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Conserved domains on  [gi|62460376|ref|NP_001014422|]
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target of Nesh-SH3 isoform 4 precursor [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 863-954 3.78e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  863 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 940
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 62460376  941 LGEGPASNTVAFST 954
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 369-885 2.68e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   369 PEFELPLSTLAPKRFPEFPEAKTAFP--------LEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSD 440
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPrmltwirgLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR 2585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   441 ETEIEI---HTATRDPILDS-VPPKTSRTAEQPRATLAPIEALFesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTP 516
Cdd:PHA03247 2586 ARRPDAppqSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPP---------SPSPAANEPDPHPPPTVPPPERPRDDP 2656

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   517 KPPRVKPaPRQTTSM--PPKLKTPHSR-MPAKEPVPKEPLHTTSKPKMPP-SPEVADTTSVPKderLSLKPDPEVTHSET 592
Cdd:PHA03247 2657 APGRVSR-PRRARRLgrAAQASSPPQRpRRRAARPTVGSLTSLADPPPPPpTPEPAPHALVSA---TPLPPGPAAARQAS 2732

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   593 APLetrgiPLIPVisPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRP--------- 663
Cdd:PHA03247 2733 PAL-----PAAPA--PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESREslpspwdpa 2805

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   664 -HGRPALNKTTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPER 742
Cdd:PHA03247 2806 dPPAAVLAPAAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAA 2877

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   743 RPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRF 822
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62460376   823 IGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 885
Cdd:PHA03247 2958 AVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 4.85e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 62460376  192 FGVK 195
Cdd:cd00063   72 FRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 863-954 3.78e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  863 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 940
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 62460376  941 LGEGPASNTVAFST 954
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 369-885 2.68e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   369 PEFELPLSTLAPKRFPEFPEAKTAFP--------LEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSD 440
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPrmltwirgLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR 2585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   441 ETEIEI---HTATRDPILDS-VPPKTSRTAEQPRATLAPIEALFesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTP 516
Cdd:PHA03247 2586 ARRPDAppqSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPP---------SPSPAANEPDPHPPPTVPPPERPRDDP 2656

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   517 KPPRVKPaPRQTTSM--PPKLKTPHSR-MPAKEPVPKEPLHTTSKPKMPP-SPEVADTTSVPKderLSLKPDPEVTHSET 592
Cdd:PHA03247 2657 APGRVSR-PRRARRLgrAAQASSPPQRpRRRAARPTVGSLTSLADPPPPPpTPEPAPHALVSA---TPLPPGPAAARQAS 2732

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   593 APLetrgiPLIPVisPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRP--------- 663
Cdd:PHA03247 2733 PAL-----PAAPA--PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESREslpspwdpa 2805

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   664 -HGRPALNKTTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPER 742
Cdd:PHA03247 2806 dPPAAVLAPAAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAA 2877

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   743 RPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRF 822
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62460376   823 IGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 885
Cdd:PHA03247 2958 AVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-944 1.63e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.63e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376     864 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 941
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 62460376     942 GEG 944
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
864-947 2.88e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 2.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    864 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 940
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 62460376    941 LGEGPAS 947
Cdd:pfam00041   79 GGEGPPS 85
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-757 4.28e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 4.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPRQTTSMP---PKLKTPHSRMPAKEPvPKEPLHTTSKP------KMP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPAPLSMPhikPPPTTPIPQLPNPQS-HKHPPHLSGPSpfqmnsNLP 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    563 PSPEVADTTSVPKDERLSLKPDPEVTHSETAPLEtrgiplipvisPRPSQEELQTAmeetdqstqelfTTKIPRTTELAK 642
Cdd:pfam03154  392 PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLP-----------PPPAQPPVLTQ------------SQSLPPPAASHP 448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    643 TTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTshkngvgtgTKQAPKPPSPGRNASVdshatrkPGSVSG 722
Cdd:pfam03154  449 PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMP---------GIQPPSSASVSSSGPV-------PAAVSC 512

