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Conserved domains on  [gi|84781785|ref|NP_001028581|]
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leucine-rich repeat-containing G-protein coupled receptor 6 isoform a precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-838 5.81e-158

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 465.42  E-value: 5.81e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 PPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-465 5.60e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 5.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 100 NHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 179
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 180 RALNNLPALQAMTLA-LNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGtHSFEGLHNLETLDLNYNELQEFPLAIRTLGR 258
Cdd:COG4886  82 LSLLLLGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 259 LQELGFHNNNIKAIPEkafmgspllqtihfydnpiqfvgrsAFQYLSKLHTLSLNGaTDIQEFPD-LKGTTSLEILTLTR 337
Cdd:COG4886 161 LKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSN-NQITDLPEpLGNLTNLEELDLSG 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 338 AGIRLLPPGVcQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIgaDTFSQLGSLQALDLSWNAIRAIHPEA 417
Cdd:COG4886 215 NQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKE 291

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 84781785 418 FSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 465
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_8 pfam13855
Leucine rich repeat;
70-126 4.01e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 4.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84781785    70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 2.76e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 84781785     34 ACPAPCHCqEDGIMlsaDCSELGLSVVPADLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-838 5.81e-158

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 465.42  E-value: 5.81e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 PPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-465 5.60e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 5.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 100 NHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 179
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 180 RALNNLPALQAMTLA-LNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGtHSFEGLHNLETLDLNYNELQEFPLAIRTLGR 258
Cdd:COG4886  82 LSLLLLGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 259 LQELGFHNNNIKAIPEkafmgspllqtihfydnpiqfvgrsAFQYLSKLHTLSLNGaTDIQEFPD-LKGTTSLEILTLTR 337
Cdd:COG4886 161 LKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSN-NQITDLPEpLGNLTNLEELDLSG 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 338 AGIRLLPPGVcQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIgaDTFSQLGSLQALDLSWNAIRAIHPEA 417
Cdd:COG4886 215 NQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKE 291

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 84781785 418 FSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 465
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-435 9.79e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 114.56  E-value: 9.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   60 VPADLDPLTAYLDLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLHSLKILMLQSNQLRG-IPAEaL 134
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLVGqIPRE-L 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  135 WELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNHIR-HIPDYAFqNLTSL 212
Cdd:PLN00113 209 GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  213 VVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQ-EFPLAIRTLGRLQ---------------ELGFHNN--------- 267
Cdd:PLN00113 287 ISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQvlqlwsnkfsgeipkNLGKHNNltvldlstn 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  268 NIKA-IPEKAFMGSPLLQTIHFYDNPIQFVGRS--AFQYLSK--LHTLSLNGATDiQEFPDLKGTTSLEILTLTRAGiRL 342
Cdd:PLN00113 367 NLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSlgACRSLRRvrLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQG-RI 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  343 lpPGVCQQLPRLRILELSHNQIE-ELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTL 421
Cdd:PLN00113 445 --NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSC 522

                        410
                 ....*....|....
gi 84781785  422 RSLVKLDLTDNQLT 435
Cdd:PLN00113 523 KKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-286 3.06e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.67  E-value: 3.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  73 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLHSLKILMLQSNQLRGIpaEALWELPSLQSLRLDANLI 150
Cdd:cd21340   7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 151 SLVpErSFEGLSSLRHLWLDDnalteipvralNNLPALQAMTLALNHIRHIpdyafqnLTSLVVLHLHNNRIQHVgtHSF 230
Cdd:cd21340  81 SVV-E-GLENLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84781785 231 EGLHNLETLDLNYNELQEFP---LAIRTLGRLQELGFHNNNIKAIP---EKAFMGSPLLQTI 286
Cdd:cd21340 139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKPkyrDKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
92-150 8.35e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 8.35e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785    92 LEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
70-126 4.01e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 4.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84781785    70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 2.76e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 84781785     34 ACPAPCHCqEDGIMlsaDCSELGLSVVPADLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-838 5.81e-158

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 465.42  E-value: 5.81e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 PPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 562-838 2.18e-138

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 415.02  E-value: 2.18e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASGPSPlSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15138   1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15138  80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 PpeGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15138 160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15138 238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 562-838 3.21e-96

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 304.46  E-value: 3.21e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15363   1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYa 721
Cdd:cd15363  80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 pPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15363 159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15363 238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 562-837 1.86e-75

