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Conserved domains on  [gi|254675193|ref|NP_001028466|]
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probable ATP-dependent RNA helicase DDX31 [Mus musculus]

Protein Classification

DEADc_DDX31 and SF2_C_DEAD domain-containing protein( domain architecture ID 12783010)

protein containing domains DEADc_DDX31, SF2_C_DEAD, and DUF4217

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 114-317 1.58e-118

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 353.04  E-value: 1.58e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 114 LISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQ 193
Cdd:cd17949    1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 194 SFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEK 273
Cdd:cd17949   81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 274 DITVILNAVNAEC----------QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17949  161 DITKILELLDDKRskaggekskpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
105-553 4.97e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 318.24  E-value: 4.97e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltsKIQRSDGPYALVL 184
Cdd:COG0513    4 FADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL-----DPSRPRAPQALIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEAD 264
Cdd:COG0513   78 APTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEAD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 265 RILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPES 344
Cdd:COG0513  156 RMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAET 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 345 LDQHVVLVPSKLRLVCLAAFIlqkcKFEKNQKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHG 424
Cdd:COG0513  216 IEQRYYLVDKRDKLELLRRLL----RDEDPERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHG 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 425 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYV 504
Cdd:COG0513  274 DLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLL 353

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254675193 505 NS---LASHKINVGEIK-MEDILAVLAKD--DCFKRRQRGAQKSRASGPQEIRER 553
Cdd:COG0513  354 RAiekLIGQKIEEEELPgFEPVEEKRLERlkPKIKEKLKGKKAGRGGRPGPKGER 408
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 558-618 6.84e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


:

Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.82  E-value: 6.84e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193  558 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 618
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
 
Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 114-317 1.58e-118

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 353.04  E-value: 1.58e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 114 LISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQ 193
Cdd:cd17949    1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 194 SFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEK 273
Cdd:cd17949   81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 274 DITVILNAVNAEC----------QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17949  161 DITKILELLDDKRskaggekskpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
105-553 4.97e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 318.24  E-value: 4.97e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltsKIQRSDGPYALVL 184
Cdd:COG0513    4 FADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL-----DPSRPRAPQALIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEAD 264
Cdd:COG0513   78 APTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEAD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 265 RILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPES 344
Cdd:COG0513  156 RMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAET 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 345 LDQHVVLVPSKLRLVCLAAFIlqkcKFEKNQKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHG 424
Cdd:COG0513  216 IEQRYYLVDKRDKLELLRRLL----RDEDPERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHG 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 425 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYV 504
Cdd:COG0513  274 DLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLL 353

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254675193 505 NS---LASHKINVGEIK-MEDILAVLAKD--DCFKRRQRGAQKSRASGPQEIRER 553
Cdd:COG0513  354 RAiekLIGQKIEEEELPgFEPVEEKRLERlkPKIKEKLKGKKAGRGGRPGPKGER 408
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 105-491 2.08e-60

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 209.03  E-value: 2.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINtvlKM--SSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKiqRSDGPYAL 182
Cdd:PRK11192   3 FSELELDESLLEALQ---DKgyTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRR--KSGPPRIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 183 VLVPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDE 262
Cdd:PRK11192  78 ILTPTRELAMQVADQARELAK-HTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKE-ENFDCRAVETLILDE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 263 ADRILDLGFEKDITVIlnavNAECQKR-QNVLLSATLT-EGVTRLVDISLHNPVSISVldkncnQPNPKEVASIQlnsfa 340
Cdd:PRK11192 156 ADRMLDMGFAQDIETI----AAETRWRkQTLLFSATLEgDAVQDFAERLLNDPVEVEA------EPSRRERKKIH----- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 341 ipesldQHVVL---VPSKLRLVClaaFILQKckfEKNQKMIVFFSSCELVefhyslflHTLlchsgtptSEHLPSASWPL 417
Cdd:PRK11192 221 ------QWYYRaddLEHKTALLC---HLLKQ---PEVTRSIVFVRTRERV--------HEL--------AGWLRKAGINC 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675193 418 KFLRlhGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGS 491
Cdd:PRK11192 273 CYLE--GEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGT 344
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 128-305 1.22e-51

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 176.28  E-value: 1.22e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQaltskiQRSDGPYALVLVPTRELALQSFDTVQKLLKpFTW 207
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD------KLDNGPQALVLAPTRELAEQIYEELKKLGK-GLG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  208 IVPGVLMGGEKRKSEKARLrKGINILISTPGRLVDHIKSTKNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQ 287
Cdd:pfam00270  74 LKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLLDMGFGPDLEEILRRLP---K 147

                         170
                  ....*....|....*...
gi 254675193  288 KRQNVLLSATLTEGVTRL 305
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
127-323 9.82e-42

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 150.33  E-value: 9.82e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193   127 MTSVQKQSIPVLLEG-RDALVRSQTGSGKTLAYCVPVVQslqaltsKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPF 205
Cdd:smart00487   9 LRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALE-------ALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193   206 TwIVPGVLMGGEKRKSEKARLRKG-INILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNa 284
Cdd:smart00487  82 G-LKVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLEN-DKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP- 158

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 254675193   285 ecQKRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNC 323
Cdd:smart00487 159 --KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 345-496 1.23e-40

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 144.96  E-value: 1.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 345 LDQHVVLVPSKLRLVCLAAFILQKckfEKNQKMIVFFSSCELVEFhyslfLHTLLCHSGtptsehlpsaswpLKFLRLHG 424
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLLLLLEK---LKPGKAIIFVNTKKRVDR-----LAELLEELG-------------IKVAALHG 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675193 425 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 496
Cdd:cd18787   60 DLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 363-487 3.66e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 111.53  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  363 AFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHtllchsgtptsehlpsaswPLKFLRLHGNMEQEERTSVFHEFSHSE 442
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKE-------------------GIKVARLHGDLSQEEREEILEDFRKGK 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 254675193  443 TGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:pfam00271  65 IDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
417-487 3.91e-26

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 102.29  E-value: 3.91e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193   417 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 558-618 6.84e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.82  E-value: 6.84e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193  558 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 618
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 129-263 4.03e-07

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 53.30  E-value: 4.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 129 SVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQslqaltsKIQRSDGPYALVLVPTRELAlqsFDTVQKLLKPFTWI 208
Cdd:COG1205   59 SHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLE-------ALLEDPGATALYLYPTKALA---RDQLRRLRELAEAL 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675193 209 VPGVLMG---GEKRKSEKARLRKGINILISTP-----GRLVDHIKSTKNlhFNRIRWLIVDEA 263
Cdd:COG1205  129 GLGVRVAtydGDTPPEERRWIREHPDIVLTNPdmlhyGLLPHHTRWARF--FRNLRYVVIDEA 189
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 423-494 4.77e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 40.26  E-value: 4.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675193  423 HGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLL 494
Cdd:PLN03137  711 HGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVL 782
 
Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 114-317 1.58e-118

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 353.04  E-value: 1.58e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 114 LISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQ 193
Cdd:cd17949    1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 194 SFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEK 273
Cdd:cd17949   81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 274 DITVILNAVNAEC----------QKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17949  161 DITKILELLDDKRskaggekskpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
105-553 4.97e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 318.24  E-value: 4.97e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltsKIQRSDGPYALVL 184
Cdd:COG0513    4 FADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL-----DPSRPRAPQALIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEAD 264
Cdd:COG0513   78 APTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIER-GALDLSGVETLVLDEAD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 265 RILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkevasiqlnsfAIPES 344
Cdd:COG0513  156 RMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN-----------------ATAET 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 345 LDQHVVLVPSKLRLVCLAAFIlqkcKFEKNQKMIVFFSSCELVEfhyslFLHTLLCHSGtptsehLPSASwplkflrLHG 424
Cdd:COG0513  216 IEQRYYLVDKRDKLELLRRLL----RDEDPERAIVFCNTKRGAD-----RLAEKLQKRG------ISAAA-------LHG 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 425 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYV 504
Cdd:COG0513  274 DLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLL 353

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254675193 505 NS---LASHKINVGEIK-MEDILAVLAKD--DCFKRRQRGAQKSRASGPQEIRER 553
Cdd:COG0513  354 RAiekLIGQKIEEEELPgFEPVEEKRLERlkPKIKEKLKGKKAGRGGRPGPKGER 408
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 127-317 2.34e-73

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 235.03  E-value: 2.34e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 127 MTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaLTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKpFT 206
Cdd:cd00268   13 PTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKL--LPEPKKKGRGPQALVLAPTRELAMQIAEVARKLGK-GT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 207 WIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAec 286
Cdd:cd00268   90 GLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIER-GKLDLSNVKYLVLDEADRMLDMGFEEDVEKILSALPK-- 166

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254675193 287 qKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd00268  167 -DRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 105-491 2.08e-60

