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Conserved domains on  [gi|56550047|ref|NP_001008225|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.74e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666   43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666  123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                 ....*.
gi 56550047  251 ELWKKG 256
Cdd:COG0666  283 LDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 532-1333 2.02e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.12  E-value: 2.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    532 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 610
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    611 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 690
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    691 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 770
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    771 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 848
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    849 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 905
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    906 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 962
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    963 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1042
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1043 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1122
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1123 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1191
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1192 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047   1271 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1333
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PLN02939 super family cl33600
transferase, transferring glycosyl groups
 238-590 1.08e-03

transferase, transferring glycosyl groups


The actual alignment was detected with superfamily member PLN02939:

Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   238 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 314
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   315 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 374
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   375 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 442
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   443 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 522
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047   523 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.74e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666   43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666  123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                 ....*.
gi 56550047  251 ELWKKG 256
Cdd:COG0666  283 LDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-218 1.59e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    35 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   111 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 56550047   189 TALMLGCEYGCRDAVEVLIKNGADISLLDA 218
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 532-1333 2.02e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.12  E-value: 2.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    532 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 610
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    611 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 690
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    691 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 770
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    771 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 848
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    849 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 905
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    906 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 962
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    963 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1042
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1043 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1122
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1123 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1191
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1192 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047   1271 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1333
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 2.39e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     92 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 56550047    172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
617-1206 2.37e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.57  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   617 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 696
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   697 LKNQTLQKEIEKVYLDNKLLKEQAhnltiemknhyvplKVSEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 776
Cdd:PRK03918  259 EKIRELEERIEELKKEIEELEEKV--------------KELKELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   777 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 856
Cdd:PRK03918  317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   857 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 936
Cdd:PRK03918  385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   937 LANYRKGQEEIVTLHAEIKAQKKELdtiqECIKVKYAPIVSFEECERKFKATEKELKDqLSEQTQKYSVSE-----EEVK 1011
Cdd:PRK03918  454 LEEYTAELKRIEKELKEIEEKERKL----RKELRELEKVLKKESELIKLKELAEQLKE-LEEKLKKYNLEElekkaEEYE 528

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1012 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQK-YTEVKNVKEKLVE---------ENA 1081
Cdd:PRK03918  529 KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgFESVEELEERLKElepfyneylELK 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1082 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQqtvtklHQLLENQKNSsvplaehlqike 1161
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEE------YEELREEYLE------------ 670

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 56550047  1162 aFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1206
Cdd:PRK03918  671 -LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 429-1198 6.59e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 6.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    429 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 508
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    509 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 583
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    584 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 663
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    664 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 738
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    739 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 817
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    818 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 891
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    892 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 970
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    971 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1039
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1040 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1115
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1186
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 56550047   1187 EVSKLQSEVQNT 1198
Cdd:pfam15921  831 EQESVRLKLQHT 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1028-1401 1.05e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1028 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1107
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1108 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1187
Cdd:COG1196  301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1188 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1267
Cdd:COG1196  374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1268 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1347
Cdd:COG1196  441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 56550047 1348 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1401
Cdd:COG1196  513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.75e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   92 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 156
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  157 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 220
Cdd:cd22192   92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 735-1108 5.06e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   735 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 814
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   815 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 890
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   891 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 970
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   971 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1032
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1033 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1106
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 56550047  1107 LK 1108
Cdd:NF033838  445 EK 446
PLN02939 PLN02939
transferase, transferring glycosyl groups
 238-590 1.08e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   238 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 314
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   315 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 374
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   375 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 442
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   443 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 522
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047   523 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 424-721 3.78e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   424 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 501
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   502 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 581
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   582 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 642
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   643 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 713
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 56550047   714 KLLKEQAH 721
Cdd:NF033838  396 KKAEEEAK 403
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 17-252 4.03e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     17 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 90
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     91 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 166
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    167 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 231
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 56550047    232 nlDILTLLKTASENTNKGREL 252
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 277-708 5.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  277 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 356
Cdd:COG1196  396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  357 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 436
Cdd:COG1196  476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  437 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 511
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  512 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 591
Cdd:COG1196  629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  592 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 665
Cdd:COG1196  709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 56550047  666 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 708
Cdd:COG1196  787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.74e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666   43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666  123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                 ....*.
gi 56550047  251 ELWKKG 256
Cdd:COG0666  283 LDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-248 1.63e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 1.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666   10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNK 248
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-239 2.60e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 119.29  E-value: 2.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADL 119
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  120 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 199
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 56550047  200 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-191 6.65e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.64  E-value: 6.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   13 RHAADWNKYDDR----LMKAAERGDVEKVTsILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAG 88
Cdd:COG0666  108 EAGADVNARDKDgetpLHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   89 RNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT 168
Cdd:COG0666  187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266

                        170       180
                 ....*....|....*....|...
gi 56550047  169 ICQLLIDRGADVNSRDKQNRTAL 191
Cdd:COG0666  267 IVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-218 1.59e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    35 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   111 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 56550047   189 TALMLGCEYGCRDAVEVLIKNGADISLLDA 218
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 532-1333 2.02e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.12  E-value: 2.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    532 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 610
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    611 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 690
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    691 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 770
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    771 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 848
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    849 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 905
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    906 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 962
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    963 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1042
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1043 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1122
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1123 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1191
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1192 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047   1271 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1333
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-239 7.43e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 7.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   71 LNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 150
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  151 DVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIG 230
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                 ....*....
gi 56550047  231 DNLDILTLL 239
Cdd:COG0666  164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 2.39e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     92 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 56550047    172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
59-151 2.62e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 2.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     59 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEhaDLQGRTALHDAAMADCPSSIQ 138
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 56550047    139 LLCDHGASVNAKD 151
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 1.54e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 1.54e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    125 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 56550047    205 VLIKNGADISLLD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 759-1401 2.04e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.03  E-value: 2.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    759 TQKYTEKKLEMEKLLLENDSLSKD--VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 836
Cdd:TIGR02168  212 AERYKELKAELRELELALLVLRLEelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    837 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 916
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    917 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS--FEECERKFKATEKELKD 994
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    995 QLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1074
Cdd:TIGR02168  452 LQEELERL----EEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1075 KL-VEENAKQTSEIL---AVQNLL-QKQHVPLEQVEALKKSLNG-------------TIENLKEELKSMQRCYEKEQ--- 1133
Cdd:TIGR02168  528 LIsVDEGYEAAIEAAlggRLQAVVvENLNAAKKAIAFLKQNELGrvtflpldsikgtEIQGNDREILKNIEGFLGVAkdl 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1134 -QTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEKEVGII--------------------KASLREKEEESQNKMEEVS 1189
Cdd:TIGR02168  608 vKFDPKLRKALSYLLGGVLVvddLDNALELAKKLRPGYRIVtldgdlvrpggvitggsaktNSSILERRREIEELEEKIE 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1190 KLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH 1266
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEeleEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1267 FSI-----------------EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLt 1329
Cdd:TIGR02168  768 ERLeeaeeelaeaeaeieelEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ- 846

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56550047   1330 ytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT-----HLLSAAQGHMDEDVQEALLQIIQMRQGL 1401
Cdd:TIGR02168  847 ------IEELSEDIESLAAEIEELEELIEELESELEALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 676-1314 3.65e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.83  E-value: 3.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    676 QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 755
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    756 LDVTQKYTEKKLEMEKllleNDSLSKDVSRLEtvfvppekheKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN 835
Cdd:TIGR04523  197 LKLELLLSNLKKKIQK----NKSLESQISELK----------KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    836 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEH 915
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---------KEQDWNKELKSELKNQEKKLEEIQNQISQN 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    916 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 995
Cdd:TIGR04523  334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    996 LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
Cdd:TIGR04523  414 IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN-------LDNTRESLETQLKVLSRSINKIKQNLEQ 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1076 LVEENAKQTSEILAVQNLlqkqhvpleqvealKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKnssvplae 1155
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEE--------------KKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE-------- 544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1156 hlqiKEAFEKEVGIIKASLrekEEESQNKMEEVSKLQSEVQNTKQALKKLETrevvDLSKYKATKSDLETQISSLNEKLA 1235
Cdd:TIGR04523  545 ----DELNKDDFELKKENL---EKEIDEKNKEIEELKQTQKSLKKKQEEKQE----LIDQKEKEKKDLIKEIEEKEKKIS 613

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047   1236 NLNRKYEEVCEEvlhaKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIeakdNKITELLND 1314
Cdd:TIGR04523  614 SLEKELEKAKKE----NEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI----DDIIELMKD 684
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
617-1206 2.37e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.57  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   617 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 696
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   697 LKNQTLQKEIEKVYLDNKLLKEQAhnltiemknhyvplKVSEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 776
Cdd:PRK03918  259 EKIRELEERIEELKKEIEELEEKV--------------KELKELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   777 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 856
Cdd:PRK03918  317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   857 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 936
Cdd:PRK03918  385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   937 LANYRKGQEEIVTLHAEIKAQKKELdtiqECIKVKYAPIVSFEECERKFKATEKELKDqLSEQTQKYSVSE-----EEVK 1011
Cdd:PRK03918  454 LEEYTAELKRIEKELKEIEEKERKL----RKELRELEKVLKKESELIKLKELAEQLKE-LEEKLKKYNLEElekkaEEYE 528

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1012 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQK-YTEVKNVKEKLVE---------ENA 1081
Cdd:PRK03918  529 KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgFESVEELEERLKElepfyneylELK 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1082 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQqtvtklHQLLENQKNSsvplaehlqike 1161
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEE------YEELREEYLE------------ 670

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 56550047  1162 aFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1206
Cdd:PRK03918  671 -LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
PTZ00121 PTZ00121
MAEBL; Provisional
 453-1260 3.43e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 78.26  E-value: 3.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   453 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKehltseaASGNHRLTEELKDQ 532
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKK-------AEAVKKAEEAKKDA 1239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   533 LKDLKVKYEGASAEVGKLRN-QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 611
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEaRMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   612 LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK 691
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   692 ITELTLKNQTLQKEIEKvyldnKLLKEQAHNLTIEMKnhyvplKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE--KKLEM 769
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAA-----KKKADEAKKKAEEKK------KADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEE 1468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   770 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNiVELKKQLSELKKkcGEDQEKIHALTSENTNLKKMMSNQYVPV 849
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-AEAKKKADEAKK--AEEAKKADEAKKAEEAKKADEAKKAEEK 1545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   850 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV 929
Cdd:PTZ00121 1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   930 QDSNAEilanyRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKfkaTEKELKDQLSEQTQKysvsEEE 1009
Cdd:PTZ00121 1626 KKAEEE-----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKA----AEA 1693

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1010 VKKNKQEndklKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKnvkeklVEENAKQTSEILA 1089
Cdd:PTZ00121 1694 LKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK------KDEEEKKKIAHLK 1763

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1090 VQNLLQKQHVPLEQVEALKKSLNgtienlKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1169
Cdd:PTZ00121 1764 KEEEKKAEEIRKEKEAVIEEELD------EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVAD 1837

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1170 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK--------LETREVVDLSKyKATKSDLETQISSLNEKLAN----- 1236
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKekdlkeddEEEIEEADEIE-KIDKDDIEREIPNNNMAGKNndiid 1916

                         810       820       830
                  ....*....|....*....|....*....|..
gi 56550047  1237 --------LNRKYEEVCEEVLHAKKKEISAKD 1260
Cdd:PTZ00121 1917 dkldkdeyIKRDAEETREEIIKISKKDMCIND 1948
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 62-213 1.06e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.06  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    62 VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLC 141
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56550047   142 dHGASVNAKDVDGRTpLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 213
Cdd:PLN03192  612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
527-1127 1.28e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   527 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF---KRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 603
Cdd:PRK03918  203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIeelEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   604 KELsaklalsipaekfenmksslsNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaqhvkpEEHEQVKSRLEQ 683
Cdd:PRK03918  283 KEL---------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEI------NGIEERIKELEE 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   684 KSGELGkkitELTLKNQTLQKEIEKVYLDNKLLkEQAHNLTIEMKNHyvplkvsedMKKSHDAIIDDLNRKLLDVTQKYT 763
Cdd:PRK03918  336 KEERLE----ELKKKLKELEKRLEELEERHELY-EEAKAKKEELERL---------KKRLTGLTPEKLEKELEELEKAKE 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   764 EKKLEMEKLllendslskdvsrletvfvppekhEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTnlKKMMS 843
Cdd:PRK03918  402 EIEEEISKI------------------------TARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHR--KELLE 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   844 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDiNQEFVKIKDKNEILKrNLENTQNQIKAEYISLAEHEakmssls 923
Cdd:PRK03918  456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLK-ELEEKLKKYNLEELEKKAEE------- 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   924 qsmrkvqdsnaeilanYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKY 1003
Cdd:PRK03918  527 ----------------YEKLKEKLIKLKGEIKSLKKELEKLEELKKKL-------AELEKKLDELEEELAELLKELEELG 583

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL-VEENAK 1082
Cdd:PRK03918  584 FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEE 663

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 56550047  1083 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1127
Cdd:PRK03918  664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 292-1124 1.60e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 1.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    292 DLKERLRKIQQeqRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSG 371
Cdd:TIGR02168  217 ELKAELRELEL--ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    372 SHFSNRKEDMLLKQGQMYMADSQctspgipahmqsrsmlrPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQ 451
Cdd:TIGR02168  295 NEISRLEQQKQILRERLANLERQ-----------------LEELEAQLEELESKLDELAEELAELEEKLEELKEELESLE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    452 NELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELKD 531
Cdd:TIGR02168  358 AELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIEE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    532 QLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 611
Cdd:TIGR02168  426 LLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    612 LsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSGE 687
Cdd:TIGR02168  493 S---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQNE 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    688 LGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLN-----RKLLD--- 757
Cdd:TIGR02168  570 LGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDLDnalelAKKLRpgy 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    758 --VT--------------------QKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLS 815
Cdd:TIGR02168  646 riVTldgdlvrpggvitggsaktnSSILERRREIEELEEKIEELEEKIAELEKAL---AELRKELEELEEELEQLRKELE 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    816 ELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 895
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    896 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY--- 972
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLner 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    973 ----APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK-TVLIEKSHEMERA 1047
Cdd:TIGR02168  883 asleEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENK 962

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56550047   1048 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEilavQNLLQKQHvplEQVEALKKSLNGTIENLKEELKS 1124
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKER----YDFLTAQK---EDLTEAKETLEEAIEEIDREARE 1032
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
873-1367 2.89e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.72  E-value: 2.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   873 VKKKFEDINQEFVKIKDKNEILKRNLENtqnqIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHA 952
Cdd:PRK03918  198 KEKELEEVLREINEISSELPELREELEK----LEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   953 EIKAQKKELDTIQEcIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKkEIFTLQKDLR 1032
Cdd:PRK03918  274 EIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1033 DKTVLIEKSHE--------MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1104
Cdd:PRK03918  352 KRLEELEERHElyeeakakKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1105 EA-------------------LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK 1165
Cdd:PRK03918  432 KKakgkcpvcgrelteehrkeLLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEK 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1166 EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevvdlsKYKATKSDLETQISSLNEKLANLNRKYEEV- 1244
Cdd:PRK03918  512 LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE--------ELKKKLAELEKKLDELEEELAELLKELEELg 583

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1245 --CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL-----NDVER 1317
Cdd:PRK03918  584 feSVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEkkyseEEYEE 663

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 56550047  1318 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
Cdd:PRK03918  664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL 713
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-232 3.45e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    32 GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAGRNALH--LAAKYGHALCLQKLL 108
Cdd:PHA03095   60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIkAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   109 QYNCPTEHADLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDVDGRTPL--VLATQMSRPTICQLLIDRGADV 180
Cdd:PHA03095  140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRAGCDP 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56550047   181 NSRDKQNRTALMLGCEYG-CRDA-VEVLIKNGADISLLDALGHDSSYYARIGDN 232
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 469-1244 5.18e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.33  E-value: 5.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    469 ERVKEDSDEQIKQL-------EDALK--DVQKRMYESEGKVkqmqtHFLALKEHLTSEAASGNHRltEELKDQLKDLKVK 539
Cdd:TIGR02169  187 ERLDLIIDEKRQQLerlrrerEKAERyqALLKEKREYEGYE-----LLKEKEALERQKEAIERQL--ASLEEELEKLTEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    540 YEGASAEVGKLRNQIKqnemivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEK 618
Cdd:TIGR02169  260 ISELEKRLEEIEQLLE------ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAkLEAEIDK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    619 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKSGELGKKITELTLK 698
Cdd:TIGR02169  334 LLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR--DELKDYREKLEKLKREINELKRELDRL 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    699 NQTLQK-EIEKVYLDNKL--LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 775
Cdd:TIGR02169  412 QEELQRlSEELADLNAAIagIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    776 NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC--------------------GEDQEKIHALTSEN 835
Cdd:TIGR02169  492 LAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYataievaagnrlnnvvveddAVAKEAIELLKRRK 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    836 TN------LKKMMSNQYVPVKTHEE-------------------VKMTLNDTLA----KTNRELLD-------------- 872
Cdd:TIGR02169  572 AGratflpLNKMRDERRDLSILSEDgvigfavdlvefdpkyepaFKYVFGDTLVvediEAARRLMGkyrmvtlegelfek 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    873 --------VKKKFEDINQefVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 944
Cdd:TIGR02169  652 sgamtggsRAPRGGILFS--RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLE 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    945 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYsvSEEEVKKNKQENDKLKKEI 1024
Cdd:TIGR02169  730 QEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLsqkyTEVKNVKEKLVEENAKQTSEILAVqnlLQKQHVPLEQV 1104
Cdd:TIGR02169  808 SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEE---LEELEAALRDL 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNK 1184
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK----------LEALEEELSEIEDPKGEDEEIPEEE 950

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1185 MEEvSKLQSEVQNTKQALKKLET----------REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEV 1244
Cdd:TIGR02169  951 LSL-EDVQAELQRVEEEIRALEPvnmlaiqeyeEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREV 1019
PTZ00121 PTZ00121
MAEBL; Provisional
 619-1317 6.30e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.02  E-value: 6.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   619 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 698
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKA 1160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   699 NQTLQKEIEKVYLDNKllKEQAHNLTIEMKNHYvPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS 778
Cdd:PTZ00121 1161 EDARKAEEARKAEDAK--KAEAARKAEEVRKAE-ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   779 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkkmmsnqyvpvKTHEEVKMT 858
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK------------KAEEKKKAD 1305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   859 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILA 938
Cdd:PTZ00121 1306 EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA-----AADEAEAAEEKAEAAEKKKEEAKKKA 1380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   939 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQE 1016
Cdd:PTZ00121 1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAEEAKKAE 1460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1017 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQlKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1093
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKaeeAKKKADEAKKA-AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1094 LQKQHV----PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1169
Cdd:PTZ00121 1540 KKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1170 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL 1249
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE 1699

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1250 HAKKKEISAKDEKELLHfSIEQEIKDQKERCDKS--LTTITELQRRIQESAKQIEAKDNKITELLNDVER 1317
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAeeAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
PTZ00121 PTZ00121
MAEBL; Provisional
 507-1304 9.36e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.64  E-value: 9.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   507 FLALKEHLTSEAASGNHRLTEELKdQLKDLKVKYEGASAEVGKLRNQIKQNEmivEEFKRDEGKLIEENKRLQKELSMCE 586
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAK-KTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRVEI 1156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   587 MEREKKGRKVTEMEGQAKELSAKlalsiPAEKFENMKSSLSNEVNEKAKKLVEMER-EHEKSLSEIRQLKRELENVKAKL 665
Cdd:PTZ00121 1157 ARKAEDARKAEEARKAEDAKKAE-----AARKAEEVRKAEELRKAEDARKAEAARKaEEERKAEEARKAEDAKKAEAVKK 1231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   666 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI--EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 743
Cdd:PTZ00121 1232 AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKA 1311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   744 HDAiiddlnRKLLDVTQKYTEKKLEMEKLLLENDSLSKdvsRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGE 823
Cdd:PTZ00121 1312 EEA------KKADEAKKKAEEAKKKADAAKKKAEEAKK---AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA 1382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   824 DQEKIHALTSENTNLKKMMSNQyvpvKTHEEVKMTlndtlAKTNRELLDVKKKFEDinqefvkiKDKNEILKRNLENTQn 903
Cdd:PTZ00121 1383 AKKKAEEKKKADEAKKKAEEDK----KKADELKKA-----AAAKKKADEAKKKAEE--------KKKADEAKKKAEEAK- 1444

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   904 qiKAEYISLAEHEAKMSSlsqsmrkvqdsNAEILANYRKGQEEIVTlHAEIKAQKKELDTIQECIKVKYApivsfeecER 983
Cdd:PTZ00121 1445 --KADEAKKKAEEAKKAE-----------EAKKKAEEAKKADEAKK-KAEEAKKADEAKKKAEEAKKKAD--------EA 1502