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 248.62  E-value: 1.86e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASGpSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15361   1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYa 721
Cdd:cd15361  80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 pPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15361 159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84781785 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDD 837
Cdd:cd15361 238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 273
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 562-838 7.61e-41

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 152.01  E-value: 7.61e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGE------YGASP 715
Cdd:cd14980  81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQpgdnrlYGYSS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 716 LCLPYAPpeGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRHVAWLIFADGLLYCPVA 790
Cdd:cd14980 161 ICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIRLALILITDLICWLPYY 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 84781785 791 FLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd14980 239 IVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 562-838 7.75e-38

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 143.12  E-value: 7.75e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 562 WGIRLAVWAIVLLSVLCNGLVLLtVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15136   1 WWLRIGVWFVFLLALVGNIIVLL-VLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15136  80 CKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 722 ppEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGL 800
Cdd:cd15136 160 --TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGL 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84781785 801 FPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15136 238 PLISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-465 5.60e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 5.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 100 NHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 179
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 180 RALNNLPALQAMTLA-LNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGtHSFEGLHNLETLDLNYNELQEFPLAIRTLGR 258
Cdd:COG4886  82 LSLLLLGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 259 LQELGFHNNNIKAIPEkafmgspllqtihfydnpiqfvgrsAFQYLSKLHTLSLNGaTDIQEFPD-LKGTTSLEILTLTR 337
Cdd:COG4886 161 LKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSN-NQITDLPEpLGNLTNLEELDLSG 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 338 AGIRLLPPGVcQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIgaDTFSQLGSLQALDLSWNAIRAIHPEA 417
Cdd:COG4886 215 NQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKE 291

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 84781785 418 FSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 465
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
121-461 4.77e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 4.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 121 LQSNQLRGIPAEALWELPSLQSLRLDANlislvpeRSFEGLSSLRHLWLDDNALTEIPVrALNNLPALQAMTLALNHIRH 200
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 201 IPDyAFQNLTSLVVLHLHNNRIQHVGThSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEkafmgs 280
Cdd:COG4886 151 LPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE------ 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 281 pllqtihfydnpiqfvgrsAFQYLSKLHTLSLNGaTDIQEFPDLKgttsleiltltragirllppgvcqQLPRLRILELS 360
Cdd:COG4886 223 -------------------PLANLTNLETLDLSN-NQLTDLPELG------------------------NLTNLEELDLS 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 361 HNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLA 440
Cdd:COG4886 259 NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                       330       340
                ....*....|....*....|.
gi 84781785 441 GLGGLMHLKLKGNLALSQAFS 461
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLL 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-446 1.11e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 1.11e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  63 DLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLHSLKILMLQSNQLRGIPAEaLWELPSLQS 142
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 143 LRLDANLISLVPErSFEGLSSLRHLWLDDNALTEIPVralnnlpalqamtlalnhirhipdyAFQNLTSLVVLHLHNNRI 222
Cdd:COG4886 141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSNNQI 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 223 QHVGtHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEkafmgspllqtihfydnpiqfvgrsaFQ 302
Cdd:COG4886 195 TDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE--------------------------LG 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 303 YLSKLHTLSLNGaTDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLR 382
Cdd:COG4886 248 NLTNLEELDLSN-NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84781785 383 HNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLM 446
Cdd:COG4886 327 LLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 564-838 1.02e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 110.76  E-value: 1.02e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 564 IRLAVWAIVLLSVLCNGLVLLTVFASGpSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQ 643
Cdd:cd15964   3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 644 ATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15964  82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 724 EgrPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15964 162 T--PLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84781785 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15964 240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRRDV 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-435 9.79e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 114.56  E-value: 9.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   60 VPADLDPLTAYLDLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLHSLKILMLQSNQLRG-IPAEaL 134
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLVGqIPRE-L 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  135 WELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNHIR-HIPDYAFqNLTSL 212
Cdd:PLN00113 209 GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  213 VVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQ-EFPLAIRTLGRLQ---------------ELGFHNN--------- 267
Cdd:PLN00113 287 ISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQvlqlwsnkfsgeipkNLGKHNNltvldlstn 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  268 NIKA-IPEKAFMGSPLLQTIHFYDNPIQFVGRS--AFQYLSK--LHTLSLNGATDiQEFPDLKGTTSLEILTLTRAGiRL 342
Cdd:PLN00113 367 NLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSlgACRSLRRvrLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQG-RI 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  343 lpPGVCQQLPRLRILELSHNQIE-ELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTL 421
Cdd:PLN00113 445 --NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSC 522

