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Conserved domains on  [gi|67846107|ref|NP_001019649|]
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cadherin-related family member 3 precursor [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 4.16e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 465 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 67846107 544 GED---RSSVTVTVNILGEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 1.35e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 242 VYSVPEEVPLGTMVANITAMDPdDEGFPGRLLYSIT--TTSSYFMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVRD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 67846107 320 RPSGGQENRMQITFIVEDINDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.82e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 141 NLYVIERTNPG-FIYQVEAFDPeDTSRSIPLGYFLIS--PSKNFRMSAN-GTLFSTTELDFEAgHKSFNLLVGVRDSGN- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSgnEDGLFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 67846107 216 -LEASTALQVTIVNIND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-679 6.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 571 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 649
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 650 HITDDNLLSGSTkakalvetgTVTLSVKVI 679
Cdd:cd11304  73 TATDGGGPPLSS---------TATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 6.17e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.91  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107  30 NVAENAPPATLVHKFSV---------NLSVSLSPVIPGfplvvnprpftEAFRVNRLSAtnfeVVTTgKEQLDFERGPKa 100
Cdd:cd11304   5 SVPENAPPGTVVLTVSAtdpdsgengEVTYSIVSGNED-----------GLFSIDPSTG----EITT-AKPLDREEQSS- 67

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 101 FDLQIYVKDDVG--VTDVQVLTVQVTDVNE 128
Cdd:cd11304  68 YTLTVTATDGGGppLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 4.16e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 465 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 67846107 544 GED---RSSVTVTVNILGEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 1.35e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 242 VYSVPEEVPLGTMVANITAMDPdDEGFPGRLLYSIT--TTSSYFMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVRD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 67846107 320 RPSGGQENRMQITFIVEDINDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
466-557 1.33e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   466 YVFDVPERRPARTQIGQVRATDADF-PRTPVVYSVSRGGSSlqypNIFWINPKTGELQLITQADHETTSVYILTVEATN- 543
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDs 76

                          90
                  ....*....|....*.
gi 67846107   544 -GEDRSSV-TVTVNIL 557
Cdd:pfam00028  77 gGPPLSSTaTVTITVL 92
Cadherin pfam00028
Cadherin domain;
241-336 1.16e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   241 RVYSVPEEVPLGTMVANITAMDPdDEGFPGRLLYSITTTSSY--FMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVR 318
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 67846107   319 DRPSGGQENRMQITFIVE 336
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-342 1.24e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    259 TAMDPDDeGFPGRLLYSIT--TTSSYFMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVE 336
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 67846107    337 DINDNP 342
Cdd:smart00112  75 DVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-564 3.37e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 3.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    484 RATDADFPR-TPVVYSVSRGGsslqYPNIFWINPKTGELQLITQADHETTSVYILTVEATNGEDR---SSVTVTVNILGE 559
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGN----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDV 76


                   ....*
gi 67846107    560 NDEKP 564
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.82e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 141 NLYVIERTNPG-FIYQVEAFDPeDTSRSIPLGYFLIS--PSKNFRMSAN-GTLFSTTELDFEAgHKSFNLLVGVRDSGN- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSgnEDGLFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 67846107 216 -LEASTALQVTIVNIND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-679 6.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 571 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 649
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 650 HITDDNLLSGSTkakalvetgTVTLSVKVI 679
Cdd:cd11304  73 TATDGGGPPLSS---------TATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-234 2.32e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    158 AFDPeDTSRSIPLGYFLISPSKN--FRMSAN-GTLFSTTELDFEAgHKSFNLLVGVRDSGN--LEASTALQVTIVNINDE 232
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSGNDDglFSIDPEtGEITTTKPLDREE-QPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 67846107    233 TP 234
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
571-679 2.51e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   571 YFMAIPVDLKVGTNIQNfkLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGSnitrLLLASRFDYSSLDTvwdYQLLV 649
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPnGRIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGE---YELTV 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 67846107   650 HITDdnllsGSTKAKalveTGTVTLSVKVI 679
Cdd:pfam00028  72 EATD-----SGGPPL----SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-679 4.92e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.56  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    593 TDLDSSPSS-FRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLVHITDdnllsGSTKAKalveTGT 671
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPE---YTLTVEATD-----GGGPPL----SST 66


                   ....*...
gi 67846107    672 VTLSVKVI 679
Cdd:smart00112  67 ATVTITVL 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 6.17e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.91  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107  30 NVAENAPPATLVHKFSV---------NLSVSLSPVIPGfplvvnprpftEAFRVNRLSAtnfeVVTTgKEQLDFERGPKa 100
Cdd:cd11304   5 SVPENAPPGTVVLTVSAtdpdsgengEVTYSIVSGNED-----------GLFSIDPSTG----EITT-AKPLDREEQSS- 67