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   984 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKdlS 1063
Cdd:PTZ00121 1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA--L 1580

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1064 QKYTEVKNVKEKLVEENAKQTSEILAVQ-NLLQKQHVPLEQVEALKKSlngtienlKEELKSMQRCYEKEQQTVTKLHQL 1142
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELKKA--------EEEKKKVEQLKKKEAEEKKKAEEL 1652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1143 LENQKNSSVPlAEHLQIKEAFEKEvgiiKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1222
Cdd:PTZ00121 1653 KKAEEENKIK-AAEEAKKAEEDKK----KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1223 LETQISSLNEKLANLNRKYEEvceevlhAKKKEisaKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIE 1302
Cdd:PTZ00121 1728 NKIKAEEAKKEAEEDKKKAEE-------AKKDE---EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797


                  ..
gi 56550047  1303 AK 1304
Cdd:PTZ00121 1798 KK 1799
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 295-1127 1.35e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.78  E-value: 1.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    295 ERLRKIQQEQRilldkvnglQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALknrfkyfESDHLGSGSHF 374
Cdd:TIGR02168  213 ERYKELKAELR---------ELELALLVLRLEELREELEELQEELKEAEEELEELTAELQEL-------EEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    375 SNRKEDMLLKQGQMYMADSQCT--SPGIPAHMQSRSMLR--PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKL 450
Cdd:TIGR02168  277 SELEEEIEELQKELYALANEISrlEQQKQILRERLANLErqLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    451 QNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELK 530
Cdd:TIGR02168  357 EAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    531 DQLKDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL 610
Cdd:TIGR02168  425 ELLKKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    611 ALsipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSG 686
Cdd:TIGR02168  492 DS---LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQN 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    687 ELGKkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLnrklldvtqkytE 764
Cdd:TIGR02168  569 ELGR----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDL------------D 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    765 KKLEMEKLLLENDSL-SKDVSRLETVFVPPEKHEKEiialKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 843
Cdd:TIGR02168  633 NALELAKKLRPGYRIvTLDGDLVRPGGVITGGSAKT----NSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    844 NQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA-------EYISLAEHE 916
Cdd:TIGR02168  709 EL-------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEleerleeAEEELAEAE 781

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    917 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    997 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK----NV 1072
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvridNL 941

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56550047   1073 KEKLVEEnakqtseilavqnllqkQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1127
Cdd:TIGR02168  942 QERLSEE-----------------YSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 538-1316 1.38e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 72.79  E-value: 1.38e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    538 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG----RKVTEMEGQAKELSAKLA-L 612
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGyellKEKEALERQKEAIERQLAsL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    613 SIPAEKFENMKSSLSNEVNEKAKKLVEMERE-HEKSLSEIRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGK 690
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLErSIAEKERELEDAEERLAKLEA 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    691 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK-VSEDMKKSHDAIiDDLNRKLLDVTQKYTEKKLEM 769
Cdd:TIGR02169  330 EIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEeVDKEFAETRDEL-KDYREKLEKLKREINELKREL 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    770 EKLLLENDSLSKDVSRletvfvppekHEKEIIALKSNIVELKKQLSELkkkcgedQEKIHALTSENTNLKKMMSNQYVPV 849
Cdd:TIGR02169  409 DRLQEELQRLSEELAD----------LNAAIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAADLSKYEQEL 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    850 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIkAEYISLAEHEAKMSSLSQSMR-- 927
Cdd:TIGR02169  472 YDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERYATAIEVAAGNRln 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    928 -------KVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYApiVSFEECERKFkatekelkdqlsEQT 1000
Cdd:TIGR02169  551 nvvveddAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKY------------EPA 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1001 QKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRDKTVLIEKSH--------------EMERALSRKTDELNKQLKDLSQ 1064
Cdd:TIGR02169  616 FKYVFGDTLVVEDIEAARRLmgKYRMVTLEGELFEKSGAMTGGSraprggilfsrsepAELQRLRERLEGLKRELSSLQS 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1065 KYTEVKN-VKEKL--VEENAKQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1137
Cdd:TIGR02169  696 ELRRIENrLDELSqeLSDASRKIGEIEKEIEQLEQEEEKlkerLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1138 KLHQLLEN--QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSK 1215
Cdd:TIGR02169  776 KLEEALNDleARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI----KS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1216 YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEllhfSIEQEIKDQKERCDKSLTTITELQRRIQ 1295
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR----ELERKIEELEAQIEKKRKRLSELKAKLE 927

                          810       820
                   ....*....|....*....|.
gi 56550047   1296 ESAKQIEAKDNKITELLNDVE 1316
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPE 948
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-222 2.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    35 EKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02874  105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   115 EHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIcQLLIDrGADVNSRDKQNRTALMLG 194
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                         170       180
                  ....*....|....*....|....*....
gi 56550047   195 CEYGC-RDAVEVLIKNGADISLLDALGHD 222
Cdd:PHA02874  262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
447-969 3.07e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.63  E-value: 3.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   447 RLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEaasgnhRLT 526
Cdd:PRK03918  229 EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS------EFY 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   527 EELKDQLKDLKVKYEGASAEVGKLRNQIKQnemiVEEFKRDEGKLIEENKRLQKELSMCEmEREKKGRKVTEMEGQAKEL 606
Cdd:PRK03918  303 EEYLDELREIEKRLSRLEEEINGIEERIKE----LEEKEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERL 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   607 SAKLAlSIPAEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 683
Cdd:PRK03918  378 KKRLT-GLTPEKLEKELEELEKakeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   684 KSGELGKKITEL-TLKNQTLQKEIEKVYLDNKLLKEQAhnlTIEMKNHYVPLKVSEDMKKSHDAiiddlnrklldvtQKY 762
Cdd:PRK03918  457 YTAELKRIEKELkEIEEKERKLRKELRELEKVLKKESE---LIKLKELAEQLKELEEKLKKYNL-------------EEL 520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   763 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ-EKIHALTSENTNLKKM 841
Cdd:PRK03918  521 EKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPF 600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   842 MsNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL-ENTQNQIKAEYISLAEHEAKMS 920
Cdd:PRK03918  601 Y-NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEELREEYLELSRELAGLR 679

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 56550047   921 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 969
Cdd:PRK03918  680 AELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE 728
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 477-1273 1.13e-11

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 70.08  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    477 EQIKQLEDALKDVQKRMYESegKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
Cdd:TIGR01612  974 DKINELDKAFKDASLNDYEA--KNNELIKYFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHT 1051

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    557 NEM-IVEEFKRDEGKLIEE-NKRLQKE--LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIpaEKFENMKSSLSNEVNE 632
Cdd:TIGR01612 1052 SIYnIIDEIEKEIGKNIELlNKEILEEaeINITNFNEIKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDH 1129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    633 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ----VKSRLEQKSG---ELGKKITELTL--KNQTLQ 703
Cdd:TIGR01612 1130 HIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDPEEIEKkienIVTKIDKKKNiydEIKKLLNEIAEieKDKTSL 1209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    704 KEIEKVYLD-----NKLLKEQAHnltiEMKnhyvplKVSEDMKKSHDAIIDDLNrkllDVTQKYTEKKLEMEKLLLENds 778
Cdd:TIGR01612 1210 EEVKGINLSygknlGKLFLEKID----EEK------KKSEHMIKAMEAYIEDLD----EIKEKSPEIENEMGIEMDIK-- 1273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    779 lskdvSRLETVFVPPEKHEKEIIALKSNivelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 858
Cdd:TIGR01612 1274 -----AEMETFNISHDDDKDHHIISKKH----DENISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLY 1344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    859 LNDTLAKTN-RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA--EYISLAEHEAKMSSLSQSmrkvQDSNaE 935
Cdd:TIGR01612 1345 LNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKikDDINLEECKSKIESTLDD----KDID-E 1419

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    936 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIvsfEECERKFKATEKELKD-----------QLSEQTQKYS 1004
Cdd:TIGR01612 1420 CIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNI---EMADNKSQHILKIKKDnatndhdfninELKEHIDKSK 1496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1005 VSEEEVKKNKQENDKlKKEIFTLQKdlRDKTVLIEKSHEMEralsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
Cdd:TIGR01612 1497 GCKDEADKNAKAIEK-NKELFEQYK--KDVTELLNKYSALA-----IKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSE 1568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1085 SEIlavqNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQrcyekeqqtvTKLHQLLENQKNSSVPLAEhlqiKEAFE 1164
Cdd:TIGR01612 1569 QKI----KEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFE----------NKFLKISDIKKKINDCLKE----TESIE 1630

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1165 KEVGIIkaSLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRevvdlskyKATKSDLETQISSLNEKLANLNRKYE-- 1242
Cdd:TIGR01612 1631 KKISSF--SIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEig 1700

                          810       820       830
                   ....*....|....*....|....*....|...
gi 56550047   1243 --EVCEEVLHAKKKEISAKdeKELLHFSIEQEI 1273
Cdd:TIGR01612 1701 iiEKIKEIAIANKEEIESI--KELIEPTIENLI 1731
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 641-1320 1.19e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.28  E-value: 1.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    641 EREHEKSLSEIRQLKRELENVKAKLAQHVKPE-EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 719
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLnKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    720 AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtqkyTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKE 799
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI-------KKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    800 IIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDVKKK 876
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQ--------------LKDNIEKKQQEINEKTTE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    877 FEDINQEFVKIKDKNEILKRNLENTQNQIKaeyislaEHEAKMSSLSQsmrKVQDSNAEILA-NYRKGQEEIVTLHAEIK 955
Cdd:TIGR04523  248 ISNTQTQLNQLKDEQNKIKKQLSEKQKELE-------QNNKKIKELEK---QLNQLKSEISDlNNQKEQDWNKELKSELK 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    956 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK-------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1028
Cdd:TIGR04523  318 NQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1029 KDLRDKTVLiekshemeralsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIlavQNLLQKQHVpleqVEALK 1108
Cdd:TIGR04523  398 SKIQNQEKL--------------NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEI---KDLTNQDSV----KELII 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1109 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNkmeEV 1188
Cdd:TIGR04523  457 KNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES---EK 533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1189 SKLQSEVQNTKQALKKLETRevvdlskykATKSDLETQISSLNEKLanlnrkyeevcEEVLHAKKKEISAKDEKELLHFS 1268
Cdd:TIGR04523  534 KEKESKISDLEDELNKDDFE---------LKKENLEKEIDEKNKEI-----------EELKQTQKSLKKKQEEKQELIDQ 593

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 56550047   1269 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1320
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-181 3.61e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.00  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    33 DVEKVTSILAKKGVNPGKLDVEGRSVFHV--VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA------LCL 104
Cdd:PHA03100   84 DVKEIVKLLLEYGANVNAPDNNGITPLLYaiSKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   105 QK------------LLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 172
Cdd:PHA03100  164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                  ....*....
gi 56550047   173 LIDRGADVN 181
Cdd:PHA03100  244 LLNNGPSIK 252
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-257 5.22e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    24 RLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALC 103
Cdd:PHA02876  147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   104 LQKLLQYNCPTEHADLQGRTALHDaamADCPSSIqLLCDHGASVNAKDVDGRTPLVLATQMsrPTICQL---LIDRGADV 180
Cdd:PHA02876  227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047   181 NSRDKQNRTALMLGCEYGC-RDAVEVLIKNGADISLLDALGHDSSYYARIGD-NLDILTLLKTASENTNkGRELWKKGP 257
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 429-1198 6.59e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 6.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    429 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 508
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    509 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 583
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    584 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 663
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    664 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 738
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    739 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 817
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    818 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 891
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    892 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 970
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    971 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1039
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1040 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1115
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1186
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 56550047   1187 EVSKLQSEVQNT 1198
Cdd:pfam15921  831 EQESVRLKLQHT 842
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-223 1.18e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.24  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    25 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYG-HAL 102
Cdd:PHA02876  277 LHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKD 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   103 CLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP-TICQLLIDRGADVN 181
Cdd:PHA02876  357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVN 436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 56550047   182 SRDKQNRTALMLGCEYGCR-DAVEVLIKNGADIS---------LLDALGHDS 223
Cdd:PHA02876  437 SKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNainiqnqypLLIALEYHG 488
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 469-1306 1.67e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.91  E-value: 1.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    469 ERVKEDSDEQIKqledalkDVQKRMYES------------------EGKVKQMQTHFLALKEHLTSEAASgnhrlTEELK 530
Cdd:pfam15921   77 ERVLEEYSHQVK-------DLQRRLNESnelhekqkfylrqsvidlQTKLQEMQMERDAMADIRRRESQS-----QEDLR 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    531 DQLKDLKVKYEGA-SAEVGKLRNQIKQNEMIVEEFKRDEGKlieenkrLQKELSMCEMEREKKGRKVTEMEgqakelsak 609
Cdd:pfam15921  145 NQLQNTVHELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGV-------LQEIRSILVDFEEASGKKIYEHD--------- 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    610 lalSIPAEKFENMKSSLSnevnekaKKLVEMEREHEKSLSEIRQLKRELENVKAKlAQHVKPEEHEQVKSRLEQKSGELG 689
Cdd:pfam15921  209 ---SMSTMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSE-SQNKIELLLQQHQDRIEQLISEHE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    690 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS--------EDMKKSHDAIIDDLNRKLLDVTQK 761
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTvsqlrselREAKRMYEDKIEELEKQLVLANSE 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    762 YTEKKLEMEKLLLENDSLSkdvSRLETVFVPPEKHEKEIialksnivelkkQLSELKKKCGEDQEKIHALTSEntNLKKM 841
Cdd:pfam15921  358 LTEARTERDQFSQESGNLD---DQLQKLLADLHKREKEL------------SLEKEQNKRLWDRDTGNSITID--HLRRE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    842 MSNQYVPVKTHEEVKMTL-NDTLAKTNRELLDVKKKFEDInQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMS 920
Cdd:pfam15921  421 LDDRNMEVQRLEALLKAMkSECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVS 499

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    921 SLSQSM----RKVQDSNAEIlanyRKGQEEIVTLHAEIKAQKKELDTIQECIKvkyapivsfeECER-KFKATEKE---- 991
Cdd:pfam15921  500 DLTASLqekeRAIEATNAEI----TKLRSRVDLKLQELQHLKNEGDHLRNVQT----------ECEAlKLQMAEKDkvie 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    992 -LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL----SQKY 1066
Cdd:pfam15921  566 iLRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagSERL 645

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1067 TEVKNVKE---KLVEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKlhqlL 1143
Cdd:pfam15921  646 RAVKDIKQerdQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKS----M 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1144 ENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSKYKATKSD 1222
Cdd:pfam15921  719 EGSDGHAMKVAMGMQKQiTAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEK----NKMAGELEV 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1223 LETQISSLNEKLANLNRKYEEVceEVLHAKKKEISAKDEKELLHFSIEQEIkDQKERCDKSLTTITELQRRIQESAKQIE 1302
Cdd:pfam15921  795 LRSQERRLKEKVANMEVALDKA--SLQFAECQDIIQRQEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTR 871


                   ....
gi 56550047   1303 AKDN 1306
Cdd:pfam15921  872 THSN 875
PHA03095 PHA03095
ankyrin-like protein; Provisional
 106-221 2.31e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 2.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   106 KLLQYNCPTEHADLQGRTALH---DAAMADCPSSIQLLCDHGASVNAKDVDGRTPL-VLATQMSRPTICQLLIDRGADVN 181
Cdd:PHA03095   32 RLLAAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVN 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 56550047   182 SRDKQNRTALMLGCEYGCRDA--VEVLIKNGADISLLDALGH 221
Cdd:PHA03095  112 AKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGM 153
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-248 2.50e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    25 LMKAAERGDVEKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCL 104
Cdd:PHA02874  128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   105 QKLLQYNCPTEHADLQGRTALHDAAMADcPSSIQLLCDHgASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGADVNSR 183
Cdd:PHA02874  207 KLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIK 284

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56550047   184 DKQNRTALMLGCEYGCRDAV-------EVLIKNGADISLLDALGHDSsyyarIGDNLDILTLLKTASENTNK 248
Cdd:PHA02874  285 DNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 40-216 2.60e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 2.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGV---DITTSDtaGRNALHLAAKYGHALCLQKLLQYNCPTEH 116
Cdd:PHA02875   53 LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   117 ADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM-LGC 195
Cdd:PHA02875  131 PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAI 210

                         170       180
                  ....*....|....*....|.
gi 56550047   196 EYGCRDAVEVLIKNGADISLL 216
Cdd:PHA02875  211 ENNKIDIVRLFIKRGADCNIM 231
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 476-1289 2.67e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.04  E-value: 2.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    476 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSeaasgnhrlteeLKDQLKDLKvkyegasAEVGKLRNQIK 555
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN------------SNNKIKILE-------QQIKDLNDKLK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    556 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLSNEVNEKAK 635
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI------KKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    636 KLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvyldnkl 715
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLL---KLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEK------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    716 LKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQkyTEKKLemeklllenDSLSKDVSRLETVF--VPP 793
Cdd:TIGR04523  237 KQQEINEKTTEISNTQTQLN---QLKDEQNKIKKQLSEKQKELEQ--NNKKI---------KELEKQLNQLKSEIsdLNN 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    794 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 873
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN--------------SESENSEKQRELEEK 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    874 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQsmrkvqdsnaeilaNYRKGQEEIVTLHAE 953
Cdd:TIGR04523  369 QNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ--------------EKELLEKEIERLKET 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    954 IKAQKKELDTIQECIKVKyapivsfeecerkfKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLrd 1033
Cdd:TIGR04523  435 IIKNNSEIKDLTNQDSVK--------------ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL-- 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1034 ktvliekshemeRALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL--EQVEALKKSL 1111
Cdd:TIGR04523  499 ------------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEK 566

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1112 NGTIENLKEELKSMQRCYEKEQQtvtKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1191
Cdd:TIGR04523  567 NKEIEELKQTQKSLKKKQEEKQE---LIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1192 QSEVQNTKQALKKLetrevvdlskyKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL------ 1265
Cdd:TIGR04523  644 KQEVKQIKETIKEI-----------RNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLpkleek 712

                          810       820
                   ....*....|....*....|....
gi 56550047   1266 HFSIEQEIKDQKErCDKSLTTITE 1289
Cdd:TIGR04523  713 YKEIEKELKKLDE-FSKELENIIK 735
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 945-1355 4.60e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.27  E-value: 4.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    945 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK-------YSVSEEEVKKNKQEN 1017
Cdd:TIGR04523   40 KKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKinklnsdLSKINSEIKNDKEQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1018 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1097
Cdd:TIGR04523  120 NKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKL 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1098 HVPLEQVEALK---KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNssvplaEHLQIKEAFEKevgiIKASL 1174
Cdd:TIGR04523  200 ELLLSNLKKKIqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT------QLNQLKDEQNK----IKKQL 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1175 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY--------KATKSDLETQISSLNEKLANLNRKYEEVCE 1246
Cdd:TIGR04523  270 SEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1247 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL---TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1323
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKnleSQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 56550047   1324 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1355
Cdd:TIGR04523  430 RLKETIIKNNSEIKDLTNQDSVKELIIKNLDN 461
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 617-1363 5.24e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 64.37  E-value: 5.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    617 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQlkrELENVKAKLAQHVKPEEHEQVKSRLEQKSGElgkkitelT 696
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQ---SVIDLQTKLQEMQMERDAMADIRRRESQSQE--------D 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    697 LKNQtLQKEIEKVYLdNKLLKEQAhnltieMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKklemeklLLEN 776
Cdd:pfam15921  143 LRNQ-LQNTVHELEA-AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK-------IYEH 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    777 DSLSKdvsrletvfvppeKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvktHEEv 855
Cdd:pfam15921  208 DSMST-------------MHFRSLGSAISKILrELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQ------HQD- 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    856 kmTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKrnlENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 935
Cdd:pfam15921  268 --RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQ---EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    936 ILANYRKgqeEIVTLHAEIKAQKKELDtiqecikvkyapivsfeecerKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1015
Cdd:pfam15921  343 KIEELEK---QLVLANSELTEARTERD---------------------QFSQESGNLDDQLQKLLADLHKREKELSLEKE 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1016 ENDKL-------KKEIFTLQKDLRDKTVLIEKsheMERALSRKTDELNKQLKdlsQKYTEVKNVKEKLvEENAKQTSEIL 1088
Cdd:pfam15921  399 QNKRLwdrdtgnSITIDHLRRELDDRNMEVQR---LEALLKAMKSECQGQME---RQMAAIQGKNESL-EKVSSLTAQLE 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1089 AVQNLLQKQhvpLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLH-------QLLENQKNSsvplAEHLQ 1158
Cdd:pfam15921  472 STKEMLRKV---VEELTAKKMTLESserTVSDLTASLQEKERAIEATNAEITKLRsrvdlklQELQHLKNE----GDHLR 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1159 IKEAfekEVGIIKASLREKE---EESQNKMEEVSKLQSE-------VQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1228
Cdd:pfam15921  545 NVQT---ECEALKLQMAEKDkviEILRQQIENMTQLVGQhgrtagaMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIR 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1229 SLNEKLANLNRKyeevceevlhaKKKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITE----LQRRIQESAKQI 1301
Cdd:pfam15921  622 ELEARVSDLELE-----------KVKLVNAGSERLRAVKDIKQErdqLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEM 690

