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Conserved domains on  [gi|58761502|ref|NP_001011708|]
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obg-like ATPase 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00258 super family cl36535
GTP-binding protein; Provisional
 1-232 1.37e-113

GTP-binding protein; Provisional


The actual alignment was detected with superfamily member PTZ00258:

Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 330.75  E-value: 1.37e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502    1 MIGPIIDKLEKVavRGGDKKLK---PEYDIMCKVKSWVIDqKKPVRFYhDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKD 77
Cdd:PTZ00258 158 FVEKRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDG-DWTDKEIEILNEYQLLTAKPMIYLVNMSEKD 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   78 YIRKKNKWLIKIKEWVDKYDPGALvIPFSGALELKLQEL-SAEERQKYL-EANMTQSALPKIIKAGFAALQLEYFFTAGP 155
Cdd:PTZ00258 234 FIRQKNKWLAKIKEWVGEKGGGPI-IPYSAEFEEELAELgSEEERKEYLeEYGIKQSMLDKIIKTGYKLLNLIHFFTAGP 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502  156 DEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTP 232
Cdd:PTZ00258 313 DEVRCWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNVS 389
 
Name Accession Description Interval E-value
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 1-232 1.37e-113

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 330.75  E-value: 1.37e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502    1 MIGPIIDKLEKVavRGGDKKLK---PEYDIMCKVKSWVIDqKKPVRFYhDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKD 77
Cdd:PTZ00258 158 FVEKRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDG-DWTDKEIEILNEYQLLTAKPMIYLVNMSEKD 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   78 YIRKKNKWLIKIKEWVDKYDPGALvIPFSGALELKLQEL-SAEERQKYL-EANMTQSALPKIIKAGFAALQLEYFFTAGP 155
Cdd:PTZ00258 234 FIRQKNKWLAKIKEWVGEKGGGPI-IPYSAEFEEELAELgSEEERKEYLeEYGIKQSMLDKIIKTGYKLLNLIHFFTAGP 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502  156 DEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTP 232
Cdd:PTZ00258 313 DEVRCWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNVS 389
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 6-230 7.19e-91

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 271.89  E-value: 7.19e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   6 IDKLEKVAvRGGDKKLKPEYDIMCKVKSwVIDQKKPVRfYHDWNDKEIEVLnKHL-FLTSKPMVYLVNLSEKDyIRKKNK 84
Cdd:COG0012 142 LERLEKKA-KSGDKEAKAELELLEKLKE-HLEEGKPAR-SLELSEEEKKLL-KELqLLTAKPVLYVANVDEDD-LAEGNP 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502  85 WLIKIKEWVDKydPGALVIPFSGALELKLQELSAEERQKYLEA-NMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTI 163
Cdd:COG0012 217 YVEKVREYAAK--EGAEVVVICAKIEAELAELDEEERAEFLEElGLEESGLDRLIRAGYDLLGLITFFTAGPKEVRAWTI 294

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502 164 RKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFN 230
Cdd:COG0012 295 KKGTTAPQAAGVIHTDFERGFIRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 5-230 5.37e-63

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 200.77  E-value: 5.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502     5 IIDKLEKVAVRG-----GDKKLKPEYDIMCKVKSwVIDQKKPVRfyHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYI 79
Cdd:TIGR00092 137 DEFLVEKRIGRSkksaeGGKDKKEELLLLEIILP-LLNGGQMAR--HVDLSKEELILIKSLNLLTKKPIILIANVSEDYL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502    80 RKKNKWLIKIKEWVDKYDPGALVIPFSGALELK-LQELSAEERQKYL-EANMTQSALPK-IIKAGFAALQLEYFFTAGPD 156
Cdd:TIGR00092 214 RNLNNNYLLIVEWIAAYSKGDPKVVFVCALEESeLSELDDEERQEFLqKLGLTESAGLNiIIRARYKLLLLSFFFTGGKE 293

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58761502   157 EVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFN 230
Cdd:TIGR00092 294 EVRAWTRKGGWAAPQAAGIIHTDFETGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 145-229 2.70e-62

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 189.28  E-value: 2.70e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502 145 LQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDI 224
Cdd:cd04867   1 LNLITFFTAGPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDI 80


                ....*
gi 58761502 225 IFFKF 229
Cdd:cd04867  81 IHFKF 85
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 147-228 3.28e-60

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 184.10  E-value: 3.28e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   147 LEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIF 226
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 58761502   227 FK 228
Cdd:pfam06071  81 FR 82
 
Name Accession Description Interval E-value
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 1-232 1.37e-113

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 330.75  E-value: 1.37e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502    1 MIGPIIDKLEKVavRGGDKKLK---PEYDIMCKVKSWVIDqKKPVRFYhDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKD 77
Cdd:PTZ00258 158 FVEKRLDELTKK--RKKKKKKKeekVELDVLKKVLEWLEE-GKPVRDG-DWTDKEIEILNEYQLLTAKPMIYLVNMSEKD 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   78 YIRKKNKWLIKIKEWVDKYDPGALvIPFSGALELKLQEL-SAEERQKYL-EANMTQSALPKIIKAGFAALQLEYFFTAGP 155
Cdd:PTZ00258 234 FIRQKNKWLAKIKEWVGEKGGGPI-IPYSAEFEEELAELgSEEERKEYLeEYGIKQSMLDKIIKTGYKLLNLIHFFTAGP 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502  156 DEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTP 232
Cdd:PTZ00258 313 DEVRCWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNVS 389
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 6-230 7.19e-91

