WD repeat-containing protein 31 isoform 2 [Homo sapiens]
WD40 repeat domain-containing protein( domain architecture ID 1000017)
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
WD40 super family | cl29593 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
5-225 | 9.36e-26 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. The actual alignment was detected with superfamily member cd00200: Pssm-ID: 453027 [Multi-domain] Cd Length: 289 Bit Score: 101.64 E-value: 9.36e-26
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Name | Accession | Description | Interval | E-value | ||||
WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
5-225 | 9.36e-26 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 101.64 E-value: 9.36e-26
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
2-218 | 1.14e-24 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 101.32 E-value: 1.14e-24
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
10-49 | 1.26e-06 | ||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.84 E-value: 1.26e-06
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WD40 | pfam00400 | WD domain, G-beta repeat; |
11-49 | 7.20e-06 | ||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 7.20e-06
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
34-206 | 1.71e-04 | ||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 1.71e-04
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Name | Accession | Description | Interval | E-value | ||||
WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
5-225 | 9.36e-26 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 101.64 E-value: 9.36e-26
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
2-218 | 1.14e-24 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 101.32 E-value: 1.14e-24
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
13-225 | 1.09e-22 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.55 E-value: 1.09e-22
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2-218 | 1.46e-22 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.17 E-value: 1.46e-22
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WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2-185 | 1.77e-22 | ||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 92.78 E-value: 1.77e-22
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
2-208 | 1.07e-16 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 78.59 E-value: 1.07e-16
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
14-232 | 1.20e-15 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 75.51 E-value: 1.20e-15
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
2-200 | 1.65e-15 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 75.13 E-value: 1.65e-15
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1-232 | 1.30e-14 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 72.43 E-value: 1.30e-14
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WD40 | COG2319 | WD40 repeat [General function prediction only]; |
1-95 | 1.29e-08 | ||||
WD40 repeat [General function prediction only]; Pssm-ID: 225201 [Multi-domain] Cd Length: 466 Bit Score: 54.71 E-value: 1.29e-08
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
10-49 | 1.26e-06 | ||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.84 E-value: 1.26e-06
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WD40 | pfam00400 | WD domain, G-beta repeat; |
11-49 | 7.20e-06 | ||||
WD domain, G-beta repeat; Pssm-ID: 425662 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 7.20e-06
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PLN00181 | PLN00181 | protein SPA1-RELATED; Provisional |
34-206 | 1.71e-04 | ||||
protein SPA1-RELATED; Provisional Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 1.71e-04
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PTZ00421 | PTZ00421 | coronin; Provisional |
2-141 | 4.54e-03 | ||||
coronin; Provisional Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 37.95 E-value: 4.54e-03
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WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
142-185 | 5.21e-03 | ||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 33.83 E-value: 5.21e-03
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Blast search parameters | ||||
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