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56550047   1302 EAKDNKITELLNDVE-RLKQALNGLSQLTYTSGNPTK----RQSQL------IDTLQHQVKSLEQQLADADRQ 1363
Cdd:pfam15921  691 ETTTNKLKMQLKSAQsELEQTRNTLKSMEGSDGHAMKvamgMQKQItakrgqIDALQSKIQFLEEAMTNANKE 763
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-239 6.07e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 6.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    59 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHADLQGRTALHDAAMADC 133
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   134 --PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT--ICQLLIDRGADVN----------------SRDKQNRTALML 193
Cdd:PHA03100  119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHY 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 56550047   194 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:PHA03100  199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 766-1357 7.11e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.98  E-value: 7.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    766 KLEMEKLLLENDSLSKDVSRleTVFVPPEKHEKEIIALKSNIVELKKQLSELK-------------KKCGED-----QEK 827
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirrreSQSQEDlrnqlQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    828 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDV-----KKKFEDINQEFVKIKDKNEILKRNLENTQ 902
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFeeasgKKIYEHDSMSTMHFRSLGSAISKILRELD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    903 NQI---KAEYISLAEHEAKMSSLSQS-----MRKVQDSNAEILANYrkgQEEIVTLHAEIKAQKKELDTIQ---ECIKVK 971
Cdd:pfam15921  231 TEIsylKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQsqlEIIQEQ 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    972 YAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendkLKKEIFTLQKDLRDKtvLIEKSHEMERALSR 1050
Cdd:pfam15921  308 ARNQNSMYMRQlSDLESTVSQLRSELREAKRMYEDKIEELEKQLV----LANSELTEARTERDQ--FSQESGNLDDQLQK 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1051 KTDELNKQLKDLSQKytevKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1130
Cdd:pfam15921  382 LLADLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1131 KEQQTVTKLHQLLENQKNSSVPLAEHLQIK----EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1206
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1207 TREvVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ---EIKDQKERCDKS 1283
Cdd:pfam15921  538 NEG-DHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDrrlELQEFKILKDKK 616

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1284 LTTITELQRRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ----LTYTSGNPTKRQSQLIDT 1345
Cdd:pfam15921  617 DAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEMETTTNK 696

                          650
                   ....*....|..
gi 56550047   1346 LQHQVKSLEQQL 1357
Cdd:pfam15921  697 LKMQLKSAQSEL 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 914-1265 8.99e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.54  E-value: 8.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    914 EHEAKMSSLSQSMRKVQDSNAEILANYRK--GQEEIVTLHAEIKAQKKELDtiqecIKVKYAPIVSFEECERKFKATEKE 991
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSleRQAEKAERYKELKAELRELE-----LALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    992 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1071
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1072 VKEKLVEEnakqtseilavqnllqkqhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsv 1151
Cdd:TIGR02168  331 KLDELAEE---------------------LAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSK-- 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1152 pLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNtkQALKKLETRevvdLSKYKATKSDLETQISSLN 1231
Cdd:TIGR02168  388 -VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAE----LEELEEELEELQEELERLE 460

                          330       340       350
                   ....*....|....*....|....*....|....
gi 56550047   1232 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1265
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSL 494
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-227 9.90e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 9.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    67 NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGAS 146
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   147 VNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLIKNgADISLLDALGHDSSYY 226
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                  .
gi 56550047   227 A 227
Cdd:PHA02874  261 A 261
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1028-1401 1.05e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1028 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1107
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1108 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1187
Cdd:COG1196  301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1188 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1267
Cdd:COG1196  374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1268 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1347
Cdd:COG1196  441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 56550047 1348 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1401
Cdd:COG1196  513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 449-1126 1.31e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.73  E-value: 1.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    449 KLQNELAHKVAECKAL---ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNhrl 525
Cdd:TIGR04523   44 TIKNELKNKEKELKNLdknLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN--- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    526 teELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEgqaKE 605
Cdd:TIGR04523  121 --KLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK---NK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    606 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKS 685
Cdd:TIGR04523  196 LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK--DEQNKIKKQLSEKQ 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    686 GEL---GKKITELTLKNQTLQKEIEKvyLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 762
Cdd:TIGR04523  274 KELeqnNKKIKELEKQLNQLKSEISD--LNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKEL 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    763 TEKKLEMEKLlleNDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
Cdd:TIGR04523  352 TNSESENSEK---QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    843 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 922
Cdd:TIGR04523  429 ERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKEL 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    923 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIqecikvkyapivsfeecerkfkatekelkdqlsEQTQK 1002
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD---------------------------------DFELK 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1003 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1082
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQ-------KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 56550047   1083 QTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ 1126
Cdd:TIGR04523  629 LSSII---KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669
PTZ00121 PTZ00121
MAEBL; Provisional
 315-899 1.55e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   315 QLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGShfSNRKEDMLLKQGQMYMADSQ 394
Cdd:PTZ00121 1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAE--AEAAADEAEAAEEKAEAAEK 1371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   395 CTS----PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ-------DRLKLQNELAHKVAECKA 463
Cdd:PTZ00121 1372 KKEeakkKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKaeekkkaDEAKKKAEEAKKADEAKK 1451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   464 LALECERVKE--DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKY 540
Cdd:PTZ00121 1452 KAEEAKKAEEakKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaEEAKKADEAKKAE 1531

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   541 EGASAEVGKLRNQIKQNEMI--VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEK 618
Cdd:PTZ00121 1532 EAKKADEAKKAEEKKKADELkkAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   619 F-----ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIT 693
Cdd:PTZ00121 1612 AkkaeeAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   694 ELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE-----MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLE 768
Cdd:PTZ00121 1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeenkIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAE 1771

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   769 MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELkkkCGEDQEKIHALTSENTNLKKMMSNQYVP 848
Cdd:PTZ00121 1772 EIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLV---INDSKEMEDSAIKEVADSKNMQLEEADA 1848

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 56550047   849 VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLE 899
Cdd:PTZ00121 1849 FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIE 1899
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 899-1375 1.91e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.43  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    899 ENTQNQIKAEYISLAEHEAKMSSLSQSMRkVQDSNAEILANYRKGQEEIVTLHAEiKAQKKELDTIQECIKVKYAPIVSF 978
Cdd:pfam05483  175 EYEREETRQVYMDLNNNIEKMILAFEELR-VQAENARLEMHFKLKEDHEKIQHLE-EEYKKEINDKEKQVSLLLIQITEK 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    979 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI----FTLQKDLRDKTVLIEKSHEMERALSRKTDE 1054
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALEEDLQIATKTICQLTEE 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1055 LNKQLKDLSQKYTEVKNVKEKLveenakqTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE---- 1130
Cdd:pfam05483  333 KEAQMEELNKAKAAHSFVVTEF-------EATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNnkev 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1131 --KEQQTVTKLHQLLENQKNSSVPLAEHLQIKE--------AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKq 1200
Cdd:pfam05483  406 elEELKKILAEDEKLLDEKKQFEKIAEELKGKEqelifllqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK- 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1201 aLKKLETREVVDL-----SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKD 1275
Cdd:pfam05483  485 -LKNIELTAHCDKlllenKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1276 QKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1355
Cdd:pfam05483  564 VKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLEL 643

                          490       500
                   ....*....|....*....|
gi 56550047   1356 QLADADRQHQEVIAIYRTHL 1375
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEI 663
PTZ00121 PTZ00121
MAEBL; Provisional
 875-1320 4.00e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   875 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDsNAEILANYRKGQEEIVTLHAEI 954
Cdd:PTZ00121 1194 RKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN-NEEIRKFEEARMAHFARRQAAI 1272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   955 KAQ-KKELDTIQECIKVKYAPIVSFEECERKF-----KATEKELKDQLSEQTQKYSVSEEEVKKNKQENdklKKEIFTLQ 1028
Cdd:PTZ00121 1273 KAEeARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA---KKAAEAAK 1349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1029 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--KLVEENAKQTSEILAVQNLLQKQHVPLEQVEA 1106
Cdd:PTZ00121 1350 AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEakKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1107 LKKSlngtiENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQiKEAFEKEVGiikASLREKEEESQNKME 1186
Cdd:PTZ00121 1430 KKKA-----DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKA---DEAKKKAEEAKKKAD 1500

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1187 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEV--CEEVLHAKKKEiSAKDEKEL 1264
Cdd:PTZ00121 1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL-KKAEELkkAEEKKKAEEAK-KAEEDKNM 1578

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047  1265 LHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1320
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-234 5.13e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLL 216
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                          90
                  ....*....|....*...
gi 56550047   217 DALGHDSSYYARIGDNLD 234
Cdd:PTZ00322  178 GANAKPDSFTGKPPSLED 195
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 635-1328 2.22e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 59.21  E-value: 2.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    635 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKsgELGKKITELTLKNQTLQKEIEKVYLDNK 714
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEK--LELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    715 LLKEQAHNLTI-EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVfvpP 793
Cdd:pfam02463  247 RDEQEEIESSKqEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE---K 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    794 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE----VKMTLNDTLAKTNRE 869
Cdd:pfam02463  324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESErlssAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    870 LLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 947
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEKKEELEILEEEEesIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    948 VTLHAEIKAQKKELDTIQEC----------IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1017
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESkarsglkvllALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1018 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI-------- 1087
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTklkesaka 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1088 --------------------LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1147
Cdd:pfam02463  644 kesglrkgvsleeglaekseVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1148 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLE 1224
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLkveEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR--IQESAKQIE 1302
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELllKEEELEEQK 883

                          730       740
                   ....*....|....*....|....*.
gi 56550047   1303 AKDNKITELLNDVERLKQALNGLSQL 1328
Cdd:pfam02463  884 LKDELESKEEKEKEEKKELEEESQKL 909
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 551-1377 2.34e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 2.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    551 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELS-MCEMEREKKGRKVT--EMEGQAKELSAKLALSIPA--EKFENMKSS 625
Cdd:TIGR00606  230 EAQLESSREIVKSYENELDPLKNRLKEIEHNLSkIMKLDNEIKALKSRkkQMEKDNSELELKMEKVFQGtdEQLNDLYHN 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    626 LSNEVNEKAKKLVEMEREHEKSLSEIRQL---KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI--------TE 694
Cdd:TIGR00606  310 HQRTVREKERELVDCQRELEKLNKERRLLnqeKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELdgfergpfSE 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    695 LTLKN-QTLQKE--IEKVYLDNKLLKEQAHNLTIEMKNhyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
Cdd:TIGR00606  390 RQIKNfHTLVIErqEDEAKTAAQLCADLQSKERLKQEQ----ADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQ 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    772 LLLENDSLSKDVSRLETVFVPPEKHEKE--IIALKSNIVELK-KQLSELKKKCGEDQEkIHALTSENTNLKKMMSNQYVP 848
Cdd:TIGR00606  466 LEGSSDRILELDQELRKAERELSKAEKNslTETLKKEVKSLQnEKADLDRKLRKLDQE-MEQLNHHTTTRTQMEMLTKDK 544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    849 VKTHEEV--------------------KMTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneilkrnLENTQNQIKAE 908
Cdd:TIGR00606  545 MDKDEQIrkiksrhsdeltsllgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELAS-----------LEQNKNHINNE 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    909 YISLaehEAKMSSLSQSMRKVQDSNAEilanyrkgQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE-------- 980
Cdd:TIGR00606  614 LESK---EEQLSSYEDKLFDVCGSQDE--------ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpv 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    981 CERKFKaTEKELKDQLSEQTQKYSV-------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1053
Cdd:TIGR00606  683 CQRVFQ-TEAELQEFISDLQSKLRLapdklksTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQ 761

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1054 ELNKQLKDlSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT----------------IEN 1117
Cdd:TIGR00606  762 RLKNDIEE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDrtvqqvnqekqekqheLDT 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1118 LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiikasLREKEEESQNKMEEVSKLQSEVQN 1197
Cdd:TIGR00606  841 VVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ-------LVELSTEVQSLIREIKDAKEQDSP 913

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1198 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEISA------------ 1258
Cdd:TIGR00606  914 LETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNihgymkdIENKIQDGKDDYLKQKETELNTvnaqleecekhq 993

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1259 -KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQALNGLSQLTYTSGNPTK 1337
Cdd:TIGR00606  994 eKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQM--QVLQMKQEHQKLEENIDLIKRNHV 1071

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 56550047   1338 ----RQSQLIDTLQHQVKSL-EQQLADADRQHQEVIAIYRTHLLS 1377
Cdd:TIGR00606 1072 lalgRQKGYEKEIKHFKKELrEPQFRDAEEKYREMMIVMRTTELV 1116
PRK01156 PRK01156
chromosome segregation protein; Provisional
 620-1207 3.12e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 58.37  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   620 ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaQHVKPEEHE-----QVKSRLEQKSGELGKKITE 694
Cdd:PRK01156  189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY-NNLKSALNElssleDMKNRYESEIKTAESDLSM 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   695 LTLKNQTLqKEIEKVYldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-----KLLDVTQKYTEKKLEM 769
Cdd:PRK01156  268 ELEKNNYY-KELEERH--MKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKyhaiiKKLSVLQKDYNDYIKK 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   770 EKlllENDSLSKDVSRLETvfvppekHEKEIIALKSNIVELKKQLSELKKKcgedQEKIHALTSENtnLKKMMSNQYVPV 849
Cdd:PRK01156  345 KS---RYDDLNNQILELEG-------YEMDYNSYLKSIESLKKKIEEYSKN----IERMSAFISEI--LKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   850 KTHEEVkmtlndtlaktNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKV 929
Cdd:PRK01156  409 KELNEI-----------NVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHI---INHY 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   930 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEcikvkyAPIVSFEECERKFKATEKELKD------QLSEQTQKY 1003
Cdd:PRK01156  475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES------EEINKSINEYNKIESARADLEDikikinELKDKHDKY 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDkTVLIEkshemerALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1083
Cdd:PRK01156  549 EEIKNRYKSLKLEDLDSKRTSWLNALAVIS-LIDIE-------TNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKS 620

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1084 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqikeaf 1163
Cdd:PRK01156  621 IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKS-------------- 686

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 56550047  1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1207
Cdd:PRK01156  687 RKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKK 730
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 36-209 3.22e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    36 KVTSILAKKGVNPGKLDVE-GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   115 EHADLQGRTALHdAAMADCPSS--IQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTicQLLIDRGADVNSRDKQNRTAL 191
Cdd:PHA02878  228 DARDKCGNTPLH-ISVGYCKDYdiLKLLLEHGVDVNAKSyILGLTALHSSIKSERKL--KLLLEYGADINSLNSYKLTPL 304

                         170
                  ....*....|....*....
gi 56550047   192 -MLGCEYGCRDAVEVLIKN 209
Cdd:PHA02878  305 sSAVKQYLCINIGRILISN 323
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 281-1025 3.32e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.54  E-value: 3.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    281 QNIQDLEIENEDLKE----RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 356
Cdd:TIGR02169  198 QQLERLRREREKAERyqalLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    357 KNRFKyfesdHLGSGSHFSnRKEDMLLKQGQMYMADSQctspgipahmQSRSMLRPLELSLPSQTSYSENEILKKELEAM 436
Cdd:TIGR02169  278 NKKIK-----DLGEEEQLR-VKEKIGELEAEIASLERS----------IAEKERELEDAEERLAKLEAEIDKLLAEIEEL 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    437 RTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQThflaLKEH 513
Cdd:TIGR02169  342 EREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQE----ELQR 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    514 LTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEME----- 588
Cdd:TIGR02169  418 LSEELADLNAAI-AGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRElaeae 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    589 --------REKKGRKVTEMEGQ------------------------------------------------AKELSAKLAL 612
Cdd:TIGR02169  497 aqaraseeRVRGGRAVEEVLKAsiqgvhgtvaqlgsvgeryataievaagnrlnnvvveddavakeaielLKRRKAGRAT 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    613 SIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLSEIRQ---LKRELENVKAKLAQ------------------ 667
Cdd:TIGR02169  577 FLPLNKMRDERRDLSilseDGVIGFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAARRLMGKyrmvtlegelfeksgamt 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    668 --HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVyldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 745
Cdd:TIGR02169  657 ggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRI---ENRLDELSQELSDASRKIGEIEKEIEQLEQEEE 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    746 A---IIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH---------EKEIIALKSNIVELKKQ 813
Cdd:TIGR02169  734 KlkeRLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsripeiQAELSKLEEEVSRIEAR 813

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    814 LSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI 893
Cdd:TIGR02169  814 LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    894 LK---RNLENTQNQIKAEYISLAEHeakMSSLSQSMRKVQDSNAEILANYRKGQEE------IVTLHAEIKAQKKELDTI 964
Cdd:TIGR02169  894 LEaqlRELERKIEELEAQIEKKRKR---LSELKAKLEALEEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRAL 970

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56550047    965 QEcikVKYAPIVSFEECERKFkatekelkDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1025
Cdd:TIGR02169  971 EP---VNMLAIQEYEEVLKRL--------DELKEKRAKLEEERKAILERIEEYEKKKREVF 1020
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-244 5.06e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    28 AAERGDVeKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHlaakygHALCLQKL 107
Cdd:PHA02876  185 AAERGNA-KMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIR------NEDLETSL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   108 LQYNC--PTEHADLQGRTALHDAAMAdcPSSIQL---LCDHGASVNAKDVDGRTPLVLATQMSRPTI-CQLLIDRGADVN 181
Cdd:PHA02876  258 LLYDAgfSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVN 335

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56550047   182 SRDKQNRTALMLGCEYG-CRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDIL-TLLKTASE 244
Cdd:PHA02876  336 AADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIInTLLDYGAD 400
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 274-1356 6.91e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 57.75  E-value: 6.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    274 KSHQREHQNIQDLEIENEDLK------ERLRKIQQEQRILLDKVNGLQLQLNEEVMVAddlESEREKLKSLLAAKEKQHE 347
Cdd:TIGR01612  904 KSIEEEYQNINTLKKVDEYIKicentkESIEKFHNKQNILKEILNKNIDTIKESNLIE---KSYKDKFDNTLIDKINELD 980

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    348 E-----SLRTIEALKNRF-KYFESDHLGSGSHfsnrKEDMLLKQ------------GQMYMADSQCTSPGIPAHMQSRSM 409
Cdd:TIGR01612  981 KafkdaSLNDYEAKNNELiKYFNDLKANLGKN----KENMLYHQfdekekatndieQKIEDANKNIPNIEIAIHTSIYNI 1056

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    410 LRPLELSLPSQTSYSENEILKKELEAMRTFCESakQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
Cdd:TIGR01612 1057 IDEIEKEIGKNIELLNKEILEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKAL 1134

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    490 QKRMYESEGKVKQMQTHFLALkEHLTSEAASGNHrlTEELKDQLKDLKVKYEGAS---AEVGKLRNQIKQNEMIVEEFKR 566
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDL-EDVADKAISNDD--PEEIEKKIENIVTKIDKKKniyDEIKKLLNEIAEIEKDKTSLEE 1211

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    567 DEGKLIEENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKEL------SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVE 639
Cdd:TIGR01612 1212 VKGINLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLdeikekSPEIENEMGIEMDIKAEMETFNISHDDDKDHHI 1291

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    640 MEREHEKSLSEIRQ--LKRELENVKAKLAQHVKPEEHEQVkSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLD 712
Cdd:TIGR01612 1292 ISKKHDENISDIREksLKIIEDFSEESDINDIKKELQKNL-LDAQKHNSDINLYLNEIAniyniLKLNKIKKIIDEVKEY 1370

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    713 NKLLKEQAHNLTIEMKNHYVPLKVSED---MKKSHDAIIDDLNRKLLD-VTQKYTEKKLEMEKLLLENDSL-------SK 781
Cdd:TIGR01612 1371 TKEIEENNKNIKDELDKSEKLIKKIKDdinLEECKSKIESTLDDKDIDeCIKKIKELKNHILSEESNIDTYfknadenNE 1450

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    782 DVSRLETVFVPPEKHEKEIIALKS---------NIVELKKQLSElKKKCGEDQEKIHALTSENTNLKK-------MMSNQ 845
Cdd:TIGR01612 1451 NVLLLFKNIEMADNKSQHILKIKKdnatndhdfNINELKEHIDK-SKGCKDEADKNAKAIEKNKELFEqykkdvtELLNK 1529

