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Conserved domains on  [gi|66472918|ref|NP_001018307|]
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serine palmitoyltransferase 1 [Danio rerio]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 23-472 2.04e-173

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 495.80  E-value: 2.04e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   23 HLILEGFLILWIIRLLFSKTYKLQERSdLTEKEKEELIEEWQPEPLVSPVSKDHpSLNYDVVTGPPSHKIIVNGKECINF 102
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEEM-RPEPPVLESAAGPHTIINGKDVVNF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  103 ASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSKRGD 182
Cdd:PLN02822 115 ASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGD 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  183 IIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDqknpRKARVIRRFILVEGLYINTADICPLPELVKL 262
Cdd:PLN02822 195 IIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  263 KYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPP 342
Cdd:PLN02822 271 KEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  343 MLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTAGLKVVGESFAPALHLQLENSTGSRVNDLKLLRAIVDYSL-DR 421
Cdd:PLN02822 351 YLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkED 430

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 66472918  422 QVALTLARY--LDKEErflPPPSIRVVVTVEQTQEEIEKAAQCIREAALHVLK 472
Cdd:PLN02822 431 SVLVVVSKRstLDKCR---LPVGIRLFVSAGHTESDILKASESLKRVAASVLK 480
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 23-472 2.04e-173

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 495.80  E-value: 2.04e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   23 HLILEGFLILWIIRLLFSKTYKLQERSdLTEKEKEELIEEWQPEPLVSPVSKDHpSLNYDVVTGPPSHKIIVNGKECINF 102
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEEM-RPEPPVLESAAGPHTIINGKDVVNF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  103 ASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSKRGD 182
Cdd:PLN02822 115 ASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGD 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  183 IIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDqknpRKARVIRRFILVEGLYINTADICPLPELVKL 262
Cdd:PLN02822 195 IIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  263 KYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPP 342
Cdd:PLN02822 271 KEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  343 MLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTAGLKVVGESFAPALHLQLENSTGSRVNDLKLLRAIVDYSL-DR 421
Cdd:PLN02822 351 YLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkED 430

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 66472918  422 QVALTLARY--LDKEErflPPPSIRVVVTVEQTQEEIEKAAQCIREAALHVLK 472
Cdd:PLN02822 431 SVLVVVSKRstLDKCR---LPVGIRLFVSAGHTESDILKASESLKRVAASVLK 480
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 83-467 2.04e-84

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 264.61  E-value: 2.04e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  83 VVTGPPSHKIIVNGKECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAII 162
Cdd:COG0156  23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 163 YSYGFATIASAIPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEqeiedqknPRKARviRRFIL 242
Cdd:COG0156 103 FSSGYAANLGVISALAGRGDLIFSDELNHASIIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKLIV 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 243 VEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVnIDDIDLISANMENALASIGGFCCGRSF 322
Cdd:COG0156 173 TDGVFSMDGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAGSKE 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 323 VIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGifrvLREKCRNVHKALQgtAGLKvvgesfapALHLQLENSTG 402
Cdd:COG0156 252 LIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPE----LRERLWENIAYFR--EGLK--------ELGFDLGPSES 317

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66472918 403 srvndlkllrAIVDYSL-DRQVALTLARYLdkEER------FLPP--PS----IRVVVTVEQTQEEIEKAAQCIREAA 467
Cdd:COG0156 318 ----------PIVPVIVgDAERALALADAL--LERgiyvsaIRPPtvPKgtarLRITLSAAHTEEDIDRLLEALAEVG 383
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 97-387 4.46e-79

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 249.79  E-value: 4.46e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  97 KECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPA 176
Cdd:cd06454   1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 177 YSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEqeiedqkNPRKARVIrrFILVEGLYINTADICPL 256
Cdd:cd06454  81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYGKK--LIVTEGVYSMDGDIAPL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 257 PELVKLKYKYKVRIFLEESMSFGVLGEHGRGVtEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCF 336
Cdd:cd06454 152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66472918 337 SASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQgTAGLKVVGE 387
Cdd:cd06454 231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLK-ELGFPVGGS 280
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
97-463 4.65e-24

