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Conserved domains on  [gi|77404405|ref|NP_001029182|]
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TLR4 interactor with leucine rich repeats precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-359 9.12e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 9.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 104 EKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEigrlsrgSFEGLESLVKLRLDGNVLGALPDAvFAPLGNLLY 183
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 184 LHLEANRIRFLGKnAFTQLGKLRFLNLSANELQpSLrhAATFVPLRSLSTLILSANSLQHLgPRVFQHLPRLGLLSLSGN 263
Cdd:COG4886 141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT-DL--PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 264 QLTHLaPEAFWGLEALRELRLEGNRLNQLPLtlLEPLHSLEALDLSGNELSALHPAtfGHQGRLRELSLRDNALSALSGD 343
Cdd:COG4886 216 QLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*.
gi 77404405 344 IFAASPALYRLDLDGN 359
Cdd:COG4886 291 ELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
65-119 1.30e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 77404405    65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-441 1.02e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405    332 LRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVfVQCRHPPALRGKYLdyLDDQLLQN 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL--LGIPLLDS 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 77404405    412 G------SCVDPSPSPTAGSR-QWPISTAPGEGMTPP 441
Cdd:TIGR00864   79 GcdeeyvACLKDNSSGGGAARsELVIFSAAHEGLFQP 115
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-56 1.98e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 1.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 77404405     27 CPERCDCqHPQHLLCTNRGLRAVPktSSLP 56
Cdd:smart00013   2 CPAPCNC-SGTAVDCSGRGLTEVP--LDLP 28
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 589-667 2.69e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   589 NLTVEAVSANSASVRWavrehRSPRPQGGA--RFRLLF-DRFGQQPKFQRFVylPERSDSATLHELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 77404405   666 GG 667
Cdd:pfam00041  78 GG 79
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-359 9.12e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 9.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 104 EKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEigrlsrgSFEGLESLVKLRLDGNVLGALPDAvFAPLGNLLY 183
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 184 LHLEANRIRFLGKnAFTQLGKLRFLNLSANELQpSLrhAATFVPLRSLSTLILSANSLQHLgPRVFQHLPRLGLLSLSGN 263
Cdd:COG4886 141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT-DL--PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 264 QLTHLaPEAFWGLEALRELRLEGNRLNQLPLtlLEPLHSLEALDLSGNELSALHPAtfGHQGRLRELSLRDNALSALSGD 343
Cdd:COG4886 216 QLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*.
gi 77404405 344 IFAASPALYRLDLDGN 359
Cdd:COG4886 291 ELELLLGLNSLLLLLL 306
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-355 1.23e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  65 SLGGNFITNITafDFHRLGQLRRLDLQYNQIRSLhpKTFEKLSRLEELYLGNNLLQALAPgtLAPLRKLRILYANGNEIG 144
Cdd:cd21340   8 YLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 145 RLsrgsfEGLESLVKLRldgnvlgalpdavfaplgnllYLHLEANRirflgknaftqlgklrflnLSANElqpSLrhaaT 224
Cdd:cd21340  82 VV-----EGLENLTNLE---------------------ELHIENQR-------------------LPPGE---KL----T 109

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 225 FVPlRSLSTLilsANSLQHLgprvfqhlprlgllSLSGNQLTHLAPeafwglealrelrlegnrlnqlpltlLEPLHSLE 304
Cdd:cd21340 110 FDP-RSLAAL---SNSLRVL--------------NISGNNIDSLEP--------------------------LAPLRNLE 145

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77404405 305 ALDLSGNELSALHP--ATFGHQGRLRELSLRDNALSALSG---DIFAASPALYRLD 355
Cdd:cd21340 146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKyrdKIILASKSLEVLD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-362 7.53e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   58 PQDVLTYS------LGGNF--------ITNITAFDF-------------HRLGQLRRLD---LQYNQIRSLHPKTFEKLS 107
Cdd:PLN00113 157 PNDIGSFSslkvldLGGNVlvgkipnsLTNLTSLEFltlasnqlvgqipRELGQMKSLKwiyLGYNNLSGEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  108 RLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVL-GALPDAVfAPLGNLLYLHL 186
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELV-IQLQNLEILHL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  187 EANRirFLGK--NAFTQLGKLRFLNLSANELQPSL------RHAATFVPLRS----------------LSTLILSANSLQ 242
Cdd:PLN00113 316 FSNN--FTGKipVALTSLPRLQVLQLWSNKFSGEIpknlgkHNNLTVLDLSTnnltgeipeglcssgnLFKLILFSNSLE 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  243 -----HLG-------------------PRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNR-LNQLPLTLL 297
Cdd:PLN00113 394 geipkSLGacrslrrvrlqdnsfsgelPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPDSFG 473