                        410
                 ....*....|....
gi 84781785  422 RSLVKLDLTDNQLT 435
Cdd:PLN00113 523 KKLVSLDLSHNQLS 536
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
208-471 1.18e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 1.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 208 NLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIh 287
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSL- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 288 fYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFpdlkgtTSLEILTLTRAGIRLLPPGVcQQLPRLRILELSHNQIEEL 367
Cdd:COG4886  80 -LLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL------TNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 368 PS-LHRCQKLEEIGLRHNRIKEIGADtFSQLGSLQALDLSWNAIRAIhPEAFSTLRSLVKLDLTDNQLTTLP--LAGLGG 444
Cdd:COG4886 152 PEpLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPepLANLTN 229

                       250       260
                ....*....|....*....|....*..
gi 84781785 445 LMHLKLKGNlALSQAFSKDSFPKLRIL 471
Cdd:COG4886 230 LETLDLSNN-QLTDLPELGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-313 5.32e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 5.32e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  51 DCSELGLSVVPADLDPLTA--YLDLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLHSLKILMLQSNQLRG 128
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLTNlkSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 129 IPAEaLWELPSLQSLRLDANLISLVPErsFEGLSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNHIRHI---PDYA 205
Cdd:COG4886 220 LPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLklkELEL 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 206 FQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQT 285
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       250       260
                ....*....|....*....|....*...
gi 84781785 286 IHFYDNPIQFVGRSAFQYLSKLHTLSLN 313
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLL 402
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 564-838 8.45e-24

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 102.24  E-value: 8.45e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 564 IRLAVWAIVLLSVLCNgLVLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQ 643
Cdd:cd15360   3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 644 ATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15360  82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 724 EgrPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15360 162 S--PLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84781785 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15360 240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 564-838 6.09e-22

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 96.86  E-value: 6.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 564 IRLAVWAIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQ 643
Cdd:cd15359   3 LRVLIWFINILAIAGNLIVLFVLLTS-RYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 644 ATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15359  82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 724 EGRPAAlgFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15359 162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 84781785 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15359 240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 564-836 2.23e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 89.57  E-value: 2.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 564 IRLAVWAIVLLSVLCNGLVLL--TVFASGPSPLSpvkLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLG 641
Cdd:cd15137   3 LRVFIWVVGIIALLGNLFVLIwrLKYKEENKVHS---FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 642 CQATGFLAVLGSEASVLLLTLAAVQCSISVTcvraygkapSPGSVRAGALGCLALAGLAA------------ALPLASVG 709
Cdd:cd15137  80 CTFAGFLATLSSEVSVLILTLITLDRFICIV---------FPFSGRRLGLRRAIIVLACIwliglllavlplLPWDYFGN 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 710 EYGASPLCLPYAPPEGRPAALGFAVALVM-MNSLCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADG 783
Cdd:cd15137 151 FYGRSGVCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDF 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84781785 784 LLYCPVAFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRD 836
Cdd:cd15137 231 LCWIPIIVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-286 3.06e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.67  E-value: 3.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  73 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLHSLKILMLQSNQLRGIpaEALWELPSLQSLRLDANLI 150
Cdd:cd21340   7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 151 SLVpErSFEGLSSLRHLWLDDnalteipvralNNLPALQAMTLALNHIRHIpdyafqnLTSLVVLHLHNNRIQHVgtHSF 230
Cdd:cd21340  81 SVV-E-GLENLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84781785 231 EGLHNLETLDLNYNELQEFP---LAIRTLGRLQELGFHNNNIKAIP---EKAFMGSPLLQTI 286
Cdd:cd21340 139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKPkyrDKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
92-150 8.35e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 8.35e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785    92 LEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-438 1.55e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.97  E-value: 1.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 161 LSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNHIRHIPDyaFQNLTSLVVLHLHNNRIQHVGthSFEGLHNLETLD 240
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 241 LNYNElqefplaIRTLGRLQELgfhnnnikaipekafmgsPLLQTIHfydnpiqfvgrsafqyLSKlhtlslngatdiQe 320
Cdd:cd21340  75 LGGNR-------ISVVEGLENL------------------TNLEELH----------------IEN------------Q- 100

