLacADTSRYELIIYVTGVTFLLLPISAIV 215
Cdd:cd14978 163 LLRQ--NETYLLKYYFWLYAIFVVLLPFILLL 192

7tmA_GnRHR_vertebrate

cd15383

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

29-243

2.07e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320505 [Multi-domain] Cd Length: 295 Bit Score: 45.44 E-value: 2.07e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFtILYMLALTSNGLLLLAITIE-ARLHMPMYLLLGQLSLMDLLFTSVVTPkalADFLRRENTISFGG---CALQMFLA 104
Cdd:cd15383   6 VTF-VLFVLSACSNLAVLWSATRNrRRKLSHVRILILHLAAADLLVTFVVMP---LDAAWNVTVQWYAGdlaCRLLMFLK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAightmytmhLPFCVSWEIRHLlceIPPL 184
Cdd:cd15383  82 LFAMYSSAFVTVVISLDRHAAILNPLA--IGSARRRNRIMLCAAWGLSALLA---------LPQLFLFHTVTA---TPPV 147

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 185 LKLACAD----TSRYELIIY--VTGVTFLLLPISAIVASYTLVLFTVLR-MPSNEGRKKALVTCSS 243
Cdd:cd15383 148 NFTQCAThgsfPAHWQETLYnmFTFFCLFLLPLLIMIFCYTRILLEISRrMKEKKDSAKNEVALRS 213

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

32-157

2.19e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 45.03 E-value: 2.19e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKAL-ADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15053   8 LLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyVEVNGGKWYLGPILCDIYIAMDVMCSTA 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15053  88 SIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIAC 134

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

29-296

2.88e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 44.79 E-value: 2.88e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALAdfLRRENTISFGGCALQMFLALT-- 106
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAV--NEVLDVWIFGHTWCQIWLAVDvw 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAightmytmhLPFCVSWEIR---HLLCEIPP 183
Cdd:cd15063  83 MCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVIC---------FPPLVGWNDGkdgIMDYSGSS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LLKLACADTSRYELIIYVTGVTFlLLPISAIVASYtlvlFTVLRMPSNEgrKKALVTCSshlIVVGMF---YGAATFMYV 260
Cdd:cd15063 154 SLPCTCELTNGRGYVIYSALGSF-YIPMLVMLFFY----FRIYRAARME--TKAAKTVA---IIVGCFifcWLPFFTVYL 223

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52353953 261 LPSSFHSPKQDNIISVFYTI--VTPALNPLIYSLRNKE 296
Cdd:cd15063 224 VRAFCEDCIPPLLFSVFFWLgyCNSALNPCIYALFSRD 261

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

29-151

3.12e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 44.56 E-value: 3.12e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLL-LLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTM 107
Cdd:cd15210   4 AVWGIVFMVVGVPGNLLtVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIL 151
Cdd:cd15210  84 VAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIF 127

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

32-295

3.43e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 44.57 E-value: 3.43e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFG--GCALQMFLALTMGS 109
Cdd:cd15074   8 TVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFA--HRWLFGdiGCVFYGFCGFLFGC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 110 AEDLLLAFMAYDRYVAICHPlKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFcVSW-----EIRHLLCEIPPL 184
Cdd:cd15074  86 CSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAV--------APL-VGWgsygpEPFGTSCSIDWT 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 LKLACADTSRYeliIYVTGVTFLLLPISAIVASYTLVLFTV----------LRMPSNEGRKKALVTCSSHLIVVGMF--- 251
Cdd:cd15074 156 GASASVGGMSY---IISIFIFCYLLPVLIIVFSYVKIIRKVkssrkrvagfDSRSKRQHKIERKVTKVAVLICAGFLiaw 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 252 --YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNK 295
Cdd:cd15074 233 tpYAVVSMWSAFGSPDSVPILASILPALFAKSSCMYNPIIYLLFSS 278

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

29-162

4.21e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 44.14 E-value: 4.21e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGGCALQMFLALTM- 107
Cdd:cd15321  11 AAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELM--GYWYFRKTWCEIYLALDVl 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 108 -GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMY 162
Cdd:cd15321  89 fCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY 144

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

31-221

4.48e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 44.21 E-value: 4.48e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFG--GCALQMFLALTMG 108
Cdd:cd15390   7 FVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLY--NDWPFGlfYCKFSNFVAITTV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 109 SAEDLLLAFMAYDRYVAICHPLKYMtlMSPRVCWIMVATSWILASLIAIGHTMY--TMHLPFCVSWEIRHLLCEIPPllk 186
Cdd:cd15390  85 AASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYstTETYYYYTGSERTVCFIAWPD--- 159

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 52353953 187 lacADTSRYELI--IYVTGVTFlLLPISAIVASYTLV 221
Cdd:cd15390 160 ---GPNSLQDFVynIVLFVVTY-FLPLIIMAVAYTRV 192

7tmA_CysLTR

cd15921

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...

31-252

7.22e-05

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320587 [Multi-domain] Cd Length: 283 Bit Score: 43.64 E-value: 7.22e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRRENTIsFGGCALQMF---LALTM 107
Cdd:cd15921   7 YILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTL-PLRLTYYVLNSHWP-FGDIACRIIlyvLYVNM 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 108 GSAEDLLLAfMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHlpfcvSWEIRHLLCEIPPLLKL 187
Cdd:cd15921  85 YSSIYFLTA-LSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSK-----QHDEGSTRCLELAHDAV 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 188 AcadtsRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEG-----RKKALVTCsshLIVVGMFY 252
Cdd:cd15921 159 D-----KLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGrtrpsRRKACALI---IISLGIFL 220

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

33-156

7.89e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 43.52 E-value: 7.89e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHM-PMYLLLGQLSLMDLLFTSVVTPKALADFLRR-ENTISFGgCALQMFLALTMGSA 110
Cdd:cd15104   8 VLSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATDELLSDgENTQKVL-CLLRMCFVITSCAA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15104  87 SVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIG 132

7tmA_Mu_opioid_R

cd15090

opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...

