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Conserved domains on  [gi|84370296|ref|NP_001028411|]
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cystatin-A [Mus musculus]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 9.48e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 91.24  E-value: 9.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296    4 GGLTEARPATAEVQEIADRVKAQLEEET-NEKYEIFKAVEYKTQVVAGVNYFIKMDVGGGCFT-HIKVFKDLSGKNN--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|
gi 84370296   80 ELTGYQTNKT 89
Cdd:pfam00031 81 GLCSAQVYKV 90
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 9.48e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 91.24  E-value: 9.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296    4 GGLTEARPATAEVQEIADRVKAQLEEET-NEKYEIFKAVEYKTQVVAGVNYFIKMDVGGGCFT-HIKVFKDLSGKNN--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|
gi 84370296   80 ELTGYQTNKT 89
Cdd:pfam00031 81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-97 5.18e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 74.77  E-value: 5.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296      1 MIPGGLTEARPATAEVQEIADRVKAQLEEETNEKYE--IFKAVEYKTQVVAGVNYFIKMDVG-GGCFT--------HIKV 69
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGeTNCKKlsvdlencPFLD 80

                           90       100
                   ....*....|....*....|....*...
gi 84370296     70 FKDLSGKNNLELTGYQtNKTEDDELTYF 97
Cdd:smart00043  81 QGEKFCTAKVWEKPWE-NKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-86 1.94e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 60.57  E-value: 1.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296   4 GGLTEARPATAEVQEIADRVKAQLEEETNEKY-EIFKAVEYKTQVVAGVNYFIKMDVGGG-------------------- 62
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdcklleeg 80

                        90       100
                ....*....|....*....|....*.
gi 84370296  63 --CFTHIKVFKDLSGkNNLELTGYQT 86
Cdd:cd00042  81 kkKFCTAKVWEKPWE-NFKELLSFKC 105
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 9.48e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 91.24  E-value: 9.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296    4 GGLTEARPATAEVQEIADRVKAQLEEET-NEKYEIFKAVEYKTQVVAGVNYFIKMDVGGGCFT-HIKVFKDLSGKNN--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|
gi 84370296   80 ELTGYQTNKT 89
Cdd:pfam00031 81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-97 5.18e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 74.77  E-value: 5.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296      1 MIPGGLTEARPATAEVQEIADRVKAQLEEETNEKYE--IFKAVEYKTQVVAGVNYFIKMDVG-GGCFT--------HIKV 69
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGeTNCKKlsvdlencPFLD 80

                           90       100
                   ....*....|....*....|....*...
gi 84370296     70 FKDLSGKNNLELTGYQtNKTEDDELTYF 97
Cdd:smart00043  81 QGEKFCTAKVWEKPWE-NKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-86 1.94e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 60.57  E-value: 1.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84370296   4 GGLTEARPATAEVQEIADRVKAQLEEETNEKY-EIFKAVEYKTQVVAGVNYFIKMDVGGG-------------------- 62
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdcklleeg 80

                        90       100
                ....*....|....*....|....*.
gi 84370296  63 --CFTHIKVFKDLSGkNNLELTGYQT 86
Cdd:cd00042  81 kkKFCTAKVWEKPWE-NFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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