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 62460376    723 TRRP------PIPHRHSSTRPVSPERRPLPPNNVTGKPGRA 757
Cdd:pfam03154  513 PLPPvqikeeALDEAEEPESPPPPPRSPSPEPTVVNTPSHA 553
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
848-959 2.35e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  848 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 927
Cdd:COG3401  220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                         90       100       110
                 ....*....|....*....|....*....|...
gi 62460376  928 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 959
Cdd:COG3401  295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 4.85e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 62460376  192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 5.33e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 5.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 62460376    193 GVK 195
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 6.04e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 6.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376     114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 62460376     190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 365-811 1.42e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  365 SVLIPEFELPLSTLAPKRFPEFPEAKTAFPLEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTsdetei 444
Cdd:COG5180   64 DIKLALGKPQLPSVAEPEAYLDPAPPKSSPDTPEEQLGAPAGDLLVLPAAKTPELAAGALPAPAAAAALPKAKV------ 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  445 eihtaTRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIftspevrPTTAAPQQTTSIPSTPKRQSTPKPPRVKPA 524
Cdd:COG5180  138 -----TREATSASAGVALAAALLQRSDPILAKDPDGDSASTLP-------PPAEKLDKVLTEPRDALKDSPEKLDRPKVE 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  525 PRQTTSMPPKLKTPHSRMPakepvpkEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETAPLETRGIPLIP 604
Cdd:COG5180  206 VKDEAQEEPPDLTGGADHP-------RPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPP 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  605 VISPRPSQEELQTAMEETDqstqelfTTKIPRTTELAKTTQAphrlhTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGT 684
Cdd:COG5180  279 GLPVLEAGSEPQSDAPEAE-------TARPIDVKGVASAPPA-----TRPVRPPGGARDPGTPRPGQPTERPAGVPEAAS 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  685 shkngvgtgtkQAPKPPSPGRNAS----VDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNV---------T 751
Cdd:COG5180  347 -----------DAGQPPSAYPPAEeavpGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMgagdlvqaaL 415

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  752 GKPGRAGiVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPT 811
Cdd:COG5180  416 DGGGRET-ASLGGAAGGAGQGPKADFVPGDAESVSGPAGLADQAGAAASTAMADFVAPVT 474
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 863-954 3.78e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  863 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 940
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 62460376  941 LGEGPASNTVAFST 954
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 369-885 2.68e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   369 PEFELPLSTLAPKRFPEFPEAKTAFP--------LEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTSD 440
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPrmltwirgLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR 2585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   441 ETEIEI---HTATRDPILDS-VPPKTSRTAEQPRATLAPIEALFesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTP 516
Cdd:PHA03247 2586 ARRPDAppqSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPP---------SPSPAANEPDPHPPPTVPPPERPRDDP 2656

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   517 KPPRVKPaPRQTTSM--PPKLKTPHSR-MPAKEPVPKEPLHTTSKPKMPP-SPEVADTTSVPKderLSLKPDPEVTHSET 592
Cdd:PHA03247 2657 APGRVSR-PRRARRLgrAAQASSPPQRpRRRAARPTVGSLTSLADPPPPPpTPEPAPHALVSA---TPLPPGPAAARQAS 2732

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   593 APLetrgiPLIPVisPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRP--------- 663
Cdd:PHA03247 2733 PAL-----PAAPA--PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESREslpspwdpa 2805

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   664 -HGRPALNKTTTRPDKTKPRGTSHKNGvgTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPER 742
Cdd:PHA03247 2806 dPPAAVLAPAAALPPAASPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAA 2877

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   743 RPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRF 822
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62460376   823 IGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 885
Cdd:PHA03247 2958 AVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-944 1.63e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.63e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376     864 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 941
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 62460376     942 GEG 944
Cdd:smart00060   81 GEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 381-701 7.83e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 56.62  E-value: 7.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   381 KRFPEFPEAKTAFPLEKPRGSWASSEEPwVVPGAKTSEdSRVVQPQTATYDVISSSTTSDETEIEI---------HTATR 451
Cdd:PTZ00449  494 KKLAPIEEEDSDKHDEPPEGPEASGLPP-KAPGDKEGE-EGEHEDSKESDEPKEGGKPGETKEGEVgkkpgpakeHKPSK 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   452 DPILDSVP-----PKTSRTAEQPRATLAPIEAlfesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPR 526
Cdd:PTZ00449  572 IPTLSKKPefpkdPKHPKDPEEPKKPKRPRSA-----------QRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQ 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   527 QTTS--MPPKLKTPHSRMPAKEPVP------KEPLHTTSKPKMPPSPEVadTTSVPKDErlSLKPDPEVTHSETAPLETR 598
Cdd:PTZ00449  641 RPSSpeRPEGPKIIKSPKPPKSPKPpfdpkfKEKFYDDYLDAAAKSKET--KTTVVLDE--SFESILKETLPETPGTPFT 716