29-157

9.92e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320218 [Multi-domain] Cd Length: 279 Bit Score: 43.06 E-value: 9.92e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRreNTISFGG--CALQMFLALT 106
Cdd:cd15090   5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLM--GTWPFGNilCKIVISIDYY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15090  82 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL 132

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

29-157

1.20e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 43.22 E-value: 1.20e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSV-VTPKALADFLRRentisFGG----CALQMFL 103
Cdd:cd15388   5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFqVLPQLVWDITDR-----FRGpdvlCRLVKYL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLkyMTLMSPRVCW-IMVATSWILASLIAI 157
Cdd:cd15388  80 QVVGMFASSYMIVAMTFDRHQAICRPM--VTFQKGRARWnGPVCVAWAISLILSL 132

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

26-301

1.22e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 43.03 E-value: 1.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd17790   2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILAsliaightmYTMHLPFCVSWEirHLLCEIPPLL 185
Cdd:cd17790  82 VASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLIS---------FVLWAPAILFWQ--YLVGERTVLA 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRmpsnegRKKALVTCSSHLIVVGMFYGAATFMyVLPSSF 265
Cdd:cd17790 151 GQCYIQFLSQPIITFGTAIAAFYLPVTIMIILYWRIYRETIK------EKKAARTLSAILLAFILTWTPYNIM-VLVSTF 223

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52353953 266 HS---PKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd17790 224 CKdcvPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

42-303

1.36e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 42.90 E-value: 1.36e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  42 NGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTMGSAEDLLLAFMAY 120
Cdd:cd15306  18 NILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCAISL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 121 DRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLceippllklacaDTSRYELIIY 200
Cdd:cd15306  98 DRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVL------------TKERFGDFIL 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 201 VTGVTFLLLPISAIVASYTLVLFTVLRMP-SNEGRKKALVTCSSHLIVvgmFYGAATFMYVLPSSFHSPKQDNIISVFYT 279
Cdd:cd15306 166 FGSLAAFFTPLAIMIVTYFLTIHALRKQTiTNEQRASKVLGIVFFLFL---LMWCPFFITNITSVLCDSCNQTTLQMLME 242

                       250       260       270
                ....*....|....*....|....*....|
gi 52353953 280 I------VTPALNPLIYSLRNKEVMRALRR 303
Cdd:cd15306 243 IfvwigyVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_Angiotensin_R-like

cd14985

angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...

26-301

1.42e-04

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.

Pssm-ID: 341320 [Multi-domain] Cd Length: 284 Bit Score: 42.75 E-value: 1.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFtsVVTPKALADFLRRENTISFGG--CAL-QMF 102
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF--VLTLPLWATYTANQYDWPFGAflCKVsSYV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 103 LALTMgSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAightmytmhLPFCVSWEIRhllcEIP 182
Cdd:cd14985  80 ISVNM-FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLS---------LPTFLLRSLQ----AIE 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 183 PLLKLACA---DTSRYELIIYVTGVTF-LLLPISAIVASYTLVLFTvLRMPSNEGRK---------KALVTCSSHLIVVG 249
Cdd:cd14985 146 NLNKTACImlyPHEAWHFGLSLELNILgFVLPLLIILTCYFHIARS-LRKRYERTGKngrkrrkslKIIFALVVAFLVCW 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 250 MFYGAATFMYVLPSSFHSPKQDNI--------ISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd14985 225 LPFHFFKFLDFLAQLGAIRPCFWElfldlglpIATCLAFTNSCLNPFIYVFVDRRFRQKV 284

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

33-301

1.45e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 42.59 E-value: 1.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTMGSAE 111
Cdd:cd15305   9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTAS 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 112 DLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIlaslIAIGhtmYTMHLPfcvsweIRHLLCEIPPLLKLACAD 191
Cdd:cd15305  89 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWT----ISIG---ISMPIP------VIGLQDDEKVFVNGTCVL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 192 TSryELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPS-NEGRKKALVTCSSHLIVVGMF--YGAATFMYVL-PSSFHS 267
Cdd:cd15305 156 ND--ENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAiNNERRASKVLGIVFFLFLIMWcpFFITNILSVLcKEACDQ 233

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52353953 268 PKQDNIISVFYTI--VTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15305 234 KLMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRAF 269

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

26-301

1.48e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 42.69 E-value: 1.48e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFtsVVTPKALADFLRRENTISFGG--CALQMFL 103
Cdd:cd15168   2 FLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLY--LLSLPFLIYYYANGDHWIFGDfmCKLVRFL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILAsLIAIGHTMYTMHLPFCVSweirhllceipp 183
Cdd:cd15168  80 FYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILV-LLQLLPILFFATTGRKNN------------ 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 llKLACADTSRYELI-------IYVTGVTFlLLPISAIVASYTLVLFTVLRMPSNEG----RKKALVTCsshLIVVGMFY 252
Cdd:cd15168 147 --RTTCYDTTSPEELndyviysMVLTGLGF-LLPLLIILACYGLIVRALIRKLGEGVtsalRRKSIRLV---IIVLALFA 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52353953 253 GAATFMYV-----LPSSFHSPKQD----NIISVFYTIVTP------ALNPLIYSLRNKEVMRAL 301
Cdd:cd15168 221 VCFLPFHVtrtinLAARLLSGTAScatlNGIYVAYKVTRPlaslnsCLNPLLYFLAGDKFRRRL 284

7tmA_GPR65_TDAG8

cd15365

proton-sensing G protein-coupled receptor 65, member of the class A family of ...

