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Conserved domains on  [gi|55743155|ref|NP_001006616|]
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WD repeat-containing protein 31 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
5-225 9.36e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 453027 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 9.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   5 WDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSED 84
Cdd:cd00200  78 WDLE-TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  85 KTLRLWDSRGLQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFL 162
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55743155 163 PRALalmpLIATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 225
Cdd:cd00200 229 PDGY----LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
5-225 9.36e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 9.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   5 WDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSED 84
Cdd:cd00200  78 WDLE-TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  85 KTLRLWDSRGLQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFL 162
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55743155 163 PRALalmpLIATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 225
Cdd:cd00200 229 PDGY----LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
2-218 1.14e-24

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 101.32  E-value: 1.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQ 80
Cdd:COG2319 136 VKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLLIA 215
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  81 T-SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRQTRNRICEYKGHFQTVASC 159
Cdd:COG2319 216 SgSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS-----SDGTIRLWDLRSSSSLLRTLSGHSSSVLSV 290
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155 160 VFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDG-SGPLTSLAVGDAISLLCAS 218
Cdd:COG2319 291 AFSPDG----KLLASGSSDGTVRLWDLETGKLLSSLTLKGhEGPVSSLSFSPDGSLLVSG 346
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
10-49 1.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.26e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55743155     10 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 49
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
11-49 7.20e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 7.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55743155    11 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 49
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
34-206 1.71e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   34 SQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT-SEDKTLRLWD-SRGLQVAHMfPAKQHIqtyC 111
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  112 EVSVDGHKCISCSngFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRAlalmpLIATSSHDCKVKIWNqdtgac 191
Cdd:PLN00181 622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSS-----TLVSSSTDNTLKLWD------ 688
                        170
                 ....*....|....*....
gi 55743155  192 lftLSLDGSG----PLTSL 206
Cdd:PLN00181 689 ---LSMSISGinetPLHSF 704
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
5-225 9.36e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 9.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   5 WDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSED 84
Cdd:cd00200  78 WDLE-TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  85 KTLRLWDSRGLQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFL 162
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFS 228
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55743155 163 PRALalmpLIATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 225
Cdd:cd00200 229 PDGY----LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
2-218 1.14e-24

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 101.32  E-value: 1.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQ 80
Cdd:COG2319 136 VKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLLIA 215
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  81 T-SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRQTRNRICEYKGHFQTVASC 159
Cdd:COG2319 216 SgSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS-----SDGTIRLWDLRSSSSLLRTLSGHSSSVLSV 290
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155 160 VFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDG-SGPLTSLAVGDAISLLCAS 218
Cdd:COG2319 291 AFSPDG----KLLASGSSDGTVRLWDLETGKLLSSLTLKGhEGPVSSLSFSPDGSLLVSG 346
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
13-225 1.09e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  13 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDS 92
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  93 RGLQVAHMFpaKQHIQ--TYCEVSVDGHkCISCSngfgGEGCEATLWDLRQTRNRICeYKGHFQTVASCVFLPRALalmp 170
Cdd:cd00200  81 ETGECVRTL--TGHTSyvSSVAFSPDGR-ILSSS----SRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGT---- 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 55743155 171 LIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 225
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFsPDGEKLLSSSSDGTIKL 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
2-218 1.46e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHGSSQPRQqLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 81
Cdd:cd00200  33 IKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  82 SEDKTLRLWDSRglqvahmfpakqhiQTYCEVSVDGHKC------ISCSNGFGGEGCE---ATLWDLRQTRnRICEYKGH 152
Cdd:cd00200 112 SRDKTIKVWDVE--------------TGKCLTTLRGHTDwvnsvaFSPDGTFVASSSQdgtIKLWDLRTGK-CVATLTGH 176
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55743155 153 FQTVASCVFLPRALALmpliATSSHDCKVKIWNQDTGACLFTLSLDgSGPLTSLAVGDAISLLCAS 218
Cdd:cd00200 177 TGEVNSVAFSPDGEKL----LSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASG 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
2-185 1.77e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 81
Cdd:cd00200 117 IKVWDVE-TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  82 SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRqTRNRICEYKGHFQTVASCVF 161
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAW 269
                       170       180
                ....*....|....*....|....
gi 55743155 162 LPRALALmpliATSSHDCKVKIWN 185
Cdd:cd00200 270 SPDGKRL----ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-208 1.07e-16