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   599 GIPLIPVISPRPSQEELQTAMEETDQSTQ--ELFTTKIPRTTelakttqaphRLHTAPVRPRIPG---RPHGRPALNKTT 673
Cdd:PTZ00449  717 TPRPLPPKLPRDEEFPFEPIGDPDAEQPDdiEFFTPPEEERT----------FFHETPADTPLPDilaEEFKEEDIHAET 786

                         330       340
                  ....*....|....*....|....*...
gi 62460376   674 TRPDKTKPRGTShkngvgtGTKQAPKPP 701
Cdd:PTZ00449  787 GEPDEAMKRPDS-------PSEHEDKPP 807
fn3 pfam00041
Fibronectin type III domain;
864-947 2.88e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 2.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    864 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 940
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 62460376    941 LGEGPAS 947
Cdd:pfam00041   79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 326-810 3.95e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   326 PVTVTPESVSRSTKPTLSSALDTAETALVLSEKTSETARSVLIPEFELPLSTLAPKRFP---EFPEAKTAFPLEKPRGSW 402
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanEPDPHPPPTVPPPERPRD 2654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   403 ASSEePWVVPGAKTSEDSRVVQ---------PQTATYDVISSSTTSDETEIEIHTATRDPILDSVPPKTSRTAEQPRATL 473
Cdd:PHA03247 2655 DPAP-GRVSRPRRARRLGRAAQassppqrprRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP 2733

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   474 APIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPS-TPKRQSTPKPPRVKPAPRQTTSMPPKLKTPHSRMPAKEPVPKEP 552
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPApAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA 2813

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   553 LHTTSKPKMPPSPEVA-DTTSVPKDERLSLKPDPEVTHSETA-----PLETRG----IPLIPVISPRP-----SQEELQT 617
Cdd:PHA03247 2814 PAAALPPAASPAGPLPpPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPpsrsPAAKPAAPARPpvrrlARPAVSR 2893

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   618 AMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNG-VGTGTKQ 696
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGaLVPGRVA 2973

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   697 APK----PPSPGRNASVDSHATRKPGSVSGTRRPPIP---HRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSpp 769
Cdd:PHA03247 2974 VPRfrvpQPAPSREAPASSTPPLTGHSLSRVSSWASSlalHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSD-- 3051

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 62460376   770 lKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSP 810
Cdd:PHA03247 3052 -LEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 449-820 1.17e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.87  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   449 ATRDPILDSVPPKTSRTAEQPR--ATLAPIEALFESRNVEIFTSPEVRPTTAAPqqtTSIPSTPK-RQSTPKPPRVKPAP 525
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFepPTGPPPGPGTEAPANESRSTPTWSLSTLAP---ASPAREGSpTPPGPSSPDPPPPT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   526 RQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETAPLETRGI----P 601
Cdd:PHA03307  121 PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPstppA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   602 LIPVISPRPSQEELQTAM----------------EETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHG 665
Cdd:PHA03307  201 AASPRPPRRSSPISASASspapapgrsaaddagaSSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   666 RPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVS---GTRRPPIPHRH-SSTRPVSPE 741
Cdd:PHA03307  281 RPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSrgaAVSPGPSPSRSpSPSRPPPPA 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   742 RRPLPPNNVTGKP-GRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPtKETDPLGKP 820
Cdd:PHA03307  361 DPSSPRKRPRPSRaPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARY-PLLTPSGEP 439
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 479-865 3.70e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   479 LFESRNVEIFTSPEVrpTTAAPQQTTSIPSTPkrqsTPKPPRVKPAPRQTTSMPPKLKTPHSRMPAKEPVPKEPlhtTSK 558
Cdd:PHA03307   42 QLVSDSAELAAVTVV--AGAAACDRFEPPTGP----PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP---GPS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   559 PKMPPSPEvADTTSVPKDERLSLKPDPEVTHSETAPLETRGIPliPVISPRPSQEELQTAMEETD--QSTQELFTTKIPR 636
Cdd:PHA03307  113 SPDPPPPT-PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPA--AGASPAAVASDAASSRQAALplSSPEETARAPSSP 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   637 TTELAKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTG---TKQAPKP-------PSPG 704
Cdd:PHA03307  190 PAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPrpapitlPTRI 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   705 RNASVDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATAR 783
Cdd:PHA03307  270 WEASGWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   784 PGAEQ--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIPKPENKP---CSITDSVRRFPTEEATEGNAT 858
Cdd:PHA03307  350 SPSPSrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPSPLDAGAASG 424