30-151

1.72e-04

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.

Pssm-ID: 320487 [Multi-domain] Cd Length: 277 Bit Score: 42.46 E-value: 1.72e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTsvVTPKALADFLRRENTISFGG--CALQMFLALTM 107
Cdd:cd15365   6 VYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYI--VILPLWIDYLWNGDNWTLSGfvCIFSAFLLYTN 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIL 151
Cdd:cd15365  84 FYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLL 127

7tmA_SWS1_opsin

cd15076

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...

42-296

1.90e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320204 [Multi-domain] Cd Length: 280 Bit Score: 42.50 E-value: 1.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  42 NGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDLLLAFMAYD 121
Cdd:cd15076  18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 122 RYVAICHPLKYMTLMSPRVCWIMVATsWILASLIAIghtmytmhlPFCVSWEiRHllceIPPLLKLAC-------ADTSR 194
Cdd:cd15076  98 RYIVICKPFGNFRFGSKHALGAVVAT-WIIGIGVSL---------PPFFGWS-RY----IPEGLQCSCgpdwytvGTKYR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 195 YELIIYVTGVTFLLLPISAIVASYTLVLFTV----LRMPSNEGRKKALVTCSSHLIV-VGMFYG-----AATFMYVLPSS 264
Cdd:cd15076 163 SEYYTWFLFIFCFIVPLSIIIFSYSQLLGALravaAQQQESASTQKAEREVSRMVVVmVGSFCLcyvpyAALAMYMVNNR 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 52353953 265 FHSPKQDNI-ISVFYTIVTPALNPLIYSLRNKE 296
Cdd:cd15076 243 DHGLDLRLVtIPAFFSKSSCVYNPIIYCFMNKQ 275

7tmA_Proton-sensing_R

cd15160

proton-sensing G protein-coupled receptors, member of the class A family of ...

51-248

1.93e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).

Pssm-ID: 320288 [Multi-domain] Cd Length: 280 Bit Score: 42.37 E-value: 1.93e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  51 IEARLHMPMYLLlgQLSLMDLLFTSVVtPKALADFLRREN-TISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHP 129
Cdd:cd15160  29 IKKENVLGVYLL--NLSLSDLLYILTL-PLWIDYTANHHNwTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHP 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 130 LKYMTLMSPRVCWIMVATSWIlasLIAIGHTMYTMHLpFCVSWEIRHLLC-EIPPLlklacadTSRYELIIYVTGVTFLL 208
Cdd:cd15160 106 LRFRGLRTRRFALKVSASIWV---LELGTHSVFLGHD-ELFRDEPNHTLCyEKYPM-------EGWQASYNYARFLVGFL 174

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 52353953 209 LPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVV 248
Cdd:cd15160 175 IPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVV 214

7tmA_prokineticin-R

cd15204

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

114-176

1.95e-04

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.

Pssm-ID: 320332 [Multi-domain] Cd Length: 288 Bit Score: 42.26 E-value: 1.95e-04

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 114 LLAfMAYDRYVAICHPLkyMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLP-------FC-VSWEIRH 176
Cdd:cd15204  93 LLV-IAIDRYLVIVHPL--KPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPyanqgkiFCgQIWPVDQ 160

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

29-300

1.98e-04

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 42.41 E-value: 1.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALA-DFLRRENTISFGgCALQMFLALTM 107
Cdd:cd15000   4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVhDFFQNYVLGSVG-CKLEGFLEGSL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAIGHTMY---------TMHLPFC--------V 170
Cdd:cd15000  83 LLASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLALPLAIYrsyrerqwkNFLETYCaentqvlpI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 171 SWE-IRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPIS-------AIVASYTLVLFTVLRMPSnegrkkalvtcS 242
Cdd:cd15000 161 YWHvIITVLVWLPLGIMLICYSAIFWKLDKYERRVLRREHPSVvrykkkaAKTLFIVLITFVVCRIPF-----------T 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953 243 SHLIVVGMFYGAATFMYVLPSSFHSPKqdnIISVFYTIVTPALNPLIYSLRNKEVMRA 300
Cdd:cd15000 230 ALIFYRYKLVPNDNTQNSVSGSFHILW---FASKYLMFLNAAVNPLIYGFTNENFRKA 284

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

33-249

2.09e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 42.14 E-value: 2.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15215   8 IFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGV 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLiaigHTMYTMHLPFCVSWEIRHLLCeippllKLACADT 192
Cdd:cd15215  88 NTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVL----QSTPPLYGWGQAAFDERNALC------SVIWGSS 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 193 SRYELIiyvTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVG 249
Cdd:cd15215 158 YSYTIL---SVVSSFVLPVIIMLACYSMVFRAARRCYHCKAAKVIFIIIFSYVLSMG 211

7tmA_NMU-R

cd15133

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...

29-221

2.58e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.

Pssm-ID: 320261 [Multi-domain] Cd Length: 298 Bit Score: 42.13 E-value: 2.58e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTM 107
Cdd:cd15133   5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPfLLGSGGCYFKTFLFETV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTmyTMHLPFCVSWEIRHLLceIPPLLKL 187
Cdd:cd15133  85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNT--SLHGIKFLGSGVPASA--QCTVRKP 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 52353953 188 ACAdtsrYELIIYVTGVTFLLLPISAIVASYTLV 221
Cdd:cd15133 161 QAI----YNMIPQHTGHLFFVLPMAVISVLYLLM 190

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

121-172

2.66e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 41.98 E-value: 2.66e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 121 DRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAightmytmHLPFCVSW 172
Cdd:cd15066  96 DRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALIS--------FLPIFLGW 139

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-236

2.93e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 41.66 E-value: 2.93e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLAL 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 106 TMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHL----PFCVSWEIRHllcei 181
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVeilvTQDGQEEEIC----- 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 182 ppllklaCADTSRYELIIY--VTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKK 236
Cdd:cd15012 156 -------VLDREMFNSKLYdtINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_Delta_opioid_R

cd15089

opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...

