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Conserved domains on  [gi|62862154|ref|NP_001015224|]
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mediator complex subunit 21, isoform B [Drosophila melanogaster]

Protein Classification

med21 domain-containing protein( domain architecture ID 10567892)

med21 (mediator of RNA polymerase II transcription subunit 21) domain-containing protein which is subunit of a multiprotein co-activator that binds the transcription pre-initiation complex and regulates RNA polymerase II.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-128 5.84e-23

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


:

Pssm-ID: 463241  Cd Length: 134  Bit Score: 87.26  E-value: 5.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862154     3 DRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQ--------EDYAQLFAQLIARCAKDIDTLI 74
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPNDPISPDKAPPQPEPepdppeefEATQRELARDLILKAQQIEYLI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62862154    75 ESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQ 128
Cdd:pfam11221  81 DSLPGIGVSEEEQLQRIKELEEELREAEEERQEAVKEKEELLKKLDELIRSVAR 134
 
Name Accession Description Interval E-value
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-128 5.84e-23

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 87.26  E-value: 5.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862154     3 DRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQ--------EDYAQLFAQLIARCAKDIDTLI 74
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPNDPISPDKAPPQPEPepdppeefEATQRELARDLILKAQQIEYLI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62862154    75 ESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQ 128
Cdd:pfam11221  81 DSLPGIGVSEEEQLQRIKELEEELREAEEERQEAVKEKEELLKKLDELIRSVAR 134
 
Name Accession Description Interval E-value
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 3-128 5.84e-23

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 87.26  E-value: 5.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862154     3 DRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQ--------EDYAQLFAQLIARCAKDIDTLI 74
Cdd:pfam11221   1 DRLTQLQDCLDQLAEQFYASVGYLNRHHPPAPLPPNDPISPDKAPPQPEPepdppeefEATQRELARDLILKAQQIEYLI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62862154    75 ESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQ 128
Cdd:pfam11221  81 DSLPGIGVSEEEQLQRIKELEEELREAEEERQEAVKEKEELLKKLDELIRSVAR 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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