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    846 YVPVKTHEEVKMTLNDTLAKTNrELLDVKKKF----EDINQEFVKIKDKNEILKRNLENTQNQIKAEY---ISLAEHEAK 918
Cdd:TIGR01612 1530 YSALAIKNKFAKTKKDSEIIIK-EIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIdiqLSLENFENK 1608

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    919 MSSLSQSMRKVQDSNAEILANYRK-GQEEIVTLHAEIKAQKKELDTIQECIKvkyapivSFEECERKFKATEKELkDQLS 997
Cdd:TIGR01612 1609 FLKISDIKKKINDCLKETESIEKKiSSFSIDSQDTELKENGDNLNSLQEFLE-------SLKDQKKNIEDKKKEL-DELD 1680

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    998 EQTQKYSVSEEEVKKNKQEN--DKLKKEIFTLQKDLRDKTVLIEKSheMERALS-------------RKTDELNKQLKDL 1062
Cdd:TIGR01612 1681 SEIEKIEIDVDQHKKNYEIGiiEKIKEIAIANKEEIESIKELIEPT--IENLISsfntndlegidpnEKLEEYNTEIGDI 1758

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1063 SQKYTEVKNV---------KEKLVEENAKQT-----SEILAVQNLLQKQHVPLEQVEAlkKSLNGTIENLKEELKSMQRC 1128
Cdd:TIGR01612 1759 YEEFIELYNIiagcletvsKEPITYDEIKNTrinaqNEFLKIIEIEKKSKSYLDDIEA--KEFDRIINHFKKKLDHVNDK 1836

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1129 YEKEQQTVTK----LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS----EVQNTkQ 1200
Cdd:TIGR01612 1837 FTKEYSKINEgfddISKSIENVKNSTDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIFINISKLANsiniQIQNN-S 1915

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1201 ALKKLETREVVDLSKYKATKSDLETQISSlNEKLANLNRKYEEVCEEVLHA-KKKEISAKDEKELLHFSIEQEIKDQKER 1279
Cdd:TIGR01612 1916 GIDLFDNINIAILSSLDSEKEDTLKFIPS-PEKEPEIYTKIRDSYDTLLDIfKKSQDLHKKEQDTLNIIFENQQLYEKIQ 1994

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047   1280 CDKSLttitelqrriQESAKQIEAKDNKItelLNDVERLKQALNGLSQLTYTSGN-PTKRQSQLIDTLQHQVKSLEQQ 1356
Cdd:TIGR01612 1995 ASNEL----------KDTLSDLKYKKEKI---LNDVKLLLHKFDELNKLSCDSQNyDTILELSKQDKIKEKIDNYEKE 2059
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-174 8.71e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 8.71e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 56550047    121 GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLI 174
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 619-887 1.08e-07

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 56.47  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   619 FENMKSSLSNEVNEKAKKLVEMEREHeksLSEIRQLkRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 698
Cdd:PRK05771   33 IEDLKEELSNERLRKLRSLLTKLSEA---LDKLRSY-LPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   699 NQTLQKEIEKvYLDNKLLKEQAHNLTIEMKNHY-------VPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY------TEK 765
Cdd:PRK05771  109 ISELENEIKE-LEQEIERLEPWGNFDLDLSLLLgfkyvsvFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvVLK 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   766 KL--EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 843
Cdd:PRK05771  188 ELsdEVEEELKKLGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEYLEIELERAEALS 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047   844 NQ-----------YVPVKTHEEVKMTLNDTlakTNR----ELLDVKKKFEDI-----NQEFVKI 887
Cdd:PRK05771  268 KFlktdktfaiegWVPEDRVKKLKELIDKA---TGGsayvEFVEPDEEEEEVptklkNPKFIKP 328
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-247 1.10e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    66 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGA 145
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   146 SVNakDV---DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHD 222
Cdd:PHA02875   93 FAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCT 170

                         170       180
                  ....*....|....*....|....*
gi 56550047   223 SSYYARIGDNLDILTLLKTASENTN 247
Cdd:PHA02875  171 PLIIAMAKGDIAICKMLLDSGANID 195
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 425-818 1.28e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    425 ENEILKKeLEAMRTFCESAKQDRLKLQNELAHKvaeckalalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 504
Cdd:pfam15921  456 KNESLEK-VSSLTAQLESTKEMLRKVVEELTAK-----------KMTLESSERTVSDLTASLQEKERAIEATNAEITKLR 523

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    505 THF-LALKE--HLTSEAASGNHRLTEelkdqLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 581
Cdd:pfam15921  524 SRVdLKLQElqHLKNEGDHLRNVQTE-----CEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    582 LSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV 661
Cdd:pfam15921  599 INDRRLELQEFKILKDKKDAKIRELEARVS------DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSL 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    662 KaklaqhvkpEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIekvyldnkllkEQAHNLTIEMK-NHYVPLKVSEDM 740
Cdd:pfam15921  673 S---------EDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-----------EQTRNTLKSMEgSDGHAMKVAMGM 732

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    741 KKSHDAI---IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSrleTVFVPPEKHEKEIIALKSNIVELKKQLSEL 817
Cdd:pfam15921  733 QKQITAKrgqIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVANM 809


                   .
gi 56550047    818 K 818
Cdd:pfam15921  810 E 810
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 859-1358 1.33e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  859 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 938
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  939 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEND 1018
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1019 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqh 1098
Cdd:COG1196  397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-- 474

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1099 vpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHqLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL---- 1174
Cdd:COG1196  475 --LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL-LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1175 ---------REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-------------------LSKYKATKSDLETQ 1226
Cdd:COG1196  552 vveddevaaAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvLGDTLLGRTLVAAR 631

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1227 ISSLNEKLANLNRKYEEV---CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1303
Cdd:COG1196  632 LEAALRRAVTLAGRLREVtleGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047 1304 KDNKITELLNDVERLKQALNGLSQ-----------LTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1358
Cdd:COG1196  712 AEEERLEEELEEEALEEQLEAEREelleelleeeeLLEEEALEELPEPPDLEELERELERLEREIE 777
PTZ00121 PTZ00121
MAEBL; Provisional
 240-905 2.19e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.92  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   240 KTASENTNKGRELWKKGPSLQQRN-LTHMQDEVNVKSHQREHQNIQDLEIENEDLK---ERLRKIQQEQRilldKVNGLQ 315
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAeAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKkkaDAAKKKAEEKK----KADEAK 1397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   316 LQLNEEVMVADDLESEREKLKSLLAAKEKQhEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSqc 395
Cdd:PTZ00121 1398 KKAEEDKKKADELKKAAAAKKKADEAKKKA-EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADE-- 1474

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   396 tspgipAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELahKVAECKALALECERVKEDS 475
Cdd:PTZ00121 1475 ------AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA--KKAEEAKKADEAKKAEEKK 1546

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   476 D-EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgnhRLTEELKDQLKDLKVKYEGA-SAEVGKLR-N 552
Cdd:PTZ00121 1547 KaDELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA---RIEEVMKLYEEEKKMKAEEAkKAEEAKIKaE 1623

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   553 QIKQNEMI---VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAklalsipAEKFENMKSSLSNE 629
Cdd:PTZ00121 1624 ELKKAEEEkkkVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK-------AEEDEKKAAEALKK 1696

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   630 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKIteltlknQTLQKEIEKV 709
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKI-------AHLKKEEEKK 1769

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   710 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK--KSHDAIIDDLNRKlldvTQKYTEKKLEMEKLLLENDSLSKDVSRLE 787
Cdd:PTZ00121 1770 AEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKdiFDNFANIIEGGKE----GNLVINDSKEMEDSAIKEVADSKNMQLEE 1845

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   788 TVFVPPEKHEKEIIALKSNIvelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPvktheevkmtlNDTLAKTN 867
Cdd:PTZ00121 1846 ADAFEKHKFNKNNENGEDGN---KEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIP-----------NNNMAGKN 1911

                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 56550047   868 RELLDVKkkfedinqefvkiKDKNEILKRNLENTQNQI 905
Cdd:PTZ00121 1912 NDIIDDK-------------LDKDEYIKRDAEETREEI 1936
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
892-1320 2.34e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.43  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   892 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 971
Cdd:PRK02224  254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   972 YAPIVSF-EECERKFKATE------KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEM 1044
Cdd:PRK02224  334 RVAAQAHnEEAESLREDADdleeraEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDF 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1045 ERALSRKTDELNKQLKDLSQKYTEVKNVKEK---LVE-----------ENAKQTSEILAVQNLLQKQHVPLEQVEALKKS 1110
Cdd:PRK02224  414 LEELREERDELREREAELEATLRTARERVEEaeaLLEagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVEE 493

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1111 LNGTIENLkEELKSMQRCYEKEQQTVTKLHQLLENQKNS----SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1186
Cdd:PRK02224  494 VEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEARE 572

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1187 EVSKLQSEVQNTKQALKKLETREVVDlskykATKSDLETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLH 1266
Cdd:PRK02224  573 EVAELNSKLAELKERIESLERIRTLL-----AAIADAEDEIERLREKREALAELNDERRERL--AEKRERKRELEAEFDE 645

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  1267 FSIEqEIKDQKERCDKSLTTITELQRRIQES----AKQIEAKDNKITELLNDVERLKQ 1320
Cdd:PRK02224  646 ARIE-EAREDKERAEEYLEQVEEKLDELREErddlQAEIGAVENELEELEELRERREA 702
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 794-1034 4.24e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 4.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  794 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 873
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------LEQELAALEAELAEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  874 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE 953
Cdd:COG4942   89 EKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  954 IKAQKKELDTIQEcikvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1033
Cdd:COG4942  169 LEAERAELEALLA----------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                 .
gi 56550047 1034 K 1034
Cdd:COG4942  239 A 239
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-213 5.01e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    21 YDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTsdtagrnalhLAAKYGh 100
Cdd:PHA02876  341 YITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA----------LSQKIG- 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   101 alclqkllqyncptehadlqgrTALHDAAMADCP-SSIQLLCDHGASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGA 178
Cdd:PHA02876  410 ----------------------TALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGA 467

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 56550047   179 DVNSRDKQNRTALMLGCEYgcRDAVEVLIKNGADI 213
Cdd:PHA02876  468 DVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
55-108 6.12e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 6.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 56550047     55 GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLL 108
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 875-1089 1.86e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  875 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 954
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  955 KAQKKE----LDTIQECIKVKY-APIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1027
Cdd:COG4942  100 EAQKEElaelLRALYRLGRQPPlALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047 1028 QKDLRDK----TVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1089
Cdd:COG4942  180 LAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK01156 PRK01156
chromosome segregation protein; Provisional
 766-1323 1.99e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   766 KLEMEKLLLEN--DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 843
Cdd:PRK01156  163 SLERNYDKLKDviDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALN 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   844 NQyvpvktheevkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 923
Cdd:PRK01156  243 EL-----------SSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKK 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   924 QSMRKVQDSNAEILANYRKgQEEIVTLHAEIKAQKKELDTIQECI------KVKYAPIV-SFEECERKFKATEKELKDQL 996
Cdd:PRK01156  312 QILSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQIlelegyEMDYNSYLkSIESLKKKIEEYSKNIERMS 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   997 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLK------DLSQKYTEvk 1070
Cdd:PRK01156  391 AFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgtTLGEEKSN-- 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1071 NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGtiENLKEelksmqrcYEKEQQTVTKLHQLLENQKNSS 1150
Cdd:PRK01156  469 HIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES--EEINK--------SINEYNKIESARADLEDIKIKI 538

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1151 VPLAE-HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVS-----KLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
Cdd:PRK01156  539 NELKDkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISlidieTNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1225 TQISSLNEKLANLNRKYEEVCE-----EVLHAK----KKEISAKDEkellhfsIEQEIKDQKERCDKSLTTITELQRRIQ 1295
Cdd:PRK01156  619 KSIREIENEANNLNNKYNEIQEnkiliEKLRGKidnyKKQIAEIDS-------IIPDLKEITSRINDIEDNLKKSRKALD 691

                         570       580
                  ....*....|....*....|....*...
gi 56550047  1296 ESAKQIEAKDNKITELLNDVERLKQALN 1323
Cdd:PRK01156  692 DAKANRARLESTIEILRTRINELSDRIN 719
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 137-239 2.20e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 2.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVD-GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISL 215
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100
                  ....*....|....*....|....*...
gi 56550047   216 LDALG----HDSSYYARigdNLDILTLL 239
Cdd:PHA02878  230 RDKCGntplHISVGYCK---DYDILKLL 254
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 266-1206 2.41e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 2.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    266 HMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILldkvnglqLQLNEEVMVADDLESEREKLKSLLaaKE 343
Cdd:TIGR00606  221 EIRDQITSKEAQLESSReiVKSYENELDPLKNRLKEIEHNLSKI--------MKLDNEIKALKSRKKQMEKDNSEL--EL 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    344 KQHEESLRTIEALKNRFKYFESDHLGSGSHFS--------NRKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLR 411
Cdd:TIGR00606  291 KMEKVFQGTDEQLNDLYHNHQRTVREKERELVdcqrelekLNKERRLLNQEKTELlveqGRLQLQADRHQEHIRARDSLI 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    412 pLELSLPSQTSYSENE-ILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQ 490
Cdd:TIGR00606  371 -QSLATRLELDGFERGpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLG 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    491 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNH--RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMI-VEEFKRD 567
Cdd:TIGR00606  440 RTIELKKEILEKKQEELKFVIKELQQLEGSSDRilELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    568 EGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP----AEKFENMKSSLSNEVNEKAKKLVEMERE 643
Cdd:TIGR00606  520 LDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKE 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    644 HEKSLSEIRQLKRELENVKAKLaqhvkpeeheqvkSRLEQKSGEL-GKKITELTLKNqtLQKEIEKVYLDNKLLKEQAH- 721
Cdd:TIGR00606  600 LASLEQNKNHINNELESKEEQL-------------SSYEDKLFDVcGSQDEESDLER--LKEEIEKSSKQRAMLAGATAv 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    722 ------NLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEK 795
Cdd:TIGR00606  665 ysqfitQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DL 741

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    796 HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVK--------MTLNDTLAKTN 867
Cdd:TIGR00606  742 KEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiaqQAAKLQGSDLD 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    868 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQdsnaeilanyrKGQEEI 947
Cdd:TIGR00606  822 RTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQL 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    948 VTLHAEikaqkkeldtIQECIKvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1027
Cdd:TIGR00606  891 VELSTE----------VQSLIR-------EIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNI 953

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1028 QKDLRDKTVLIEKSheMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLveENAKQTSEILAVQNLLQKQHVPLEQVEAL 1107
Cdd:TIGR00606  954 HGYMKDIENKIQDG--KDDYLKQKETELNTVNAQLEECEKHQEKINEDM--RLMRQDIDTQKIQERWLQDNLTLRKRENE 1029

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1108 KKSLNGTIENLKEELKSMQRCYEKeqQTVTKLHQLLENQKNSSVPLAEHLQikeAFEKEVGIIKASLREKeeESQNKMEE 1187
Cdd:TIGR00606 1030 LKEVEEELKQHLKEMGQMQVLQMK--QEHQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEK 1102

                          970
                   ....*....|....*....
gi 56550047   1188 VSKLQSEVQNTKQALKKLE 1206
Cdd:TIGR00606 1103 YREMMIVMRTTELVNKDLD 1121
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.75e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   92 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 156
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  157 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 220
Cdd:cd22192   92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 884-1356 3.52e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.89  E-value: 3.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    884 FVKIKDKNEILKRNLENTQNQIKAeyisLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT 963
Cdd:TIGR00618  367 IREISCQQHTLTQHIHTLQQQKTT----LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAEL 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    964 ----IQECIKVKYAPIVSFEECERKFKATEKELKD--QLSEQTQKYSVSEEEVKKNKQENDK-LKKEIFTLQKDLRDKTV 1036
Cdd:TIGR00618  443 caaaITCTAQCEKLEKIHLQESAQSLKEREQQLQTkeQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIDN 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1037 LIEKSHEMERALSRKT-------------DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1103
Cdd:TIGR00618  523 PGPLTRRMQRGEQTYAqletseedvyhqlTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEK 602

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1104 VEALKKSLNGTIENLKEELK----------SMQRCYEKEQQTVTKLHQLLENQKNSSVplAEHLQIKEAFEKEVGiikAS 1173
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQpeqdlqdvrlHLQQCSQELALKLTALHALQLTLTQERV--REHALSIRVLPKELL---AS 677

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1174 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLET------REVVDLSKYKAT-KSDLETQISSLNEKLANLNRKYEEVCE 1246
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTLLRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1247 E--VLHAKKKEISAKDEKELLHFS-IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLndVERLKQALN 1323
Cdd:TIGR00618  758 ArtEAHFNNNEEVTAALQTGAELShLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL--VQEEEQFLS 835

                          490       500       510
                   ....*....|....*....|....*....|...
gi 56550047   1324 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1356
Cdd:TIGR00618  836 RLEEKSATLGEITHQLLKYEECSKQLAQLTQEQ 868
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
934-1385 4.10e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 4.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  934 AEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKvKYAPIVSFEECERKFKATEKELKdQLSEQTQKYSVSEEEVKKN 1013
Cdd:COG4717   84 EEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELA-ELPERLEELEERLEELREL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1014 KQENDKLKKEIFTLQKDLRDKtvLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL--VEENAKQTSEILAVQ 1091
Cdd:COG4717  162 EEELEELEAELAELQEELEEL--LEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELeeLEEELEQLENELEAA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1092 NLLQKQHVPLEQ---------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1162
Cdd:COG4717  240 ALEERLKEARLLlliaaallaLLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEE 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1163 fekEVGIIKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETREvvdlskYKATKSDLETQISSLnekLANLNRKYE 1242
Cdd:COG4717  320 ---ELEELLAALGLPPDLSP---EELLELLDRIEELQELLREAEELE------EELQLEELEQEIAAL---LAEAGVEDE 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1243 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKslTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322
Cdd:COG4717  385 EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEA--LDEEELEEELEELEEELEELEEELEELREELAELEAEL 462

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56550047 1323 NGLsqltytsgnptkRQSQLIDTLQHQVKSLEQQLADADRQHQeVIAIYRTHLLSAAQGHMDE 1385
Cdd:COG4717  463 EQL------------EEDGELAELLQELEELKAELRELAEEWA-ALKLALELLEEAREEYREE 512
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 472-1240 4.38e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.51  E-value: 4.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    472 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAasgnhrLTEELKDQLKDLKVKYEGASAEVGKLR 551
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL------LTLCTPCMPDTYHERKQVLEKELKHLR 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    552 NQIKQnEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSnevn 631
Cdd:TIGR00618  233 EALQQ-TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE-----------LRAQEAVLEETQERINRARKAAPLA---- 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    632 EKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQksgelgkkitelTLKNQTLQKEIE-KVY 710
Cdd:TIGR00618  297 AHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ------------TLHSQEIHIRDAhEVA 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    711 LDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
Cdd:TIGR00618  365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    791 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ------EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 864
Cdd:TIGR00618  445 AAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEqihlqeTRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPG 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    865 KTNRELLdvkkkfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 944
Cdd:TIGR00618  525 PLTRRMQ--------------RGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQ 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    945 EEIVTLHAEIKAQKKEldtiqecikvkyapivsfeecERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK---LK 1021
Cdd:TIGR00618  591 NITVRLQDLTEKLSEA---------------------EDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltaLH 649

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1022 KEIFTLQKDLRDKTVLIEKSHEMERALSRKtdelnKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1101
Cdd:TIGR00618  650 ALQLTLTQERVREHALSIRVLPKELLASRQ-----LALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1102 EQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA--------FEKEVGIIKAS 1173
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMH----QARTVLKARTEAHFNNNEEVTAALQTGAELShlaaeiqfFNRLREEDTHL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1174 LREKEEESQNKME--------EVSKLQSEVQNTKQALKKLET---------REVVDLSKYKATKSDLETQISSLNEKLAN 1236
Cdd:TIGR00618  801 LKTLEAEIGQEIPsdedilnlQCETLVQEEEQFLSRLEEKSAtlgeithqlLKYEECSKQLAQLTQEQAKIIQLSDKLNG 880