29-157

3.07e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320217 [Multi-domain] Cd Length: 281 Bit Score: 41.86 E-value: 3.07e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRreNTISFGGCALQMFLALTMG 108
Cdd:cd15089   5 ALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTL-PFQSAKYLM--ETWPFGELLCKAVLSIDYY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52353953 109 S--AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15089  82 NmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGV 132

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

27-156

3.09e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 41.46 E-value: 3.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGGCALQMFLALT 106
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELM--GYWYFGQVWCNIYLALD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 107 M--GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15323  81 VlfCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVIS 132

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

26-163

3.18e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 41.58 E-value: 3.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRReNTISFGG--CALQMFL 103
Cdd:cd15392   2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLIL-QYWPFGEfmCPVVNYL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAIGHTMYT 163
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITS 138

7tmA_NMU-R1

cd15358

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-221

3.22e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.

Pssm-ID: 320480 [Multi-domain] Cd Length: 305 Bit Score: 41.68 E-value: 3.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTM 107
Cdd:cd15358   5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPfLLGAGGCYFKTLLFETV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTmyTMHLPFCVSWEIRHLLCEIPPLLKL 187
Cdd:cd15358  85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNT--SLHGIFQLTVPCRGPVPDSATCMLV 162

                       170       180       190
                ....*....|....*....|....*....|....
gi 52353953 188 ACADTsrYELIIYVTGVTFLLLPISAIVASYTLV 221
Cdd:cd15358 163 KPRWM--YNLIIQITTLLFFFLPMGTISVLYLLI 194

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

31-301

3.37e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 41.49 E-value: 3.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKAL-ADFLRRENTISFGGCALQMFLALTMGS 109
Cdd:cd15310   7 YCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMCT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 110 AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVC---WIMVATSWILAsliaightmytmhlpFCVSWEirhLLCEIPPLLK 186
Cdd:cd15310  87 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCrrvSLMITAVWVLA---------------FAVSCP---LLFGFNTTGD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRmpsNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFH 266
Cdd:cd15310 149 PTVCSISNPDFVIYSSVVSF-YLPFGVTLLVYVRIYVVLLR---EKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACH 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52353953 267 SPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15310 225 VPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

61-224

3.42e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 41.65 E-value: 3.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  61 LLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRV 140
Cdd:cd14992  37 YFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 141 CWIMVATSWILASLIAIGHTMYTMHLP-FCVSWEIRHLLCEIPPLLKlacaDTSRYELIIYVTGVTFlLLPISAIVASYT 219
Cdd:cd14992 117 TVIIIITIWVVSLLLAIPQLYYATTEVlFSVKNQEKIFCCQIPPVDN----KTYEKVYFLLIFVVIF-VLPLIVMTLAYA 191


                ....*
gi 52353953 220 LVLFT 224
Cdd:cd14992 192 RISRE 196

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

25-300

4.72e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 41.22 E-value: 4.72e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGC-ALQMFL 103
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCkLIPYFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAfMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFcvSWEIRHLLCEIPP 183
Cdd:cd15206  81 AVSVSVSTFTLVA-ISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPM--SRPGGHKCREVWP 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LlklacadtSRYELIIYVTGVTFLL-LPISAIVASYTLVLFTVLrmpsnEGRKKALvtcSSHLIVVGMFYGAATFMYVLP 262
Cdd:cd15206 158 N--------EIAEQAWYVFLDLMLLvIPGLVMSVAYGLISWTLL-----EAKKRVI---RMLFVIVVEFFICWTPLYVIN 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 263 --SSFHSPKQDN-----IISVFYTI--VTPALNPLIYSLRNKEVMRA 300
Cdd:cd15206 222 twKAFDPPSAARyvsstTISLIQLLayISSCVNPITYCFMNKRFRQA 268

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

33-156

5.02e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 41.08 E-value: 5.02e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGGCALQMFLALTM--GSA 110
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM--GYWYFGKVWCEIYLALDVlfCTS 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15322  87 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVIS 132

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

66-219

5.08e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 41.10 E-value: 5.08e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  66 LSLMDLLFTSVVTP-KALADFlrrENTISFGG-CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWI 143
Cdd:cd15319  43 LAVSDLFVALLVMPwKAVAEV---AGYWPFGAfCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALV 119

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 144 MVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLcEIPPLLKLACADTSRYELIIYVTGVTFlLLPISAIVASYT 219
Cdd:cd15319 120 MISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNS-SISRQVEENCDSSLNRTYAISSSLISF-YIPVAIMIVTYT 193

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

97-292

5.18e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 41.16 E-value: 5.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  97 CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRH 176
Cdd:cd15134  74 CKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL---------PFAIQTRIVY 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 177 LlcEIPPLLK------LACADTSRYELIIYVTGVT---FLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHL-- 245
Cdd:cd15134 145 L--EYPPTSGealeesAFCAMLNEIPPITPVFQLStflFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSqs 222

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52353953 246 ----------IVVGMFYGAATF-----MYVLPSSFHSPKQDNIISVFYT-----IVTPALNPLIYSL 292
Cdd:cd15134 223 rrtvlrmlvaVVVAFFICWAPFhaqrlLTVYAKNMTPPYLFINRILFYIsgvlyYVSSTVNPILYNV 289

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-157

5.18e-04

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 41.22 E-value: 5.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  27 LYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALT 106
Cdd:cd15208   3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTlmSPRVCWIMVATSWILASLIAI 157
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMI 131

7tmA_GPR4

cd15366

proton-sensing G protein-coupled receptor 4, member of the class A family of ...