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 321 fpDLKGTTSLEILTLTRAGIRllppgvcqqlPRLRILELSHNQIEELPSLhrcqkleeiglrhnrikeigadtfSQLGSL 400
Cdd:cd21340 101 --RLPPGEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPL------------------------APLRNL 144

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 84781785 401 QALDLSWNAIRAIHP--EAFSTLRSLVKLDLTDNQLTTLP 438
Cdd:cd21340 145 EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 304-453 2.78e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 304 LSKLHTLSLNGaTDIQEFPDLKGTTSLEILTLTRAGIRLLPPgvCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRH 383
Cdd:cd21340   1 LKRITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 384 NRIKEI-GADTFSQL---------------------------GSLQALDLSWNAIRAIHPeaFSTLRSLVKLDLTDNQLT 435
Cdd:cd21340  78 NRISVVeGLENLTNLeelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|...
gi 84781785 436 -----TLPLAGLGGLMHLKLKGN 453
Cdd:cd21340 156 dleelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
186-246 5.19e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 5.19e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   186 PALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNEL 246
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
374-434 5.19e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 5.19e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   374 QKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQL 434
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 156-386 2.29e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 2.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 156 RSFEGLS---SLRHLWLDDNALTEIPvrALNNLPALQAMTLALNHIRHIPDyaFQNLTSLVVLHLHNNRIQHVGthSFEG 232
Cdd:cd21340  15 TKIDNLSlckNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--GLEN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 233 LHNLETLDLNYNELQEfplairtlgrlqelgfhnnnikaipekafmGSPLLqtihfydnpiqFVGRSafqylskLHTLSl 312
Cdd:cd21340  89 LTNLEELHIENQRLPP------------------------------GEKLT-----------FDPRS-------LAALS- 119

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84781785 313 ngatdiqefpdlkgtTSLEILTLTRAGIRLLPPGVCqqLPRLRILELSHNQIEEL----PSLHRCQKLEEIGLRHNRI 386
Cdd:cd21340 120 ---------------NSLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 564-838 1.81e-11

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 65.96  E-value: 1.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 564 IRLAVWAIVLLSVLCNGLVL-LTVFASGPSPLSPVKLVVgaMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGC 642
Cdd:cd15966   3 LRVFVWVMAFITCFGNLFVIgMRSFIRAENKTHAMCIKI--LCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 643 QATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKapsPGSVRAGALGCLALAGLAAALPLASVGE------YGASPL 716
Cdd:cd15966  81 RIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFSNIR---PGKCQTLIILISIWLVGFIIAVIPFWNEdffgnyYGKNGV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 717 CLP-YAPPEGRPAALGFAVALVM-MNSLCFLVVAGAYIKLYCDLPRGDFEAV-------WDCAMVRHVAWLIFADGLLYC 787
Cdd:cd15966 158 CFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTevrshihRDVAVANRFFFIVFSDAICWI 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 84781785 788 PVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFRDDL 838
Cdd:cd15966 238 PIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLTTSFFKEKL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-262 2.76e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   60 VPADL---DPLTAyLDLSMNNLTELQP-------GLFHHLRF-----------------LEELRLSGNHLSHIPGQAFSG 112
Cdd:PLN00113 348 IPKNLgkhNNLTV-LDLSTNNLTGEIPeglcssgNLFKLILFsnslegeipkslgacrsLRRVRLQDNSFSGELPSEFTK 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  113 LHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFeGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 192
Cdd:PLN00113 427 LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84781785  193 LALNHIR-HIPDyAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQ-EFPlaiRTLGRLQEL 262
Cdd:PLN00113 506 LSENKLSgEIPD-ELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIP---KNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
70-126 4.01e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 4.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84781785    70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
210-269 3.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.28e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   210 TSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEF-PLAIRTLGRLQELGFHNNNI 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
162-222 3.99e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   162 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRI 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-291 9.38e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.79  E-value: 9.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   55 LGLSVVPADLDPLTAYLDLSMNNLTELQPGlfhhlrfleelrLSGNhlshipgqafsglhsLKILMLQSNQLRGIPAeal 134
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEN------------LQGN---------------IKTLYANSNQLTSIPA--- 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  135 wELP-SLQSLRLDANLISLVPERSfegLSSLRHLWLDDNALTEIPvralNNLP-ALQAMTLALNHIRHIPDYAfqnLTSL 212
Cdd:PRK15370 238 -TLPdTIQEMELSINRITELPERL---PSALQSLDLFHNKISCLP----ENLPeELRYLSVYDNSIRTLPAHL---PSGI 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  213 VVLHLHNNRIqhvgTHSFEGL-HNLETLDLNYNELQEFPLAIRTlgRLQELGFHNNNIKAIPEKAfmgSPLLQTIHFYDN 291
Cdd:PRK15370 307 THLNVQSNSL----TALPETLpPGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL---PPTITTLDVSRN 377
LRR_8 pfam13855
Leucine rich repeat;
352-410 1.25e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.25e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   352 PRLRILELSHNQIEELP--SLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAI 410
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-250 2.11e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   57 LSVVPADLDPLTAYLDLSMNNLTELQPglfHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILmlqSNQLRGIPAealwE 136
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTLPA----H 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  137 LPS-LQSLRLDANLISLVPERSFEGLSSLRhlwLDDNALTEIPVRAlnnLPALQAMTLALNHIRHIPDYAFQNLTSLVVL 215
Cdd:PRK15370 302 LPSgITHLNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASL---PPELQVLDVSKNQITVLPETLPPTITTLDVS 375

