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Conserved domains on  [gi|66730294|ref|NP_001019485|]
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lysophosphatidylserine lipase ABHD12 [Rattus norvegicus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Gene Ontology:  GO:0016787
PubMed:  12369917|19508187

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-349 1.14e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 144.67  E-value: 1.14e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 158 MWYEDALASN-HPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073  26 DLYLPAGASKkYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073 104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66730294 311 -KFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAA 349
Cdd:COG1073 178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAA 217
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-349 1.14e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 144.67  E-value: 1.14e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 158 MWYEDALASN-HPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073  26 DLYLPAGASKkYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073 104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66730294 311 -KFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAA 349
Cdd:COG1073 178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAA 217
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 170-372 9.13e-17

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 78.80  E-value: 9.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   170 IILYLHGnagtrGGDH--R-VELYKVLSSLGYHVVTFDYRGWGDSVGT----PSERGMTYDALHVFDWIKARSGDNPVYI 242
Cdd:pfam12146   6 VVVLVHG-----LGEHsgRyAHLADALAAQGFAVYAYDHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEHPGLPLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   243 WGHSLGTGVATNLVRRlceRETPPDALILESPFTNIREE-------------AKSHP---------FSVIYRYFPGFDWF 300
Cdd:pfam12146  81 LGHSMGGLIAALYALR---YPDKVDGLILSAPALKIKPYlappilkllakllGKLFPrlrvpnnllPDSLSRDPEVVAAY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   301 FLDPITSSGI--KFAND---------ENMKHISCPLLILHAEDDPVVPFHLGRKLYNiAAPSrsfRDFKVQFIPfhsdlG 369
Cdd:pfam12146 158 AADPLVHGGIsaRTLYElldagerllRRAAAITVPLLLLHGGADRVVDPAGSREFYE-RAGS---TDKTLKLYP-----G 228


                  ...
gi 66730294   370 YRH 372
Cdd:pfam12146 229 LYH 231
PLN02511 PLN02511
hydrolase
 156-337 1.03e-06

hydrolase


Pssm-ID: 215282 [Multi-domain]  Cd Length: 388  Bit Score: 50.55  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294  156 DQMWYED-ALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDS-VGTPS--ERGMTYDALHVFDWI 231
Cdd:PLN02511  87 DWVSGDDrALPADAPVLILLPGLTGGSDDSYVRHMLLRARSKGWRVVVFNSRGCADSpVTTPQfySASFTGDLRQVVDHV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294  232 KARSGDNPVYIWGHSLGtgvATNLVRRLCER-ETPP--DALILESPFT-NIREEAKSHPFSVIY---------RYF---- 294
Cdd:PLN02511 167 AGRYPSANLYAAGWSLG---ANILVNYLGEEgENCPlsGAVSLCNPFDlVIADEDFHKGFNNVYdkalakalrKIFakha 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66730294  295 ------PG---------------FDwfflDPIT--SSGIKFAND--------ENMKHISCPLLILHAEDDPVVP 337
Cdd:PLN02511 244 llfeglGGeyniplvanaktvrdFD----DGLTrvSFGFKSVDAyysnssssDSIKHVRVPLLCIQAANDPIAP 313
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 158-349 1.14e-40

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 144.67  E-value: 1.14e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 158 MWYEDALASN-HPIILYLHGNAGTRggDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGM--TYDALHVFDWIKAR 234
Cdd:COG1073  26 DLYLPAGASKkYPAVVVAHGNGGVK--EQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSpeRRDARAAVDYLRTL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 235 SGDNP--VYIWGHSLGTGVATNLVRRLcereTPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDwfFLDPITSSGI-- 310
Cdd:COG1073 104 PGVDPerIGLLGISLGGGYALNAAATD----PRVKAVILDSPFTSLEDLAAQRAKEARGAYLPGVP--YLPNVRLASLln 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66730294 311 -KFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAA 349
Cdd:COG1073 178 dEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAA 217
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
167-391 3.52e-26

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 105.10  E-value: 3.52e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 167 NHPIILYLHGNAGTRGgDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSeRGMTYDALHVFDWIKARSGDNP--VYIWG 244
Cdd:COG1506  22 KYPVVVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWG-GDEVDDVLAAIDYLAARPYVDPdrIGIYG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 245 HSLGTGVATNLvrrLCERETPPDALILESPFTNIREEAK-SHPFSVIYRYFPGFDWFFLDpitssgiKFANDENMKHISC 323
Cdd:COG1506 100 HSYGGYMALLA---AARHPDRFKAAVALAGVSDLRSYYGtTREYTERLMGGPWEDPEAYA-------ARSPLAYADKLKT 169

