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Conserved domains on  [gi|73912707|ref|NP_001027540|]
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homeobox protein OTX isoform beta [Strongylocentrotus purpuratus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677
PubMed:  26464018

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
56-111 4.04e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.57  E-value: 4.04e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 73912707    56 RRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
121-198 2.60e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14948:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 620  Bit Score: 39.18  E-value: 2.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 73912707  121 PNSNNTTNKPRPAKKKTPPPTPRENDA-PTTTSSDTPPFKASPSVSSSMPNNNSIWSPASIAPQPMSSDHLAANMSNNS 198
Cdd:PRK14948 515 GSASNTAKTPPPPQKSPPPPAPTPPLPqPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPSPTKDSS 593
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
56-111 4.04e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.57  E-value: 4.04e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 73912707    56 RRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 55-111 7.74e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 88.85  E-value: 7.74e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 73912707     55 QRRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 56-111 4.15e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.91  E-value: 4.15e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 73912707  56 RRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
53-111 1.19e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 64.38  E-value: 1.19e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 73912707  53 RKQRRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
121-198 2.60e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.18  E-value: 2.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 73912707  121 PNSNNTTNKPRPAKKKTPPPTPRENDA-PTTTSSDTPPFKASPSVSSSMPNNNSIWSPASIAPQPMSSDHLAANMSNNS 198
Cdd:PRK14948 515 GSASNTAKTPPPPQKSPPPPAPTPPLPqPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPSPTKDSS 593
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
56-111 4.04e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.57  E-value: 4.04e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 73912707    56 RRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 55-111 7.74e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 88.85  E-value: 7.74e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 73912707     55 QRRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 56-111 4.15e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.91  E-value: 4.15e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 73912707  56 RRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
53-111 1.19e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 64.38  E-value: 1.19e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 73912707  53 RKQRRERTTFTRAQLDVLETLFSRTRYPDIFMREEVAMKINLPESRVQVWFKNRRAKCR 111
Cdd:COG5576  49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
121-198 2.60e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.18  E-value: 2.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 73912707  121 PNSNNTTNKPRPAKKKTPPPTPRENDA-PTTTSSDTPPFKASPSVSSSMPNNNSIWSPASIAPQPMSSDHLAANMSNNS 198
Cdd:PRK14948 515 GSASNTAKTPPPPQKSPPPPAPTPPLPqPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPSPTKDSS 593
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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