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 84781785  216 HlhnnriqHVGTHSFEGL-HNLETLDLNYNELQEFP 250
Cdd:PRK15370 376 R-------NALTNLPENLpAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
138-198 5.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 5.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   138 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHI 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 565-836 3.08e-08

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 56.03  E-value: 3.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 565 RLAVWAIVLLSVLCNGLVLLT-VFASGPSPLSPVKLVvgAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQ 643
Cdd:cd15965   4 RVFVWVVSAVTCFGNIFVICMrPYIRSENKLHAMSII--SLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 644 ATGFLAVLGSEASVLLLTLAAVQCSIsvtCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGE------YGASPLC 717
Cdd:cd15965  82 LVGSLAILSTEVSVLLLTYLTLEKYI---CIVYPFRCLTPGKCRTITILILIWIIGFIIAFIPLSNKeffrnyYGTNGVC 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 718 LPY--APPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVW-------DCAMVRHVAWLIFADGLLYCP 788
Cdd:cd15965 159 FPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTAIMATEisnhikkEMTLAKRFFFIVFTDALCWIP 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 84781785 789 VAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFRD 836
Cdd:cd15965 239 IFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTLTTRPFKE 285
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 201-320 3.32e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 52.93  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   201 IPDYAFQN--LTSLVVlhlhNNRIQHVGTHSFEGLHNLETLDLNYNelqefplaIRTLGR-------LQELGFhNNNIKA 271
Cdd:pfam13306   3 IGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCTSLKSITLPSS--------LTSIGSyafyncsLTSITI-PSSLTS 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 84781785   272 IPEKAFMGSPLLQTIHFYDNpIQFVGRSAFQYlSKLHTLSL-NGATDIQE 320
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITIpSSVTTIGS 117
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
49-203 4.80e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   49 SADCSELGLSVVPADLDPLTAYLDLSMNNLTELQPglfHHLRFLEELRLSGNHLSHIPGQAFSGlhsLKILMLQSNQLRG 128
Cdd:PRK15370 266 SLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTS 339

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 84781785  129 IPAEAlweLPSLQSLRLDANLISLVPERSfegLSSLRHLWLDDNALTEIPvralNNLP-ALQAMTLALNHIRHIPD 203
Cdd:PRK15370 340 LPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-392 5.26e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.82  E-value: 5.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 143 LRLDANLISLVPERSFEGLSSLRH---LWLDDNALTEIPVRALNNL----PALQAMTLALNHIRHIPDY------AFQNL 209
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLClqvLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGlqsllqGLTKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 210 TSLVVLHLHNNRIQHVGTHSFEGLH---NLETLDLNYNELQEFPLAI--RTLG----RLQELGFHNNNIKAIP----EKA 276
Cdd:cd00116  81 CGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLlaKGLKdlppALEKLVLGRNRLEGAScealAKA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 277 FMGSPLLQTIHFYDNPIQFVG----RSAFQYLSKLHTLSLN-------GATDIQE-FPDLKgttSLEILTL-----TRAG 339
Cdd:cd00116 161 LRANRDLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNLgdnnlTDAG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785 340 IRLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQ------KLEEIGLRHNRIKEIGAD 392
Cdd:cd00116 238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-248 6.57e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 6.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  70 YLDLSMNNLTELQPGLF---HHLRFLEELRLSGN-----HLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWE-LPSL 140
Cdd:cd00116  85 ELDLSDNALGPDGCGVLeslLRSSSLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKaLRAN 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 141 QSLR---------LDANLISLVpeRSFEGLSSLRHLWLDDNALTEIPVRAL----NNLPALQAMTLALNHIRHIPDYAFQ 207
Cdd:cd00116 165 RDLKelnlanngiGDAGIRALA--EGLKANCNLEVLDLNNNGLTDEGASALaetlASLKSLEVLNLGDNNLTDAGAAALA 242