                   ....
gi 56550047   1237 LNRK 1240
Cdd:TIGR00618  881 INQI 884
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-235 5.01e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.99  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVDGRTPLV-----LATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLIK 208
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                          90       100
                  ....*....|....*....|....*...
gi 56550047   209 NGADISLLDALGHDS-SYYARIGDNLDI 235
Cdd:PHA02798  134 NGADTTLLDKDGFTMlQVYLQSNHHIDI 161
Ank_2 pfam12796
Ankyrin repeats (3 copies);
158-239 5.89e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 5.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    158 LVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAdislLDALGHDSS--YYARIGDNLDI 235
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 56550047    236 LTLL 239
Cdd:pfam12796   77 VKLL 80
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 937-1237 6.02e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  937 LANYRKGQEEIVTLHAEIKAQKKELDTIQecikvkyapivsfeecerkfkATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1016
Cdd:COG1196  231 LLKLRELEAELEELEAELEELEAELEELE---------------------AELAELEAELEELRLELEELELELEEAQAE 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1017 NDKLKKEIFTLQKDlrdktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1096
Cdd:COG1196  290 EYELLAELARLEQD-------IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1097 QhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiiKASLRE 1176
Cdd:COG1196  363 A---EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA----LAELEE 435

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56550047 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1237
Cdd:COG1196  436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 984-1302 8.23e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.22  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   984 KFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--KTVLiEKSHEMERALsrktDELNKQ 1058
Cdd:PRK04778   99 RFRKAKHEINEiesLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRElrKSLL-ANRFSFGPAL----DELEKQ 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1059 LKDLSQKYTEVKNVKEklvEENAKQTSEILAVQ----NLLQKQ--HVPlEQVEALKKSLNGTIENLKEELKSMQRC-YEK 1131
Cdd:PRK04778  174 LENLEEEFSQFVELTE---SGDYVEAREILDQLeeelAALEQImeEIP-ELLKELQTELPDQLQELKAGYRELVEEgYHL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1132 EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAfEKEVGIIKA------SLREKEEESQNKMEE-VSKLQSEVQNTKQALKK 1204
Cdd:PRK04778  250 DHLDIEKEIQDLKEQIDENLALLEELDLDEA-EEKNEEIQEridqlyDILEREVKARKYVEKnSDTLPDFLEHAKEQNKE 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1205 LETR-EVVDLSkYKATKSDLETQiSSLNEKLANLNRKYEEVCEEVlhaKKKEISakdekellhFSieqEIKDQKERCDKS 1283
Cdd:PRK04778  329 LKEEiDRVKQS-YTLNESELESV-RQLEKQLESLEKQYDEITERI---AEQEIA---------YS---ELQEELEEILKQ 391

                         330
                  ....*....|....*....
gi 56550047  1284 LTTITELQRRIQESAKQIE 1302
Cdd:PRK04778  392 LEEIEKEQEKLSEMLQGLR 410
PHA03095 PHA03095
ankyrin-like protein; Provisional
 137-213 9.20e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 9.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVDGRTPLVLATQMS---RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR-DAVEVLIKNGAD 212
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGAD 109


                  .
gi 56550047   213 I 213
Cdd:PHA03095  110 V 110
COG5022 COG5022
Myosin heavy chain [General function prediction only];
798-1328 9.58e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.46  E-value: 9.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  798 KEIIALKSNIVELKKQLSELKKKCGED-QEKIHALTSENTNLKKMMSNqyVPVKTHEEVKMTLNDTLAKtnreLLDVKKK 876
Cdd:COG5022  892 KSISSLKLVNLELESEIIELKKSLSSDlIENLEFKTELIARLKKLLNN--IDLEEGPSIEYVKLPELNK----LHEVESK 965

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  877 FEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS---MRKVQDSNAEILANYRKGQEEIVTLHAE 953
Cdd:COG5022  966 LKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEStkqLKELPVEVAELQSASKIISSESTELSIL 1045

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  954 IKAQK-------KELDTIQECIKVKYAPIVSFEEC------------ERKFKATEKELKDQ-----------LSEQTQKY 1003
Cdd:COG5022 1046 KPLQKlkgllllENNQLQARYKALKLRRENSLLDDkqlyqlestenlLKTINVKDLEVTNRnlvkpanvlqfIVAQMIKL 1125

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER----ALSRKTDELNKQLKDLSQKYT----EVKNVKEK 1075
Cdd:COG5022 1126 NLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpsppPFAALSEKRLYQSALYDEKSKlsssEVNDLKNE 1205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1076 LVEENAKQTSEIL---AVQNLLQKQHVPLEQVEALKKSLNG----------TIENLKEELKSMQRCYEKEQQTVTKLHQL 1142
Cdd:COG5022 1206 LIALFSKIFSGWPrgdKLKKLISEGWVPTEYSTSLKGFNNLnkkfdtpasmSNEKLLSLLNSIDNLLSSYKLEEEVLPAT 1285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1143 LENQ-KNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvVDLSKYKATKS 1221
Cdd:COG5022 1286 INSLlQYINVGLFNALRTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEELEELIQAVKVLQLLK-DDLNKLDELLD 1364

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1222 DLETQissLNEKLANLNRKYEevCEEVLHAKKKEISAKDEkellhfsieqeikdqKERCDKSLTTITELQRRIQESAKQI 1301
Cdd:COG5022 1365 ACYSL---NPAEIQNLKSRYD--PADKENNLPKEILKKIE---------------ALLIKQELQLSLEGKDETEVHLSEI 1424

                        570       580
                 ....*....|....*....|....*..
gi 56550047 1302 EAKDNKITELLNDVERLKQALNGLSQL 1328
Cdd:COG5022 1425 FSEEKSLISLDRNSIYKEEVLSSLSAL 1451
PRK01156 PRK01156
chromosome segregation protein; Provisional
 990-1368 1.17e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   990 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV 1069
Cdd:PRK01156  172 KDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1070 KNVKEKLVEENAKQTSEILAVQNL--LQKQHVPLEQVEALKK--------SLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
Cdd:PRK01156  252 NRYESEIKTAESDLSMELEKNNYYkeLEERHMKIINDPVYKNrnyindyfKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1140 HQL-------LENQKNSSVPLAEHLQIKEAFEKEVGIIKA--SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREv 1210
Cdd:PRK01156  332 SVLqkdyndyIKKKSRYDDLNNQILELEGYEMDYNSYLKSieSLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE- 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1211 vdLSKYKATKSDLETQISSLNEKLANLNRKYEE---------------VCEEVLHAKKKEISAKD--------EKELLHF 1267
Cdd:PRK01156  411 --LNEINVKLQDISSKVSSLNQRIRALRENLDElsrnmemlngqsvcpVCGTTLGEEKSNHIINHynekksrlEEKIREI 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1268 SIEQEIKDQKERCDKSLTTITELQ--RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT--------------YT 1331
Cdd:PRK01156  489 EIEVKDIDEKIVDLKKRKEYLESEeiNKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKnrykslkledldskRT 568

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 56550047  1332 SGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVI 1368
Cdd:PRK01156  569 SWLNALAVISLIDieTNRSRSNEIKKQLNDLESRLQEIE 607
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1019-1270 1.18e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.93  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1019 KLKK-EIFTLqKDLRDKTVliEKSHEMERA--LSRKTDELNKQLKDLSQKYTEVKNVKEKL--------VEENAKQTSEI 1087
Cdd:PRK05771    5 RMKKvLIVTL-KSYKDEVL--EALHELGVVhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpklnPLREEKKKVSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1088 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQQTVTKLH------QLLENQKNSSVPLAEhlqIKE 1161
Cdd:PRK05771   82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----LEQEIERLEPWGnfdldlSLLLGFKYVSVFVGT---VPE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1162 AFEKEVGIIKaSLREKEEESQNKMEE-----VSKLQSEVQNTkqALKKLETREVV---------DLSKYKATKSDLETQI 1227
Cdd:PRK05771  155 DKLEELKLES-DVENVEYISTDKGYVyvvvvVLKELSDEVEE--ELKKLGFERLEleeegtpseLIREIKEELEEIEKER 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 56550047  1228 SSLNEKLANLNRKYEE---VCEEVL--HAKKKEISAKDEKELLHFSIE 1270
Cdd:PRK05771  232 ESLLEELKELAKKYLEellALYEYLeiELERAEALSKFLKTDKTFAIE 279
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 477-709 1.35e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  477 EQIKQLEDALKDVQKRMYESEGKVKQMQthflalkehltseaasgnhRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALK-------------------KEEKALLKQLAALERRIAALARRIRALEQELAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  557 NEMIVEEFKRDEGKLIEENKRLQKELSmcEMERekkgrkVTEMEGQAKELSAKLALSIPAEKFENMK---------SSLS 627
Cdd:COG4942   81 LEAELAELEKEIAELRAELEAQKEELA--ELLR------ALYRLGRQPPLALLLSPEDFLDAVRRLQylkylaparREQA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  628 NEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKpeEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 707
Cdd:COG4942  153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA--ERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                 ..
gi 56550047  708 KV 709
Cdd:COG4942  231 RL 232
COG5022 COG5022
Myosin heavy chain [General function prediction only];
932-1313 1.51e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.69  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  932 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFKATEKELKDQLSEQTQK-------- 1002
Cdd:COG5022  804 SLLGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIqKFGRSLKAKKRFSLLKKETIYLQSAQrvelaerq 883

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1003 ---YSVSEEEVKKNKQENDKLKKEIF----TLQKDLRDKT-VLIEKSHEMERALS------------RKTDELNK----- 1057
Cdd:COG5022  884 lqeLKIDVKSISSLKLVNLELESEIIelkkSLSSDLIENLeFKTELIARLKKLLNnidleegpsieyVKLPELNKlheve 963

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1058 -QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTV 1136
Cdd:COG5022  964 sKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQL----KELPVEVAELQSASKIISSES 1039

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1137 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQnkMEEVSKLQSEVQNTKQALKKLET---REVVDL 1213
Cdd:COG5022 1040 TELSILKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQ--LESTENLLKTINVKDLEVTNRNLvkpANVLQF 1117

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1214 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTI-TELQR 1292
Cdd:COG5022 1118 IVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKsKLSSS 1197

                        410       420
                 ....*....|....*....|.
gi 56550047 1293 RIQESAKQIEAKDNKITELLN 1313
Cdd:COG5022 1198 EVNDLKNELIALFSKIFSGWP 1218
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1046-1262 1.71e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1046 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQnllqkqhvplEQVEALKKSLNGTIENLKEELKSM 1125
Cdd:COG3883   26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQ----------AEIAEAEAEIEERREELGERARAL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1126 QRcyekEQQTVTKLHQLLENQKNSSVplaehlqikeafekevgIIKASLREKEEESQNK-MEEVSKLQSEVQNTKQALKK 1204
Cdd:COG3883   96 YR----SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADlLEELKADKAELEAKKAELEA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEK 1262
Cdd:COG3883  155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAA-EAQLAELEAELAAAEAA 211
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 476-788 1.81e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  476 DEQIKQLE-DALKDVQKRMYESEGKVKQMQTHFLALKEhLTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQI 554
Cdd:COG1196  199 ERQLEPLErQAEKAERYRELKEELKELEAELLLLKLRE-LEAELEELEAEL-EELEAELEELEAELAELEAELEELRLEL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  555 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALsipaekfenmkssLSNEVNEKA 634
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE-------------LEEELEELE 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  635 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 713
Cdd:COG1196  344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEElEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56550047  714 KLLKEQAHNLTIEMKNHyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 788
Cdd:COG1196  424 EELEEALAELEEEEEEE---EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
477-675 1.90e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  477 EQIKQLEDALKDVQKrmYEsegKVKQMQTHFLALKEHLTSEAAsgnHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
Cdd:COG4913  249 EQIELLEPIRELAER--YA---AARERLAELEYLRAALRLWFA---QRRLELLEAELEELRAELARLEAELERLEARLDA 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  557 NEMIVEEFKR----DEGKLIEenkRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA------------EKFE 620
Cdd:COG4913  321 LREELDELEAqirgNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalraeaaallEALE 397

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56550047  621 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR-------ELENVKAKLAQHVKPEEHE 675
Cdd:COG4913  398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDALAEALGLDEAE 459
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 64-191 1.98e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   64 SKGNLECLNAILI-HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-----YNCPTEHADLQGRTALHDAAMADCPSSI 137
Cdd:cd22192   26 KENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLV 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  138 QLLCDHGASVNAKDVD--------------GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192  106 RELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 525-818 2.14e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  525 LTEELKDQLKDLK-----------VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
Cdd:COG1196  194 ILGELERQLEPLErqaekaeryreLKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  594 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQH---- 668
Cdd:COG1196  274 LELEELELELEEAQAEEyELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAeeel 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  669 ----VKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHyvplkvsEDMKKSH 744
Cdd:COG1196  354 eeaeAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL-------EEELEEL 426

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047  745 DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLSELK 818
Cdd:COG1196  427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA---ALLEAALAELLEELAEAAARLLLLL 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1006-1240 2.32e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1006 SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1085
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1086 EILAVQNLLQKQHV---PLEQVEALKKSLNGtiENLKEELKSMQRcyekeqqtvtkLHQLLENQKNSSVPLAEHLQIKEA 1162
Cdd:COG4942   98 ELEAQKEELAELLRalyRLGRQPPLALLLSP--EDFLDAVRRLQY-----------LKYLAPARREQAEELRADLAELAA 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047 1163 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1240
Cdd:COG4942  165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 480-1365 2.50e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.02  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    480 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEvgkLRNQIKQNEM 559
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    560 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA-EKFENMKSSLSNEVnEKAKKLV 638
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAArNKAEKQRRDLGEEL-EALKTEL 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    639 EMEREHEKSLSEIRQlKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvylDNKLLKE 718
Cdd:pfam01576  309 EDTLDTTAAQQELRS-KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK---AKQALES 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    719 QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEK 798
Cdd:pfam01576  385 ENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSK 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    799 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFE 878
Cdd:pfam01576  462 DVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    879 DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIK 955
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    956 AqkkeldtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDL 1031
Cdd:pfam01576  615 A-----------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDD 675

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1032 RDKTVlieksHEME---RALSRKTDELNKQLKDLSQkytevknvkEKLVEENAKQTSEIlavqnllqkqhvpleQVEALK 1108
Cdd:pfam01576  676 VGKNV-----HELErskRALEQQVEEMKTQLEELED---------ELQATEDAKLRLEV---------------NMQALK 726

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1109 KSLNGTIENLKEELKsmqrcyEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV 1188
Cdd:pfam01576  727 AQFERDLQARDEQGE------EKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1189 SKLQSEVQNTKQALK--KLETREVVDLSKYKATKS-DLETQISSLNEKLANLNR-------KYEEVCEEVLHAKKKEISA 1258
Cdd:pfam01576  801 KKLQAQMKDLQRELEeaRASRDEILAQSKESEKKLkNLEAELLQLQEDLAASERarrqaqqERDELADEIASGASGKSAL 880

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1259 KDEKELLhfsiEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL--------SQLTY 1330
Cdd:pfam01576  881 QDEKRRL----EARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnkelkAKLQE 956

                          890       900       910
                   ....*....|....*....|....*....|....*
gi 56550047   1331 TSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQ 1365
Cdd:pfam01576  957 MEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQ 991
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 703-1346 2.54e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.28  E-value: 2.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    703 QKEIEKvyldNKLLKEQAHNLTIEMKNHYVPLKVSEDM---KKSHDAIID---DLNRKLLDVTQKYTEK--KLEMEKLLL 774
Cdd:TIGR01612 1506 AKAIEK----NKELFEQYKKDVTELLNKYSALAIKNKFaktKKDSEIIIKeikDAHKKFILEAEKSEQKikEIKKEKFRI 1581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    775 ENDSLSKDVSRLETVFVPPEKHEKEIIALKsnIVELKKQLSELKKKCGEDQEKIHALT--SENTNLKKMMSNqyvpVKTH 852
Cdd:TIGR01612 1582 EDDAAKNDKSNKAAIDIQLSLENFENKFLK--ISDIKKKINDCLKETESIEKKISSFSidSQDTELKENGDN----LNSL 1655

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    853 EEVKMTLNDTlaKTNREllDVKKKFEDINQEFVKIKDKNEILKRNLE-NTQNQIKAEYISlaeHEAKMSSLSQSmrkVQD 931
Cdd:TIGR01612 1656 QEFLESLKDQ--KKNIE--DKKKELDELDSEIEKIEIDVDQHKKNYEiGIIEKIKEIAIA---NKEEIESIKEL---IEP 1725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    932 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKD-QLSEQTQKYSVSEEEV 1010
Cdd:TIGR01612 1726 TIENLISSFNTNDLEGIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNtRINAQNEFLKIIEIEK 1805

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1011 KKNKQENDKLKKEIFTLQKDLRDKTvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKN-VKEKLVEENAKQTSEILA 1089
Cdd:TIGR01612 1806 KSKSYLDDIEAKEFDRIINHFKKKL------DHVNDKFTKEYSKINEGFDDISKSIENVKNsTDENLLFDILNKTKDAYA 1879

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1090 vqNLLQKQHVP--------LEQVEALKKSLNGTIEN------LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplae 1155
Cdd:TIGR01612 1880 --GIIGKKYYSykdeaekiFINISKLANSINIQIQNnsgidlFDNINIAILSSLDSEKEDTLKFIPSPEKEPEI------ 1951

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1156 HLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKqalkklETREVVDLSKYKATK--SDLETQISSLN 1231
Cdd:TIGR01612 1952 YTKIRDSYDTLLDIFKKSqdLHKKEQDTLNIIFENQQLYEKIQASN------ELKDTLSDLKYKKEKilNDVKLLLHKFD 2025

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1232 E--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1309
Cdd:TIGR01612 2026 ElnKLSCDSQNYDTILELSKQDKIKEKIDNYEKEKEKFGIDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKD 2105

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 56550047   1310 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1346
Cdd:TIGR01612 2106 NIIQSKKKLKELTEAFNTEIKIIEDKIIEKNDLIDKL 2142
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
469-667 4.53e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.09  E-value: 4.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  469 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEH----LTSEAASGNHRLTeELKDQLKDLKVKYEGAS 544
Cdd:COG3206  167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNglvdLSEEAKLLLQQLS-ELESQLAEARAELAEAE 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  545 AEVGKLRNQIKQNEMIVEEFKRDegkliEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaekfeNMKS 624
Cdd:COG3206  240 ARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA---------ALRA 305

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 56550047  625 SLSNEVnekAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ 667
Cdd:COG3206  306 QLQQEA---QRILASLEAELEALQAREASLQAQLAQLEARLAE 345
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 236-880 4.66e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 4.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    236 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILLDKVng 313
Cdd:TIGR02168  353 LESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNneIERLEARLERLEDRRERLQQEIEELLKKL-- 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    314 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQmymads 393
Cdd:TIGR02168  431 EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF------ 504

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    394 qctSPGIPAHMQSRSMLRPLELSLPSQTSYSENeiLKKELEA----------MRTFcESAKQDRLKLQNELAHKVAECkA 463
Cdd:TIGR02168  505 ---SEGVKALLKNQSGLSGILGVLSELISVDEG--YEAAIEAalggrlqavvVENL-NAAKKAIAFLKQNELGRVTFL-P 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    464 LALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVkqmqthflalkeHLTSEAASGNHRLTEELKDQLKDLKVKYEGA 543
Cdd:TIGR02168  578 LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKL------------RKALSYLLGGVLVVDDLDNALELAKKLRPGY 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    544 saevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKelsmcEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEKFENM 622
Cdd:TIGR02168  646 -------RIVTLDGDLVRPGGVITGGSAKTNSSILER-----RREIEELEEKIEELEEKIAELEKALAeLRKELEELEEE 713

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    623 KSSLSNEVNEKAKKLVEM-------EREHEKSLSEIRQLKRELENVKAKLA-QHVKPEEHEQVKSRLEQKSGELGKKITE 694
Cdd:TIGR02168  714 LEQLRKELEELSRQISALrkdlarlEAEVEQLEERIAQLSKELTELEAEIEeLEERLEEAEEELAEAEAEIEELEAQIEQ 793

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 774
Cdd:TIGR02168  794 LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELES 873

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    775 ENDSLSKDVSRLETVFVPPEKH----EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY-VPV 849
Cdd:TIGR02168  874 ELEALLNERASLEEALALLRSEleelSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYsLTL 953

                          650       660       670
                   ....*....|....*....|....*....|.
gi 56550047    850 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 880
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIKEL 984
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 735-1108 5.06e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   735 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 814
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   815 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 890
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   891 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 970
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   971 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1032
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1033 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1106
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 56550047  1107 LK 1108
Cdd:NF033838  445 EK 446
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 426-907 6.05e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.79  E-value: 6.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    426 NEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL-------EDALKDVQKRMYESEG 498
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLliqitekENKMKDLTFLLEESRD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    499 KVKQMQ----------THFLALKEHLTSE----------AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 558
Cdd:pfam05483  269 KANQLEektklqdenlKELIEKKDHLTKEledikmslqrSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    559 MIVEEFKRDEGKLIE----ENKRLQK---ELSMCEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKfenmkSSLSNE 629
Cdd:pfam05483  349 FVVTEFEATTCSLEEllrtEQQRLEKnedQLKIITMELQKKSSELEEMTKfkNNKEVELEELKKILAED-----EKLLDE 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    630 vNEKAKKLVEMEREHEKSLSEIRQLK-RELENVKAKLAQHVKPEEHeqvksrLEQKSGELGKKITELTLKNQTLQKEIEK 708
Cdd:pfam05483  424 -KKQFEKIAEELKGKEQELIFLLQAReKEIHDLEIQLTAIKTSEEH------YLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    709 VYLDNKLLKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 788
Cdd:pfam05483  497 LLLENKELTQEASDMTLELKKHQEDII---NCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    789 vfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEevkmtlnDTLAKTNR 868
Cdd:pfam05483  574 ---NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYE-------IKVNKLEL 643