24-151

5.31e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.

Pssm-ID: 320488 [Multi-domain] Cd Length: 280 Bit Score: 40.93 E-value: 5.31e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  24 PELLYAtftILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRRENTI-SFGGCALQMF 102
Cdd:cd15366   3 PPTLYI---IVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATL-PLWIDYFLHRDNWIhGPESCKLFGF 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52353953 103 LALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIL 151
Cdd:cd15366  79 IFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAI 127

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

31-157

5.70e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 40.91 E-value: 5.70e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTP-KALADFLRRENTISFGGCALQMFLALTMgS 109
Cdd:cd14971   7 FALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPfTATIYPLPGWVFGDFMCKFVHYFQQVSM-H 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52353953 110 AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd14971  86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

31-167

5.91e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 40.94 E-value: 5.91e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQ--------MF 102
Cdd:cd15103   7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsMI 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52353953 103 LALTMGSAEDLLLafMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLP 167
Cdd:cd15103  87 CSSLLASICSLLA--IAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSVP 149

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

33-305

5.94e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 40.71 E-value: 5.94e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15307   9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILAsliaightmYTMHLPFCVSWEIRHL------LCEIP-PLL 185
Cdd:cd15307  89 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLS---------IAMSLPLSLMYSKDHAsvlvngTCQIPdPVY 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 186 KLacadtsryeliiyVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF----YGAATFMYVL 261
Cdd:cd15307 160 KL-------------VGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfviLWSPFFVLNL 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52353953 262 PSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNKEVMRALRRVL 305
Cdd:cd15307 227 LPTVCAECEERISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKVL 276

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

33-296

6.55e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 40.84 E-value: 6.55e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAED 112
Cdd:cd15195   9 VLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSS 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTlmSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHLLCEIPPLLKlaCADT 192
Cdd:cd15195  89 FMLVVIALDRVFAILSPLSANQ--ARKRVKIMLTVAWVLSALCSI---------PQSFIFSVLRKMPEQPGFHQ--CVDF 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 193 S----RYELIIYVTGVTFL--LLPISAIVASYTLVLFTVLRMP----------------SNEGRKKALVTCSSHLIVVGM 250
Cdd:cd15195 156 GsaptKKQERLYYFFTMILsfVIPLIITVTCYLLILFEISKMAkrardtpisnrrrsrtNSLERARMRTLRMTALIVLTF 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 52353953 251 F-----YGAATFMYVLPSSFHSPKQDNIISVFYTIVT--PALNPLIYSLRNKE 296
Cdd:cd15195 236 IvcwgpYYVLGLWYWFDKESIKNLPPALSHIMFLLGYlnPCLHPIIYGVFMKE 288

7tmA_PAR

cd15162

protease-activated receptors, member of the class A family of seven-transmembrane G ...

26-157

7.42e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 341328 [Multi-domain] Cd Length: 280 Bit Score: 40.51 E-value: 7.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKaLADFLRRENTIsFGGCALQMFLAL 105
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFK-IAYHIHGNNWI-FGEALCRLVTVA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 52353953 106 TMGS--AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15162  80 FYGNmyCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL 133

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

24-167

7.80e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 40.54 E-value: 7.80e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  24 PELLYATFTILymlALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTsVVTPKALADFLRRENTISFGGCALQMFL 103
Cdd:cd15094   3 SAVLYGLICIV---GLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLP 167
Cdd:cd15094  79 TSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVP 142

7tmA_P2Y11

cd15376

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...

25-236

7.89e-04

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320498 [Multi-domain] Cd Length: 284 Bit Score: 40.45 E-value: 7.89e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  25 ELLYATFTILYMLALTSNGL-LLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaLADFLRRENTISFG--GCALQM 101
Cdd:cd15376   1 DFLWPILGVEFLVAVLGNGLaLWLFVTRERRPWHTGVVFSFNLAVSDLLYALSLPL--LAAYYYPPKNWRFGeaACKLER 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 102 FLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAightMYTMHLPFCVSWEIRHLLCei 181
Cdd:cd15376  79 FLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALS----APVLSFSHLEVERHNKTEC-- 152

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 182 ppllkLACADTSR------YELIIYVTGVtflLLPISAIVASYTLVLFTVLRMPSNEGRKK 236
Cdd:cd15376 153 -----LGTAVDSRlptylpYSLFLAVVGC---GLPFLLTLASYLAIVWAVLRSPGITTLEK 205

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

33-157

7.97e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 40.69 E-value: 7.97e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALadflrrenTISFGGCA-------LQMF-LA 104
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFCTdfhsclfLACFvLV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 52353953 105 LTMGSAEDLLLafMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15069  81 LTQSSIFSLLA--VAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGL 131

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

32-295

8.14e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 40.30 E-value: 8.14e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLR-RENTISFGGCALQMFLALTMGSA 110
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYgYRWPLPSKLCAVWIYLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEippllklaca 190
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLAD---------- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 191 dtsryELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGM--FYGAATFMYVLPSSFHSP 268
Cdd:cd15304 158 -----ENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWcpFFITNVMAVICKESCNEV 232

                       250       260
                ....*....|....*....|....*....
gi 52353953 269 KQDNIISVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15304 233 VIGGLLNVFVWIgyLSSAVNPLVYTLFNK 261

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

30-157

8.17e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 40.34 E-value: 8.17e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGS 109
Cdd:cd15001   5 VYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFI 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52353953 110 AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15001  85 CSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAS 132

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

115-237

1.04e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 40.09 E-value: 1.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 115 LAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMY--TMHLP------FCvsWEIRHllceiPPLLK 186
Cdd:cd15098  93 LVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHqdLVHHWtasnqtFC--WENWP-----EKQQK 165

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52353953 187 LAcadtsrYELIIYVTGvtfLLLPISAIVASYTLVLFTVLRMPSNeGRKKA 237
Cdd:cd15098 166 PV------YVVCTFVFG---YLLPLLLITFCYAKVLNHLHKKLKN-MSKKS 206

7tmA_NOFQ_opioid_R

cd15092

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...