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 77404405  298 EplHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWT 362
Cdd:PLN00113 474 S--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRR_8 pfam13855
Leucine rich repeat;
229-289 4.55e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 4.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77404405   229 RSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
65-119 1.30e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 77404405    65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-441 1.02e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405    332 LRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVfVQCRHPPALRGKYLdyLDDQLLQN 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL--LGIPLLDS 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 77404405    412 G------SCVDPSPSPTAGSR-QWPISTAPGEGMTPP 441
Cdd:TIGR00864   79 GcdeeyvACLKDNSSGGGAARsELVIFSAAHEGLFQP 115
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-56 1.98e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 1.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 77404405     27 CPERCDCqHPQHLLCTNRGLRAVPktSSLP 56
Cdd:smart00013   2 CPAPCNC-SGTAVDCSGRGLTEVP--LDLP 28
fn3 pfam00041
Fibronectin type III domain;
589-667 2.69e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   589 NLTVEAVSANSASVRWavrehRSPRPQGGA--RFRLLF-DRFGQQPKFQRFVylPERSDSATLHELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 77404405   666 GG 667
Cdd:pfam00041  78 GG 79
LRRCT smart00082
Leucine rich repeat C-terminal domain;
359-406 5.00e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 5.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 77404405    359 NGWTCDCRLRGLKRW-MGNWHSQGRLLTVfvqCRHPPALRGKYLDYLDD 406
Cdd:smart00082   1 NPFICDCELRWLLRWlQANEHLQDPVDLR---CASPSSLRGPLLELLHS 46
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 589-661 5.15e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 5.15e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77404405    589 NLTVEAVSANSASVRWavrehRSPRPQGGARFRLLFDRFGQQPKFQ-RFVYLPERSDSATLHELRGDTPYLVCV 661
Cdd:smart00060   6 NLRVTDVTSTSVTLSW-----EPPPDDGITGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
LRR smart00370
Leucine-rich repeats, outliers;
82-104 6.47e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.47e-03
                           10        20
                   ....*....|....*....|...
gi 77404405     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN03150 PLN03150
hypothetical protein; Provisional
 43-139 9.49e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 9.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   43 NRGLRA-VPktSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA 121
Cdd:PLN03150 427 NQGLRGfIP--NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504

                         90       100
                 ....*....|....*....|
gi 77404405  122 LAPGTLA--PLRKLRILYAN 139
Cdd:PLN03150 505 RVPAALGgrLLHRASFNFTD 524
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-359 9.12e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 9.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 104 EKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEigrlsrgSFEGLESLVKLRLDGNVLGALPDAvFAPLGNLLY 183
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 184 LHLEANRIRFLGKnAFTQLGKLRFLNLSANELQpSLrhAATFVPLRSLSTLILSANSLQHLgPRVFQHLPRLGLLSLSGN 263
Cdd:COG4886 141 LDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLT-DL--PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 264 QLTHLaPEAFWGLEALRELRLEGNRLNQLPLtlLEPLHSLEALDLSGNELSALHPAtfGHQGRLRELSLRDNALSALSGD 343
Cdd:COG4886 216 QLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*.
gi 77404405 344 IFAASPALYRLDLDGN 359
Cdd:COG4886 291 ELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-308 1.98e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 1.98e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  78 DFHRLGQLRRLDLQYNQIRSLhPKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANGNEIGRLSRgSFEGLESL 157
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 158 VKLRLDGNVLGALPDAvFAPLGNLLYLHLEANRIRFLGKnAFTQLGKLRFLNLSANELQ--PSLRHaatfvpLRSLSTLI 235
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTdlPELGN------LTNLEELD 256

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 77404405 236 LSANSLQHLGPrvFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDL 308
Cdd:COG4886 257 LSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-344 1.74e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 1.74e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  61 VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNqirslhpKTFEKLSRLEELYLGNNLLQALaPGTLAPLRKLRILYANG 140
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 141 NEIGRLSRgSFEGLESLVKLRLDGNVLGALPDAvFAPLGNLLYLHLEANRIRFLGKnAFTQLGKLRFLNLSANELqpslr 220
Cdd:COG4886 146 NQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL----- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 221 haatfvplrslSTLilsanslqhlgPRVFQHLPRLGLLSLSGNQLTHLapEAFWGLEALRELRLEGNRLNQLPLtlLEPL 300
Cdd:COG4886 218 -----------TDL-----------PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANL 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 77404405 301 HSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDI 344
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-359 6.18e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 6.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 106 LSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIGRLSrgSFEGLESLVKLRLDGNvlgalpdAVFAPLGNLLYLH 185
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT--DLGDLTNLTELDLSGN-------EELSNLTNLESLD 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 186 LEANRIRFLGKnAFTQLGKLRFLNLSAN---ELQPSLRHaatfvpLRSLSTLILSANSLQHLgPRVFQHLPRLGLLSLSG 262
Cdd:COG4886 120 LSGNQLTDLPE-ELANLTNLKELDLSNNqltDLPEPLGN------LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 263 NQLTHLaPEAFWGLEALRELRLEGNRLNQLPLTlLEPLHSLEALDLSGNELSALhpATFGHQGRLRELSLRDNALSALSG 342
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP 267