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 209.03  E-value: 2.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINtvlKM--SSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKiqRSDGPYAL 182
Cdd:PRK11192   3 FSELELDESLLEALQ---DKgyTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRR--KSGPPRIL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 183 VLVPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDE 262
Cdd:PRK11192  78 ILTPTRELAMQVADQARELAK-HTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKE-ENFDCRAVETLILDE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 263 ADRILDLGFEKDITVIlnavNAECQKR-QNVLLSATLT-EGVTRLVDISLHNPVSISVldkncnQPNPKEVASIQlnsfa 340
Cdd:PRK11192 156 ADRMLDMGFAQDIETI----AAETRWRkQTLLFSATLEgDAVQDFAERLLNDPVEVEA------EPSRRERKKIH----- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 341 ipesldQHVVL---VPSKLRLVClaaFILQKckfEKNQKMIVFFSSCELVefhyslflHTLlchsgtptSEHLPSASWPL 417
Cdd:PRK11192 221 ------QWYYRaddLEHKTALLC---HLLKQ---PEVTRSIVFVRTRERV--------HEL--------AGWLRKAGINC 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675193 418 KFLRlhGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGS 491
Cdd:PRK11192 273 CYLE--GEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGT 344
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 117-313 4.63e-58

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 194.89  E-value: 4.63e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 117 TINTVLKM--SSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALtsKIQRSDGPYALVLVPTRELALQS 194
Cdd:cd17942    1 TLKAIEEMgfTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKL--KFKPRNGTGVIIISPTRELALQI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 195 FDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKD 274
Cdd:cd17942   79 YGVAKELLK-YHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEE 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 254675193 275 ITVILNAVNaecQKRQNVLLSATLTEGVTRLVDISLHNP 313
Cdd:cd17942  158 MRQIIKLLP---KRRQTMLFSATQTRKVEDLARISLKKK 193
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 101-507 1.07e-57

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 202.34  E-value: 1.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 101 SPEAFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpy 180
Cdd:PRK11776   2 SMTAFSTLPLPPALLANLNE-LGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQ------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 181 ALVLVPTRELALQSFDTVQKL------LKPFTwivpgvLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNR 254
Cdd:PRK11776  75 ALVLCPTRELADQVAKEIRRLarfipnIKVLT------LCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRK-GTLDLDA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 255 IRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSIsvldkncnqpnpkEVASI 334
Cdd:PRK11776 148 LNTLVLDEADRMLDMGFQDAIDAIIRQAPAR---RQTLLFSATYPEGIAAISQRFQRDPVEV-------------KVEST 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 335 QLNSfaipeSLDQHVVLVPSKLRLVCLAAFILQkckfEKNQKMIVFfssC-------ELVEfhyslflhtLLCHSGTpts 407
Cdd:PRK11776 212 HDLP-----AIEQRFYEVSPDERLPALQRLLLH----HQPESCVVF---CntkkecqEVAD---------ALNAQGF--- 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 408 ehlpSAswplkfLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:PRK11776 268 ----SA------LALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAG 337

                        410       420
                 ....*....|....*....|
gi 254675193 488 CHGSSLLILAPSEAEYVNSL 507
Cdd:PRK11776 338 SKGLALSLVAPEEMQRANAI 357
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 126-318 1.22e-55

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 188.27  E-value: 1.22e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 126 SMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALtsKIQRSDGPYALVLVPTRELALQSFDTVQKLLKpF 205
Cdd:cd17941   12 KMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRE--RWTPEDGLGALIISPTRELAMQIFEVLRKVGK-Y 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 206 TWIVPGVLMGGEKRKSEKARLrKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNae 285
Cdd:cd17941   89 HSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAIVENLP-- 165

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254675193 286 cQKRQNVLLSATLTEGVTRLVDISLHNPVSISV 318
Cdd:cd17941  166 -KSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
PTZ00110 PTZ00110
helicase; Provisional
 78-498 4.44e-55

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 197.30  E-value: 4.44e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  78 FKNNPEIPELHSTVVKQAR----------EQVFSP-EAFQELDLHPHLISTINTVlKMSSMTSVQKQSIPVLLEGRDALV 146
Cdd:PTZ00110  94 YKEHPEVSALSSKEVDEIRkekeitiiagENVPKPvVSFEYTSFPDYILKSLKNA-GFTEPTPIQVQGWPIALSGRDMIG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 147 RSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTwIVPGVLMGGEKRKSEKARL 226
Cdd:PTZ00110 173 IAETGSGKTLAFLLPAIVHINA-QPLLRYGDGPIVLVLAPTRELAEQIREQCNKFGASSK-IRNTVAYGGVPKRGQIYAL 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 227 RKGINILISTPGRLVDHIKST-KNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRL 305
Cdd:PTZ00110 251 RRGVEILIACPGRLIDFLESNvTNL--RRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPD---RQTLMWSATWPKEVQSL 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 306 V-DISLHNPVSISV--LD-KNCNqpnpkevaSIQLNSFAIPESLDQhvvlvpSKLRLvclaafILQKCkFEKNQKMIVFf 381
Cdd:PTZ00110 326 ArDLCKEEPVHVNVgsLDlTACH--------NIKQEVFVVEEHEKR------GKLKM------LLQRI-MRDGDKILIF- 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 382 ssCELVEfhyslflhtllcHSGTPTSEhLPSASWPLkfLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQV 461
Cdd:PTZ00110 384 --VETKK------------GADFLTKE-LRLDGWPA--LCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDV 446

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 254675193 462 TWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAP 498
Cdd:PTZ00110 447 KYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 128-317 8.64e-54

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 183.22  E-value: 8.64e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDgpyALVLVPTRELALQSFDTVQKLLKpFTW 207
Cdd:cd17947   14 TPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATR---VLVLVPTRELAMQCFSVLQQLAQ-FTD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVnaeCQ 287
Cdd:cd17947   90 ITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEILRLC---PR 166

                        170       180       190
                 ....*....|....*....|....*....|
gi 254675193 288 KRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17947  167 TRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 128-493 8.08e-53

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 188.86  E-value: 8.08e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKpFTW 207
Cdd:PRK10590  25 TPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALILTPTRELAAQIGENVRDYSK-YLN 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAecq 287
Cdd:PRK10590 104 IRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLAKLPA--- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 288 KRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNcnqpnpkeVASiqlnsfaipESLDQHVVLVPSKLRLVCLAAFIlq 367
Cdd:PRK10590 180 KRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRN--------TAS---------EQVTQHVHFVDKKRKRELLSQMI-- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 368 kckFEKN-QKMIVFfsscelvefhyslflhTLLCHSGTPTSEHLPSASwpLKFLRLHGNMEQEERTSVFHEFSHSETGVL 446
Cdd:PRK10590 241 ---GKGNwQQVLVF----------------TRTKHGANHLAEQLNKDG--IRSAAIHGNKSQGARTRALADFKSGDIRVL 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 254675193 447 LCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSL 493
Cdd:PRK10590 300 VATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEAL 346
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 105-553 2.10e-52

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 186.72  E-value: 2.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTVlKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaLTSKI---QRSDGPYA 181
Cdd:PRK04837  10 FSDFALHPQVVEALEKK-GFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYL--LSHPApedRKVNQPRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 182 LVLVPTRELALQSFDTVQKLLKPfTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVD 261
Cdd:PRK04837  87 LIMAPTRELAVQIHADAEPLAQA-TGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQ-NHINLGAIQVVVLD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 262 EADRILDLGFEKDITVILNAVnAECQKRQNVLLSATLTEGVTRLVDISLHNPVSIsvldkncnqpnpkEVASIQLNSFAI 341
Cdd:PRK04837 165 EADRMFDLGFIKDIRWLFRRM-PPANQRLNMLFSATLSYRVRELAFEHMNNPEYV-------------EVEPEQKTGHRI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 342 PESLdqhvvLVPS---KLRLvcLAAFILQkckfEKNQKMIVFFS---SCELVEFHYSLFLHtllchsgtptsehlpsasw 415
Cdd:PRK04837 231 KEEL-----FYPSneeKMRL--LQTLIEE----EWPDRAIIFANtkhRCEEIWGHLAADGH------------------- 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 416 plkflR---LHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSS 492
Cdd:PRK04837 281 -----RvglLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHS 355

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675193 493 lLILA--------PSEAEYVNslasHKINVGEIKMEDILAVLAKDDCFKRRQRGAQKSRASGPQEIRER 553
Cdd:PRK04837 356 -ISLAceeyalnlPAIETYIG----HSIPVSKYDSDALLTDLPKPLRLTRPRTGNGPRRSGAPRNRRRR 419
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 105-318 1.10e-51

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 178.45  E-value: 1.10e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTVlKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSL----QALTSKIQRSDGPY 180
Cdd:cd17967    2 FEEAGLRELLLENIKRA-GYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgPPSVGRGRRKAYPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 181 ALVLVPTRELALQSFDTVQKLLKPfTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIV 260
Cdd:cd17967   81 ALILAPTRELAIQIYEEARKFSYR-SGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGR-ISLSSIKFLVL 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675193 261 DEADRILDLGFEKDITVILNAVN-AECQKRQNVLLSATLTEGVTRLVDISLHNPVSISV 318
Cdd:cd17967  159 DEADRMLDMGFEPQIRKIVEHPDmPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTV 217
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 128-305 1.22e-51