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 102.77  E-value: 4.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918    97 KECINFASFNFLGLLdNERVKLKALAslkkygVGTCGPRGFYGTFDVHLELEERLAKFMRTEE--------AIIYSYGFA 168
Cdd:pfam00155   1 TDKINLGSNEYLGDT-LPAVAKAEKD------ALAGGTRNLYGPTDGHPELREALAKFLGRSPvlkldreaAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   169 TIASAIPAYSK-RGDIIFVDEAACFSIQKGLQASRSFIKYFK-------HNDMEDLERLLKEQeiedqknprkarviRRF 240
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   241 ILVEGLYINTADICPLPELVKL---KYKYKVRIFLEESMSFGVLGEHGRgVTEHFGVNIDDIDLISANMENALASIG--- 314
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDA-VATRALLAEGPNLLVVGSFSKAFGLAGwrv 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   315 GFCCGRSFVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQgTAGLKVVGeSFAPALH 394
Cdd:pfam00155 219 GYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQ-AAGLSVLP-SQAGFFL 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66472918   395 LQLenstGSRVNDLKLLRAIVDYSldrQVALTLARYldkeerFLPPPSIRVVVTVeQTQEEIEKAAQCI 463
Cdd:pfam00155 297 LTG----LDPETAKELAQVLLEEV---GVYVTPGSS------PGVPGWLRITVAG-GTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 23-472 2.04e-173

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 495.80  E-value: 2.04e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   23 HLILEGFLILWIIRLLFSKTYKLQERSdLTEKEKEELIEEWQPEPLVSPVSKDHpSLNYDVVTGPPSHKIIVNGKECINF 102
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEEM-RPEPPVLESAAGPHTIINGKDVVNF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  103 ASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSKRGD 182
Cdd:PLN02822 115 ASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGD 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  183 IIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDqknpRKARVIRRFILVEGLYINTADICPLPELVKL 262
Cdd:PLN02822 195 IIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  263 KYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPP 342
Cdd:PLN02822 271 KEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  343 MLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTAGLKVVGESFAPALHLQLENSTGSRVNDLKLLRAIVDYSL-DR 421
Cdd:PLN02822 351 YLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkED 430

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 66472918  422 QVALTLARY--LDKEErflPPPSIRVVVTVEQTQEEIEKAAQCIREAALHVLK 472
Cdd:PLN02822 431 SVLVVVSKRstLDKCR---LPVGIRLFVSAGHTESDILKASESLKRVAASVLK 480
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 100-471 1.81e-117

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 349.97  E-value: 1.81e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  100 INFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSK 179
Cdd:PLN03227   1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  180 RGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDQKNPRKARVIRRFILVEGLYINTADICPLPEL 259
Cdd:PLN03227  81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  260 VKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVN-IDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSA 338
Cdd:PLN03227 161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  339 SLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTA---------GLKVVGESFAPALHLQLENSTGSRVND-L 408
Cdd:PLN03227 241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66472918  409 KLLRAIVDYSLDRQVALTLAR-YLDKEERFLPPPSIRVVVTVEQTQEEIEKAAQCIREAALHVL 471
Cdd:PLN03227 321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAIL 384
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 83-467 2.04e-84

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 264.61  E-value: 2.04e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  83 VVTGPPSHKIIVNGKECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAII 162
Cdd:COG0156  23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 163 YSYGFATIASAIPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEqeiedqknPRKARviRRFIL 242
Cdd:COG0156 103 FSSGYAANLGVISALAGRGDLIFSDELNHASIIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKLIV 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 243 VEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVnIDDIDLISANMENALASIGGFCCGRSF 322
Cdd:COG0156 173 TDGVFSMDGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAGSKE 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 323 VIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGifrvLREKCRNVHKALQgtAGLKvvgesfapALHLQLENSTG 402
Cdd:COG0156 252 LIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPE----LRERLWENIAYFR--EGLK--------ELGFDLGPSES 317

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66472918 403 srvndlkllrAIVDYSL-DRQVALTLARYLdkEER------FLPP--PS----IRVVVTVEQTQEEIEKAAQCIREAA 467
Cdd:COG0156 318 ----------PIVPVIVgDAERALALADAL--LERgiyvsaIRPPtvPKgtarLRITLSAAHTEEDIDRLLEALAEVG 383
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 97-387 4.46e-79

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 249.79  E-value: 4.46e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  97 KECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPA 176
Cdd:cd06454   1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 177 YSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEqeiedqkNPRKARVIrrFILVEGLYINTADICPL 256
Cdd:cd06454  81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYGKK--LIVTEGVYSMDGDIAPL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918 257 PELVKLKYKYKVRIFLEESMSFGVLGEHGRGVtEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCF 336
Cdd:cd06454 152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66472918 337 SASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQgTAGLKVVGE 387
Cdd:cd06454 231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLK-ELGFPVGGS 280
PLN02483 PLN02483
serine palmitoyltransferase
 95-467 1.44e-57

