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Conserved domains on  [gi|71043768|ref|NP_001020874|]
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desumoylating isopeptidase 1 [Rattus norvegicus]

Protein Classification

C97 family peptidase( domain architecture ID 10531274)

C97 family peptidase (deubiquitinating isopeptidase PPPDE superfamily) such as the deSUMOylase DeSI-1, which reverses post-translational modification by the small ubiquitin-like modifier (SUMO)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 7-149 1.70e-63

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


:

Pssm-ID: 461775  Cd Length: 151  Bit Score: 191.78  E-value: 1.70e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043768     7 YPVKLYVYDLS---KGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFG-----SSGISSCTPGGTLLG-PPDSVVDVGNT 77
Cdd:pfam05903   1 HPVYLNVYDLSpdnYGLARRYYPTLLGKQIDGIFHTGVEVYGVEYFFGghekgSGGIFELPPGTTCPGfTPRESIDIGTT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71043768    78 EVTEEIFLEYLSSLGESlFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLD 149
Cdd:pfam05903  81 EVTEEEVRDYLEELSEE-YTGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 7-149 1.70e-63

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


Pssm-ID: 461775  Cd Length: 151  Bit Score: 191.78  E-value: 1.70e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043768     7 YPVKLYVYDLS---KGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFG-----SSGISSCTPGGTLLG-PPDSVVDVGNT 77
Cdd:pfam05903   1 HPVYLNVYDLSpdnYGLARRYYPTLLGKQIDGIFHTGVEVYGVEYFFGghekgSGGIFELPPGTTCPGfTPRESIDIGTT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71043768    78 EVTEEIFLEYLSSLGESlFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLD 149
Cdd:pfam05903  81 EVTEEEVRDYLEELSEE-YTGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 7-149 1.70e-63

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


Pssm-ID: 461775  Cd Length: 151  Bit Score: 191.78  E-value: 1.70e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043768     7 YPVKLYVYDLS---KGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFG-----SSGISSCTPGGTLLG-PPDSVVDVGNT 77
Cdd:pfam05903   1 HPVYLNVYDLSpdnYGLARRYYPTLLGKQIDGIFHTGVEVYGVEYFFGghekgSGGIFELPPGTTCPGfTPRESIDIGTT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71043768    78 EVTEEIFLEYLSSLGESlFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLD 149
Cdd:pfam05903  81 EVTEEEVRDYLEELSEE-YTGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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