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 101 FDLQIYVKDDVG--VTDVQVLTVQVTDVNE 128
Cdd:cd11304  68 YTLTVTATDGGGppLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-561 4.16e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 465 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 543
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|.
gi 67846107 544 GED---RSSVTVTVNILGEND 561
Cdd:cd11304  77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-341 1.35e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 242 VYSVPEEVPLGTMVANITAMDPdDEGFPGRLLYSIT--TTSSYFMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVRD 319
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 67846107 320 RPSGGQENRMQITFIVEDINDN 341
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
466-557 1.33e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   466 YVFDVPERRPARTQIGQVRATDADF-PRTPVVYSVSRGGSSlqypNIFWINPKTGELQLITQADHETTSVYILTVEATN- 543
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDs 76

                          90
                  ....*....|....*.
gi 67846107   544 -GEDRSSV-TVTVNIL 557
Cdd:pfam00028  77 gGPPLSSTaTVTITVL 92
Cadherin pfam00028
Cadherin domain;
241-336 1.16e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   241 RVYSVPEEVPLGTMVANITAMDPdDEGFPGRLLYSITTTSSY--FMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVR 318
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 67846107   319 DRPSGGQENRMQITFIVE 336
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-342 1.24e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    259 TAMDPDDeGFPGRLLYSIT--TTSSYFMVDQLTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVE 336
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 67846107    337 DINDNP 342
Cdd:smart00112  75 DVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-564 3.37e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 3.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    484 RATDADFPR-TPVVYSVSRGGsslqYPNIFWINPKTGELQLITQADHETTSVYILTVEATNGEDR---SSVTVTVNILGE 559
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGN----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDV 76


                   ....*
gi 67846107    560 NDEKP 564
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-231 1.82e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.48  E-value: 1.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 141 NLYVIERTNPG-FIYQVEAFDPeDTSRSIPLGYFLIS--PSKNFRMSAN-GTLFSTTELDFEAgHKSFNLLVGVRDSGN- 215
Cdd:cd11304   3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSgnEDGLFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                        90
                ....*....|....*..
gi 67846107 216 -LEASTALQVTIVNIND 231
Cdd:cd11304  81 pLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-679 6.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107 571 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 649
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 650 HITDDNLLSGSTkakalvetgTVTLSVKVI 679
Cdd:cd11304  73 TATDGGGPPLSS---------TATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-234 2.32e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.49  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    158 AFDPeDTSRSIPLGYFLISPSKN--FRMSAN-GTLFSTTELDFEAgHKSFNLLVGVRDSGN--LEASTALQVTIVNINDE 232
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSGNDDglFSIDPEtGEITTTKPLDREE-QPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 67846107    233 TP 234
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
571-679 2.51e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107   571 YFMAIPVDLKVGTNIQNfkLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGSnitrLLLASRFDYSSLDTvwdYQLLV 649
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPnGRIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGE---YELTV 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 67846107   650 HITDdnllsGSTKAKalveTGTVTLSVKVI 679
Cdd:pfam00028  72 EATD-----SGGPPL----SSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 241-301 1.11e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 41.36  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67846107   241 RVYSVPEEVPLGTMVANITAmdpdDEGFPGRLLYS----ITTTSS--YFMVDQLTGTIQVARRLDRD 301
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAK----DLGLEVGELAArgarVVSKGNkqYFQLNPETGDLLLNEKLDRE 64
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-679 4.92e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.56  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107    593 TDLDSSPSS-FRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLVHITDdnllsGSTKAKalveTGT 671
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPE---YTLTVEATD-----GGGPPL----SST 66


                   ....*...
gi 67846107    672 VTLSVKVI 679
Cdd:smart00112  67 ATVTITVL 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 6.17e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 36.91  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67846107  30 NVAENAPPATLVHKFSV---------NLSVSLSPVIPGfplvvnprpftEAFRVNRLSAtnfeVVTTgKEQLDFERGPKa 100
Cdd:cd11304   5 SVPENAPPGTVVLTVSAtdpdsgengEVTYSIVSGNED-----------GLFSIDPSTG----EITT-AKPLDREEQSS- 67

                        90       100       110
                ....*....|....*....|....*....|
gi 67846107 101 FDLQIYVKDDVG--VTDVQVLTVQVTDVNE 128
Cdd:cd11304  68 YTLTVTATDGGGppLSSTATVTITVLDVND 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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