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 197.68  E-value: 1.44e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   95 NGKECINFASFNFLGLLD-NERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASA 173
Cdd:PLN02483  98 KTRRCLNLGSYNYLGFAAaDEYCTPRVIESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYATNSTI 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  174 IPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDQknPRKARVIRRFI-LVEGLYINTAD 252
Cdd:PLN02483 178 IPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIvIVEGIYSMEGE 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  253 ICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQ 332
Cdd:PLN02483 256 LCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLKRTCP 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  333 GYCFSASLPPMLAAAAIEALN-IMEEDpGIFR------VLREKCRNVHKALQgTAGLKVVGESFAPALHLQLENSTgsrv 405
Cdd:PLN02483 336 AHLYATSMSPPAVQQVISAIKvILGED-GTNRgaqklaQIRENSNFFRSELQ-KMGFEVLGDNDSPVMPIMLYNPA---- 409

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66472918  406 ndlkllrAIVDYS---LDRQVA----------LTLARyldkeerflpppsIRVVVTVEQTQEEIEKAAQCIREAA 467
Cdd:PLN02483 410 -------KIPAFSrecLKQNVAvvvvgfpatpLLLAR-------------ARICISASHSREDLIKALEVISEVG 464
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 83-467 6.05e-55

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 188.06  E-value: 6.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   83 VVTGPPSHKIIVNGKECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAII 162
Cdd:PRK05958  25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  163 YSYGFATIASAIPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLkeqeiedqknpRKARVIRRFIL 242
Cdd:PRK05958 105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  243 VEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVnIDDIDLIS-ANMENALASIGGFCCGRS 321
Cdd:PRK05958 174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  322 FVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGifrvLREKC-RNVHKALQGTAglkvvgesfapALHLQLENS 400
Cdd:PRK05958 253 TLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPE----RRERLaALIARLRAGLR-----------ALGFQLMDS 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66472918  401 TGsrvndlkllrAIVDYSL-DRQVALTLARYLDKEERFLP---PPS-------IRVVVTVEQTQEEIEKAAQCIREAA 467
Cdd:PRK05958 318 QS----------AIQPLIVgDNERALALAAALQEQGFWVGairPPTvpagtsrLRITLTAAHTEADIDRLLEALAEAL 385
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 82-368 2.58e-54

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 186.56  E-value: 2.58e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   82 DVVTGPPSHKIIV-NGKECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEA 160
Cdd:PRK06939  26 RVITSPQGADITVaDGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  161 IIYSYGFATIASAIPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQeieDQKNPRKarvirRF 240
Cdd:PRK06939 106 ILYSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA---KEAGARH-----KL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  241 ILVEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVnIDDIDLISANMENALA-SIGGFCCG 319
Cdd:PRK06939 178 IATDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGV-MDRVDIITGTLGKALGgASGGYTAG 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 66472918  320 RSFVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGifrvLREK 368
Cdd:PRK06939 257 RKEVIDWLRQRSRPYLFSNSLAPAIVAASIKVLELLEESDE----LRDR 301
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 97-380 4.03e-30

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 121.11  E-value: 4.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   97 KECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPA 176
Cdd:PRK13392  46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  177 YSKR--GDIIFVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLLKEQEIEDQKnprkarvirrFILVEGLYINTADIC 254
Cdd:PRK13392 126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  255 PLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVnIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGY 334
Cdd:PRK13392 196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 66472918  335 CFSASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTA 380
Cdd:PRK13392 275 IFTTALPPAVAAGATAAIRHLKTSQTERDAHQDRVAALKAKLNANG 320
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
97-463 4.65e-24

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 102.77  E-value: 4.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918    97 KECINFASFNFLGLLdNERVKLKALAslkkygVGTCGPRGFYGTFDVHLELEERLAKFMRTEE--------AIIYSYGFA 168
Cdd:pfam00155   1 TDKINLGSNEYLGDT-LPAVAKAEKD------ALAGGTRNLYGPTDGHPELREALAKFLGRSPvlkldreaAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   169 TIASAIPAYSK-RGDIIFVDEAACFSIQKGLQASRSFIKYFK-------HNDMEDLERLLKEQeiedqknprkarviRRF 240
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   241 ILVEGLYINTADICPLPELVKL---KYKYKVRIFLEESMSFGVLGEHGRgVTEHFGVNIDDIDLISANMENALASIG--- 314
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDA-VATRALLAEGPNLLVVGSFSKAFGLAGwrv 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   315 GFCCGRSFVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQgTAGLKVVGeSFAPALH 394
Cdd:pfam00155 219 GYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQ-AAGLSVLP-SQAGFFL 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66472918   395 LQLenstGSRVNDLKLLRAIVDYSldrQVALTLARYldkeerFLPPPSIRVVVTVeQTQEEIEKAAQCI 463
Cdd:pfam00155 297 LTG----LDPETAKELAQVLLEEV---GVYVTPGSS------PGVPGWLRITVAG-GTEEELEELLEAI 351
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
91-470 4.82e-17