                  ....*..
gi 62460376   859 SPPQNPP 865
Cdd:PHA03307  425 AFYARYP 431
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-757 4.28e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 4.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPRQTTSMP---PKLKTPHSRMPAKEPvPKEPLHTTSKP------KMP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPAPLSMPhikPPPTTPIPQLPNPQS-HKHPPHLSGPSpfqmnsNLP 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    563 PSPEVADTTSVPKDERLSLKPDPEVTHSETAPLEtrgiplipvisPRPSQEELQTAmeetdqstqelfTTKIPRTTELAK 642
Cdd:pfam03154  392 PPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLP-----------PPPAQPPVLTQ------------SQSLPPPAASHP 448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    643 TTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTshkngvgtgTKQAPKPPSPGRNASVdshatrkPGSVSG 722
Cdd:pfam03154  449 PTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMP---------GIQPPSSASVSSSGPV-------PAAVSC 512

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 62460376    723 TRRP------PIPHRHSSTRPVSPERRPLPPNNVTGKPGRA 757
Cdd:pfam03154  513 PLPPvqikeeALDEAEEPESPPPPPRSPSPEPTVVNTPSHA 553
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
848-959 2.35e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  848 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 927
Cdd:COG3401  220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                         90       100       110
                 ....*....|....*....|....*....|...
gi 62460376  928 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 959
Cdd:COG3401  295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 489-866 2.37e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    489 TSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPRQTTSMPPKLKTPHSRM-------PAKEPVPKEPLHTTSKPkm 561
Cdd:pfam03154  178 SGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIqqtptlhPQRLPSPHPPLQPMTQP-- 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    562 PPSPEVADTTSVPKDERLSLKPDPEvthsetaPLETrGIPLIPviSPRPSQeelqtAMEETDQSTQelftTKIPRTTELA 641
Cdd:pfam03154  256 PPPSQVSPQPLPQPSLHGQMPPMPH-------SLQT-GPSHMQ--HPVPPQ-----PFPLTPQSSQ----SQVPPGPSPA 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    642 KTTQAPHRLHTAPVRPR-----------IPGRPHGRPALNKTTTRPDKTKPRGTSHKNgvgTGTKQAPKPPSpgRNASVD 710
Cdd:pfam03154  317 APGQSQQRIHTPPSQSQlqsqqppreqpLPPAPLSMPHIKPPPTTPIPQLPNPQSHKH---PPHLSGPSPFQ--MNSNLP 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    711 SHATRKPGSVSGTRRPpiPHRHSSTRPVSPERRPLPPnnvtgKPGRAGIVSSSRVTSPPlkATLHPigtataRPGAEQKE 790
Cdd:pfam03154  392 PPPALKPLSSLSTHHP--PSAHPPPLQLMPQSQQLPP-----PPAQPPVLTQSQSLPPP--AASHP------PTSGLHQV 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    791 PTAPAseeeFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSV-------------RRFPTEEATEGNA 857
Cdd:pfam03154  457 PSQSP----FPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVpaavscplppvqiKEEALDEAEEPES 532


                   ....*....
gi 62460376    858 TSPPQNPPT 866
Cdd:pfam03154  533 PPPPPRSPS 541
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
848-1002 3.14e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  848 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 925
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62460376  926 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1002
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 610-853 3.69e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   610 PSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQ--APHRLHTAPVRPRIPGRPHGrPALNKTTTRPDKTKprgtSHK 687
Cdd:PTZ00449  524 PGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKkpGPAKEHKPSKIPTLSKKPEF-PKDPKHPKDPEEPK----KPK 598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   688 NGVgtgTKQAP-KPPSPGRNASVD-SHATRKPGSVSGTRRPPIPhrhssTRPVSPERRPLPPNNVTGKPGRagivSSSRV 765
Cdd:PTZ00449  599 RPR---SAQRPtRPKSPKLPELLDiPKSPKRPESPKSPKRPPPP-----QRPSSPERPEGPKIIKSPKPPK----SPKPP 666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   766 TSPPLKATLHpigTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVR 845
Cdd:PTZ00449  667 FDPKFKEKFY---DDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQ 743