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66730294 324 PLLILHAEDDPVVPFHLGRKLYNIAApsrsFRDFKVQFIPFHsdlGYRHKYIYK-SPELPRILREFLGK 391
Cdd:COG1506 170 PLLLIHGEADDRVPPEQAERLYEALK----KAGKPVELLVYP---GEGHGFSGAgAPDYLERILDFLDR 231
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
128-372 3.47e-24

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 99.31  E-value: 3.47e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 128 YYLQPEDDVTIGVWHTIPSvwwknaqgkdqmwyedalASNHPIILYLHGnagtrGGDHRVELYKV---LSSLGYHVVTFD 204
Cdd:COG2267   6 VTLPTRDGLRLRGRRWRPA------------------GSPRGTVVLVHG-----LGEHSGRYAELaeaLAAAGYAVLAFD 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 205 YRGWGDSVGT----PSERGMTYDALHVFDWIKARSGDnPVYIWGHSLGTGVATNLVRRlceRETPPDALILESPftnire 280
Cdd:COG2267  63 LRGHGRSDGPrghvDSFDDYVDDLRAALDALRARPGL-PVVLLGHSMGGLIALLYAAR---YPDRVAGLVLLAP------ 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 281 eakshpfsviyryfpgfdWFFLDPITSSGIKFAND----ENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRD 356
Cdd:COG2267 133 ------------------AYRADPLLGPSARWLRAlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVL 194

                       250
                ....*....|....*.
gi 66730294 357 FKvqfipfhsdlGYRH 372
Cdd:COG2267 195 LP----------GARH 200
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 170-372 9.13e-17

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 78.80  E-value: 9.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   170 IILYLHGnagtrGGDH--R-VELYKVLSSLGYHVVTFDYRGWGDSVGT----PSERGMTYDALHVFDWIKARSGDNPVYI 242
Cdd:pfam12146   6 VVVLVHG-----LGEHsgRyAHLADALAAQGFAVYAYDHRGHGRSDGKrghvPSFDDYVDDLDTFVDKIREEHPGLPLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   243 WGHSLGTGVATNLVRRlceRETPPDALILESPFTNIREE-------------AKSHP---------FSVIYRYFPGFDWF 300
Cdd:pfam12146  81 LGHSMGGLIAALYALR---YPDKVDGLILSAPALKIKPYlappilkllakllGKLFPrlrvpnnllPDSLSRDPEVVAAY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   301 FLDPITSSGI--KFAND---------ENMKHISCPLLILHAEDDPVVPFHLGRKLYNiAAPSrsfRDFKVQFIPfhsdlG 369
Cdd:pfam12146 158 AADPLVHGGIsaRTLYElldagerllRRAAAITVPLLLLHGGADRVVDPAGSREFYE-RAGS---TDKTLKLYP-----G 228


                  ...
gi 66730294   370 YRH 372
Cdd:pfam12146 229 LYH 231
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 157-344 1.79e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 1.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 157 QMWYEDALASNHPIILyLHGNAGTrgGDHRVELYKVLSSlGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARsG 236
Cdd:COG0596  13 RLHYREAGPDGPPVVL-LHGLPGS--SYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDAL-G 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 237 DNPVYIWGHSLGTGVATNLVRRLCERetpPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITssgikfandE 316
Cdd:COG0596  88 LERVVLVGHSMGGMVALELAARHPER---VAGLVLVDEVLAALAEPLRRPGLAPEALAALLRALARTDLR---------E 155

                       170       180
                ....*....|....*....|....*...
gi 66730294 317 NMKHISCPLLILHAEDDPVVPFHLGRKL 344
Cdd:COG0596 156 RLARITVPTLVIWGEKDPIVPPALARRL 183
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
168-338 2.60e-16

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 76.74  E-value: 2.60e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 168 HPiilyLHGnaGTRggDHRV--ELYKVLSSLGYHVVTFDYRGWGDSVGTPSE-RGMTYDALHVFDWIKARsgdNPVYIW- 243
Cdd:COG2945  32 HP----LFG--GTM--DNKVvyTLARALVAAGFAVLRFNFRGVGRSEGEFDEgRGELDDAAAALDWLRAQ---NPLPLWl 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 244 -GHSLGTGVATNLVRRLCEretpPDALILESPFTNIreeakshpfsviyryfpgFDWFFLDPITssgikfandenmkhis 322
Cdd:COG2945 101 aGFSFGAYVALQLAMRLPE----VEGLILVAPPVNR------------------YDFSFLAPCP---------------- 142