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 56550047    869 ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 907
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKA 682
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1170-1396 6.42e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 6.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1170 IKASLREKEEESQNKM----EEVSKLQSEVQNTKQALKKLETRE-VVDLSkykATKSDLETQISSLNEKLANLNRKYEEV 1244
Cdd:COG3206  162 LEQNLELRREEARKALefleEQLPELRKELEEAEAALEEFRQKNgLVDLS---EEAKLLLQQLSELESQLAEARAELAEA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1245 ceEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG 1324
Cdd:COG3206  239 --EARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILA 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047 1325 LSQLTYTSGNPTKRQ-SQLIDTLQHQVKSL---EQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQ 1396
Cdd:COG3206  317 SLEAELEALQAREASlQAQLAQLEARLAELpelEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVID 392
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 567-1278 7.53e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 47.74  E-value: 7.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    567 DEGKLIEENKRLQKELSMCE-MEREKKGRKVTEMEGQAKELSaklalSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHE 645
Cdd:TIGR01612  694 DKAKLDDLKSKIDKEYDKIQnMETATVELHLSNIENKKNELL-----DIIVEIKKHIHGEINKDLNKILEDFKNKEKELS 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    646 KSLSEIRQLKRELENVKAKLAQhVKPEEHEQ--VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 723
Cdd:TIGR01612  769 NKINDYAKEKDELNKYKSKISE-IKNHYNDQinIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNK 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    724 TiemkNHYVPLK--VSEDMKKSHDAIIDDLNRKLLDVTQkytEKKLEMEKLLLENDSLSKDVSrletvfvppekheKEII 801
Cdd:TIGR01612  848 V----DKFINFEnnCKEKIDSEHEQFAELTNKIKAEISD---DKLNDYEKKFNDSKSLINEIN-------------KSIE 907

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    802 ALKSNIVELKKqLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND----TLAKTNRELLDVKKK- 876
Cdd:TIGR01612  908 EEYQNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDkfdnTLIDKINELDKAFKDa 986

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    877 ----FEDINQEFVK-IKDKNEILKRNLENTQnqikaeYISLAEHEAKMSSLSQsmrKVQDSNAEI----LANYRKGQEEI 947
Cdd:TIGR01612  987 slndYEAKNNELIKyFNDLKANLGKNKENML------YHQFDEKEKATNDIEQ---KIEDANKNIpnieIAIHTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    948 VTLHAEIKAQKKELDTiqECIKVKYAPIVSFEECERKFK---------------ATE-KELKDQLSEQTQK--YSVSEEE 1009
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNK--EILEEAEINITNFNEIKEKLKhynfddfgkeenikyADEiNKIKDDIKNLDQKidHHIKALE 1135

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1010 VKKNKQEN--DKLKKEIFTLQkDLRDKTVLIEKSHEMERALSRKTDELNKQlkdlSQKYTEVKNVKEKLVEENAKQTS-E 1086
Cdd:TIGR01612 1136 EIKKKSENyiDEIKAQINDLE-DVADKAISNDDPEEIEKKIENIVTKIDKK----KNIYDEIKKLLNEIAEIEKDKTSlE 1210

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1087 ILAVQNLLQKQHVP---LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE------------------- 1144
Cdd:TIGR01612 1211 EVKGINLSYGKNLGklfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDikaemetfnishdddkdhh 1290

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1145 -----NQKNSSVPLAEHLQIKEAFEKEVGI--IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDlsKYK 1217
Cdd:TIGR01612 1291 iiskkHDENISDIREKSLKIIEDFSEESDIndIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID--EVK 1368

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56550047   1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVlhaKKKEISAKDEKELLHFSIEQEIKDQKE 1278
Cdd:TIGR01612 1369 EYTKEIEENNKNIKDELDKSEKLIKKIKDDI---NLEECKSKIESTLDDKDIDECIKKIKE 1426
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-95 7.76e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 7.76e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047     40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLA 95
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
46 PHA02562
endonuclease subunit; Provisional
 476-686 8.26e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 8.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   476 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 555
Cdd:PHA02562  187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   556 QNEMIVEEFKRDE-----------------------GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKlal 612
Cdd:PHA02562  266 KIKSKIEQFQKVIkmyekggvcptctqqisegpdriTKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLEL--- 342

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56550047   613 sipAEKFENMKSSLSNEVNEKAKKLVEMER---EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG 686
Cdd:PHA02562  343 ---KNKISTNKQSLITLVDKAKKVKAAIEElqaEFVDNAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKDSG 416
Ank_5 pfam13857
Ankyrin repeats (many copies);
173-220 1.11e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 56550047    173 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALG 220
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 934-1396 1.13e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    934 AEILANYrKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERK--------FKATEKELKDQLSE--QTQKY 1003
Cdd:TIGR00618  166 KELLMNL-FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREALQQtqQSHAY 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEmERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1083
Cdd:TIGR00618  245 LTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQE-RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSR 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1084 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT-----VTKLHQLLENQKNSSVPLAEHLQ 1158
Cdd:TIGR00618  324 AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQKLQSLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1159 IKEAFEKEVGIIKASLR---------EKEEESQNKMEEVSKLQSEVQNTKQALKKLE-------TREVVDLSKYKATKSD 1222
Cdd:TIGR00618  404 ILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHlqesaqsLKEREQQLQTKEQIHL 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1223 LETQISSLNEKLANLNRKYE-EVCEEVLH--AKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1299
Cdd:TIGR00618  484 QETRKKAVVLARLLELQEEPcPLCGSCIHpnPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1300 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL---------QHQVKSLEQQLADADRQHQEVIAI 1370
Cdd:TIGR00618  564 QMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceqhallrKLQPEQDLQDVRLHLQQCSQELAL 643

                          490       500
                   ....*....|....*....|....*.
gi 56550047   1371 YRTHLLSAAQGHMDEDVQEALLQIIQ 1396
Cdd:TIGR00618  644 KLTALHALQLTLTQERVREHALSIRV 669
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 894-1145 1.23e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.69  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    894 LKRNLENtqnQIKAEYISLAEHEAKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTL--HAEIKAQKKELdtiqecikvk 971
Cdd:pfam18971  557 VRRNLEN---KLTAKGLSLQEANKLIKDFLSSNKEL----AGKALNFNKAVAEAKSTgnYDEVKKAQKDL---------- 619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    972 yapivsfEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendklKKEIFTL--QKDLRDKTVL--IEKSHEMERA 1047
Cdd:pfam18971  620 -------EKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALinKEANRDARAIayTQNLKGIKRE 687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1048 LSRKTDELNKQLKDLSQKYTEVKNVKEKlveENAKQTSEILAVQNLLQKQHVPLEQVEalkkslngTIENLKEELKSMQR 1127
Cdd:pfam18971  688 LSDKLEKISKDLKDFSKSFDEFKNGKNK---DFSKAEETLKALKGSVKDLGINPEWIS--------KVENLNAALNEFKN 756

                          250
                   ....*....|....*...
gi 56550047   1128 CYEKEQQTVTKLHQLLEN 1145
Cdd:pfam18971  757 GKNKDFSKVTQAKSDLEN 774
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-173 1.61e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    93 HLAAKyGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 172
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  .
gi 56550047   173 L 173
Cdd:PTZ00322  167 L 167
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1198-1322 2.00e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1198 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEVCEEVLHAKKKEIsAKDEKELLHFSIEQEIKDQK 1277
Cdd:COG2433  386 IEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERL-EAEVEELEAELEEKDERI-ERLERELSEARSEERREIRK 463

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 56550047 1278 ERcdksltTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322
Cdd:COG2433  464 DR------EISRLDREIERLERELEEERERIEELKRKLERLKELW 502
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-185 2.03e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 56550047    153 DGRTPLVLA-TQMSRPTICQLLIDRGADVNSRDK 185
Cdd:pfam00023    1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 171-239 2.06e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047   171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-140 2.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 2.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 56550047     88 GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 140
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 977-1326 2.18e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.79  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    977 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEndklkkeifTLQKDLRDK-TVLIEKSHEMERALSRKTDEL 1055
Cdd:pfam05667  207 SLLERNAAELAAAQEWEEEWNSQGLASRLTPEEYRKRKRT---------KLLKRIAEQlRSAALAGTEATSGASRSAQDL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1056 NKQLKDLSQKYTEVKNV--------KEKLV--EENAKQTSEILAV----QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1121
Cdd:pfam05667  278 AELLSSFSGSSTTDTGLtkgsrfthTEKLQftNEAPAATSSPPTKveteEELQQQREEELEELQEQLEDLESSIQELEKE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1122 LKSMQrcyekeqQTVTKLHQLLENQKNSSVPLAEHLQIKEafeKEVGIIkaslrekeEESQNKMEevsKLQSEVQNTKQA 1201
Cdd:pfam05667  358 IKKLE-------SSIKQVEEELEELKEQNEELEKQYKVKK---KTLDLL--------PDAEENIA---KLQALVDASAQR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1202 LKKLEtrevvdlSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV--LHAKKKEISAK-DEKELLHfsieQEIKDQKE 1278
Cdd:pfam05667  417 LVELA-------GQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIkeLREKIKEVAEEaKQKEELY----KQLVAEYE 485

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 56550047   1279 RCDKSlTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1326
Cdd:pfam05667  486 RLPKD-VSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1057-1237 2.31e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.15  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1057 KQLKDLSQKYTE---VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQ 1133
Cdd:COG1579    7 RALLDLQELDSEldrLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1134 QTVTKLHQLlenqknssvplaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1213
Cdd:COG1579   83 GNVRNNKEY------------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKK 144

                        170       180
                 ....*....|....*....|....
gi 56550047 1214 SKYKATKSDLETQISSLNEKLANL 1237
Cdd:COG1579  145 AELDEELAELEAELEELEAEREEL 168
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 813-1318 2.43e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   813 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyVPVKTHEEVkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNE 892
Cdd:PTZ00440  985 KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD--LIKKQHDDI-IELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSF 1061

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   893 ILKRNLENTQNQIKAEYISLAEHeaKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-------KKELDTIQ 965
Cdd:PTZ00440 1062 HFNIDIKKYKNPKIKEEIKLLEE--KVEAL---LKKIDENKNKLIEIKNKSHEHVVNADKEKNKQtehynkkKKSLEKIY 1136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   966 ECIKVKYAPIVSFEECERKFKATEK-----------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDlrdk 1034
Cdd:PTZ00440 1137 KQMEKTLKELENMNLEDITLNEVNEieieyerilidHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKNMSKERND---- 1212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1035 tvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKlvEENAKQTSEILAVQNLLqkqHVPLEQVealkKSLNGT 1114
Cdd:PTZ00440 1213 -------HLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEIKLQV---FSYLQQV----IKENNK 1276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1115 IENLKEELKSMqrcyeKEQQTVTKLHQLLENQKNSSVPLAEH-LQIKEAFEKEVGIIKASLR--EKEEESQNKM---EEV 1188
Cdd:PTZ00440 1277 MENALHEIKNM-----YEFLISIDSEKILKEILNSTKKAEEFsNDAKKELEKTDNLIKQVEAkiEQAKEHKNKIygsLED 1351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1189 SKLQSEVQNTKQALKKL-ETREVVD--LSKYKATKSDLETQISSLNEKLANLNrkyeevceevLHAKKKEISAKDEKEll 1265
Cdd:PTZ00440 1352 KQIDDEIKKIEQIKEEIsNKRKEINkyLSNIKSNKEKCDLHVRNASRGKDKID----------FLNKHEAIEPSNSKE-- 1419

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56550047  1266 hFSIeQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1318
Cdd:PTZ00440 1420 -VNI-IKITDNINKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSIL 1470
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 849-1359 2.43e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.94  E-value: 2.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    849 VKTHEEVKMTLNDTLAKTNRElldvKKKFEDINQEFVKIKDKNEILKRNLENTQNQikaeyislaeHEAKMSSLSQSMRK 928
Cdd:pfam01576  133 IKKLEEDILLLEDQNSKLSKE----RKLLEERISEFTSNLAEEEEKAKSLSKLKNK----------HEAMISDLEERLKK 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    929 VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELdtiqecikvkyapivsfEECERKFKATEKELKDQLSEQTQKYSVSEE 1008
Cdd:pfam01576  199 EEKGRQELEKAKRKLEGESTDLQEQIAELQAQI-----------------AELRAQLAKKEEELQAALARLEEETAQKNN 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1009 EVKKNKQendkLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----------SQKYTEVKNVKEKLV 1077
Cdd:pfam01576  262 ALKKIRE----LEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTldttaaqqelrSKREQEVTELKKALE 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1078 EENAKQTSEilaVQNLLQKQHVPLEQ--------------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH-QL 1142
Cdd:pfam01576  338 EETRSHEAQ---LQEMRQKHTQALEElteqleqakrnkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEgQL 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1143 LENQKNSSVPLAEHLQIKEAFEK---EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTkQALKKLETREvvdlskykat 1219
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKlqsELESVSSLLNEAEGKNIKLSKDVSSLESQLQDT-QELLQEETRQ---------- 483

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1220 KSDLETQISSLNEKLANLNRKYEEvceevlhakkkEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1299
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEE-----------EEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQR 552

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1300 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1359
Cdd:pfam01576  553 ELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAE 612
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 978-1341 2.75e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    978 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1057
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1058 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1137
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1138 KLHQLLENQKNSSVPLaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1217
Cdd:pfam02463  325 KAEKELKKEKEEIEEL-------EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1218 ATKSDLETQISSLNEklanlNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1297
Cdd:pfam02463  398 ELKSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSED 472

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 56550047   1298 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1341
Cdd:pfam02463  473 LLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALI 516
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
482-683 2.78e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  482 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE------ELKDQLKDLKVKYEGASAEVGKLRnQIK 555
Cdd:COG4717   47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAElqeeleELEEELEELEAELEELREELEKLE-KLL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  556 QNEMIVEEFKRDEGKLIEENKRLQkELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaEKFENMKSSLSNEVNEKAK 635
Cdd:COG4717  126 QLLPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELE-----ELLEQLSLATEEELQDLAE 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 56550047  636 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 683
Cdd:COG4717  200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKE 247
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 123-247 2.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   123 TALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGAD----------------------- 179
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   180 VNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL--KTASENTN 247
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLleKGAYANVK 186
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1046-1307 2.91e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1046 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSM 1125
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1126 QRCYEKeqqtvtklhQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKAsLREKEEESQNKMEEVSKLQSEVQNTKQALKkl 1205
Cdd:COG4942  103 KEELAE---------LLRALYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELE-- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1206 etrevvdlskykATKSDLETQISSLNEKLANLNrkyeevceevlhakkkeiSAKDEKELLHFSIEQEIKDQKERCDKSLT 1285
Cdd:COG4942  171 ------------AERAELEALLAELEEERAALE------------------ALKAERQKLLARLEKELAELAAELAELQQ 220

                        250       260
                 ....*....|....*....|..
gi 56550047 1286 TITELQRRIQESAKQIEAKDNK 1307
Cdd:COG4942  221 EAEELEALIARLEAEAAAAAER 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
476-653 3.09e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  476 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 555
Cdd:COG4913  616 EAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALEEQLE 695

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  556 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAKLALSIPAEKFENMKSSLSNEV 630
Cdd:COG4913  696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARlelraLLEERFAAALGDAVERELRENLEERI 775

                        170       180
                 ....*....|....*....|...
gi 56550047  631 NEKAKKLVEMEREHEKSLSEIRQ 653
Cdd:COG4913  776 DALRARLNRAEEELERAMRAFNR 798
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1037-1325 3.18e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1037 LIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLvEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGT 1114
Cdd:PRK03918  140 ILESDESREKVVRQILglDDYENAYKNLGEVIKEIKRRIERL-EKFIKRTENI---EELIKEKEKELEEVLREINEISSE 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1115 IENLKEELKSMqrcyEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1194
Cdd:PRK03918  216 LPELREELEKL----EKEVKELEELKEEIEELEKE----------LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1195 VQNTKQ---------ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEevLHAKKKEIS---AKDEK 1262
Cdd:PRK03918  282 VKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE--LKKKLKELEkrlEELEE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56550047  1263 ELLHFSIEQEIKDQKERCDKSLT--TITELQRRIQESAK---QIEAKDNKIT----ELLNDVERLKQALNGL 1325
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLTglTPEKLEKELEELEKakeEIEEEISKITarigELKKEIKELKKAIEEL 431
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 25-172 3.25e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   25 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLEcLNAILIHGV------DITTSDTAGRNALHLAAKY 98
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-AAVVLMEAApelvnePMTSDLYQGETALHIAVVN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   99 GHALCLQKLLQYNcptehADLQ-----------GRTAL-----HDAAMADCPSS---IQLLCDHGASVNAKDVDGRTPL- 158
Cdd:cd22192  100 QNLNLVRELIARG-----ADVVspratgtffrpGPKNLiyygeHPLSFAACVGNeeiVRLLIEHGADIRAQDSLGNTVLh 174

                        170
                 ....*....|....
gi 56550047  159 VLATQMSRPTICQL 172
Cdd:cd22192  175 ILVLQPNKTFACQM 188
Ank_5 pfam13857
Ankyrin repeats (many copies);
107-161 3.43e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 3.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 56550047    107 LLQY-NCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLA 161
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1168-1399 3.50e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1168 GIIKasLREKEEESQNKMEEVS-------------------------------KLQSEVQNTKQALKKLETREV-VDLSK 1215
Cdd:COG1196  166 GISK--YKERKEEAERKLEATEenlerledilgelerqleplerqaekaeryrELKEELKELEAELLLLKLRELeAELEE 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1216 YKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEKELLHFS----IEQEIKDQKERCDKSLTTITELQ 1291
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEEL-RLELEELELELEEAQAEEYELLAelarLEQDIARLEERRRELEERLEELE 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1292 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQhQEVIAIY 1371
Cdd:COG1196  323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA-AAELAAQ 401

                        250       260
                 ....*....|....*....|....*...
gi 56550047 1372 RTHLLSAAQGHMDEdvQEALLQIIQMRQ 1399
Cdd:COG1196  402 LEELEEAEEALLER--LERLEEELEELE 427
PRK11281 PRK11281
mechanosensitive channel MscK;
748-1111 3.81e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 45.29  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   748 IDDLN-RKLLDVTQKYTEKKLEMEKLLLENdslskdvsrletvfvppekhekeIIALKSNIVELKKQLSELKKKCGEDQE 826
Cdd:PRK11281   45 LDALNkQKLLEAEDKLVQQDLEQTLALLDK-----------------------IDRQKEETEQLKQQLAQAPAKLRQAQA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   827 KIHALTSENTN-LKKMMSNQYVPvktheevkmTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneiLKRNLENTQNQI 905
Cdd:PRK11281  102 ELEALKDDNDEeTRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYNSQLVS-------LQTQPERAQAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   906 KAEYISLAEHEAKMSSLSQSMRKVQDSNAEILanyrkgQEEIVTLHAEIKAQKKEL---DTIQECIKVKYapivsfEECE 982
Cdd:PRK11281  166 YANSQRLQQIRNLLKGGKVGGKALRPSQRVLL------QAEQALLNAQNDLQRKSLegnTQLQDLLQKQR------DYLT 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   983 RKFKATEKELKD----------QLSEQTQKYSVSEEEVKKnKQENDKLKKEiftlqkdlrdktvlIEKSHEMERALSRKT 1052
Cdd:PRK11281  234 ARIQRLEHQLQLlqeainskrlTLSEKTVQEAQSQDEAAR-IQANPLVAQE--------------LEINLQLSQRLLKAT 298

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047  1053 DELNkqlkDLSQKYTEVKNVKEklveenakqtseilavqNLLQKQHVPLEQVEALKKSL 1111
Cdd:PRK11281  299 EKLN----TLTQQNLRVKNWLD-----------------RLTQSERNIKEQISVLKGSL 336
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-214 4.06e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.83  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVDGRTPLVlaTQMSRPTICQL-----LIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLIK 208
Cdd:PHA02798   92 VKILIENGADINKKNSDGETPLY--CLLSNGYINNLeillfMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLE 169


