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Conserved domains on  [gi|268370275|ref|NP_001028606|]
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leucine-rich repeat-containing protein 37A [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1248-1394 3.83e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


:

Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.46  E-value: 3.83e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  1248 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 1327
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268370275  1328 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 1394
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 67-131 5.13e-21

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 88.19  E-value: 5.13e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275    67 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 131
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 170-238 9.68e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 73.17  E-value: 9.68e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   170 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 238
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 276-343 8.86e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.47  E-value: 8.86e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   276 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 343
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
601-658 2.26e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.26e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 268370275   601 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 658
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
578-729 1.46e-10

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  578 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 655
Cdd:COG4886   117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  656 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 729
Cdd:COG4886   192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4-179 7.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 7.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275     4 QPLDQELTMSSQPPGYTHHSPNAAKTENHTPENNFFPYAEPPMgmVVQPPDLFFLKSTKSNLVQETPSLitkspkevaah 83
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA--TSQPPNQTQSTAAPHTLIQQTPTL----------- 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275    84 tleYKKRLPP--VPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPPNPKETKNYTPGKIFLHYADTPLGMiVEPPD 161
Cdd:pfam03154  238 ---HPQRLPSphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQ-VPPGP 313

                          170
                   ....*....|....*...
gi 268370275   162 LFFLKTTTSEPVQETPSQ 179
Cdd:pfam03154  314 SPAAPGQSQQRIHTPPSQ 331
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1248-1394 3.83e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.46  E-value: 3.83e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  1248 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 1327
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268370275  1328 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 1394
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 67-131 5.13e-21

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 88.19  E-value: 5.13e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275    67 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 131
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 170-238 9.68e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 73.17  E-value: 9.68e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   170 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 238
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 276-343 8.86e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.47  E-value: 8.86e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   276 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 343
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
601-658 2.26e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.26e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 268370275   601 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 658
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
578-729 1.46e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  578 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 655
Cdd:COG4886   117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  656 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 729
Cdd:COG4886   192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 603-704 1.67e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  603 LILSENHLTELhkESFEGLLSLQVLDLSCNKIR--------------YIER-----G---TFEP------LPFLKYMNL- 653
Cdd:cd21340    51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISvveglenltnleelHIENqrlppGeklTFDPrslaalSNSLRVLNIs 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  654 GCNL--LTELSfgtfqawhGMQFLQQLILSRNPLAVVED--PYFFKLPALKYLDL 704
Cdd:cd21340   129 GNNIdsLEPLA--------PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4-179 7.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 7.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275     4 QPLDQELTMSSQPPGYTHHSPNAAKTENHTPENNFFPYAEPPMgmVVQPPDLFFLKSTKSNLVQETPSLitkspkevaah 83
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA--TSQPPNQTQSTAAPHTLIQQTPTL----------- 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275    84 tleYKKRLPP--VPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPPNPKETKNYTPGKIFLHYADTPLGMiVEPPD 161
Cdd:pfam03154  238 ---HPQRLPSphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQ-VPPGP 313

                          170
                   ....*....|....*...
gi 268370275   162 LFFLKTTTSEPVQETPSQ 179
Cdd:pfam03154  314 SPAAPGQSQQRIHTPPSQ 331
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1248-1394 3.83e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.46  E-value: 3.83e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  1248 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 1327
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268370275  1328 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 1394
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 67-131 5.13e-21

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 88.19  E-value: 5.13e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275    67 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 131
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 170-238 9.68e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 73.17  E-value: 9.68e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   170 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 238
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 276-343 8.86e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.47  E-value: 8.86e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370275   276 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 343
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
601-658 2.26e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.26e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 268370275   601 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 658
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
623-685 1.30e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 268370275   623 SLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLLTELSFGTFqawHGMQFLQQLILSRNPL 685
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
578-729 1.46e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  578 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 655
Cdd:COG4886   117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  656 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 729
Cdd:COG4886   192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
579-729 4.08e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 4.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  579 LNFKGNDISFIDKNVWKVYRwTEKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERgTFEPLPFLKYMNLGCNLL 658
Cdd:COG4886   164 LDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370275  659 TELSfgtfqAWHGMQFLQQLILSRNPLAVVedPYFFKLPALKYLDLGTTQVQLTTVESILIKTLELEHLIL 729
Cdd:COG4886   241 TDLP-----ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-729 3.79e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  561 LQQVPVPRPNTYNDTFVILNFKGNDISFIDKNVWKVYRWTEKLILSENHLTELHKESFEGLLSLQVLDLSCNKiryierg 640
Cdd:COG4886    35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  641 TFEPLPFLKYMNLGCNLLTELSFGTFQawhgMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESILIK 720
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEELAN----LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN--QLTDLPEELGN 180


                  ....*....
gi 268370275  721 TLELEHLIL 729
Cdd:COG4886   181 LTNLKELDL 189
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
545-729 5.04e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  545 CENETLLCVHLSPKWRLQQVPVPRPNTYNDTFVILNFKGNDISFIDKNVWKVYRWTEKLILSENhltelhkESFEGLLSL 624
Cdd:COG4886    43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  625 QVLDLSCNKIRYIERgTFEPLPFLKYMNLGCNLLTEL--SFGTFQAwhgmqfLQQLILSRNPLAVVEDPyFFKLPALKYL 702
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLpePLGNLTN------LKSLDLSNNQLTDLPEE-LGNLTNLKEL 187

                         170       180
                  ....*....|....*....|....*..
gi 268370275  703 DLGTTqvQLTTVESILIKTLELEHLIL 729
Cdd:COG4886   188 DLSNN--QITDLPEPLGNLTNLEELDL 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
601-735 8.37e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 8.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  601 EKLILSENHLTELhkESFEGLLSLQVLDLSCNKIRYIerGTFEPLPFLKYMNLGCNLLTELSFGTFQAWHGMQFLQQLIL 680
Cdd:COG4886   231 ETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  681 SRNPLAVVEDPYFFKLPALKYLDLGTTQVQLTTVESILIKTLELEHLILPSHMAC 735
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 603-704 1.67e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275  603 LILSENHLTELhkESFEGLLSLQVLDLSCNKIR--------------YIER-----G---TFEP------LPFLKYMNL- 653
Cdd:cd21340    51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISvveglenltnleelHIENqrlppGeklTFDPrslaalSNSLRVLNIs 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 268370275  654 GCNL--LTELSfgtfqawhGMQFLQQLILSRNPLAVVED--PYFFKLPALKYLDL 704
Cdd:cd21340   129 GNNIdsLEPLA--------PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4-179 7.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 7.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275     4 QPLDQELTMSSQPPGYTHHSPNAAKTENHTPENNFFPYAEPPMgmVVQPPDLFFLKSTKSNLVQETPSLitkspkevaah 83
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA--TSQPPNQTQSTAAPHTLIQQTPTL----------- 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370275    84 tleYKKRLPP--VPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPPNPKETKNYTPGKIFLHYADTPLGMiVEPPD 161
Cdd:pfam03154  238 ---HPQRLPSphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQ-VPPGP 313

                          170
                   ....*....|....*...
gi 268370275   162 LFFLKTTTSEPVQETPSQ 179
Cdd:pfam03154  314 SPAAPGQSQQRIHTPPSQ 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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