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 82.75  E-value: 4.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   91 KIIVNGK----ECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYG 166
Cdd:PRK07179  44 KHLVLGKtpgpDAIILQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESCLLCQSG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  167 FA-------TIASA-IPAYskrgdiifVDEAACFSIQKGLQASRSFIKYFKHNDMEDLERLlkeqeiedqknprkarvIR 238
Cdd:PRK07179 124 WAanvgllqTIADPnTPVY--------IDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQ-----------------IE 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  239 RF----ILVEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNiDDIDLISANMENALASIG 314
Cdd:PRK07179 179 RHgpgiIVVDSVYSTTGTIAPLADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  315 GFCCGRSFVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVHKALQGTaGLKVVGESFAPALH 394
Cdd:PRK07179 258 GIITCPRELAEYVPFVSYPAIFSSTLLPHEIAGLEATLEVIESADDRRARLHANARFLREGLSEL-GYNIRSESQIIALE 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  395 LQLENSTgsrvndlKLLRaivDYSLDRQV--ALtlaryldkeerFLPPPS------IRVVVTVEQTQEEIEKAAQCIREA 466
Cdd:PRK07179 337 TGSERNT-------EVLR---DALEERNVfgAV-----------FCAPATpknrnlIRLSLNADLTASDLDRVLEVCREA 395


                 ....
gi 66472918  467 ALHV 470
Cdd:PRK07179 396 RDEV 399
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 97-378 1.24e-16

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 82.03  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   97 KECINFASFNFLGLLDNERVKLKALASLKKYGVGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFA-------- 168
Cdd:PLN02955 102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAanmaamva 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  169 --TIASAIPAYSK----RGDIIFVDEAACFSIQKGLQ-ASR---SFIKYFKHNDMEDLERLLKEQEIEdqknprkarviR 238
Cdd:PLN02955 182 igSVASLLAASGKplknEKVAIFSDALNHASIIDGVRlAERqgnVEVFVYRHCDMYHLNSLLSSCKMK-----------R 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  239 RFILVEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGVTEHFGVNiDDIDLISANMENALASIGGF-- 316
Cdd:PLN02955 251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66472918  317 CCGRSFVIDHQRlsGQGYCFSASLPPMLAAAAIEALNIMEEDPGIFRVLREKCRNVhKALQG 378
Cdd:PLN02955 330 CSKKWKQLIQSR--GRSFIFSTAIPVPMAAAAYAAVVVARKEKWRRKAIWERVKEF-KALSG 388
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 129-293 2.81e-16

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 80.21  E-value: 2.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  129 VGTCGPRGFYGTFDVHLELEERLAKFMRTEEAIIYSYGFATIASAIPAYSKRGDIIFVDEAACFSIQKGLQASRSFIKYF 208
Cdd:PRK05937  43 LGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLGLCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSF 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  209 KHNDMEDLERLLKEQEIEDQKnprkarviRRFILVEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRGV 288
Cdd:PRK05937 123 RHNDLDHLESLLESCRQRSFG--------RIFIFVCSVYSFKGTLAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGF 194


                 ....*
gi 66472918  289 TEHFG 293
Cdd:PRK05937 195 CHSLG 199
PRK07505 PRK07505
hypothetical protein; Provisional
 96-347 2.19e-13

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 71.55  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918   96 GKECINFASFNFLGLLDNERVKLKALASLKKYGV-GTCGPRGFYgTFDVHLELEERLAKFMRTEEAIIYSYGFAT----- 169
Cdd:PRK07505  45 GHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGASVLTFTSCSAAHlgilp 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  170 -IASAIPAYSKRGDIIFvDEAACFSIQ--KGLQASRSFIKYFKHNDMEDLERLLKEQEiedqknprkaRVIrrfILVEGL 246
Cdd:PRK07505 124 lLASGHLTGGVPPHMVF-DKNAHASLNilKGICADETEVETIDHNDLDALEDICKTNK----------TVA---YVADGV 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472918  247 YiNTADICPLPELVKLKYKYKVRIFLEESMSFGVLGEHGRG-VTEHFGVNIDDIDLISANMENALASIGGFC-CGRSFVI 324
Cdd:PRK07505 190 Y-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKAFGASGGVImLGDAEQI 268

                        250       260
                 ....*....|....*....|....
gi 66472918  325 DHQRLSGQGYCFSASLP-PMLAAA 347
Cdd:PRK07505 269 ELILRYAGPLAFSQSLNvAALGAI 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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