                       170
                ....*....|....*.
gi 66730294 323 CPLLILHAEDDPVVPF 338
Cdd:COG2945 143 APTLVIHGEQDEVVPP 158
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
164-346 4.99e-12

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 65.35  E-value: 4.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 164 LASNHPIILYLHGNAGTRGgDHRvELYKVLSSLGYHVVTFDYRGWGDSVGTPseRGMTYDalhvfDWIKA--------RS 235
Cdd:COG1647  11 LEGGRKGVLLLHGFTGSPA-EMR-PLAEALAKAGYTVYAPRLPGHGTSPEDL--LKTTWE-----DWLEDveeayeilKA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 236 GDNPVYIWGHSLGTGVATnlvrRLCERETPPDALILESPftNIREEAKSHPFSVIYRYF-------------PGFDWFFL 302
Cdd:COG1647  82 GYDKVIVIGLSMGGLLAL----LLAARYPDVAGLVLLSP--ALKIDDPSAPLLPLLKYLarslrgigsdiedPEVAEYAY 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66730294 303 DPITSSGI----KFAND--ENMKHISCPLLILHAEDDPVVPFHLGRKLYN 346
Cdd:COG1647 156 DRTPLRALaelqRLIREvrRDLPKITAPTLIIQSRKDEVVPPESARYIYE 205
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 169-301 1.11e-11

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 64.45  E-value: 1.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   169 PIILYLHGNAGTRGGDHrvELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDAL-HVFDWIKARSGDNPVYIWGHSL 247
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWR--KLAPALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLaEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 66730294   248 GTGVATNLvrrLCERETPPDALILESPFTNireeaKSHPFSVIYRYFPGFDWFF 301
Cdd:pfam00561  79 GGLIALAY---AAKYPDRVKALVLLGALDP-----PHELDEADRFILALFPGFF 124
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
193-337 7.59e-11

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 62.59  E-value: 7.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 193 LSSLGYHVVTFDYRGWGDSVGTPSeRGMTYDALH--------VFDWIKARSGDNPVYIWGHSLGtGV------ATNLVRR 258
Cdd:COG4757  55 LAERGFAVLTYDYRGIGLSRPGSL-RGFDAGYRDwgeldlpaVLDALRARFPGLPLLLVGHSLG-GQllglapNAERVDR 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 259 LCE--------RETPPDALILESPFTNIReeakSHPFSVIYRYFPG-----------------------FDWFFLDPits 307
Cdd:COG4757 133 LVTvasgsgywRDYPPRRRLKVLLFWHLL----GPLLTRLLGYFPGrrlgfgedlpagvarqwrrwcrrPRYFFDDD--- 205

                       170       180       190
                ....*....|....*....|....*....|
gi 66730294 308 sgiKFANDENMKHISCPLLILHAEDDPVVP 337
Cdd:COG4757 206 ---GEDLEAALAAVTAPVLAISFTDDELAP 232
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
159-337 1.74e-10

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 61.70  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 159 WYEDAlASNHPIILYLHGnagtRGGDHR----VELYKVLSSLGYHVVTFDYRGWGdsvGTP--SER----GMTYDALHVF 228
Cdd:COG0429  53 WSDPP-APSKPLVVLLHG----LEGSSDshyaRGLARALYARGWDVVRLNFRGCG---GEPnlLPRlyhsGDTEDLVWVL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 229 DWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALI-------LESPFTNIreeakSHPFSVIY---------- 291
Cdd:COG0429 125 AHLRARYPYAPLYAVGFSLGGNLLLKYLGEQGDDAPPLKAAVavsppldLAASADRL-----ERGFNRLYqryflrslkr 199

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66730294 292 ------RYFPG---------------FDWFFLDPIT-----------SSGIKFandenMKHISCPLLILHAEDDPVVP 337
Cdd:COG0429 200 klrrklALFPGlidlealkrirtlreFDDAYTAPLHgfkdaedyyqrASALPF-----LPQIRVPTLILNAADDPFLP 272
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
162-337 1.40e-09