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 84781785 208 N-----LTSLVVLHLHNNRIQHVGTHSF-EGLHN---LETLDLNYNELQE 248
Cdd:cd00116 243 SallspNISLLTLSLSCNDITDDGAKDLaEVLAEkesLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
399-454 1.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.18e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785   399 SLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGNL 454
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 139-283 2.05e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 50.62  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   139 SLQSLRLDANLISlVPERSFEGLSSLRHLWLDDNaLTEIPVRALNNLPaLQAMTLAlNHIRHIPDYAFQNLTSLVVLHLH 218
Cdd:pfam13306  12 SLTSITIPSSLTS-IGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 84781785   219 NNrIQHVGTHSFEGLhNLETLDLnynelqefplairtlgrlqelgfhNNNIKAIPEKAFMGSPLL 283
Cdd:pfam13306  88 SN-LTSIGSYAFSNC-SLKSITI------------------------PSSVTTIGSYAFSNCSNL 126
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 85-432 2.14e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 55.27  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785    85 LFHHLRFLeelRLSGNHLSHIPgqafSGLHSLKILMLQsnqLRGIPAEALWE----LPSLQS--LRLDANLISlVPERSF 158
Cdd:PLN03210  587 LPPKLRLL---RWDKYPLRCMP----SNFRPENLVKLQ---MQGSKLEKLWDgvhsLTGLRNidLRGSKNLKE-IPDLSM 655

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   159 EglSSLRHLWLDD-NALTEIP--VRALNNLPALQaMTlALNHIRHIPDYAfqNLTSLVVLHLHN-NRIQhvgthSFEGLH 234
Cdd:PLN03210  656 A--TNLETLKLSDcSSLVELPssIQYLNKLEDLD-MS-RCENLEILPTGI--NLKSLYRLNLSGcSRLK-----SFPDIS 724

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   235 -NLETLDLNYNELQEFPLAIRtLGRLQELGFHNNNIKAIPEKA-------FMGSPLLQTIHFYDNPIQFVGRSAFQYLSK 306
Cdd:PLN03210  725 tNISWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVqpltplmTMLSPSLTRLFLSDIPSLVELPSSIQNLHK 803

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   307 LHTLS-----------------------LNGATDIQEFPDLkgTTSLEILTLTRAGIRLLPPGVcQQLPRLRILelshnq 363
Cdd:PLN03210  804 LEHLEiencinletlptginleslesldLSGCSRLRTFPDI--STNISDLNLSRTGIEEVPWWI-EKFSNLSFL------ 874

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785   364 ieelpSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQalDLSWNAIRAIHPEAFSTLRSLVKLDLTDN 432
Cdd:PLN03210  875 -----DMNGCNNLQRVSLNISKLKHLETVDFSDCGALT--EASWNGSPSEVAMATDNIHSKLPSTVCIN 936
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-442 3.08e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 3.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 230 FEGLHNLETLDLNYNELQEFPL-----AIRTLGRLQELGFHNNNIKAIPEkaFMGSPLlqtihfydnpiqfvgrSAFQYL 304
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEEAAkalasALRPQPSLKELCLSLNETGRIPR--GLQSLL----------------QGLTKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 305 SKLHTLSLN----GATDIQEFPDLKGTTSLEILTLTRAGI-----RLLPPGVCQQLPRLRILELSHNQIE---------E 366
Cdd:cd00116  81 CGLQELDLSdnalGPDGCGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgascealakA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 367 LPSLhrcQKLEEIGLRHNRIKEIGADT----FSQLGSLQALDLSWNAIR----AIHPEAFSTLRSLVKLDLTDNQLTTLP 438
Cdd:cd00116 161 LRAN---RDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAG 237