                  ....*...
gi 62460376   846 RFPTEEAT 853
Cdd:PTZ00449  744 PDDIEFFT 751
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 460-751 4.58e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 4.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    460 PKT---SRTAEQprATLAPIEALFESRNVEIFTSPEVRPTT-AAPQQTTSIPST---PKRQSTPKPPRVKPAPRQTTSMP 532
Cdd:pfam05109  400 PKTliiTRTATN--ATTTTHKVIFSKAPESTTTSPTLNTTGfAAPNTTTGLPSSthvPTNLTAPASTGPTVSTADVTSPT 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    533 PKLKTPHSRMPAKEPVPKEPLHTTSKPKMPpSPEVADTTSVPKderlSLKPDPEVTH---SETAPLETRGIPLIPVISPR 609
Cdd:pfam05109  478 PAGTTSGASPVTPSPSPRDNGTESKAPDMT-SPTSAVTTPTPN----ATSPTPAVTTptpNATSPTLGKTSPTSAVTTPT 552

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    610 PSQEELQTAMeetdqstqelfTTKIPRTT--ELAKTTqaphrlhtapvrpriPGRPHGRPALNKTTTRPDKTKPRGTSHK 687
Cdd:pfam05109  553 PNATSPTPAV-----------TTPTPNATipTLGKTS---------------PTSAVTTPTPNATSPTVGETSPQANTTN 606

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62460376    688 NGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVT 751
Cdd:pfam05109  607 HTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 4.85e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 62460376  192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 5.33e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 5.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 62460376    193 GVK 195
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 6.04e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 6.04e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376     114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 62460376     190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
448-610 6.74e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   448 TATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPqqTTSIPSTPKRQSTPKPPRVKPAPRQ 527
Cdd:PRK12323  398 APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAP--APAPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   528 TTSMPPklktPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSE-----------TAPLE 596
Cdd:PRK12323  476 AAAAPA----RAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDdafetlapapaAAPAP 551

                         170
                  ....*....|....
gi 62460376   597 TRGIPLIPVISPRP 610
Cdd:PRK12323  552 RAAAATEPVVAPRP 565
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 365-811 1.42e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  365 SVLIPEFELPLSTLAPKRFPEFPEAKTAFPLEKPRGSWASSEEPWVVPGAKTSEDSRVVQPQTATYDVISSSTTsdetei 444
Cdd:COG5180   64 DIKLALGKPQLPSVAEPEAYLDPAPPKSSPDTPEEQLGAPAGDLLVLPAAKTPELAAGALPAPAAAAALPKAKV------ 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  445 eihtaTRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIftspevrPTTAAPQQTTSIPSTPKRQSTPKPPRVKPA 524
Cdd:COG5180  138 -----TREATSASAGVALAAALLQRSDPILAKDPDGDSASTLP-------PPAEKLDKVLTEPRDALKDSPEKLDRPKVE 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  525 PRQTTSMPPKLKTPHSRMPakepvpkEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETAPLETRGIPLIP 604
Cdd:COG5180  206 VKDEAQEEPPDLTGGADHP-------RPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPP 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  605 VISPRPSQEELQTAMEETDqstqelfTTKIPRTTELAKTTQAphrlhTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGT 684
Cdd:COG5180  279 GLPVLEAGSEPQSDAPEAE-------TARPIDVKGVASAPPA-----TRPVRPPGGARDPGTPRPGQPTERPAGVPEAAS 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  685 shkngvgtgtkQAPKPPSPGRNAS----VDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNV---------T 751
Cdd:COG5180  347 -----------DAGQPPSAYPPAEeavpGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMgagdlvqaaL 415

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  752 GKPGRAGiVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPT 811
Cdd:COG5180  416 DGGGRET-ASLGGAAGGAGQGPKADFVPGDAESVSGPAGLADQAGAAASTAMADFVAPVT 474
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 473-593 8.26e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   473 LAPIEALFESRNVeiftspevrPTTAAPQQTTSIPSTPKRQSTPKPPrvKPAPRQTTSMPPKLKTPHsrmpaKEPVPKEP 552
Cdd:PRK14950  353 LAVIEALLVPVPA---------PQPAKPTAAAPSPVRPTPAPSTRPK--AAAAANIPPKEPVRETAT-----PPPVPPRP 416