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 57.58  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 162 DALASNHPIILYLHGNAGTRGG--DHRVELYKVLSSLGYHVVTFDYR-----GWGDSVgtpsergmtYDALHVFDWIKAR 234
Cdd:COG0657   7 AGAKGPLPVVVYFHGGGWVSGSkdTHDPLARRLAARAGAAVVSVDYRlapehPFPAAL---------EDAYAALRWLRAN 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 235 SGD-----NPVYIWGHSLGTGVATNLVRRLCERETP-PDALILESPFTNIReeakshpFSVIYRYFPGFdwffldpitss 308
Cdd:COG0657  78 AAElgidpDRIAVAGDSAGGHLAAALALRARDRGGPrPAAQVLIYPVLDLT-------ASPLRADLAGL----------- 139

                       170       180
                ....*....|....*....|....*....
gi 66730294 309 gikfandenmkhisCPLLILHAEDDPVVP 337
Cdd:COG0657 140 --------------PPTLIVTGEADPLVD 154
PLN02511 PLN02511
hydrolase
 156-337 1.03e-06

hydrolase


Pssm-ID: 215282 [Multi-domain]  Cd Length: 388  Bit Score: 50.55  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294  156 DQMWYED-ALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDS-VGTPS--ERGMTYDALHVFDWI 231
Cdd:PLN02511  87 DWVSGDDrALPADAPVLILLPGLTGGSDDSYVRHMLLRARSKGWRVVVFNSRGCADSpVTTPQfySASFTGDLRQVVDHV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294  232 KARSGDNPVYIWGHSLGtgvATNLVRRLCER-ETPP--DALILESPFT-NIREEAKSHPFSVIY---------RYF---- 294
Cdd:PLN02511 167 AGRYPSANLYAAGWSLG---ANILVNYLGEEgENCPlsGAVSLCNPFDlVIADEDFHKGFNNVYdkalakalrKIFakha 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66730294  295 ------PG---------------FDwfflDPIT--SSGIKFAND--------ENMKHISCPLLILHAEDDPVVP 337
Cdd:PLN02511 244 llfeglGGeyniplvanaktvrdFD----DGLTrvSFGFKSVDAyysnssssDSIKHVRVPLLCIQAANDPIAP 313
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 171-344 1.03e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 49.01  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   171 ILYLHGnagtrGGDHRVELYKVLSSlGYHVVTFDYRGWGDSVGTPSErgmTYDALHVFDWIKARSGDNPVYIWGHSLGTG 250
Cdd:pfam12697   1 VVLVHG-----AGLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLD---LADLADLAALLDELGAARPVVLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294   251 VATNLVRR-------LCERETPPDALILESPFTNIREEAKSHP-FSVIYRYFPGF--------DWFFLDPITS---SGIK 311
Cdd:pfam12697  72 VALAAAAAalvvgvlVAPLAAPPGLLAALLALLARLGAALAAPaWLAAESLARGFlddlpadaEWAAALARLAallAALA 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 66730294   312 FANDENMKHISCPLLILHaEDDPVVPFHLGRKL 344
Cdd:pfam12697 152 LLPLAAWRDLPVPVLVLA-EEDRLVPELAQRLL 183
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 165-259 9.33e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 44.05  E-value: 9.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294 165 ASNHPIILyLHGNAGTRGGDHRveLYKVLSSLGYHVVTFDYRGWGDSVgtpSERGmtyDALHVF-DWIKARSGDNPVYIW 243
Cdd:COG1075   3 ATRYPVVL-VHGLGGSAASWAP--LAPRLRAAGYPVYALNYPSTNGSI---EDSA---EQLAAFvDAVLAATGAEKVDLV 73

                        90
                ....*....|....*.
gi 66730294 244 GHSLGTGVATNLVRRL 259
Cdd:COG1075  74 GHSMGGLVARYYLKRL 89
luxD PRK13604
acyl transferase; Provisional
 125-238 4.06e-03

acyl transferase; Provisional


Pssm-ID: 184175  Cd Length: 307  Bit Score: 39.02  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730294  125 TCNYYLQPEDDVTIGVWHTIPSvwwknaqgkdqmwyEDALASNHPIILylhGNAGTRGGDHRVELYKVLSSLGYHVVTFD 204
Cdd:PRK13604   9 TIDHVICLENGQSIRVWETLPK--------------ENSPKKNNTILI---ASGFARRMDHFAGLAEYLSSNGFHVIRYD 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 66730294  205 -YRGWGDSVGTPSERGMT---YDALHVFDWIKARSGDN 238
Cdd:PRK13604  72 sLHHVGLSSGTIDEFTMSigkNSLLTVVDWLNTRGINN 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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