                  ....*.
gi 56550047   209 NGADIS 214
Cdd:PHA02798  170 KGVDIN 175
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 986-1201 4.06e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  986 KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRdktvliekshEMERALSRKTDELNKQLKDLSQK 1065
Cdd:COG3883   29 QAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEERREELGERARALYRS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1066 YTEVkNVKEKLVeeNAKQTSEIL----AVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTVTKLHQ 1141
Cdd:COG3883   99 GGSV-SYLDVLL--GSESFSDFLdrlsALSKIADADADLLEELKADKAEL----EAKKAELEAKLAELEALKAELEAAKA 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1142 LLENQKnssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1201
Cdd:COG3883  172 ELEAQQ------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 564-828 4.70e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   564 FKRDEGKLIEEnkrLQKE-----LSMCEMEREKKGRKVTEMEGQAKELSAKL------ALSIPAEKFENMKSSLSNEVNE 632
Cdd:PRK05771   14 LKSYKDEVLEA---LHELgvvhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpkLNPLREEKKKVSVKSLEELIKD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   633 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhVKP-------EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 705
Cdd:PRK05771   91 VEEELEKIEKEIKELEEEISELENEIKELEQEIER-LEPwgnfdldLSLLLGFKYVSVFVGTVPEDKLEELKLESDVENV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   706 IEKVYLDNKL------LKEQAHNLTIEMKNH-YVPLKVSE------------DMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
Cdd:PRK05771  170 EYISTDKGYVyvvvvvLKELSDEVEEELKKLgFERLELEEegtpselireikEELEEIEKERESLLEELKELAKKYLEEL 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047   767 LEMEKLLL----ENDSLSKDVSRLETVFVP---PEKHEKEIIALKSNIVELKKQLSELKKKcgEDQEKI 828
Cdd:PRK05771  250 LALYEYLEieleRAEALSKFLKTDKTFAIEgwvPEDRVKKLKELIDKATGGSAYVEFVEPD--EEEEEV 316
46 PHA02562
endonuclease subunit; Provisional
 595-820 4.89e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   595 KVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEMEREhekslsEIRQLKRELENVKAKLAQHVK 670
Cdd:PHA02562  175 KIRELNQQIQTLDMKIDHIQQQiktyNKNIEEQRKKNGENIARKQNKYDELVE------EAKTIKAEIEELTDELLNLVM 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   671 PEEheqvksRLEQKSGELGKKITELTLKNQTLQKEIeKVYLDNKL-----------------LKEQAHNLTI---EMKNH 730
Cdd:PHA02562  249 DIE------DPSAALNKLNTAAAKIKSKIEQFQKVI-KMYEKGGVcptctqqisegpdritkIKDKLKELQHsleKLDTA 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   731 YVPLKVSEDMkkshdaiIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALKSNIVEL 810
Cdd:PHA02562  322 IDELEEIMDE-------FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFV---DNAEELAKLQDELDKI 391

                         250
                  ....*....|
gi 56550047   811 KKQLSELKKK 820
Cdd:PHA02562  392 VKTKSELVKE 401
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 982-1148 4.99e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   982 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--------- 1052
Cdd:PRK05771   74 EEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvp 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1053 -DELNKQLKDLSQKYTE-VKNVKEKLV------EENAKQTSEILAvQNLLQKQHVP--------LEQVEALKKSLNGTIE 1116
Cdd:PRK05771  154 eDKLEELKLESDVENVEyISTDKGYVYvvvvvlKELSDEVEEELK-KLGFERLELEeegtpselIREIKEELEEIEKERE 232

                         170       180       190
                  ....*....|....*....|....*....|..
gi 56550047  1117 NLKEELKSMQRCYEKEQQTVtklHQLLENQKN 1148
Cdd:PRK05771  233 SLLEELKELAKKYLEELLAL---YEYLEIELE 261
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 120-151 5.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 5.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 56550047    120 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 151
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 514-723 5.34e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  514 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
Cdd:COG4942   10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  594 RKVTEMEGQAKELSAKLALSIPA-EKFEN-------MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 665
Cdd:COG4942   90 KEIAELRAELEAQKEELAELLRAlYRLGRqpplallLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  666 AQhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 723
Cdd:COG4942  170 EA--ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1115-1326 6.39e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1115 IENLKEELKSMQ-RCYEKEQQTVTKLHQLLENQKNssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1193
Cdd:PRK05771   33 IEDLKEELSNERlRKLRSLLTKLSEALDKLRSYLP-----KLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1194 EVQNTKQALKKLEtREVVDLSKYKATKSDLETQISSLN----------EKLANLNRKYEEVCEEVLHAKK---------- 1253
Cdd:PRK05771  108 EISELENEIKELE-QEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvpeDKLEELKLESDVENVEYISTDKgyvyvvvvvl 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1254 KEISAKDEKELLHFS-IEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKITE--------LLNDVERLKQA 1321
Cdd:PRK05771  187 KELSDEVEEELKKLGfERLELEEEGtpsELIREIKEELEEIEKERESLLEELKELAKKYLEellalyeyLEIELERAEAL 266


                  ....*
gi 56550047  1322 LNGLS 1326
Cdd:PRK05771  267 SKFLK 271
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1015-1300 6.97e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 44.38  E-value: 6.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1015 QENDKLKKEIFTLQKDLRDKTVLIEKS-----------------HEMERALsRKTDELNKQLKDLSQKYTEVKNVKEKLV 1077
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGKALNFNKAvaeakstgnydevkkaqKDLEKSL-RKREHLEKEVEKKLESKSGNKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1078 EENAkQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKeqqtvtklhqlLENQKNSSVPL 1153
Cdd:pfam18971  652 QANS-QKDEIFALINKEANRDARaiayTQNLKGIKRELSDKLEKISKDLKDFSKSFDE-----------FKNGKNKDFSK 719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1154 AEH-LQIKEAFEKEVGIikaslrekeeesqnKMEEVSKlqseVQNTKQALKKLETREVVDLSKYKATKSDLETQISS--L 1230
Cdd:pfam18971  720 AEEtLKALKGSVKDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviI 781

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56550047   1231 NEKLANlnrKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQ 1300
Cdd:pfam18971  782 NQKVTD---KVDNLNQAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
PTZ00121 PTZ00121
MAEBL; Provisional
 915-1304 7.62e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   915 HEAKMSSLSQ--SMRKVQDSNAEILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYApiVSFEECERKFKAT 988
Cdd:PTZ00121 1056 HEGKAEAKAHvgQDEGLKPSYKDFDFDAKEDNRADEATEEAFGkaeeAKKTETGKAEEARKAEEA--KKKAEDARKAEEA 1133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   989 EKELKDQLSEQTQKySVSEEEVKKNKQENDKLKKEIFTLQKDLRdKTVLIEKSHEMERALS-RKTDELNKqlKDLSQKYT 1067
Cdd:PTZ00121 1134 RKAEDARKAEEARK-AEDAKRVEIARKAEDARKAEEARKAEDAK-KAEAARKAEEVRKAEElRKAEDARK--AEAARKAE 1209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1068 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP--LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1145
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1146 QKNSSVPLAEHLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1223
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1224 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1303
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449


                  .
gi 56550047  1304 K 1304
Cdd:PTZ00121 1450 K 1450
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1179-1323 8.00e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1179 EESQNKMEEVSKLQSEVQNTKQALKKLEtREVVDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKK 1254
Cdd:COG1579    3 PEDLRALLDLQELDSELDRLEHRLKELP-AELAELEDelaaLEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56550047 1255 EISAKDEKELLhfSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1323
Cdd:COG1579   82 LGNVRNNKEYE--ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1171-1366 8.41e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1171 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevVDLSKYKATKSDLETQISSLNEKLAnlnRKYEEVCEEVLH 1250
Cdd:COG3883   22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQ----AELEALQAEIDKLQAEIAEAEAEIE---ERREELGERARA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1251 AKKKE---------ISAKDEKELLH--FSIEQEIKDQKERcdksLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1319
Cdd:COG3883   95 LYRSGgsvsyldvlLGSESFSDFLDrlSALSKIADADADL----LEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 56550047 1320 QALNGLsqltytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1366
Cdd:COG3883  171 AELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-85 8.49e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 8.49e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047     16 ADWNKYDDR----LMKAAERGDVEKVTSILAKKGVNpgkLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSD 85
Cdd:pfam12796   21 ADANLQDKNgrtaLHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 443-1098 8.97e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 43.80  E-value: 8.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    443 AKQDRLKLQNELAHKVAECKAL------------ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 510
Cdd:TIGR00618  251 AQEEQLKKQQLLKQLRARIEELraqeavleetqeRINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKR 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    511 KEHLTSEAASGNHRLTEEL-----------KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 579
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTlhsqeihirdaHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQA 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    580 KELSMCEMEREKKGRKV---TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 656
Cdd:TIGR00618  411 TIDTRTSAFRDLQGQLAhakKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKA 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    657 ELENVKAKLAQHVKP----EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYV 732
Cdd:TIGR00618  491 VVLARLLELQEEPCPlcgsCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQ 570

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    733 PLKVSEDMKKSHDAIIDDLnRKLLDVTQKYTEKKLEMEKLLLEndslskdVSRLETVFVPPEKHEKEIIALKSNIVE--- 809
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNL-QNITVRLQDLTEKLSEAEDMLAC-------EQHALLRKLQPEQDLQDVRLHLQQCSQela 642

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    810 -LKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND--TLAKTNRELLDVKKKFEDINQEFVK 886
Cdd:TIGR00618  643 lKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWkeMLAQCQTLLRELETHIEEYDREFNE 722

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    887 IKDKNEILKRNLeNTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEivTLHAEIKAQKKELDTIQE 966
Cdd:TIGR00618  723 IENASSSLGSDL-AAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELS--HLAAEIQFFNRLREEDTH 799

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    967 CIKVKYAPIvsfeECERKFKATEKELKDQLSEQtqkysvSEEEVKKNKQENDKLKKEIFTLQKDLRDKtvliekshemer 1046
Cdd:TIGR00618  800 LLKTLEAEI----GQEIPSDEDILNLQCETLVQ------EEEQFLSRLEEKSATLGEITHQLLKYEEC------------ 857

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 56550047   1047 alSRKTDELNKQLKDLSQ--KYTEVKNVKEKLVEENA--KQTSEILAVQN-LLQKQH 1098
Cdd:TIGR00618  858 --SKQLAQLTQEQAKIIQlsDKLNGINQIKIQFDGDAliKFLHEITLYANvRLANQS 912
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-191 9.25e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 56550047    142 DHG-ASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
79-126 9.72e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 56550047     79 VDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALH 126
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1212-1369 9.83e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 9.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1212 DLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLhakkkeisakdekellhfSIEQEIKDQKERcdkslttITELQ 1291
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYN------------------ELQAELEALQAE-------IDKLQ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1292 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyTSGNP-------------TKRQSQLIDTLQHQVKSLEQQLA 1358
Cdd:COG3883   72 AEIAEAEAEIEERREELGERARALYRSGGSVSYLDVLL-GSESFsdfldrlsalskiADADADLLEELKADKAELEAKKA 150

                        170
                 ....*....|.
gi 56550047 1359 DADRQHQEVIA 1369
Cdd:COG3883  151 ELEAKLAELEA 161
PRK12704 PRK12704
phosphodiesterase; Provisional
 1107-1279 1.02e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1107 LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhQLLENQKnssvplaEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1186
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKE-ALLEAKE-------EIHKLRNEFEKELRERRNELQKLEKRLLQKEE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1187 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL---ANLNRkyEEVCEEVLHAKKKEisAKDEKE 1263
Cdd:PRK12704   97 NLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELeriSGLTA--EEAKEILLEKVEEE--ARHEAA 172

                         170
                  ....*....|....*.
gi 56550047  1264 LLHFSIEQEIKDQKER 1279
Cdd:PRK12704  173 VLIKEIEEEAKEEADK 188
PLN02939 PLN02939
transferase, transferring glycosyl groups
 238-590 1.08e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.74  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   238 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEI-ENEDLKERLRKIQQEQRI-LLDKVNGL 314
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQqTNSKDGEQLSDFQLEDLVgMIQNAEKN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   315 QLQLNEEVMVA-DDLE---SEREKL----------------KSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSHF 374
Cdd:PLN02939  144 ILLLNQARLQAlEDLEkilTEKEALqgkinilemrlsetdaRIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLCV 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   375 SN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCES 442
Cdd:PLN02939  222 HSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCWW 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   443 AKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasgn 522
Cdd:PLN02939  300 EKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL------------ 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047   523 hrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
Cdd:PLN02939  356 ------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
PHA02946 PHA02946
ankyin-like protein; Provisional
 137-214 1.11e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.12  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLIKNGADIS 214
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN 134
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
985-1279 1.53e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  985 FKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKdlrdktvlIEKSHEME---RALSRKTDELNKQL 1059
Cdd:COG4913  606 FDNRAKlaALEAELAELEEELAEAEERLEALEAELDALQERREALQR--------LAEYSWDEidvASAEREIAELEAEL 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1060 KDLSQKYTEVKNVKEKLVEenakqtseilavqnlLQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTkl 1139
Cdd:COG4913  678 ERLDASSDDLAALEEQLEE---------------LEAE---LEELEEELDELKGEIGRLEKELEQAEE----ELDELQ-- 733

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047 1140 HQLLENQKNSSVPLAEHLQikEAFEkevgiikaslREKEEESQNKMEEvsKLQSEVQNTKQALKKLETReVVDL-----S 1214
Cdd:COG4913  734 DRLEAAEDLARLELRALLE--ERFA----------AALGDAVERELRE--NLEERIDALRARLNRAEEE-LERAmrafnR 798

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56550047 1215 KYKATKSDLETQISSLNEKLAnlnrKYEEVCEEVLHAKKKEI------SAKDEKELLHFSIEQEIKDQKER 1279
Cdd:COG4913  799 EWPAETADLDADLESLPEYLA----LLDRLEEDGLPEYEERFkellneNSIEFVADLLSKLRRAIREIKER 865
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-71 1.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 56550047     21 YDDRLMKAAERGDVEkVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECL 71
Cdd:pfam13637    1 ELTALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
473-706 1.77e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.72  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   473 EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQThflalkehltseaasgnhrlTEELKDQLKDLKVKYEGASAEVGKLRN 552
Cdd:PRK02224  471 EEDRERVEELEAELEDLEEEVEEVEERLERAED--------------------LVEAEDRIERLEERREDLEELIAERRE 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   553 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLS----- 627
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI------ESLERIRTLLAaiada 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   628 ----NEVNEKAKKLVEMEREHEKSLSEIRQLKRELEnvkAKLaQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 703
Cdd:PRK02224  605 edeiERLREKREALAELNDERRERLAEKRERKRELE---AEF-DEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQ 680


                  ...
gi 56550047   704 KEI 706
Cdd:PRK02224  681 AEI 683
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 187-214 2.48e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 2.48e-03
                           10        20
                   ....*....|....*....|....*...
gi 56550047    187 NRTALMLGCEYGCRDAVEVLIKNGADIS 214
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1037-1179 2.49e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1037 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKqtseilavqnLLQKQHVPLEQ-VEALKKSLNGTI 1115
Cdd:PRK00409  521 LIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDK----------LLEEAEKEAQQaIKEAKKEADEII 590

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047  1116 ENLkeelksmqRCYEKEQQTVTKLHQLLENQKNssvpLAEHLQIKEAFEKEVGIIKASLREKEE 1179
Cdd:PRK00409  591 KEL--------RQLQKGGYASVKAHELIEARKR----LNKANEKKEKKKKKQKEKQEELKVGDE 642
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 527-672 2.50e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  527 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF----KRDEGKLieENKRLQKELSMCEMEREKKGRKVTEMEGQ 602
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVeariKKYEEQL--GNVRNNKEYEALQKEIESLKRRISDLEDE 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  603 AKELSAKLalsipaEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 672
Cdd:COG1579  112 ILELMERI------EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPE 175
PRK12704 PRK12704
phosphodiesterase; Provisional
 982-1132 2.59e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   982 ERKFKATEKELKDQLSE-QTQKYSVSEEEVKKNKQENDKLK-----------KEIFTLQKDLRDKTVLIEKSHEmerALS 1049
Cdd:PRK12704   30 EAKIKEAEEEAKRILEEaKKEAEAIKKEALLEAKEEIHKLRnefekelrerrNELQKLEKRLLQKEENLDRKLE---LLE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1050 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqhvpleqvEALKKSLNGTIENLKEELKSMQRCY 1129
Cdd:PRK12704  107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE--------EAKEILLEKVEEEARHEAAVLIKEI 178


                  ...
gi 56550047  1130 EKE 1132
Cdd:PRK12704  179 EEE 181
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 858-1320 3.04e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    858 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL---ENTQNQIKAEYISL-AEHEAKMSSLSQSMRKVQDSn 933
Cdd:pfam10174  293 QLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLtakEQRAAILQTEVDALrLRLEEKESFLNKKTKQLQDL- 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    934 aeilanyrkgQEEIVTLHAEIKAQKKELDtiqecikVKyapivsfeecERKFKATEKE---LKDQLSEQTQKYSVSEEEV 1010
Cdd:pfam10174  372 ----------TEEKSTLAGEIRDLKDMLD-------VK----------ERKINVLQKKienLQEQLRDKDKQLAGLKERV 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1011 KKNKQENDKLKKEIFTLQKDLRDKTVLIEK-SHEMERALSRKTDELNKQLKDLsqkytevKNVKEKLVeenakqtseilA 1089
Cdd:pfam10174  425 KSLQTDSSNTDTALTTLEEALSEKERIIERlKEQREREDRERLEELESLKKEN-------KDLKEKVS-----------A 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1090 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhqllENQKNSSVPLAEHLQIKEAFEKEVgi 1169
Cdd:pfam10174  487 LQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKL----ENQLKKAHNAEEAVRTNPEINDRI-- 560

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1170 ikaslREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEvcEEVL 1249
Cdd:pfam10174  561 -----RLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQE--MKKK 633

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56550047   1250 HAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQ 1320
Cdd:pfam10174  634 GAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNL--RAERRKQ 702
PRK12704 PRK12704
phosphodiesterase; Provisional
 952-1087 3.13e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   952 AEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDL 1031
Cdd:PRK12704   51 AEAIKKEALLEAKEEIHKLR-------NEFEKELRERRNELQKLEKRLLQK----EENLDRKLELLEKREEELEKKEKEL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56550047  1032 RDKTVLIEKsheMERALSRKTDELNKQLKDLSQKYTE------VKNVKEKLVEENAKQTSEI 1087
Cdd:PRK12704  120 EQKQQELEK---KEEELEELIEEQLQELERISGLTAEeakeilLEKVEEEARHEAAVLIKEI 178
mukB PRK04863
chromosome partition protein MukB;
1013-1380 3.32e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1013 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYtevknvkeklveenakqtseilavqn 1092
Cdd:PRK04863  277 HANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDY-------------------------- 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1093 llqkqhvpleqvealkkslngtiENLKEELKSMQ---RCYEKEQQTVTKLHQLLENqknssvpLAEHLQIKEafekEVGI 1169
Cdd:PRK04863  331 -----------------------QAASDHLNLVQtalRQQEKIERYQADLEELEER-------LEEQNEVVE----EADE 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1170 IKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1243
Cdd:PRK04863  377 QQEENEARAEAAE---EEVDELKSQLADYQQALDVQQTRAiqyqqaVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1244 VCEEVLHAKKKeisakdekellhFSIEQEIKDQKERCDKSLTTIT-------------ELQRRIQES---AKQIEAKDNK 1307
Cdd:PRK04863  454 ATEELLSLEQK------------LSVAQAAHSQFEQAYQLVRKIAgevsrseawdvarELLRRLREQrhlAEQLQQLRMR 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1308 ITEL------LNDVERLKQALNGLSQLTYTS----GNPTKRQSQLIDTLQHQVKSLEQQLADAdRQHQEVIAIYRTHLLS 1377
Cdd:PRK04863  522 LSELeqrlrqQQRAERLLAEFCKRLGKNLDDedelEQLQEELEARLESLSESVSEARERRMAL-RQQLEQLQARIQRLAA 600


                  ...
gi 56550047  1378 AAQ 1380
Cdd:PRK04863  601 RAP 603
Ank_4 pfam13637
Ankyrin repeats (many copies);
154-207 3.36e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 3.36e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 56550047    154 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLI 207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 424-666 3.78e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  424 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKV 500
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEleeELAELEEELEELEEELEELEEEL 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  501 KQMQTHFLALKEHLTS--EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 578
Cdd:COG1196  347 EEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  579 QKELsmcemerekkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 658
Cdd:COG1196  427 EEAL--------------------AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486