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 62460376   553 LhTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSETA 593
Cdd:PRK14950  417 V-APPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKA 456
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
432-585 8.88e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 43.11  E-value: 8.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376    432 VISSSTTSDETEIEIHTATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEiftspevrpTTAAPQQTTSIPSTPK 511
Cdd:pfam05539  172 VTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTT---------SSNPEPQTEPPPSQRG 242

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62460376    512 RQSTPKPPRVKPAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDP 585
Cdd:pfam05539  243 PSGSPQHPPSTTSQDQSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPP 316
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
416-563 2.98e-03

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 41.27  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   416 TSEDSRVVQPQTATYDVISSSTTSDETEIEIHTATRDPILDSVPPKTSRTAEQPRATLAPIEalfesrNVEIFTSPEVRP 495
Cdd:PRK13335   24 TTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEE------KTSASKIEKISQ 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62460376   496 TTAAPQQTTSIPSTP---KRQSTPKPPRVKPAPRQTTsmPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPP 563
Cdd:PRK13335   98 PKQEEQKSLNISATPapkQEQSQTTTESTTPKTKVTT--PPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTP 166
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
860-959 3.24e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 41.30  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376  860 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 938
Cdd:COG3979    2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                         90       100
                 ....*....|....*....|.
gi 62460376  939 nplgeGPASNTVAFSTESADP 959
Cdd:COG3979   72 -----DAAGNVSAASGTSTAM 87
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 473-614 4.19e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   473 LAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPRQTTSMPPKLKTPHSRMPAKEPV--PK 550
Cdd:PRK10263  729 FSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYqqPQ 808

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62460376   551 EPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTH------SETAPLE--TRGIPLIPVISPRPSQEE 614
Cdd:PRK10263  809 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHpllmrnGDSRPLHkpTTPLPSLDLLTPPPSEVE 880
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 489-572 7.72e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   489 TSPEVRPTTAAPQQTTSiPSTPKRQSTPKPPRVKPAPRqttsmppklktPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVA 568
Cdd:PRK14959  415 TPSSAAPATPAPSAAPS-PRVPWDDAPPAPPRSGIPPR-----------PAPRMPEASPVPGAPDSVASASDAPPTLGDP 482


                  ....
gi 62460376   569 DTTS 572
Cdd:PRK14959  483 SDTA 486
PHA03378 PHA03378
EBNA-3B; Provisional
 357-754 9.93e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.05  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   357 EKTSETARSVLIPEFELPlsTLAPKRFPEFPEAKTAFPLEKPrgswaSSEEPWvvPGAKTSEDSRVVQPQTATYDVISSS 436
Cdd:PHA03378  433 KKAARTEQPRATPHSQAP--TVVLHRPPTQPLEGPTGPLSVQ-----APLEPW--QPLPHPQVTPVILHQPPAQGVQAHG 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   437 TTSDETEIEIHTATRDPILDSVPPktsrTAEQPRATLAPIEALFESRNVEiftspEVRPTTAAPQQTTSIPStpkrqSTP 516
Cdd:PHA03378  504 SMLDLLEKDDEDMEQRVMATLLPP----SPPQPRAGRRAPCVYTEDLDIE-----SDEPASTEPVHDQLLPA-----PGL 569

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   517 KPPRVKPAPRQTTSMPPKLKTPHSRMPakEPVPkeplHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPevthseTAPLE 596
Cdd:PHA03378  570 GPLQIQPLTSPTTSQLASSAPSYAQTP--WPVP----HPSQTPEPPTTQSHIPETSAPRQWPMPLRPIP------MRPLR 637

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62460376   597 TRGIPLIPVISPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAkttqAPHRLHTAPVRPRIPGRPHGRpalnkttTRP 676
Cdd:PHA03378  638 MQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN----TMLPIQWAPGTMQPPPRAPTP-------MRP 706

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62460376   677 DKTKPrgtshkngvgtGTKQAPK-PPSPGRNASVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKP 754
Cdd:PHA03378  707 PAAPP-----------GRAQRPAaATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAP 774
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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