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 176.28  E-value: 1.22e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQaltskiQRSDGPYALVLVPTRELALQSFDTVQKLLKpFTW 207
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD------KLDNGPQALVLAPTRELAEQIYEELKKLGK-GLG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  208 IVPGVLMGGEKRKSEKARLrKGINILISTPGRLVDHIKSTKNLhfNRIRWLIVDEADRILDLGFEKDITVILNAVNaecQ 287
Cdd:pfam00270  74 LKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLLDMGFGPDLEEILRRLP---K 147

                         170
                  ....*....|....*...
gi 254675193  288 KRQNVLLSATLTEGVTRL 305
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 110-310 8.63e-50

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 172.77  E-value: 8.63e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 110 LHPHLISTInTVLKMSSMTSVQKQSIPVLLE-GRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPyALVLVPTR 188
Cdd:cd17964    1 LDPSLLKAL-TRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSGVS-ALIISPTR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 189 ELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRK-GINILISTPGRLVDHIKSTKNL-HFNRIRWLIVDEADRI 266
Cdd:cd17964   79 ELALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVAkAFTDLDYLVLDEADRL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 254675193 267 LDLGFEKDITVILNAVNAECQ-KRQNVLLSATLTEGVTRLVDISL 310
Cdd:cd17964  159 LDMGFRPDLEQILRHLPEKNAdPRQTLLFSATVPDEVQQIARLTL 203
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 122-317 1.61e-49

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 171.99  E-value: 1.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 122 LKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRsDGPYALVLVPTRELALQSFDTVQKL 201
Cdd:cd17960    8 LGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKK-GQVGALIISPTRELATQIYEVLQSF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 202 LKP-FTWIVPGVLMGGEKRKSE-KARLRKGINILISTPGRLVD------HIKSTKNLHFnrirwLIVDEADRILDLGFEK 273
Cdd:cd17960   87 LEHhLPKLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEEllsrkaDKVKVKSLEV-----LVLDEADRLLDLGFEA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 254675193 274 DITVILNAVNaecQKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17960  162 DLNRILSKLP---KQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 105-317 2.12e-48

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 168.65  E-value: 2.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltskIQRSDGPYALVL 184
Cdd:cd17954    2 FKELGVCEELCEACEK-LGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL------LENPQRFFALVL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQ---SFDTVQKLLKpftwIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVD 261
Cdd:cd17954   75 APTRELAQQiseQFEALGSSIG----LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMD 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675193 262 EADRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17954  151 EADRLLNMDFEPEIDKILKVIPRE---RTTYLFSATMTTKVAKLQRASLKNPVKIE 203
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 105-314 2.66e-47

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 165.86  E-value: 2.66e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINtVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltskiqRSD--GPYAL 182
Cdd:cd17955    1 FEDLGLSSWLVKQCA-SLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL--------SEDpyGIFAL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 183 VLVPTRELALQSFDTVQKLLKPftwivPG----VLMGGEKRKSEKARLRKGINILISTPGRLVDHIKS----TKNLHfnR 254
Cdd:cd17955   72 VLTPTRELAYQIAEQFRALGAP-----LGlrccVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSsddtTKVLS--R 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 255 IRWLIVDEADRILDLGFEKDITVILNAVNAecqKRQNVLLSATLTEGVTRLVDISLHNPV 314
Cdd:cd17955  145 VKFLVLDEADRLLTGSFEDDLATILSALPP---KRQTLLFSATLTDALKALKELFGNKPF 201
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 6-504 2.70e-47

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 173.95  E-value: 2.70e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193   6 EATKRKHQVSSDAPPAKRRSEISSVLAKKASDKETQRTFKGSTHKTFPPKKYLDSIGNGRQEEKPciKTSSLFKnnpeip 85
Cdd:PRK01297   3 KALKKIFGKGEAEQPAPAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRERKP--KPASLWK------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  86 eLHSTVVkqarEQVFSPEAFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQS 165
Cdd:PRK01297  75 -LEDFVV----EPQEGKTRFHDFNLAPELMHAIHD-LGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 166 LQALTSKIQRSDG-PYALVLVPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLR-KGINILISTPGRLVDH 243
Cdd:PRK01297 149 LLQTPPPKERYMGePRALIIAPTRELVVQIAKDAAALTK-YTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDF 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 244 IKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQkRQNVLLSATLTEGVTRLVDISLHNPVSISVldknc 323
Cdd:PRK01297 228 NQR-GEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEE-RQTLLFSATFTDDVMNLAKQWTTDPAIVEI----- 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 324 nqpNPKEVASiqlnsfaipESLDQHVVLVPSKLRLVCLAAFILQkckfEKNQKMIVFFSSCELVEFHYslflhtllchsg 403
Cdd:PRK01297 301 ---EPENVAS---------DTVEQHVYAVAGSDKYKLLYNLVTQ----NPWERVMVFANRKDEVRRIE------------ 352

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 404 tptsEHLPSASwpLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRT 483
Cdd:PRK01297 353 ----ERLVKDG--INAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRT 426

                        490       500
                 ....*....|....*....|.
gi 254675193 484 ARIGCHGSSLLILAPSEAEYV 504
Cdd:PRK01297 427 GRAGASGVSISFAGEDDAFQL 447
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 128-317 9.92e-46

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 162.10  E-value: 9.92e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPV---VQSLQALTSKIqRSDGPYALVLVPTRELALQSFDTVQKLLKP 204
Cdd:cd17945   14 TPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLlvyISRLPPLDEET-KDDGPYALILAPTRELAQQIEEETQKFAKP 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 205 FTWIVPgVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNA 284
Cdd:cd17945   93 LGIRVV-SIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLER-RLLVLNQCTYVVLDEADRMIDMGFEPQVTKILDAMPV 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 254675193 285 ECQK-----------------RQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17945  171 SNKKpdteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 105-493 1.32e-45

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 171.29  E-value: 1.32e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTVlKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRS-DGPYALV 183
Cdd:PRK04537  11 FSSFDLHPALLAGLESA-GFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKpEDPRALI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 184 LVPTRELALQSFDTVQKLLKPFTwIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEA 263
Cdd:PRK04537  90 LAPTRELAIQIHKDAVKFGADLG-LRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 264 DRILDLGFEKDITVILNAVNAECQkRQNVLLSATLTEGVTRLVdislhnpvsisvlDKNCNQPNpKEVASIQlnsfAIPE 343
Cdd:PRK04537 169 DRMFDLGFIKDIRFLLRRMPERGT-RQTLLFSATLSHRVLELA-------------YEHMNEPE-KLVVETE----TITA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 344 SLDQHVVLVPSKLRLVCLAAFILQKckfEKNQKMIVFFSSCELVEfhyslflhtllchsgtPTSEHLPSASWPLKFLRlh 423
Cdd:PRK04537 230 ARVRQRIYFPADEEKQTLLLGLLSR---SEGARTMVFVNTKAFVE----------------RVARTLERHGYRVGVLS-- 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 424 GNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSL 493
Cdd:PRK04537 289 GDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAI 358
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 128-318 2.16e-43

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 155.05  E-value: 2.16e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKiqrsDGPYALVLVPTRELALQSFDTVQKLLK--PF 205
Cdd:cd17957   14 TPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKK----KGLRALILAPTRELASQIYRELLKLSKgtGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 206 TWIVpgVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAE 285
Cdd:cd17957   90 RIVL--LSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGP-IDLSSVEYLVLDEADKLFEPGFREQTDEILAACTNP 166

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254675193 286 CQKRqnVLLSATLTEGVTRLVDISLHNPVSISV 318
Cdd:cd17957  167 NLQR--SLFSATIPSEVEELARSVMKDPIRIIV 197
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 122-316 3.68e-43

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 154.66  E-value: 3.68e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 122 LKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKL 201
Cdd:cd17961   12 LGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTRELAQQVSKVLEQL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 202 LKPFTWIVPGVLMGGEKRKSEKARLRKGI-NILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILN 280
Cdd:cd17961   92 TAYCRKDVRVVNLSASSSDSVQRALLAEKpDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLS 171

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 254675193 281 AVNAECqkrQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17961  172 YLPKNY---QTFLMSATLSEDVEALKKLVLHNPAIL 204
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 128-317 1.06e-42

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 152.95  E-value: 1.06e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTW 207
Cdd:cd17952   14 TPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMD-QRELEKGEGPIAVIVAPTRELAQQIYLEAKKFGKAYNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKArLRKGINILISTPGRLVDHIKsTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEcq 287
Cdd:cd17952   93 RVVAVYGGGSKWEQAKA-LQEGAEIVVATPGRLIDMVK-KKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHVRPD-- 168