                ....
gi 84781785 439 LAGL 442
Cdd:cd00116 238 AAAL 241
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-224 1.22e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  67 LTAyLDLSMNNLTELQPglFHHLRFLEELRLSGNHLSHIPGqaFSGLHSLKILMLqSNQlrgipaealwELPSLQSLRLD 146
Cdd:cd21340  48 LTH-LYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ----------RLPPGEKLTFD 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 147 anlislvpERSFEGLS-SLRHLWLDDNALTEIpvRALNNLPALQAMTLALNHIRHIPD--YAFQNLTSLVVLHLHNNRIQ 223
Cdd:cd21340 112 --------PRSLAALSnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181


                .
gi 84781785 224 H 224
Cdd:cd21340 182 K 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 208-473 2.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  208 NLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQ-EFPLAIRTLG-RLQELGFHNNNIKAIPEKAFMgsPLLQT 285
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSI--PNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  286 IHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFP-DLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQI 364
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  365 E-ELP-SLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTtlplagl 442
Cdd:PLN00113 225 SgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS------- 297

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 84781785  443 GGLMHLKLK-GNLALSQAFSKD----------SFPKLRILEV 473
Cdd:PLN00113 298 GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPRLQVLQL 339
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-453 2.14e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 51.33  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  67 LTAYLDLSMNNLTELQpgLFHHLR-FLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSN-QLRGIPAEALWELpslQSLR 144
Cdd:COG5238  10 RNIEELLSANPATTEQ--SELTKRaTIVNLRSYHLHGGAILLARYLQSRSSITQYLRFEgQGDPGLNPVALEK---AAEA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 145 LDANLISLVPERSfEGLSSLRhLWLDDNALTEIPV---RALNNLpALQAMTLALNHIRHIPDYA---FQNLTSLVVLHLH 218
Cdd:COG5238  85 FPTQLLVVDWEGA-EEVSPVA-LAETATAVATPPPdlrRIMAKT-LEDSLILYLALPRRINLIQvlkDPLGGNAVHLLGL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 219 NNRIQHVGTHS---FEGLHNLETLDLNYNELQEfpLAIRTLGrlqelgfhnnnikaipeKAFMGSPLLQTIHFYDNPIQF 295
Cdd:COG5238 162 AARLGLLAAISmakALQNNSVETVYLGCNQIGD--EGIEELA-----------------EALTQNTTVTTLWLKRNPIGD 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 296 VGRSAF----QYLSKLHTLSL--NGATD--IQEFPD-LKGTTSLEILTL-----TRAGIRLLPPGVcQQLPRLRILELSH 361
Cdd:COG5238 223 EGAEILaealKGNKSLTTLDLsnNQIGDegVIALAEaLKNNTTVETLYLsgnqiGAEGAIALAKAL-QGNTTLTSLDLSV 301

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 362 NQIEE------LPSLHRCQKLEEIGLRHNRIKEIGadtfsqlgslqaldlsWNAIraihPEAFSTLRSLVKLDLTDNQLT 435
Cdd:COG5238 302 NRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQG----------------AIAL----AKALQENTTLHSLDLSDNQIG 361

                       410
                ....*....|....*...
gi 84781785 436 TlplAGLGGLMHLkLKGN 453
Cdd:COG5238 362 D---EGAIALAKY-LEGN 375
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 92-212 2.16e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.92  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785    92 LEELRLSgNHLSHIPGQAFSGLHSLKILMLQSNqLRGIPAEALWELpSLQSLRLDANLISLvPERSFEGLSSLRHLWLDD 171
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSSLTSI-GEYAFSNCSNLKSITLPS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 84781785   172 NaLTEIPVRALNNLPaLQAMTLAlNHIRHIPDYAFQNLTSL 212
Cdd:pfam13306  89 N-LTSIGSYAFSNCS-LKSITIP-SSVTTIGSYAFSNCSNL 126
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 570-831 3.14e-06