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 271.89  E-value: 7.19e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   6 IDKLEKVAvRGGDKKLKPEYDIMCKVKSwVIDQKKPVRfYHDWNDKEIEVLnKHL-FLTSKPMVYLVNLSEKDyIRKKNK 84
Cdd:COG0012 142 LERLEKKA-KSGDKEAKAELELLEKLKE-HLEEGKPAR-SLELSEEEKKLL-KELqLLTAKPVLYVANVDEDD-LAEGNP 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502  85 WLIKIKEWVDKydPGALVIPFSGALELKLQELSAEERQKYLEA-NMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTI 163
Cdd:COG0012 217 YVEKVREYAAK--EGAEVVVICAKIEAELAELDEEERAEFLEElGLEESGLDRLIRAGYDLLGLITFFTAGPKEVRAWTI 294

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502 164 RKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFN 230
Cdd:COG0012 295 KKGTTAPQAAGVIHTDFERGFIRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 5-230 5.37e-63

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 200.77  E-value: 5.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502     5 IIDKLEKVAVRG-----GDKKLKPEYDIMCKVKSwVIDQKKPVRfyHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYI 79
Cdd:TIGR00092 137 DEFLVEKRIGRSkksaeGGKDKKEELLLLEIILP-LLNGGQMAR--HVDLSKEELILIKSLNLLTKKPIILIANVSEDYL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502    80 RKKNKWLIKIKEWVDKYDPGALVIPFSGALELK-LQELSAEERQKYL-EANMTQSALPK-IIKAGFAALQLEYFFTAGPD 156
Cdd:TIGR00092 214 RNLNNNYLLIVEWIAAYSKGDPKVVFVCALEESeLSELDDEERQEFLqKLGLTESAGLNiIIRARYKLLLLSFFFTGGKE 293

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58761502   157 EVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFN 230
Cdd:TIGR00092 294 EVRAWTRKGGWAAPQAAGIIHTDFETGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 145-229 2.70e-62

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 189.28  E-value: 2.70e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502 145 LQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDI 224
Cdd:cd04867   1 LNLITFFTAGPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDI 80


                ....*
gi 58761502 225 IFFKF 229
Cdd:cd04867  81 IHFKF 85
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 147-228 3.28e-60

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 184.10  E-value: 3.28e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58761502   147 LEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIF 226
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 58761502   227 FK 228
Cdd:pfam06071  81 FR 82
TGS_Obg cd04938
TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases ...
 152-228 3.00e-10

TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases function has been implicated in cellular processes as diverse as sporulation, stress response, control of DNA replication, and ribosome assembly. It consists of several subfamilies such as DRG and YchF with TGS domain. The TGS domain is named after the various RNA-binding multidomain ThrRS, GTPase, and SpoT/RelA proteins in which this domain occurs. The TGS domain of Obg-like GTPases such as those present in DRG (developmentally regulated GTP-binding protein), and GTP-binding proteins Ygr210 and YchF has a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340517 [Multi-domain]  Cd Length: 77  Bit Score: 55.14  E-value: 3.00e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58761502 152 TAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVmkyedfkeegsenavkaAGKYRQQGRNYIVEDGDIIFFK 228
Cdd:cd04938  18 SGNSVFRDCVLVKKGTTVKDFANKIHTDLEKGFINAEG-----------------IGGRRLEGEDYILQDNDVVKFT 77
TGS cd01616
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ...
 150-227 4.01e-08

TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role.


Pssm-ID: 340455 [Multi-domain]  Cd Length: 61  Bit Score: 48.75  E-value: 4.01e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58761502 150 FFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMkyedfkeegsenavkaagkYRQQGRNYIVEDGDIIFF 227
Cdd:cd01616   2 VFTVGKTPGTVFVMNKGATAYSCAMHLHEDYCRKSILALVD-------------------GQLWDMYYPLTKGDEIKF 60
TGS_DRG cd01666
TGS (ThrRS, GTPase and SpoT) domain found in developmentally regulated GTP binding protein ...
 155-225 9.60e-03

TGS (ThrRS, GTPase and SpoT) domain found in developmentally regulated GTP binding protein (DRG) family; DRG-1 and DRG-2 comprise a highly conserved DRG subfamily of GTP-binding proteins found in archaea, plants, fungi and animals. The exact function of DRG proteins is unknown, although phylogenetic and biochemical fraction studies have linked them to translation, differentiation and growth. Their abnormal expressions may trigger cell transformation or cell cycle arrest. DRG-1 and DRG-2 bind to DFRP1 (DRG family regulatory protein 1) and DFRP2, respectively. Both DRG-1 and DRG-2 contain a domain of characteristic Obg-type G-motifs that may be the core of GTPase activity, as well as the C-terminal TGS (ThrRS, GTPase and SpoT) domain, which has a predominantly beta-grasp ubiquitin-like fold and may be related to RNA binding. DRG subfamily belongs to the Obg family of GTPases.


Pssm-ID: 340457 [Multi-domain]  Cd Length: 77  Bit Score: 34.13  E-value: 9.60e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58761502 155 PDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMkyedfkeeGSEnavkaaGKYRQQ--GRNYIVEDGDII 225
Cdd:cd01666  15 PDFDEPFILRRGSTVEDVAEKIHKDLAENFKYARVW--------GKS------VKFDGQrvGLDHVLEDGDIV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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