                        170       180       190
                 ....*....|....*....|....*....|
gi 254675193 288 kRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17952  169 -RQTLLFSATFKKKIEQLARDILSDPIRVV 197
DEXDc smart00487
DEAD-like helicases superfamily;
127-323 9.82e-42

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 150.33  E-value: 9.82e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193   127 MTSVQKQSIPVLLEG-RDALVRSQTGSGKTLAYCVPVVQslqaltsKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPF 205
Cdd:smart00487   9 LRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALE-------ALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193   206 TwIVPGVLMGGEKRKSEKARLRKG-INILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNa 284
Cdd:smart00487  82 G-LKVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLEN-DKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP- 158

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 254675193   285 ecQKRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNC 323
Cdd:smart00487 159 --KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 120-313 5.73e-41

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 149.32  E-value: 5.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 120 TVLKMSSMTSVQKQSIPVLLEG---------RDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRsdgpyALVLVPTREL 190
Cdd:cd17956    6 QNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRLR-----ALIVVPTKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 191 ALQSFDTVQKLLKPFTWIVpGVLMGGEKRKSEKARLRKG--------INILISTPGRLVDHIKSTKNLHFNRIRWLIVDE 262
Cdd:cd17956   81 VQQVYKVFESLCKGTGLKV-VSLSGQKSFKKEQKLLLVDtsgrylsrVDILVATPGRLVDHLNSTPGFTLKHLRFLVIDE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193 263 ADRILDLGFEKDITVILNAVNAE--------------------CQKrqnVLLSATLTEGVTRLVDISLHNP 313
Cdd:cd17956  160 ADRLLNQSFQDWLETVMKALGRPtapdlgsfgdanllersvrpLQK---LLFSATLTRDPEKLSSLKLHRP 227
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 128-317 6.21e-41

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 147.90  E-value: 6.21e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTw 207
Cdd:cd17966   14 TAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINA-QPPLERGDGPIVLVLAPTRELAQQIQQEANKFGGSSR- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTK-NLHfnRIRWLIVDEADRILDLGFEKDITVILNAVNAEc 286
Cdd:cd17966   92 LRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKtNLR--RVTYLVLDEADRMLDMGFEPQIRKIVDQIRPD- 168

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254675193 287 qkRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17966  169 --RQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 105-316 1.18e-40

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 147.45  E-value: 1.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLIstiNTVLKM--SSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIqrsdGPYAL 182
Cdd:cd17959    3 FQSMGLSPPLL---RAIKKKgyKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV----GARAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 183 VLVPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVdHIKSTKNLHFNRIRWLIVDE 262
Cdd:cd17959   76 ILSPTRELALQTLKVTKELGK-FTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLL-HLLVEMNLKLSSVEYVVFDE 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 263 ADRILDLGFEKDITVILNAVNaecQKRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17959  154 ADRLFEMGFAEQLHEILSRLP---ENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 345-496 1.23e-40

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 144.96  E-value: 1.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 345 LDQHVVLVPSKLRLVCLAAFILQKckfEKNQKMIVFFSSCELVEFhyslfLHTLLCHSGtptsehlpsaswpLKFLRLHG 424
Cdd:cd18787    1 IKQLYVVVEEEEKKLLLLLLLLEK---LKPGKAIIFVNTKKRVDR-----LAELLEELG-------------IKVAALHG 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675193 425 NMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 496
Cdd:cd18787   60 DLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 104-494 1.90e-40

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 157.32  E-value: 1.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 104 AFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSkiqrsdGPYALV 183
Cdd:PRK11634   7 TFADLGLKAPILEALND-LGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELK------APQILV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 184 LVPTRELALQsfdtVQKLLKPFTWIVPGV----LMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLI 259
Cdd:PRK11634  80 LAPTRELAVQ----VAEAMTDFSKHMRGVnvvaLYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKR-GTLDLSKLSGLV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 260 VDEADRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKE----VASIQ 335
Cdd:PRK11634 155 LDEADEMLRMGFIEDVETIMAQIPEG---HQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQsywtVWGMR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 336 LNS----FAIPESLDQHVVLVPSklrlvclaafilqkckfeKNQKMIVffssCELVEFH-YSlflhtllchsgtptsehl 410
Cdd:PRK11634 232 KNEalvrFLEAEDFDAAIIFVRT------------------KNATLEV----AEALERNgYN------------------ 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 411 pSASwplkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHG 490
Cdd:PRK11634 272 -SAA-------LNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAG 343


                 ....
gi 254675193 491 SSLL 494
Cdd:PRK11634 344 RALL 347
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 102-305 2.42e-40

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 148.58  E-value: 2.42e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 102 PEAFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDG--- 178
Cdd:cd18052   42 ILTFEEANLCETLLKNIRK-AGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEvqe 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 179 PYALVLVPTRELALQSFDTVQKllkpF---TWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRI 255
Cdd:cd18052  121 PQALIVAPTRELANQIFLEARK----FsygTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK-ISLSKL 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 254675193 256 RWLIVDEADRILDLGFEKDITVILNAVN-AECQKRQNVLLSATLTEGVTRL 305
Cdd:cd18052  196 KYLILDEADRMLDMGFGPEIRKLVSEPGmPSKEDRQTLMFSATFPEEIQRL 246
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 122-316 1.86e-39

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 144.83  E-value: 1.86e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 122 LKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQSFDTVQKL 201
Cdd:cd17953   30 LGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKD-QRPVKPGEGPIGLIMAPTRELALQIYVECKKF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 202 LKPFTWIVPGVlMGGEKRKSEKARLRKGINILISTPGRLVDHI--KSTKNLHFNRIRWLIVDEADRILDLGFEKDITVIL 279
Cdd:cd17953  109 SKALGLRVVCV-YGGSGISEQIAELKRGAEIVVCTPGRMIDILtaNNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIV 187

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 254675193 280 NAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17953  188 NNIRPD---RQTVLFSATFPRKVEALARKVLHKPIEI 221
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 128-496 1.40e-38

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 149.94  E-value: 1.40e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSK-IQRSDGPYALVLVPTRELALQSFDTVQKLLK--P 204
Cdd:PLN00206 145 TPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGhPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKglP 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 205 F-TWIVpgvlMGGEKRKSEKARLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN 283
Cdd:PLN00206 225 FkTALV----VGGDAMPQQLYRIQQGVELIVGTPGRLID-LLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALS 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 284 aecqKRQNVLLSATLTEGVTRLVDISLHNPVSISVldKNCNQPNpkevasiqlnsfaipESLDQHVVLVPSKLRLVCLAA 363
Cdd:PLN00206 300 ----QPQVLLFSATVSPEVEKFASSLAKDIILISI--GNPNRPN---------------KAVKQLAIWVETKQKKQKLFD 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 364 FILQKCKFEKnqKMIVFFSSCELVEfhyslflhtLLCHSGTPTSEhlpsaswpLKFLRLHGNMEQEERTSVFHEFSHSET 443
Cdd:PLN00206 359 ILKSKQHFKP--PAVVFVSSRLGAD---------LLANAITVVTG--------LKALSIHGEKSMKERREVMKSFLVGEV 419

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 254675193 444 GVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 496
Cdd:PLN00206 420 PVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 128-316 3.17e-37

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 137.60  E-value: 3.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVP-VVQSLQALTSKIQRsDGPYALVLVPTRELALQSFDTVQKLLkpFT 206
Cdd:cd17958   14 SPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgFIHLDLQPIPREQR-NGPGVLVLTPTRELALQIEAECSKYS--YK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 207 WIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDhIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAEc 286
Cdd:cd17958   91 GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKILLDIRPD- 168

                        170       180       190
                 ....*....|....*....|....*....|
gi 254675193 287 qkRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17958  169 --RQTIMTSATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 123-316 1.57e-36

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 135.93  E-value: 1.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 123 KMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVqsLQALTSK----IQRSDGPYALVLVPTRELALQSFDTV 198
Cdd:cd17951    9 GIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLI--MFALEQEkklpFIKGEGPYGLIVCPSRELARQTHEVI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 199 QKLLKPFT-----WIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKsTKNLHFNRIRWLIVDEADRILDLGFEK 273
Cdd:cd17951   87 EYYCKALQeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLN-KKKINLDICRYLCLDEADRMIDMGFEE 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 254675193 274 DITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17951  166 DIRTIFSYFKGQ---RQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 105-316 1.99e-36

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 135.50  E-value: 1.99e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpyALVL 184
Cdd:cd17940    1 FEDYGLKRELLMGIFE-KGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQ------ALIL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKstKNL-HFNRIRWLIVDEA 263
Cdd:cd17940   74 VPTRELALQTSQVCKELGK-HMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAK--KGVaDLSHCKTLVLDEA 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 254675193 264 DRILDLGFEKDITVILNAVNAEcqkRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17940  151 DKLLSQDFQPIIEKILNFLPKE---RQILLFSATFPLTVKNFMDRHMHNPYEI 200
PTZ00424 PTZ00424
helicase 45; Provisional
 103-520 4.41e-35