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 49.98  E-value: 3.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 570 AIVLLSVLCNGLVLLTVFASgPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTygqfaeyGARWESGLGCQATGFLA 649
Cdd:cd00637   7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-------GRWWFGDALCKLLGFLQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 650 VLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGRPAA 729
Cdd:cd00637  79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785 730 LGFAVALVMMN-SLCFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 795
Cdd:cd00637 159 KAYTIFLFVLLfLLPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 84781785 796 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 831
Cdd:cd00637 239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
LRR_8 pfam13855
Leucine rich repeat;
258-314 1.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 84781785   258 RLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNG 314
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 372-445 1.54e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.66  E-value: 1.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84781785  372 RCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGL 445
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
51-273 4.64e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.46  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   51 DCSELGLSVVPADLDPLTAYLDLSMNNLTELqPGLFHHLRFLEelrLSGNHLSHIPGQAfSGLHSLKILmlqSNQLRGIP 130
Cdd:PRK15387 207 NVGESGLTTLPDCLPAHITTLVIPDNNLTSL-PALPPELRTLE---VSGNQLTSLPVLP-PGLLELSIF---SNPLTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  131 AealweLPSlqslrldanlislvpersfeglsSLRHLWLDDNALTEIPVRAlnnlPALQAMTLALNHIRHIPDYAfqnlT 210
Cdd:PRK15387 279 A-----LPS-----------------------GLCKLWIFGNQLTSLPVLP----PGLQELSVSDNQLASLPALP----S 322

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 84781785  211 SLVVLHLHNNRIQHVGTHSfEGLHNLETLDlnyNELQEFPlairTL-GRLQELGFHNNNIKAIP 273
Cdd:PRK15387 323 ELCKLWAYNNQLTSLPTLP-SGLQELSVSD---NQLASLP----TLpSELYKLWAYNNRLTSLP 378
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 352-389 6.42e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 6.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 84781785   352 PRLRILELSHNQIEELPSLHRCQKLEEIGLRHN-RIKEI 389
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDL 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
333-472 1.31e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  333 LTLTRAGIRLLPPGVCQQ-------------LPR-----LRILELSHNQIEELPSLHRcQKLEEIGLRHNRIKEIGADTF 394
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQittlildnnelksLPEnlqgnIKTLYANSNQLTSIPATLP-DTIQEMELSINRITELPERLP 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84781785  395 SqlgSLQALDLSWNAIRAIhPEAFStlRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNlalSQAFSKDSFP-KLRILE 472
Cdd:PRK15370 262 S---ALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPpGLKTLE 331
PLN03150 PLN03150
hypothetical protein; Provisional
 379-453 2.78e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 2.78e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 84781785  379 IGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 453
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRilnLNGN 500
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-199 4.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 4.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785  71 LDLSMNNLTElqPG---LFHHLRF---LEELRLSGNHLSHiPG-----QAFSGLHSLKILMLQSNQLRG---IP-AEALW 135
Cdd:COG5238 269 LYLSGNQIGA--EGaiaLAKALQGnttLTSLDLSVNRIGD-EGaialaEGLQGNKTLHTLNLAYNGIGAqgaIAlAKALQ 345

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785 136 ELPSLQSLRLDANLIS----LVPERSFEGLSSLRHLWLDDNALTEIPVRALN---NLPALQAMTLALNHIR 199
Cdd:COG5238 346 ENTTLHSLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
305-364 4.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84781785   305 SKLHTLSLNGaTDIQEFPD--LKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQI 364
Cdd:pfam13855   1 PNLRSLDLSN-NRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 210-244 1.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 84781785   210 TSLVVLHLHNNRIQHVGthSFEGLHNLETLDLNYN 244
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 2.76e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.14  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 84781785     34 ACPAPCHCqEDGIMlsaDCSELGLSVVPADLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 267-335 4.28e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 4.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 84781785   267 NNIKAIPEKAFMGSPLLQTIHFYDNpIQFVGRSAFqYLSKLHTLSLNgaTDIQEFPD--LKGTTSLEILTL 335
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAF-YNCSLTSITIP--SSLTSIGEyaFSNCSNLKSITL 86
PLN03150 PLN03150
hypothetical protein; Provisional
 91-186 6.22e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   91 FLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLIS-LVPErSFEGLSSLRHLWL 169
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPE-SLGQLTSLRILNL 497

                         90
                 ....*....|....*...
gi 84781785  170 DDNALT-EIPVrALNNLP 186
Cdd:PLN03150 498 NGNSLSgRVPA-ALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 71-151 9.14e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 9.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781785   71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLI 150
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 84781785  151 S 151
Cdd:PLN03150 503 S 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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