115-157

1.07e-03

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320220 [Multi-domain] Cd Length: 279 Bit Score: 40.23 E-value: 1.07e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 52353953 115 LAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15092  90 LTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGV 132

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

31-179

1.48e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 39.80 E-value: 1.48e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15979   7 YSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSV 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLC 179
Cdd:cd15979  87 STFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQC 155

7tmA_GnRHR_invertebrate

cd15384

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

30-157

1.76e-03

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320506 [Multi-domain] Cd Length: 293 Bit Score: 39.34 E-value: 1.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGS 109
Cdd:cd15384   6 VLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52353953 110 AEDLLLAFMAYDRYVAICHPLKymTLMSPRVCWIMVATSWILASLIAI 157
Cdd:cd15384  86 LSTYITVLISLDRCVAILYPMK--RNQAPERVRRMVTVAWILSPIFSI 131

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

23-163

1.76e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 39.51 E-value: 1.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  23 SPELlyatFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLF-------TSVVTPKALADFLRRENTISFG 95
Cdd:cd15353   3 SPEV----FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVsvsngseTVVITLLNGNDTDAQSFTVNID 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953  96 GCALQMFLALTMGSAEDLLLafMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYT 163
Cdd:cd15353  79 NVIDSVICSSLLASICSLLS--IAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYS 144

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

32-172

1.88e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 39.46 E-value: 1.88e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  32 TILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRreNTISFGG--CALQMFLALTMGS 109
Cdd:cd15957   8 SLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILL--KTWTFGNfwCEFWTSIDVLCVT 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52353953 110 AEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFCVSW 172
Cdd:cd15957  86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSF--------LPIQMHW 140

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

26-227

2.15e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.99 E-value: 2.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILY-MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPkaLADFLRRENTISFGGCALQMFLA 104
Cdd:cd15070   1 VTYISIEILIgLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGhTMYTMHlpfcvsweiRHLLCEIPPL 184
Cdd:cd15070  79 VVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLT-PMFGWN---------RKPSLESVNT 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 52353953 185 LKLACADTS--RYELIIYVTGVTFLLLPISAIVASYTLVLFTVLR 227
Cdd:cd15070 149 TPLQCQFTSvmRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRN 193

7tmA_NTSR2

cd15356

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...

66-291

2.21e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320478 [Multi-domain] Cd Length: 285 Bit Score: 39.08 E-value: 2.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  66 LSLMDLLFTSVVTPKALADFLRRENTISFG--GCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWI 143
Cdd:cd15356  45 LALSDLLILLISVPIELYNFVWFHYPWVFGdlVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKW 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 144 MVATSWiLASLIaightmytMHLPFCVSWEIRHLL----CEIPPLLKLACADTSRYELIIYVTGVTFL--LLPISaIVAS 217
Cdd:cd15356 125 LLALIW-ASSLG--------FALPMAFIMGQKYELetadGEPEPSSRVCTVLVSRATLKVFIQVNAFVsfVLPLA-LIAF 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 218 YTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYV-LPSSFHSPKQDNIISVFYTI------VTPALNPLIY 290
Cdd:cd15356 195 LNGVTVSHLRIQSLQHSVQVLRAIVIAYVICWLPYHARRLMFCyVPDDAWTDSLYNFYHYFYMLtntlfyVSSAVNPLLY 274


                .
gi 52353953 291 S 291
Cdd:cd15356 275 N 275

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

113-228

2.23e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 39.19 E-value: 2.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 113 LLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYtmHLPFCVSWEIRHLLCEIPpllklacADT 192
Cdd:cd15095  89 LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIY--YRLEEGYWYGPQTYCREV-------WPS 159

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 52353953 193 SRYE--LIIYVTGVTFlLLPISAIVASYTLVLFTVLRM 228
Cdd:cd15095 160 KAFQkaYMIYTVLLTY-VIPLAIIAVCYGLILRRLWRR 196

7tmA_P2Y6_P2Y3-like

cd15968

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...

26-240

3.24e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320634 [Multi-domain] Cd Length: 285 Bit Score: 38.60 E-value: 3.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFtSVVTPKALADFLRRENTIsFGG--CALQMFL 103
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLY-ALSLPLLIYNYAMRDRWL-FGDfmCRLVRFL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYT---MHLPFCVSWEIrhllcE 180
Cdd:cd15968  80 FYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFArtgIIRNRTVCYDL-----A 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52353953 181 IPPLLklacADTSRYELIIYVTGvtfLLLPISAIVASYTLVLFTVLR------MPSNEGRKKALVT 240
Cdd:cd15968 155 PPALF----PHYVPYGMALTVSG---FLLPFSIILWCYCLVVRTLCRtlgpaePPAQARRRKSIRT 213

7tmA_GRPR

cd15124

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

29-168

3.27e-03

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.