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 137.65  E-value: 4.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 103 EAFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYcvpVVQSLQALTSKIQRSDgpyAL 182
Cdd:PTZ00424  28 DSFDALKLNEDLLRGIYS-YGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATF---VIAALQLIDYDLNACQ---AL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 183 VLVPTRELAlQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDE 262
Cdd:PTZ00424 101 ILAPTRELA-QQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDK-RHLRVDDLKLFILDE 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 263 ADRILDLGFEKDITVILNAVNAECQKrqnVLLSATLTEGVTRLVDISLHNPVSISVldkncnqpnPKEVASIqlnsfaip 342
Cdd:PTZ00424 179 ADEMLSRGFKGQIYDVFKKLPPDVQV---ALFSATMPNEILELTTKFMRDPKRILV---------KKDELTL-------- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 343 ESLDQHVVLVPS---KLRLVC---LAAFILQKCKFEKNQKMIVFFSScelvEFHYSLFlhTLLChsgtptsehlpsaswp 416
Cdd:PTZ00424 239 EGIRQFYVAVEKeewKFDTLCdlyETLTITQAIIYCNTRRKVDYLTK----KMHERDF--TVSC---------------- 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 417 lkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL 496
Cdd:PTZ00424 297 -----MHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFV 371

                        410       420
                 ....*....|....*....|....*
gi 254675193 497 APSEAEYVNSLASH-KINVGEIKME 520
Cdd:PTZ00424 372 TPDDIEQLKEIERHyNTQIEEMPME 396
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 105-314 1.10e-34

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 130.90  E-value: 1.10e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTInTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQaltskiqrsdgpyALVL 184
Cdd:cd17938    1 FEELGVMPELIKAV-EELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-------------ALIL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 185 VPTRELALQSFDTVQKLLKPFT--WIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDE 262
Cdd:cd17938   67 EPSRELAEQTYNCIENFKKYLDnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGK-LDLSSVRFFVLDE 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675193 263 ADRILDLGFEKDITVILN---AVNAECQKRQNVLLSATL-TEGVTRLVDISLHNPV 314
Cdd:cd17938  146 ADRLLSQGNLETINRIYNripKITSDGKRLQVIVCSATLhSFEVKKLADKIMHFPT 201
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 122-300 1.93e-34

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 131.21  E-value: 1.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 122 LKMSSMTSVQKQSIPV-LLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSK---IQRSDGPYALVLVPTRELALQSFDT 197
Cdd:cd17946    8 LGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSngvGGKQKPLRALILTPTRELAVQVKDH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 198 VQKLLKpFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNR---IRWLIVDEADRILDLGFEKD 274
Cdd:cd17946   88 LKAIAK-YTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQE-GNEHLANlksLRFLVLDEADRMLEKGHFAE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 254675193 275 ITVILNAVN----AECQKRQNVLLSATLTE 300
Cdd:cd17946  166 LEKILELLNkdraGKKRKRQTFVFSATLTL 195
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 103-297 6.34e-34

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 130.16  E-value: 6.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 103 EAFQELDLHphliSTINTVLKMSSM---TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPV---------VQSLQALT 170
Cdd:cd18051   21 ETFSDLDLG----EIIRNNIELARYtkpTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPIlsqiyeqgpGESLPSES 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 171 SKIQRSDG-PYALVLVPTRELALQSFDTVQKllkpFTW---IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKS 246
Cdd:cd18051   97 GYYGRRKQyPLALVLAPTRELASQIYDEARK----FAYrsrVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLER 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 254675193 247 TKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN-AECQKRQNVLLSAT 297
Cdd:cd18051  173 GK-IGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTmPPTGERQTLMFSAT 223
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 128-317 6.38e-34

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 128.44  E-value: 6.38e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVqsLQALTskiqRSDGPYALVLVPTRELALQSFDTVQKLLKPFTW 207
Cdd:cd17962   14 TPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI--IRCLT----EHRNPSALILTPTRELAVQIEDQAKELMKGLPP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIK-STKNLHfnRIRWLIVDEADRILDLGFEKDITVILNAVNAEC 286
Cdd:cd17962   88 MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKqSSVELD--NIKIVVVDEADTMLKMGFQQQVLDILENISHDH 165

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254675193 287 qkrQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17962  166 ---QTILVSATIPRGIEQLAGQLLQNPVRIT 193
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 128-318 1.06e-32

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 126.28  E-value: 1.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQsfdtVQKLLKPF-- 205
Cdd:cd18049   48 TAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINH-QPFLERGDGPICLVLAPTRELAQQ----VQQVAAEYgr 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 206 -TWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNlHFNRIRWLIVDEADRILDLGFEKDITVILNAVNA 284
Cdd:cd18049  123 aCRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 201

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254675193 285 EcqkRQNVLLSATLTEGVTRLVDISLHNPVSISV 318
Cdd:cd18049  202 D---RQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 128-318 3.65e-32

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 125.89  E-value: 3.65e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAlTSKIQRSDGPYALVLVPTRELALQsfdtVQKLLKPF-- 205
Cdd:cd18050   86 TPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINH-QPYLERGDGPICLVLAPTRELAQQ----VQQVADDYgk 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 206 -TWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNlHFNRIRWLIVDEADRILDLGFEKDITVILNAVNA 284
Cdd:cd18050  161 sSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 239

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254675193 285 EcqkRQNVLLSATLTEGVTRLVDISLHNPVSISV 318
Cdd:cd18050  240 D---RQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 128-316 1.54e-31

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 121.66  E-value: 1.54e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVqKLLKPFTW 207
Cdd:cd17939   21 SAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQ------ALVLAPTRELAQQIQKVV-KALGDYMG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQ 287
Cdd:cd17939   94 VKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQR-RSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQ 172

                        170       180
                 ....*....|....*....|....*....
gi 254675193 288 KrqnVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17939  173 V---VLFSATMPHEVLEVTKKFMRDPVRI 198
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 128-317 4.31e-30

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 117.36  E-value: 4.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVQKLLKPFTW 207
Cdd:cd17943   14 SPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQ------VLILAPTREIAVQIHDVFKKIGKKLEG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLrKGINILISTPGRlvdhIKSTKNLHF---NRIRWLIVDEADRILDLGFEKDITVILNAVNA 284
Cdd:cd17943   88 LKCEVFIGGTPVKEDKKKL-KGCHIAVGTPGR----IKQLIELGAlnvSHVRLFVLDEADKLMEGSFQKDVNWIFSSLPK 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254675193 285 ecqKRQNVLLSATLTEGVTRLVDISLHNPVSIS 317
Cdd:cd17943  163 ---NKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 363-487 3.66e-29

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 111.53  E-value: 3.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  363 AFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHtllchsgtptsehlpsaswPLKFLRLHGNMEQEERTSVFHEFSHSE 442
Cdd:pfam00271   4 EALLELLKKERGGKVLIFSQTKKTLEAELLLEKE-------------------GIKVARLHGDLSQEEREEILEDFRKGK 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 254675193  443 TGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:pfam00271  65 IDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 128-305 7.56e-29

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 115.16  E-value: 7.56e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRS-DGPYALVLVPTRELALQSFDTVQKLLKPFT 206
Cdd:cd17948   14 TTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPfNAPRGLVITPSRELAEQIGSVAQSLTEGLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 207 wIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVdhiKSTKN--LHFNRIRWLIVDEADRILDLGFEKDITVIL----- 279
Cdd:cd17948   94 -LKVKVITGGRTKRQIRNPHFEEVDILVATPGALS---KLLTSriYSLEQLRHLVLDEADTLLDDSFNEKLSHFLrrfpl 169

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254675193 280 -----NAVNAECQKRQNVLLSATLTEGVTRL 305
Cdd:cd17948  170 asrrsENTDGLDPGTQLVLVSATMPSGVGEV 200
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 128-316 2.53e-27

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 109.86  E-value: 2.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVQKLLKpFTW 207
Cdd:cd18045   23 SAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQ------ALILSPTRELAVQIQKVLLALGD-YMN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAecq 287
Cdd:cd18045   96 VQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRR-RSLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYLPP--- 171

                        170       180
                 ....*....|....*....|....*....
gi 254675193 288 KRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd18045  172 ATQVVLVSATLPQDILEMTNKFMTDPIRI 200
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 130-297 1.03e-26

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 108.01  E-value: 1.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 130 VQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTwiv 209
Cdd:cd17944   16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFKDITRKLS--- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 210 PGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKnLHFNRIRWLIVDEADRILDLGFEKDITVILNAV---NAEc 286
Cdd:cd17944   93 VACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGR-LDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSykkDSE- 170

                        170
                 ....*....|.
gi 254675193 287 QKRQNVLLSAT 297
Cdd:cd17944  171 DNPQTLLFSAT 181
HELICc smart00490
helicase superfamily c-terminal domain;
417-487 3.91e-26

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 102.29  E-value: 3.91e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193   417 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 130-316 5.38e-25