                 ....*...
gi 56550047  659 ENVKAKLA 666
Cdd:COG1196  487 AEAAARLL 494
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 424-721 3.78e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   424 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 501
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   502 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 581
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   582 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 642
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   643 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 713
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 56550047   714 KLLKEQAH 721
Cdd:NF033838  396 KKAEEEAK 403
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 17-252 4.03e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     17 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 90
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047     91 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 166
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    167 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 231
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 56550047    232 nlDILTLLKTASENTNKGREL 252
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
PRK01156 PRK01156
chromosome segregation protein; Provisional
 894-1361 4.40e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.43  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   894 LKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYA 973
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSIT---LKEIERLSIEYNNAMDDYNNLKSALN-ELSSLEDMKNRYESEIKTAES 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   974 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS---- 1049
Cdd:PRK01156  264 DLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNdyik 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1050 --RKTDELNKQLKDLSQ---KYT----EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1120
Cdd:PRK01156  344 kkSRYDDLNNQILELEGyemDYNsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISS 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1121 ELKSMQ---RCYEKEQQTVTKLHQLLENQKNSSVpLAEHLqikeAFEKEVGIIKASLREKE--EESQNKME-EVSKLQSE 1194
Cdd:PRK01156  424 KVSSLNqriRALRENLDELSRNMEMLNGQSVCPV-CGTTL----GEEKSNHIINHYNEKKSrlEEKIREIEiEVKDIDEK 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1195 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEISAKDEKELLHFS--- 1268
Cdd:PRK01156  499 IVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELkdkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAvis 578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1269 -------------IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgNP 1335
Cdd:PRK01156  579 lidietnrsrsneIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKI----DN 654

                         490       500
                  ....*....|....*....|....*.
gi 56550047  1336 TKRQSQLIDTLQHQVKSLEQQLADAD 1361
Cdd:PRK01156  655 YKKQIAEIDSIIPDLKEITSRINDIE 680
PRK11281 PRK11281
mechanosensitive channel MscK;
988-1401 4.50e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   988 TEKELKDQLseqtqkysvseEEVKKNKQENDKLKkeifTLQKDLRDKTVLIEKSHEMERalsrKTDELNKQLKDLSQKYT 1067
Cdd:PRK11281   37 TEADVQAQL-----------DALNKQKLLEAEDK----LVQQDLEQTLALLDKIDRQKE----ETEQLKQQLAQAPAKLR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1068 EVKNVKEKLVEENAKQTSEILAVQNL--LQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-------K 1138
Cdd:PRK11281   98 QAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYansqrlqQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1139 LHQLLENQKNSSVPLAEHLQIKEAFEKevgiikASLREKEEESQNKMEEVSKLQsevqntkqalkkletrevvDLskYKA 1218
Cdd:PRK11281  175 IRNLLKGGKVGGKALRPSQRVLLQAEQ------ALLNAQNDLQRKSLEGNTQLQ-------------------DL--LQK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1219 TKSDLETQISSLNEKLANLnrkyeevcEEVLHAKKKEISAKDEKEllhfsieQEIKDQKERCDKSLTTITELQRRIQESA 1298
Cdd:PRK11281  228 QRDYLTARIQRLEHQLQLL--------QEAINSKRLTLSEKTVQE-------AQSQDEAARIQANPLVAQELEINLQLSQ 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1299 KQIEAKDnKITELLNDVERLKQALNGLSQltytsgnpTKR---------------------QSQLIDTLQhQVKSLEQQL 1357
Cdd:PRK11281  293 RLLKATE-KLNTLTQQNLRVKNWLDRLTQ--------SERnikeqisvlkgslllsrilyqQQQALPSAD-LIEGLADRI 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 56550047  1358 ADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1401
Cdd:PRK11281  363 ADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
PHA02798 PHA02798
ankyrin-like protein; Provisional
 37-248 4.59e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.36  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    37 VTSILAKKGVNPGKLDVEGRSVFHVVTSKG---NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA-------LCLQK 106
Cdd:PHA02798   91 IVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidieiikLLLEK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   107 LLQYNcptEHADLQGRTALH-------DAAMADCpssIQLLCDHGASVNAKDVDGRTPLVlatqmsrPTICQLLIDRGA- 178
Cdd:PHA02798  171 GVDIN---THNNKEKYDTLHcyfkyniDRIDADI---LKLFVDNGFIINKENKSHKKKFM-------EYLNSLLYDNKRf 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   179 ------------DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHdssyyarigdnldilTLLKTASENT 246
Cdd:PHA02798  238 kknildfifsyiDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGN---------------TCLFTAFENE 302


                  ..
gi 56550047   247 NK 248
Cdd:PHA02798  303 SK 304
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 545-1203 5.27e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.31  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    545 AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELsmcemerekkgRKVTEMEGQAKELSAKLAlsipaekfenmks 624
Cdd:pfam01576   12 EELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL-----------QAETELCAEAEEMRARLA------------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    625 slsnevnEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-----EEHEQVKSRLEQKSGELGKKITELTLKN 699
Cdd:pfam01576   68 -------ARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDI 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    700 QTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtQKYTEKKLEMEKLllendsl 779
Cdd:pfam01576  141 LLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL----KKEEKGRQELEKA------- 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    780 skdvsrletvfvpPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALtsentnlkkmmsnqyvpvKTHEEVKMTL 859
Cdd:pfam01576  210 -------------KRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAA------------------LARLEEETAQ 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    860 NDTLAKTNRELL-DVKKKFEDINQEFVKiKDKNEILKRNLENTQNQIKAEyislaeheakmsslsqsMRKVQDSNAEILA 938
Cdd:pfam01576  259 KNNALKKIRELEaQISELQEDLESERAA-RNKAEKQRRDLGEELEALKTE-----------------LEDTLDTTAAQQE 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    939 NYRKGQEEIVTLHAEIKAQKKELDTiqecikvkyapivSFEECERKFKATEKELKDQLsEQTQKYSVSEEevkKNKQend 1018
Cdd:pfam01576  321 LRSKREQEVTELKKALEEETRSHEA-------------QLQEMRQKHTQALEELTEQL-EQAKRNKANLE---KAKQ--- 380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1019 KLKKEIFTLQKDLRdktVLIEKSHEMERalsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ--- 1095
Cdd:pfam01576  381 ALESENAELQAELR---TLQQAKQDSEH----KRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNeae 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1096 -KQHVPLEQVEALKKSLNGTIENLKEELKsmqrcyeKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1174
Cdd:pfam01576  454 gKNIKLSKDVSSLESQLQDTQELLQEETR-------QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQL 526

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 56550047   1175 R------EKEEESQNKMEEVSK-LQSEVQNTKQALK 1203
Cdd:pfam01576  527 SdmkkklEEDAGTLEALEEGKKrLQRELEALTQQLE 562
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 277-708 5.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 5.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  277 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 356
Cdd:COG1196  396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  357 KNrfkyfESDHLGSGSHFSNRKEDMLLKQGQMYMADSQctSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAM 436
Cdd:COG1196  476 EA-----ALAELLEELAEAAARLLLLLEAEADYEGFLE--GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  437 RTFCESAKQDRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLED----ALKDVQKRMYESEGKVKQMQTHFLALK 511
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLkAAKAGRATFLPLDKIRARAALAAALARGAIgaavDLVASDLREADARYYVLGDTLLGRTLV 628

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  512 EHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 591
Cdd:COG1196  629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  592 KGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE-----NVKAkl 665
Cdd:COG1196  709 LAEAEEERLEEELEEEALEeQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEalgpvNLLA-- 786

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 56550047  666 aqhvkPEEHEQVKSRLEqksgelgkkitELTLKNQTLQKEIEK 708
Cdd:COG1196  787 -----IEEYEELEERYD-----------FLSEQREDLEEARET 813
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 795-1355 5.64e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.58  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    795 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMmsnqyVPVKTHEEVKMTLNDTLAKTNRelLDVK 874
Cdd:TIGR01612  576 HLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIKKA-----IDLKKIIENNNAYIDELAKISP--YQVP 648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    875 KKFEDINQEFVKIKDK-NEILKRNLENTQNQ----IKAEYISLAEHEAKMSSLSQSMRKVQD--SNAEI------LANYR 941
Cdd:TIGR01612  649 EHLKNKDKIYSTIKSElSKIYEDDIDALYNElssiVKENAIDNTEDKAKLDDLKSKIDKEYDkiQNMETatvelhLSNIE 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    942 KGQEEIVTLHAEIKAQ-----KKELDTIQECIKVKYAPIVS-------FEECERKFKATEKELKDQLSEQTQKYSVSEEE 1009
Cdd:TIGR01612  729 NKKNELLDIIVEIKKHihgeiNKDLNKILEDFKNKEKELSNkindyakEKDELNKYKSKISEIKNHYNDQINIDNIKDED 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1010 VKKNKQENDKLKKEIfTLQKDLRDKTV------------LIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEKL 1076
Cdd:TIGR01612  809 AKQNYDKSKEYIKTI-SIKEDEIFKIInemkfmkddflnKVDKFINFENNCKEKIDSEHEQFAELTNKIkAEISDDKLND 887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1077 VEENAKQT-SEILAVQNLLQKQHvplEQVEALKKsLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV---- 1151
Cdd:TIGR01612  888 YEKKFNDSkSLINEINKSIEEEY---QNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLieks 963

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1152 --PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlsKYKATkSDLETQISS 1229
Cdd:TIGR01612  964 ykDKFDNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDE-----KEKAT-NDIEQKIED 1037

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1230 LNEKLANLnrkyeevcEEVLHAKKKEISAKDEKELLHfSIEQEIKDQKERCDKSLTTITELQRRIQ-----ESAKQIEAK 1304
Cdd:TIGR01612 1038 ANKNIPNI--------EIAIHTSIYNIIDEIEKEIGK-NIELLNKEILEEAEINITNFNEIKEKLKhynfdDFGKEENIK 1108

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 56550047   1305 -DNKITELLNDVERLKQALN-GLSQLTYTSgnptKRQSQLIDTLQHQVKSLEQ 1355
Cdd:TIGR01612 1109 yADEINKIKDDIKNLDQKIDhHIKALEEIK----KKSENYIDEIKAQINDLED 1157
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
453-831 6.27e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 6.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   453 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMyesegkvkqmqTHFLALKEhLTSEAASGNHRLTEELKDQ 532
Cdd:PRK02224  255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEER-----------DDLLAEAG-LDDADAEAVEARREELEDR 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   533 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 612
Cdd:PRK02224  323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   613 SipAEKFENMkSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-----KLAQHVKPEEHEQVKSRLEQKSGE 687
Cdd:PRK02224  403 A--PVDLGNA-EDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpECGQPVEGSPHVETIEEDRERVEE 479

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   688 LGKKITELTLKNQTLQKEIEKVyldnkllkeqahnltiemknhyvplkvsEDMKKSHDAiIDDLNRKLLDVTQKYTEKKL 767
Cdd:PRK02224  480 LEAELEDLEEEVEEVEERLERA----------------------------EDLVEAEDR-IERLEERREDLEELIAERRE 530

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56550047   768 EMEKLLLENDSLSKDVSRLETvfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL 831
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEA---EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESL 591
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 441-688 6.53e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 6.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  441 ESAKQDRLKLQNELAHKVAECKALALECERVK---EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtse 517
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLkqlAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL--- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  518 aasgnHRLTEELKDQLKDLkVKYEGASAEVGKLR----NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSmcemerekkg 593
Cdd:COG4942  100 -----EAQKEELAELLRAL-YRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELA---------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  594 RKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE---LENVKAKLAQHVK 670
Cdd:COG4942  164 ALRAELEAERAELEALLA------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEaeeLEALIARLEAEAA 237

                        250
                 ....*....|....*...
gi 56550047  671 PEEHEQVKSRLEQKSGEL 688
Cdd:COG4942  238 AAAERTPAAGFAALKGKL 255
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 103-191 6.65e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  103 CLQKLLqyNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNA---------KDVD-----GRTPLVLATQMSRPT 168
Cdd:cd22194  125 ILDRFI--NAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpKYKHegfyfGETPLALAACTNQPE 202

                         90       100
                 ....*....|....*....|....
gi 56550047  169 ICQLLIDRGAD-VNSRDKQNRTAL 191
Cdd:cd22194  203 IVQLLMEKESTdITSQDSRGNTVL 226
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 273-810 7.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 7.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  273 VKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT 352
Cdd:COG1196  294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  353 IEALKNRFKYFESDHLgsgsHFSNRKEDMLLKQGQMYMADSQctspgipaHMQSRSMLRplelslpsqtsySENEILKKE 432
Cdd:COG1196  374 LAEAEEELEELAEELL----EALRAAAELAAQLEELEEAEEA--------LLERLERLE------------EELEELEEA 429

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  433 LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 512
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  513 HLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQikqnemIVEEFKRDEGKLIEENKrlqkelsmcemeREKK 592
Cdd:COG1196  510 VKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQN------IVVEDDEVAAAAIEYLK------------AAKA 571

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  593 GRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 672
Cdd:COG1196  572 GRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTL 651

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  673 EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEmknhyvplkvSEDMKKSHDAIIDDLN 752
Cdd:COG1196  652 EGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE----------ERELAEAEEERLEEEL 721

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 56550047  753 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 810
Cdd:COG1196  722 EEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1034-1350 7.82e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 7.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1034 KTVLIEKSHE-------MERALSrKTDELNKQLKDL--SQKYTEVK-NVKEKLVE-ENAKQTSEILAVQNLLQKQHVplE 1102
Cdd:pfam07902   63 APVVVEGSGEstglfksLEEMLS-QLKELNLELTDTknSNLWSKIKlNNNGMLREyHNDTIKTEIVESAEGIATRIS--E 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1103 QVEALKKSLNGTIENLKEELKSMQR-CYEKEQQTVTKLHQLLENQKNSsvplaehlqikeafekevgiikaslrekeees 1181
Cdd:pfam07902  140 DTDKKLALINETISGIRREYQDADRqLSSSYQAGIEGLKATMASDKIG-------------------------------- 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1182 qnkmeevskLQSEVQNTKQALKKLETREVVDLS-KYKATKSDletQISSLNEKLANLNRKYEEVCEEVLHAKKKEISA-K 1259
Cdd:pfam07902  188 ---------LQAEIQASAQGLSQRYDNEIRKLSaKITTTSSG---TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQ 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   1260 DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAkdnkitellndverLKQALNGL-SQLTYTSGNPTKR 1338
Cdd:pfam07902  256 STQQSTAYQISQEISNREGAVSRVQQDLDSYQRRLQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESR 321

                          330
                   ....*....|..
gi 56550047   1339 QSQLIDTLQHQV 1350
Cdd:pfam07902  322 ITQLAGLIEQKV 333
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 753-1083 8.29e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 8.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  753 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET-----VFVPPEKHEKEIIALKSNIVELKKQLSELK-KKCGEDQE 826
Cdd:COG5185  196 KKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIeealkGFQDPESELEDLAQTSDKLEKLVEQNTDLRlEKLGENAE 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  827 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR-ELLDVKKKFEDINQEFVKikdKNEILKRNLENTQNQI 905
Cdd:COG5185  276 SSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQlAAAEAEQELEESKRETET---GIQNLTAEIEQGQESL 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  906 KAEYISLaeheakmsslsqsmrKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 985
Cdd:COG5185  353 TENLEAI---------------KEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKA 417

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  986 KATE-KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIftlqkDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1064
Cdd:COG5185  418 ADRQiEELQRQIEQATSSNEEVSKLLNELISELNKVMREA-----DEESQSRLEEAYDEINRSVRSKKEDLNEELTQIES 492

                        330
                 ....*....|....*....
gi 56550047 1065 KYTEVKNVKEKLVEENAKQ 1083
Cdd:COG5185  493 RVSTLKATLEKLRAKLERQ 511
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-181 8.33e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 8.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 56550047    153 DGRTPLVLATQMSRPTICQLLIDRGADVN 181
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 787-1187 8.50e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 40.61  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   787 ETVFVPPEK--HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkKMMSnqyvpvKTHEEVKMTLNDTLa 864
Cdd:PLN03229  409 EGVPVDPERkvNMKKREAVKTPVRELEGEVEKLKEQILKAKESSSKPSELALN--EMIE------KLKKEIDLEYTEAV- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   865 ktnrELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 944
Cdd:PLN03229  480 ----IAMGLQERLENLREEFSKANSQDQLMHPVLMEKIEKLKDEFNKRLSRAPNYLSLKYKLDMLNEFSRAKALSEKKSK 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047   945 EEivTLHAEIKAQKKELDTIQEcikvkyapivsfeecerkFKATEKELKDQlseqtqkysVSEEEVKKNKQENDKLKKEI 1024
Cdd:PLN03229  556 AE--KLKAEINKKFKEVMDRPE------------------IKEKMEALKAE---------VASSGASSGDELDDDLKEKV 606

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDelnkqlKDLSQKyTEVKNVKEKLVEENAKQTSEILAVQNLlqkqhvpleqv 1104
Cdd:PLN03229  607 EKMKKEIELELAGVLKSMGLEVIGVTKKN------KDTAEQ-TPPPNLQEKIESLNEEINKKIERVIRS----------- 668

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047  1105 ealkKSLNGTIENLKEEL-KSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVgiikASLREKEEESQN 1183
Cdd:PLN03229  669 ----SDLKSKIELLKLEVaKASKTPDVTEKEKIEALEQQIKQKIAEALNSSELKEKFEELEAEL----AAARETAAESNG 740


                  ....
gi 56550047  1184 KMEE 1187
Cdd:PLN03229  741 SLKN 744
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 738-1028 9.18e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 40.40  E-value: 9.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    738 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLlleNDSLSKDVSRLETVfvppekhEKEIIALKSNiVELKKQLSEL 817
Cdd:pfam05667  327 EELQQQREEELEELQEQLEDLESSIQELEKEIKKL---ESSIKQVEEELEEL-------KEQNEELEKQ-YKVKKKTLDL 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    818 KKKCGEDQEKIHALTSENTNLKKMMSNQY----VP-VKTHEEVKmtlndtLAKTNRELlDVKKKFEDINQEFVKIKDKNE 892
Cdd:pfam05667  396 LPDAEENIAKLQALVDASAQRLVELAGQWekhrVPlIEEYRALK------EAKSNKED-ESQRKLEEIKELREKIKEVAE 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    893 ILKRNlENTQNQIKAEYISLAeheaKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIkvky 972
Cdd:pfam05667  469 EAKQK-EELYKQLVAEYERLP----KDVSRSAYTRRI----LEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKL---- 535

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 56550047    973 apivsfeecERKFKATEKEL-----KDQLSEQTQKYSVSE----EEVKKNKQENDKLKKEIFTLQ 1028
Cdd:pfam05667  536 ---------DRTFTVTDELVfkdakKDESVRKAYKYLAALhencEQLIQTVEETGTIMREIRDLE 591
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 480-1076 9.45e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.54  E-value: 9.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    480 KQLEDALKDVQKRMYESEGKV-------KQMQTHFLALKEHLTSEAASGNHRLTEE--LKDQLKDLKVKYEGASAEVGKL 550
Cdd:pfam01576   71 QELEEILHELESRLEEEEERSqqlqnekKKMQQHIQDLEEQLDEEEAARQKLQLEKvtTEAKIKKLEEDILLLEDQNSKL 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    551 RNQIKQNEMIVEEFKRDEGKLIEENKRLQK-----ELSMCEME----REKKGRKVTE-----MEGQAKELSAKLA----- 611
Cdd:pfam01576  151 SKERKLLEERISEFTSNLAEEEEKAKSLSKlknkhEAMISDLEerlkKEEKGRQELEkakrkLEGESTDLQEQIAelqaq 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    612 ----LSIPAEKFENMKSSLSNEVNEKAKK--LVEMEREHEKSLSEI------------------RQLKRELENVKAKLAQ 667
Cdd:pfam01576  231 iaelRAQLAKKEEELQAALARLEEETAQKnnALKKIRELEAQISELqedleseraarnkaekqrRDLGEELEALKTELED 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    668 HVKPEEHEQ-VKSRLEQKSGELGKKITELT--------------------LKNQTLQKEIEKVYLD--NKLLKEQAHNLT 724
Cdd:pfam01576  311 TLDTTAAQQeLRSKREQEVTELKKALEEETrsheaqlqemrqkhtqaleeLTEQLEQAKRNKANLEkaKQALESENAELQ 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    725 IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALK 804
Cdd:pfam01576  391 AELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLE 467

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    805 SNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEF 884
Cdd:pfam01576  468 SQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTL 540

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    885 VKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIKAqkkel 961
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEKA----- 615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550047    962 dtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDLRDKTVl 1037
Cdd:pfam01576  616 ------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDDVGKNV- 680

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 56550047   1038 ieksHEME---RALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1076
Cdd:pfam01576  681 ----HELErskRALEQQVEEMKTQLEELEDELQATEDAKLRL 718
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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