Pssm-ID: 320252 [Multi-domain] Cd Length: 293 Bit Score: 38.73 E-value: 3.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSN-GLLLLAITIEARLHMPmYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTM 107
Cdd:cd15124   5 TVYGIIILIGLIGNiTLIKIFCTVKSMRNVP-NLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTS 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 108 GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPF 168
Cdd:cd15124  84 VGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPF 144

7tmA_S1PR4_Edg6

cd15349

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...

26-301

3.38e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320471 [Multi-domain] Cd Length: 271 Bit Score: 38.61 E-value: 3.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLftsVVTPKALADFLRRENTISFGGCA--LQMFL 103
Cdd:cd15349   2 ALTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLL---TGTSYLVNICLSGERTFRLTPALwfLREGL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhLPFcVSWeirHLLCEIPP 183
Cdd:cd15349  79 LFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGF--------LPL-LGW---NCLCDFRS 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMF---YGAATFMYV 260
Cdd:cd15349 147 CSSLLPLYSKSYILFCLVIFFIILLTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFmvcWGPLFILLL 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52353953 261 LPSSFHSPKQDNIISVFYTI----VTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15349 227 VDFFCSSRSCKPLFGMEWVLalavLNSAINPLIYSFRSLEVRRAV 271

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

29-301

3.40e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 38.62 E-value: 3.40e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLfTSVVTPKALADfLRRENTISFGG--CALQMFLALT 106
Cdd:cd15928   5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYR-LWRYRPWRFGDllCRLMYFFSET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 107 MGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlPFCVSWEIRHLLCEIPPLLK 186
Cdd:cd15928  83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAG---------PALVLVGVEHIQGQQTPRGF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 187 LACADTSRYELIIYVTGVT--FLLLPISAIVASYTLVLFTV------LRMPSNEGRKKALVTCSSHLIVVGMFY------ 252
Cdd:cd15928 154 ECTVVNVSSGLLSVMLWVStsFFFVPMVCLSLLYGLIGRALwdrrqrSRTAGASRRDNNHRQTVRMLAVIVLAFvlcwlp 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52353953 253 ---GAATFMYVLPSSFHS---PKQDNIISVFYTIVTPALNPLIYSLRNKEVMRAL 301
Cdd:cd15928 234 fhvGRVIFNHSRASTKHLhyvSQYFNLVSFVLFYLSAAINPILYNLMSKRYRYAV 288

7tmA_mAChR_GAR-2-like

cd15302

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...

33-155

3.42e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320429 [Multi-domain] Cd Length: 266 Bit Score: 38.57 E-value: 3.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRREN-TISFGGCALQMFLALTMGSAE 111
Cdd:cd15302   9 ILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYwPLGWVLCDLWLSVDYTVCLVS 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 52353953 112 DLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLI 155
Cdd:cd15302  89 IYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALL 132

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

26-296

3.58e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 38.38 E-value: 3.58e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILY-MLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALAdfLRRENTISFGGCALQMFLA 104
Cdd:cd15068   1 SVYITVELAIaVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILAslIAIGHT-MYTMHLPFCVSWEIRHLLCEIPP 183
Cdd:cd15068  79 LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS--FAIGLTpMLGWNNCGQPKEGKNHSQGCGEG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 LLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLR---------MPSNEGR---KKALVTCSSHLIVVGMF 251
Cdd:cd15068 157 QVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRqlkqmesqpLPGERARstlQKEVHAAKSLAIIVGLF 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 52353953 252 -------YGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKE 296
Cdd:cd15068 237 alcwlplHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIRE 288

7tmA_D2_dopamine_R

cd15309

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

31-156

4.52e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320435 [Multi-domain] Cd Length: 254 Bit Score: 38.09 E-value: 4.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15309   7 LTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMT-LMSPRVCWIMVATSWILASLIA 156
Cdd:cd15309  87 SILNLCAISIDRYTAVAMPMLYNTrYSSKRRVTVMISVVWVLSFAIS 133

7tmA_AKHR

cd15382

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...

29-245

4.60e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320504 [Multi-domain] Cd Length: 298 Bit Score: 38.06 E-value: 4.60e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALTSNgLLLLAITIEARLH--MPMYLLLGQLSLMDLLFTSVVTPKALADFLrrenTIS-FGG---CALQMF 102
Cdd:cd15382   5 IVYSVLFLIAAVGN-LTVLLILLRNRRRkrSRVNILLMHLAIADLLVTFIMMPLEIGWAA----TVAwLAGdflCRLMLF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 103 L---ALTMGSaedLLLAFMAYDRYVAICHPLKYMTlmSPRVCWIMVATSWILASLIAIGHtMYTMHL---PfCVSWEIRh 176
Cdd:cd15382  80 FrafGLYLSS---FVLVCISLDRYFAILKPLRLSD--ARRRGRIMLAVAWVISFLCSIPQ-SFIFHVeshP-CVTWFSQ- 151

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 177 llCEIPPLLKlacadTSRYELIIYVTGVTFL-LLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHL 245
Cdd:cd15382 152 --CVTFNFFP-----SHDHELAYNIFNMITMyALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRL 214

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

33-156

4.64e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 37.89 E-value: 4.64e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  33 ILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTP-KALADFLRRENTISFGGCALQMFLALTMGSAE 111
Cdd:cd15308   9 LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTAS 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 52353953 112 DLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIA 156
Cdd:cd15308  89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVA 133

7tmA_TXA2_R

cd15143

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...

96-167

4.76e-03

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.