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 102.65  E-value: 5.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 130 VQKQSIPVLLEG--RDALVRSQTGSGKTLAYCVPVVqslqaltSKIQRSD-GPYALVLVPTRELALQSFDTVQKLLKpFT 206
Cdd:cd17963   20 IQETALPLILSDppENLIAQSQSGTGKTAAFVLAML-------SRVDPTLkSPQALCLAPTRELARQIGEVVEKMGK-FT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 207 WIVPGVLMggekrKSEKARLRKGIN--ILISTPGRLVDHIKsTKNLHFNRIRWLIVDEADRILDL-GFEKDITVILNAVN 283
Cdd:cd17963   92 GVKVALAV-----PGNDVPRGKKITaqIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTqGHGDQSIRIKRMLP 165

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254675193 284 AECQKrqnVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd17963  166 RNCQI---LLFSATFPDSVRKFAEKIAPNANTI 195
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 128-316 5.25e-22

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 94.43  E-value: 5.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQslqaltsKIQRSD-GPYALVLVPTRELALQsfdtVQKL---LK 203
Cdd:cd18046   23 SAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQ-------QIDTSLkATQALVLAPTRELAQQ----IQKVvmaLG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 204 PFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVN 283
Cdd:cd18046   92 DYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINR-RYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLP 170

                        170       180       190
                 ....*....|....*....|....*....|...
gi 254675193 284 aecQKRQNVLLSATLTEGVTRLVDISLHNPVSI 316
Cdd:cd18046  171 ---PDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 128-300 4.80e-21

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 92.02  E-value: 4.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 128 TSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVQKLLKPFTW 207
Cdd:cd17950   26 SEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS------VLVICHTRELAFQISNEYERFSKYMPN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 208 IVPGVLMGGEKRKSEKARLR-KGINILISTPGRLVDHIKStKNLHFNRIRWLIVDEADRIL-DLGFEKDITVILNAVNae 285
Cdd:cd17950  100 VKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVRE-KKLKLSHVKHFVLDECDKMLeQLDMRRDVQEIFRATP-- 176

                        170
                 ....*....|....*
gi 254675193 286 cQKRQNVLLSATLTE 300
Cdd:cd17950  177 -HDKQVMMFSATLSK 190
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 105-298 1.18e-19

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 88.97  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 105 FQELDLHPHLISTINTVLKMSSM--------TSVQKQSIPVLLEGRDALVRSQ----------------TGSGKTLAYCV 160
Cdd:cd17965    1 FDQLKLLPSVREAIIKEILKGSNktdeeikpSPIQTLAIKKLLKTLMRKVTKQtsneepklevfllaaeTGSGKTLAYLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 161 PVVQSLQ-----------ALTSKIQRSDGPYALVLVPTRELALQSFDTVQKL-------LKPFTWIvpgvlMGGEKRKSE 222
Cdd:cd17965   81 PLLDYLKrqeqepfeeaeEEYESAKDTGRPRSVILVPTHELVEQVYSVLKKLshtvklgIKTFSSG-----FGPSYQRLQ 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675193 223 KArLRKGINILISTPGRLVDHIKSTKNLhFNRIRWLIVDEADRILDLGFEKDIT-VILNAVNAECQkrqnVLLSATL 298
Cdd:cd17965  156 LA-FKGRIDILVTTPGKLASLAKSRPKI-LSRVTHLVVDEADTLFDRSFLQDTTsIIKRAPKLKHL----ILCSATI 226
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 141-297 5.42e-18

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 81.30  E-value: 5.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 141 GRDALVRSQTGSGKTLAYCVPVVQSLqaltskiqRSDGPYALVLVPTRELALQsfdTVQKLLKPFTWIVPGVLMGGEKRK 220
Cdd:cd00046    1 GENVLITAPTGSGKTLAALLAALLLL--------LKKGKKVLVLVPTKALALQ---TAERLRELFGPGIRVAVLVGGSSA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 221 SEKARLRKG-INILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDIT--VILNAVNAECQKrqnVLLSAT 297
Cdd:cd00046   70 EEREKNKLGdADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILdlAVRKAGLKNAQV---ILLSAT 146
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 558-618 6.84e-18

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 77.82  E-value: 6.84e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675193  558 QTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPkeLKSIFHVRALHLGHVAKSFGLRDAPR 618
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
140-647 1.51e-15

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 80.07  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 140 EGRDALVRSQTGSGKTLaycvpvvqsLQALTSKIQRSDGPyALVLVPTRELALQSFDTVQKLLkpftwivPGVLMGGEKR 219
Cdd:COG1061   99 GGGRGLVVAPTGTGKTV---------LALALAAELLRGKR-VLVLVPRRELLEQWAEELRRFL-------GDPLAGGGKK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 220 KSEKarlrkgiNILISTPGRLvdhiksTKNLHFNRI--RW--LIVDEADRILDLGFEKditvILNAVNAecQKRqnVLLS 295
Cdd:COG1061  162 DSDA-------PITVATYQSL------ARRAHLDELgdRFglVIIDEAHHAGAPSYRR----ILEAFPA--AYR--LGLT 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 296 AT------LTEGVTRLVDIS-------------LHNPVSISVLDKNCNQPNPKEVASiqlnsfaipESLDQHVVLVPSKL 356
Cdd:COG1061  221 ATpfrsdgREILLFLFDGIVyeyslkeaiedgyLAPPEYYGIRVDLTDERAEYDALS---------ERLREALAADAERK 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 357 RLVCLAafILQKCKfeKNQKMIVFFSSCELVEFhyslfLHTLLCHSGTPTsehlpsaswplkfLRLHGNMEQEERTSVFH 436
Cdd:COG1061  292 DKILRE--LLREHP--DDRKTLVFCSSVDHAEA-----LAELLNEAGIRA-------------AVVTGDTPKKEREEILE 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 437 EFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLIL------APSEAEYVNSLASH 510
Cdd:COG1061  350 AFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYdfvgndVPVLEELAKDLRDL 429

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 511 KINVGEIKMEDILAVLAKDDCFKRRQRGAQKSRASGPQEIRERATVLQTVFEDYVHSSQRMVSWAKKALQSFIRAYATYP 590
Cdd:COG1061  430 AGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEE 509

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675193 591 KELKSIFHVRALHLGHVAKSFGLRDAPRNLSVSAVKKASLKRPHPRRKTQRKQHLVP 647
Cdd:COG1061  510 EEKELLLLLALAKLLKLLLLLLLLLLLELLELLAALLRLEELAALLLKELLRAALAA 566
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 99-302 8.00e-14

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 71.59  E-value: 8.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  99 VFSPEAFQELDLHPHLISTInTVLKMSSMTSVQKQSIPVLLEG--RDALVRSQTGSGKTLAYCVPVVQSLQALTSKiqrs 176
Cdd:cd18048   14 LFSVKSFEELHLKEELLRGI-YAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY---- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 177 dgPYALVLVPTRELALQSFDTVQKLLKpFTWIVPGVLMGGEKRKSEKARLRKgiNILISTPGRLVDHIKSTKNLHFNRIR 256
Cdd:cd18048   89 --PQCLCLSPTFELALQTGKVVEEMGK-FCVGIQVIYAIRGNRPGKGTDIEA--QIVIGTPGTVLDWCFKLRLIDVTNIS 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 254675193 257 WLIVDEADRILDL-GFEKDITVILNAVNAECQKrqnVLLSATLTEGV 302
Cdd:cd18048  164 VFVLDEADVMINVqGHSDHSVRVKRSMPKECQM---LLFSATFEDSV 207
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 126-298 5.39e-11

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 61.89  E-value: 5.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 126 SMTSVQKQSI-PVLLEGRDALVRSQTGSGKTLA--YCVpvvqsLQALTSKIQRsdgpyALVLVPTRELALQSFDTVQKLL 202
Cdd:cd17921    1 LLNPIQREALrALYLSGDSVLVSAPTSSGKTLIaeLAI-----LRALATSGGK-----AVYIAPTRALVNQKEADLRERF 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 203 KPFTwIVPGVLMGGEKRKSEKARLRkgiNILISTPGRLVDHIKSTKNLHFNRIRWLIVDEA------DRILDLgfEkdit 276
Cdd:cd17921   71 GPLG-KNVGLLTGDPSVNKLLLAEA---DILVATPEKLDLLLRNGGERLIQDVRLVVVDEAhligdgERGVVL--E---- 140

                        170       180
                 ....*....|....*....|..
gi 254675193 277 VILNAVNAECQKRQNVLLSATL 298
Cdd:cd17921  141 LLLSRLLRINKNARFVGLSATL 162
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 103-313 2.54e-10