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 78.59  E-value: 1.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSS-QLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQ 80
Cdd:COG2319 180 IKLWDLR-TGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLAS 258
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  81 TSEDKTLRLWDSRGLQVAHMFPAKqHIQTYCEVSVDGHKCISCSngfGGEGCEATLWDLRQTRNR-ICEYKGHFQTVASC 159
Cdd:COG2319 259 GSSDGTIRLWDLRSSSSLLRTLSG-HSSSVLSVAFSPDGKLLAS---GSSDGTVRLWDLETGKLLsSLTLKGHEGPVSSL 334
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 55743155 160 VFLPRalaLMPLIATSSHDCKVKIWNQDTGACLFTlsLDGSGPLTSLAV 208
Cdd:COG2319 335 SFSPD---GSLLVSGGSDDGTIRLWDLRTGKPLKT--LEGHSNVLSVSF 378
WD40 COG2319
WD40 repeat [General function prediction only];
14-232 1.20e-15

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 75.51  E-value: 1.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  14 RQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERA---SVSRNVVTHLCWVPREPYIL--QTSEDKTLR 88
Cdd:COG2319  58 SLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSlegLHDSSVSKLALSSPDGNSILlaSSSLDGTVK 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  89 LWDSRGL-QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGgegcEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALa 167
Cdd:COG2319 138 LWDLSTPgKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDG----TIKLWDLRTGKP-LSTLAGHTDPVSSLAFSPDGG- 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55743155 168 lmPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQ 232
Cdd:COG2319 212 --LLIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSSS 274
WD40 COG2319
WD40 repeat [General function prediction only];
2-200 1.65e-15

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 75.13  E-value: 1.65e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   2 VMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASV--SRNVVTHLCWVPREPYIL 79
Cdd:COG2319 265 IRLWDLRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLkgHEGPVSSLSFSPDGSLLV 344
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  80 -QTSEDKTLRLWDSRGLQVAHMFpaKQHIQTYCEVSVDGHKCIScsngFGGEGCEATLWDLrQTRNRICEYKGHFQTVAS 158
Cdd:COG2319 345 sGGSDDGTIRLWDLRTGKPLKTL--EGHSNVLSVSFSPDGRVVS----SGSTDGTVRLWDL-STGSLLRNLDGHTSRVTS 417
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 55743155 159 CVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDGS 200
Cdd:COG2319 418 LDFSPDG----KSLASGSSDNTIRLWDLKTSLKSVSFSPDGK 455
WD40 COG2319
WD40 repeat [General function prediction only];
1-232 1.30e-14

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 72.43  E-value: 1.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   1 MVMMWDLHGSSQPRQQLCG-HAMVVTGLAV-SPDSSQL--CTGSRDNTLLLWDVVT-GQSVERASVSRNVVTHLCWVPRE 75
Cdd:COG2319  88 TIKLWDLDNGEKLIKSLEGlHDSSVSKLALsSPDGNSIllASSSLDGTVKLWDLSTpGKLIRTLEGHSESVTSLAFSPDG 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  76 PYILQTSE-DKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCsngfGGEGCEATLWDLRQTRNRICEYKGHFQ 154
Cdd:COG2319 168 KLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLLIAS----GSSDGTIRLWDLSTGKLLRSTLSGHSD 243
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55743155 155 TVASCvFLPRalalMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMDHSQ 232
Cdd:COG2319 244 SVVSS-FSPD----GSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFsPDGKLLASGSSDGTVRLWDLETGK 317
WD40 COG2319
WD40 repeat [General function prediction only];
1-95 1.29e-08

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 54.71  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   1 MVMMWDLHGSSQPRQQLCGHAmvVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQ 80
Cdd:COG2319 352 TIRLWDLRTGKPLKTLEGHSN--VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLAS 429
                        90
                ....*....|....*
gi 55743155  81 TSEDKTLRLWDSRGL 95
Cdd:COG2319 430 GSSDNTIRLWDLKTS 444
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
10-49 1.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.26e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55743155     10 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 49
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
11-49 7.20e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 7.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 55743155    11 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 49
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
34-206 1.71e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155   34 SQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT-SEDKTLRLWD-SRGLQVAHMfPAKQHIqtyC 111
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155  112 EVSVDGHKCISCSngFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRAlalmpLIATSSHDCKVKIWNqdtgac 191
Cdd:PLN00181 622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSS-----TLVSSSTDNTLKLWD------ 688
                        170
                 ....*....|....*....
gi 55743155  192 lftLSLDGSG----PLTSL 206
Cdd:PLN00181 689 ---LSMSISGinetPLHSF 704
PTZ00421 PTZ00421
coronin; Provisional
2-141 4.54e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.95  E-value: 4.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55743155    2 VMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPR 74
Cdd:PTZ00421 100 IMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD 179
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55743155   75 EPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SNGFGGEGC------EATLWDLRQ 141
Cdd:PTZ00421 180 GSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKDLIITLGCsksqqrQIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
142-185 5.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 55743155    142 TRNRICEYKGHFQTVASCVFLPRalalMPLIATSSHDCKVKIWN 185
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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