shugoshin 1 isoform 1AB [Homo sapiens]
Protein Classification
Shugoshin_N and Shugoshin_C domain-containing protein( domain architecture ID 10540877)
Shugoshin_N and Shugoshin_C domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Shugoshin_C | pfam07557 | Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ... |
205-226 | 1.12e-05 | ||
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres. : Pssm-ID: 462207 Cd Length: 24 Bit Score: 41.31 E-value: 1.12e-05
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| Shugoshin_N | pfam07558 | Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ... |
22-66 | 3.03e-05 | ||
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process. : Pssm-ID: 462208 Cd Length: 45 Bit Score: 40.29 E-value: 3.03e-05
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| Name | Accession | Description | Interval | E-value | ||
| Shugoshin_C | pfam07557 | Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ... |
205-226 | 1.12e-05 | ||
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres. Pssm-ID: 462207 Cd Length: 24 Bit Score: 41.31 E-value: 1.12e-05
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| Shugoshin_N | pfam07558 | Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ... |
22-66 | 3.03e-05 | ||
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process. Pssm-ID: 462208 Cd Length: 45 Bit Score: 40.29 E-value: 3.03e-05
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| Name | Accession | Description | Interval | E-value | ||
| Shugoshin_C | pfam07557 | Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ... |
205-226 | 1.12e-05 | ||
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres. Pssm-ID: 462207 Cd Length: 24 Bit Score: 41.31 E-value: 1.12e-05
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| Shugoshin_N | pfam07558 | Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ... |
22-66 | 3.03e-05 | ||
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process. Pssm-ID: 462208 Cd Length: 45 Bit Score: 40.29 E-value: 3.03e-05
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