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 60.50  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 103 EAFQELDLHPHLISTINTvLKMSSMTSVQKQSIPVLLEG--RDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQrsdgpy 180
Cdd:cd18047    1 KSFEELRLKPQLLQGVYA-MGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 181 ALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEkRKSEKARLRKgiNILISTPGRLVDHIKSTKNLHFNRIRWLIV 260
Cdd:cd18047   74 CLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGN-KLERGQKISE--QIVIGTPGTVLDWCSKLKFIDPKKIKVFVL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 261 DEADRILDLGFEKDITV-ILNAVNAECQKrqnVLLSATLTEGVTRLVDISLHNP 313
Cdd:cd18047  151 DEADVMIATQGHQDQSIrIQRMLPRNCQM---LLFSATFEDSVWKFAQKVVPDP 201
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 426-485 1.25e-09

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 56.98  E-value: 1.25e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 426 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTAR 485
Cdd:cd18801   74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
 141-262 1.66e-09

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 57.21  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 141 GRDALVRSQTGSGKTLAYCVPVVQSLqaltsKIQRSDGPYALVLVPTRELALqsfDTVQKLLKPFTWIVPGVLMG---GE 217
Cdd:cd17922    1 GRNVLIAAPTGSGKTEAAFLPALSSL-----ADEPEKGVQVLYISPLKALIN---DQERRLEEPLDEIDLEIPVAvrhGD 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 254675193 218 KRKSEKARLRKGI-NILISTPGRLVDHIKSTKNLH-FNRIRWLIVDE 262
Cdd:cd17922   73 TSQSEKAKQLKNPpGILITTPESLELLLVNKKLRElFAGLRYVVVDE 119
PRK13767 PRK13767
ATP-dependent helicase; Provisional
 123-262 1.83e-09

ATP-dependent helicase; Provisional


Pssm-ID: 237497 [Multi-domain]  Cd Length: 876  Bit Score: 61.06  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 123 KMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELAlqsFDTVQKLL 202
Cdd:PRK13767  29 KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLGREGELEDKVYCLYVSPLRALN---NDIHRNLE 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675193 203 KPFTWI----------VPGVLMG---GEKRKSEKAR-LRKGINILISTPGRLVDHIKSTKnlhFNR----IRWLIVDE 262
Cdd:PRK13767 106 EPLTEIreiakergeeLPEIRVAirtGDTSSYEKQKmLKKPPHILITTPESLAILLNSPK---FREklrtVKWVIVDE 180
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
 131-263 7.85e-09

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 55.67  E-value: 7.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 131 QKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltskIQRSdGPYALVLVPTRELALQSFDTVQKLLKPFTW-IV 209
Cdd:cd17923    5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEAL------LRDP-GSRALYLYPTKALAQDQLRSLRELLEQLGLgIR 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675193 210 PGVLMGGEKRKSEKARLRKGINILISTPGRL---VDHIKSTKNLHFNRIRWLIVDEA 263
Cdd:cd17923   78 VATYDGDTPREERRAIIRNPPRILLTNPDMLhyaLLPHHDRWARFLRNLRYVVLDEA 134
DEXHc_RecG cd17992
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ...
 151-265 1.11e-07

DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350750 [Multi-domain]  Cd Length: 225  Bit Score: 52.92  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 151 GSGKTLaycVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVQKLLKPFTwIVPGVL---MGGEKRKSEKARLR 227
Cdd:cd17992   76 GSGKTV---VAALAMLAAVENGYQ------VALMAPTEILAEQHYDSLKKLLEPLG-IRVALLtgsTKAKEKREILEKIA 145

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 254675193 228 KG-INILISTpgrlvdHIKSTKNLHFNRIRWLIVDEADR 265
Cdd:cd17992  146 SGeIDIVIGT------HALIQEDVEFHNLGLVIIDEQHR 178
DDXDc_reverse_gyrase cd17924
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ...
 125-299 1.68e-07

DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350682 [Multi-domain]  Cd Length: 189  Bit Score: 51.94  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 125 SSMTSVQKQSIPVLLEGRDALVRSQTGSGKT---LAYCVpvvqslqALTSKIQRSdgpyaLVLVPTRELALQSFDTVQKL 201
Cdd:cd17924   16 FPPWGAQRTWAKRLLRGKSFAIIAPTGVGKTtfgLATSL-------YLASKGKRS-----YLIFPTKSLVKQAYERLSKY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 202 LKPFTWIVPGVLMGGEKRKSEKARLRKGI-----NILISTPGRLVDHIKSTKNLHFNRIrwlIVDEADRILDLGfeKDIT 276
Cdd:cd17924   84 AEKAGVEVKILVYHSRLKKKEKEELLEKIekgdfDILVTTNQFLSKNFDLLSNKKFDFV---FVDDVDAVLKSS--KNID 158

                        170       180
                 ....*....|....*....|...
gi 254675193 277 VILNAVNAecqkRQNVLLSATLT 299
Cdd:cd17924  159 RLLKLLGF----GQLVVSSATGR 177
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 441-487 2.20e-07

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 48.47  E-value: 2.20e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 254675193 441 SETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:cd18785   21 SSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 346-487 2.64e-07

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 50.17  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 346 DQHVVLVPSKLRLVCLaafILQKCKfEKNQKMIVFfsScelvefHYSLFLHTLlchsgtptSEHLPSASWplKFLRLHGN 425
Cdd:cd18793    3 PKIEEVVSGKLEALLE---LLEELR-EPGEKVLIF--S------QFTDTLDIL--------EEALRERGI--KYLRLDGS 60

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675193 426 MEQEERTSVFHEFSHSETG--VLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:cd18793   61 TSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIG 124
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 129-263 4.03e-07

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 53.30  E-value: 4.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 129 SVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQslqaltsKIQRSDGPYALVLVPTRELAlqsFDTVQKLLKPFTWI 208
Cdd:COG1205   59 SHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLE-------ALLEDPGATALYLYPTKALA---RDQLRRLRELAEAL 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675193 209 VPGVLMG---GEKRKSEKARLRKGINILISTP-----GRLVDHIKSTKNlhFNRIRWLIVDEA 263
Cdd:COG1205  129 GLGVRVAtydGDTPPEERRWIREHPDIVLTNPdmlhyGLLPHHTRWARF--FRNLRYVVIDEA 189
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
126-298 4.45e-07

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 52.98  E-value: 4.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 126 SMTSVQKQSIP-VLLEGRDALVRSQTGSGKTL-AYcVPVVQSLQAltskiqrsdGPYALVLVPTRELALQSFDTVQKLLK 203
Cdd:COG1204   22 ELYPPQAEALEaGLLEGKNLVVSAPTASGKTLiAE-LAILKALLN---------GGKALYIVPLRALASEKYREFKRDFE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 204 PFTWIVpGVLMGGekRKSEKARLRKGiNILISTPGRLvDHIKSTKNLHFNRIRWLIVDEA------DRILDLgfEkditV 277
Cdd:COG1204   92 ELGIKV-GVSTGD--YDSDDEWLGRY-DILVATPEKL-DSLLRNGPSWLRDVDLVVVDEAhliddeSRGPTL--E----V 160

                        170       180
                 ....*....|....*....|.
gi 254675193 278 ILNAVNAECQKRQNVLLSATL 298
Cdd:COG1204  161 LLARLRRLNPEAQIVALSATI 181
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 150-298 4.60e-07

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 49.61  E-value: 4.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 150 TGSGKTLaycvpVVQSLQALTSKiqrsdgPYALVLVPTRELALQsfdTVQKLLKPFTWIVPGVLmGGEKRKSEkarlrKG 229
Cdd:cd17926   27 TGSGKTL-----TALALIAYLKE------LRTLIVVPTDALLDQ---WKERFEDFLGDSSIGLI-GGGKKKDF-----DD 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675193 230 INILISTPGRLVDHIKSTKNLhFNRIRWLIVDEADRILDLGFEKditvILNAVNAECQkrqnVLLSATL 298
Cdd:cd17926   87 ANVVVATYQSLSNLAEEEKDL-FDQFGLLIVDEAHHLPAKTFSE----ILKELNAKYR----LGLTATP 146
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
426-487 2.59e-06

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 50.88  E-value: 2.59e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675193 426 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG 487
Cdd:COG1111  395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKR 456
ResIII pfam04851
Type III restriction enzyme, res subunit;
126-297 2.80e-06

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 47.67  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  126 SMTSVQKQSIPVLLEGRD-----ALVRSQTGSGKTLAycvpvvqSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQK 200
Cdd:pfam04851   3 ELRPYQIEAIENLLESIKngqkrGLIVMATGSGKTLT-------AAKLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193  201 LLkPFTWIVPGVLMGGEKRKSekarlRKGINILISTPGRLVDHIKSTKNLHF-NRIRWLIVDEADRILDLGFEKditvIL 279
Cdd:pfam04851  76 FL-PNYVEIGEIISGDKKDES-----VDDNKIVVTTIQSLYKALELASLELLpDFFDVIIIDEAHRSGASSYRN----IL 145

                         170
                  ....*....|....*...
gi 254675193  280 NAVNAECQkrqnVLLSAT 297
Cdd:pfam04851 146 EYFKPAFL----LGLTAT 159
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
125-262 4.67e-06