Pssm-ID: 320271 [Multi-domain] Cd Length: 296 Bit Score: 38.26 E-value: 4.76e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52353953  96 GCALQMFLALTM---GSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAI----GHTMYTMHLP 167
Cdd:cd15143  78 DCYLCNFMGLSMvfyGLCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLlpilGLGRYTLQYP 156

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

26-174

4.99e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 38.05 E-value: 4.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHM--PMYLLlgQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFL 103
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTvsNFFLL--NLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVV 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLiaightmytMHLPFCVSWEI 174
Cdd:cd15048  80 DYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFL---------LYGPAIIGWDL 141

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

26-292

5.04e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 37.82 E-value: 5.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFtsVVTPKALADFLRRENTISFGG--CALQMFL 103
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF--MLGMPFLIHQFAIDGQWYFGEvmCKIITAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 104 ALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLlcEIPP 183
Cdd:cd15088  80 DANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYV--SLPS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 184 llklacaDTSRYELIIYVTGVTFlLLPISAIVASYTLVLFTVLRM--PSNEG--RKKALVTCSSHLIVVGMFYGAATFMY 259
Cdd:cd15088 158 -------PDDLYWFTIYHFILGF-AVPLVVITVCYILILHRLARGvaPGNQShgSSRTKRVTKMVILIVVVFIVCWLPFH 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 52353953 260 VLP---SSFHSPKQDNIISVFYTI----VTPALNPLIYSL 292
Cdd:cd15088 230 VVQlvnLAMNRPTLAFEVAYFLSIclgyANSCLNPFVYIL 269

7tmA_PGI2

cd15141

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...

21-154

5.61e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.

Pssm-ID: 320269 [Multi-domain] Cd Length: 301 Bit Score: 37.88 E-value: 5.61e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  21 SGSPellyATFTILYMLALTSNGLLLLAITIEARLHM----PMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGG 96
Cdd:cd15141   1 DGHP----ATSTLMFAAGVVGNLLALGILGVHRKERRtkssAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAA 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52353953  97 ----CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASL 154
Cdd:cd15141  77 gqplCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGAL 138

7tmA_GPR39

cd15135

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...

30-157

6.04e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.

Pssm-ID: 320263 [Multi-domain] Cd Length: 320 Bit Score: 37.85 E-value: 6.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  30 TFTILYMLALTSnGLLLLAITIEAR--LHMPMYLL------LGQLSLMDLLFTSVVTPKAL-----ADFLRRENTIsfgG 96
Cdd:cd15135   2 TLTLLYSLILVA-GILGNSATIKVTqvLQKKGYLQksvtdhMVSLACSDLLVLLLGMPVELysaiwDPFATPSGNI---A 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52353953  97 CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLmSPRVCWIMVATSWILASLIAI 157
Cdd:cd15135  78 CKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKAL-SGSRVRLLICFVWLTSALVAL 137

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

31-168

7.31e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 37.54 E-value: 7.31e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSA 110
Cdd:cd15978   7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 52353953 111 EDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPF 168
Cdd:cd15978  87 STFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_FFAR

cd14983

free fatty acid receptors, member of the class A family of seven-transmembrane G ...

26-151

7.71e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.

Pssm-ID: 320114 [Multi-domain] Cd Length: 278 Bit Score: 37.41 E-value: 7.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  26 LLYATFTILYMLALTSNGLLLLAITIEARLHM-PMYLLLGQLSLMDLLFTSVVTPKALaDFLRRENTISFGGCALQMFLA 104
Cdd:cd14983   2 LSLMVYVLTILLGLPSNLLALYAFVNRARLRLtPNVIYMINLCLSDLVFILSLPIKIV-EALSSAWTLPAVLCPLYNLAH 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIL 151
Cdd:cd14983  81 FSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWAL 127

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

29-300

8.44e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 37.03 E-value: 8.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  29 ATFTILYMLALT--SNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLrrENTISFGGCALQMFLA-- 104
Cdd:cd15060   3 TTILLSVIIAFTivGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFL--LGKWLFGIHLCQMWLTcd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 105 LTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIghtmytmhlpfcvsweirhllceiPPL 184
Cdd:cd15060  81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISV------------------------PPL 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953 185 L-----------KLACADTSRYELIIY-VTGVTFLLLPIsaivasYTLVLFTVLRMPSNEgrKKALVTCSshlIVVGMF- 251
Cdd:cd15060 137 IgwndwpenfteTTPCTLTEEKGYVIYsSSGSFFIPLLI------MTIVYVKIFIATSKE--RRAARTLG---IIMGVFv 205

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52353953 252 --YGAATFMYVL----PSSFHSPKQDNIIsVFYTIVTPALNPLIYSLRNKEVMRA 300
Cdd:cd15060 206 vcWLPFFLMYVIlpfcETCSPSAKVVNFI-TWLGYVNSALNPVIYTIFNLDFRRA 259

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

62-163

8.93e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 37.39 E-value: 8.93e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  62 LLGQLSLMDLLFTSVVTPKALADFLRreNTISFGG--CALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLmSPR 139
Cdd:cd15002  39 LILNLSAADLLLLLFSVPFRAAAYSK--GSWPLGWfvCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTI-KQR 115

                        90       100
                ....*....|....*....|....
gi 52353953 140 VCWIMVATSWILASLIAIGHTMYT 163
Cdd:cd15002 116 RITAVVASIWVPACLLPLPQWLFR 139

7tmA_HCAR-like

cd14991

hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...

31-151

9.62e-03

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).

Pssm-ID: 320122 [Multi-domain] Cd Length: 280 Bit Score: 37.04 E-value: 9.62e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52353953  31 FTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVtPKALADFLRRENTIsFG--GCALQMFLALTMG 108
Cdd:cd14991   7 LILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICL-PFRIDYYLRGEHWI-FGeaWCRVNLFMLSVNR 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 52353953 109 SAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWIL 151
Cdd:cd14991  85 SASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWAL 127

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01