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 50.10  E-value: 4.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 125 SSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELAlqsFDTVQKLLKP 204
Cdd:COG1201   23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDELARRPRPGELPDGLRVLYISPLKALA---NDIERNLRAP 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675193 205 FTWIvpGVLMGGEKRK------------SEKARLRKGI-NILISTPGRLvdHI----KSTKNlHFNRIRWLIVDE 262
Cdd:COG1201  100 LEEI--GEAAGLPLPEirvgvrtgdtpaSERQRQRRRPpHILITTPESL--ALlltsPDARE-LLRGVRTVIVDE 169
SF2_C_RecG_TRCF cd18792
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ...
 407-469 3.67e-05

C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350179 [Multi-domain]  Cd Length: 160  Bit Score: 44.57  E-value: 3.67e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675193 407 SEHLPSASWPLkflrLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSA 469
Cdd:cd18792   55 KELVPEARVAL----LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDA 113
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
 406-500 5.67e-05

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 43.87  E-value: 5.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 406 TSEHLPSASWP-LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRI-GRT 483
Cdd:cd18811   50 MYEYLKERFRPeLNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHQLrGRV 129

                         90
                 ....*....|....*..
gi 254675193 484 ARiGCHGSSLLILAPSE 500
Cdd:cd18811  130 GR-GDHQSYCLLVYKDP 145
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 370-498 8.17e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 43.41  E-value: 8.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 370 KFEKNQKMIVFFSSCELVEfhysLFLHTLLchsgtptsEHLPSASWPLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCT 449
Cdd:cd18796   34 LLERHKSTLVFTNTRSQAE----RLAQRLR--------ELCPDRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVAT 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 254675193 450 DVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGcHGSSLLILAP 498
Cdd:cd18796  102 SSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRP-GAASKGRLVP 149
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
 353-485 8.51e-05

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 43.39  E-value: 8.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 353 PSKLRLVclaAFILQKckFEKNQKMIVFFSSCELVEfHYSLFLHTLLCHSGTPTSEhlpsaswplkflrlhgnmeqeeRT 432
Cdd:cd18789   33 PNKLRAL---EELLKR--HEQGDKIIVFTDNVEALY-RYAKRLLKPFITGETPQSE----------------------RE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254675193 433 SVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSA-PSSPAEYIHRIGRTAR 485
Cdd:cd18789   85 EILQNFREGEYNTLVVSKVGDEGIDLPEANVAIQISGhGGSRRQEAQRLGRILR 138
DEXHc_RIG-I cd17927
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ...
 139-265 1.92e-04

DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350685 [Multi-domain]  Cd Length: 201  Bit Score: 43.19  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 139 LEGRDALVRSQTGSGKTLaycVPVVQSLQALTsKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGvLMGGEK 218
Cdd:cd17927   15 LKGKNTIICLPTGSGKTF---VAVLICEHHLK-KFPAGRKGKVVFLANKVPLVEQQKEVFRKHFERPGYKVTG-LSGDTS 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 254675193 219 RKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADR 265
Cdd:cd17927   90 ENVSVEQIVESSDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 417-489 2.10e-04

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 41.81  E-value: 2.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675193 417 LKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTdVA-SRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIG----CH 489
Cdd:cd18794   55 ISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGlpseCI 131
SF2_C_TRCF cd18810
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ...
 422-465 2.33e-04

C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350197 [Multi-domain]  Cd Length: 151  Bit Score: 41.95  E-value: 2.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 254675193 422 LHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIV 465
Cdd:cd18810   57 AHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTII 100
PRK10917 PRK10917
ATP-dependent DNA helicase RecG; Provisional
 151-262 4.32e-04

ATP-dependent DNA helicase RecG; Provisional


Pssm-ID: 236794 [Multi-domain]  Cd Length: 681  Bit Score: 43.60  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 151 GSGKTLaycVPVVQSLQALTSKIQrsdgpyALVLVPTRELALQSFDTVQKLLKPFTwIVPGVLMGGEK---RKSEKARLR 227
Cdd:PRK10917 292 GSGKTV---VAALAALAAIEAGYQ------AALMAPTEILAEQHYENLKKLLEPLG-IRVALLTGSLKgkeRREILEAIA 361

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 254675193 228 KG-INILISTpgrlvdH--IKstKNLHFNRIRWLIVDE 262
Cdd:PRK10917 362 SGeADIVIGT------HalIQ--DDVEFHNLGLVIIDE 391
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
 129-302 5.66e-04

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 41.75  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 129 SVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPvvqslqALTskiqrSDGPyALVLVPTreLALQSfDTVQKLL---KPF 205
Cdd:cd17920   15 PGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLP------ALL-----LDGV-TLVVSPL--ISLMQ-DQVDRLQqlgIRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 206 TWIvPGVLMGGEKRKSEKARLRKGINILISTPGRLV--DHIKSTKNLH-FNRIRWLIVDEADRILDLG--FEKDITViLN 280
Cdd:cd17920   80 AAL-NSTLSPEEKREVLLRIKNGQYKLLYVTPERLLspDFLELLQRLPeRKRLALIVVDEAHCVSQWGhdFRPDYLR-LG 157

                        170       180
                 ....*....|....*....|..
gi 254675193 281 AVNAECQKRQNVLLSATLTEGV 302
Cdd:cd17920  158 RLRRALPGVPILALTATATPEV 179
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
 126-265 1.16e-03

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 40.48  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 126 SMTSVQKQSIPVLL------EGRDALVRSQTGSGKTLAYCVPVVQSLQAltskiqrsdGPYALVLVPTRELALQSFDTVQ 199
Cdd:cd17918   15 SLTKDQAQAIKDIEkdlhspEPMDRLLSGDVGSGKTLVALGAALLAYKN---------GKQVAILVPTEILAHQHYEEAR 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675193 200 KLLKPFtwivPGVLMGGEKRKSEKArlrkGINILISTPGRLvdHIKStknlHFNRIRWLIVDEADR 265
Cdd:cd17918   86 KFLPFI----NVELVTGGTKAQILS----GISLLVGTHALL--HLDV----KFKNLDLVIVDEQHR 137
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
 131-304 3.74e-03

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 39.16  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 131 QKQSIPVLLEGRDALVRSQTGSGKTLAYCVPvvqslqaltSKIQRSDGPyALVLVPTRELALQSfDTVQKlLKPftwIVP 210
Cdd:cd18018   17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLP---------ALLLRRRGP-GLTLVVSPLIALMK-DQVDA-LPR---AIK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 211 GVL----MGGEKRKSEKARLRKG-INILISTPGRLVdhikstkNLHF-------NRIRWLIVDEADRILDLG--FEKDIT 276
Cdd:cd18018   82 AAAlnssLTREERRRILEKLRAGeVKILYVSPERLV-------NESFrellrqtPPISLLVVDEAHCISEWShnFRPDYL 154

                        170       180
                 ....*....|....*....|....*...
gi 254675193 277 VILNAVNAECQKRQNVLLSATLTEGVTR 304
Cdd:cd18018  155 RLCRVLRELLGAPPVLALTATATKRVVE 182
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 138-298 4.00e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 38.85  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 138 LLEGRDALVRSQTGSGKTLAYCVPVVQSLqaltskiqrSDGPYALVLVPTRELALQSFDTVQKllkpftWIVPGVLMG-- 215
Cdd:cd18028   14 LLKGENLLISIPTASGKTLIAEMAMVNTL---------LEGGKALYLVPLRALASEKYEEFKK------LEEIGLKVGis 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 216 -GEKRksEKARLRKGINILISTPGRLVDHIKSTKNLhFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQKRQNVLL 294
Cdd:cd18028   79 tGDYD--EDDEWLGDYDIIVATYEKFDSLLRHSPSW-LRDVGVVVVDEIHLISDEERGPTLESIVARLRRLNPNTQIIGL 155


                 ....
gi 254675193 295 SATL 298
Cdd:cd18028  156 SATI 159
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 423-494 4.77e-03

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 40.26  E-value: 4.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675193  423 HGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLL 494
Cdd:PLN03137  711 HGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVL 782
DEXHc_TRCF cd17991
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair ...
 176-265 5.17e-03

DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350749 [Multi-domain]  Cd Length: 193  Bit Score: 38.71  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 176 SDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVpGVLMGGEKRKSEKA---RLRKG-INILISTpGRLVdhiksTKNLH 251
Cdd:cd17991   62 LSGKQVAVLVPTTLLAQQHYETFKERFANFPVNV-ELLSRFTTAAEQREileGLKEGkVDIVIGT-HRLL-----SKDVE 134

                         90
                 ....*....|....
gi 254675193 252 FNRIRWLIVDEADR 265
Cdd:cd17991  135 FKNLGLLIIDEEQR 148
PRK13766 PRK13766
Hef nuclease; Provisional
 426-485 6.58e-03

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 39.86  E-value: 6.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675193 426 MEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTAR 485
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR 466
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
 117-165 8.74e-03

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 38.12  E-value: 8.74e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 254675193 117 TINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQS 165
Cdd:cd18015    9 TLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCS 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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