                       250
                ....*....|....*..
gi 77404405 343 diFAASPALYRLDLDGN 359
Cdd:COG4886 268 --LANLTNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-316 1.31e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  37 QHLLCTNRGLRAVPKT-SSLPSpqdvLTY-SLGGNFITNITAFdFHRLGQLRRLDLQYNQIRSLhPKTFEKLSRLEELYL 114
Cdd:COG4886 139 KELDLSNNQLTDLPEPlGNLTN----LKSlDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 115 GNNLLQALaPGTLAPLRKLRILYANGNEIGRLSrgSFEGLESLVKLRLDGNVLGALPDAvfAPLGNLLYLHLEANRIRFL 194
Cdd:COG4886 213 SGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDL 287

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 195 GKNAFTQLGKLRFL--NLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEA 272
Cdd:COG4886 288 KLKELELLLGLNSLllLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 77404405 273 FWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSAL 316
Cdd:COG4886 368 TLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-355 1.23e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.53  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  65 SLGGNFITNITafDFHRLGQLRRLDLQYNQIRSLhpKTFEKLSRLEELYLGNNLLQALAPgtLAPLRKLRILYANGNEIG 144
Cdd:cd21340   8 YLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 145 RLsrgsfEGLESLVKLRldgnvlgalpdavfaplgnllYLHLEANRirflgknaftqlgklrflnLSANElqpSLrhaaT 224
Cdd:cd21340  82 VV-----EGLENLTNLE---------------------ELHIENQR-------------------LPPGE---KL----T 109

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 225 FVPlRSLSTLilsANSLQHLgprvfqhlprlgllSLSGNQLTHLAPeafwglealrelrlegnrlnqlpltlLEPLHSLE 304
Cdd:cd21340 110 FDP-RSLAAL---SNSLRVL--------------NISGNNIDSLEP--------------------------LAPLRNLE 145

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77404405 305 ALDLSGNELSALHP--ATFGHQGRLRELSLRDNALSALSG---DIFAASPALYRLD 355
Cdd:cd21340 146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKyrdKIILASKSLEVLD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-362 7.53e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   58 PQDVLTYS------LGGNF--------ITNITAFDF-------------HRLGQLRRLD---LQYNQIRSLHPKTFEKLS 107
Cdd:PLN00113 157 PNDIGSFSslkvldLGGNVlvgkipnsLTNLTSLEFltlasnqlvgqipRELGQMKSLKwiyLGYNNLSGEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  108 RLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVL-GALPDAVfAPLGNLLYLHL 186
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPELV-IQLQNLEILHL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  187 EANRirFLGK--NAFTQLGKLRFLNLSANELQPSL------RHAATFVPLRS----------------LSTLILSANSLQ 242
Cdd:PLN00113 316 FSNN--FTGKipVALTSLPRLQVLQLWSNKFSGEIpknlgkHNNLTVLDLSTnnltgeipeglcssgnLFKLILFSNSLE 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  243 -----HLG-------------------PRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNR-LNQLPLTLL 297
Cdd:PLN00113 394 geipkSLGacrslrrvrlqdnsfsgelPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPDSFG 473

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 77404405  298 EplHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWT 362
Cdd:PLN00113 474 S--KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-317 4.34e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 4.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  38 HLLCTNRGLRAVPKTSSLPSPQdVLtYsLGGNFITNITAFDFhrLGQLRRLDLQYNQIRslhpktfeklsRLEElylgnn 117
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLK-VL-Y-LYDNKITKIENLEF--LTNLTHLYLQNNQIE-----------KIEN------ 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 118 llqalapgtLAPLRKLRILYANGNEIGRLsrgsfEGLESLVKLRldgnvlgalpdavfaplgnllYLHLEANRirflgkn 197
Cdd:cd21340  64 ---------LENLVNLKKLYLGGNRISVV-----EGLENLTNLE---------------------ELHIENQR------- 101

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 198 aftqlgklrflnLSANElqpSLrhaaTFVPlRSLSTLilsANSLQHlgprvfqhlprlglLSLSGNQLTHLAPeaFWGLE 277
Cdd:cd21340 102 ------------LPPGE---KL----TFDP-RSLAAL---SNSLRV--------------LNISGNNIDSLEP--LAPLR 142

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 77404405 278 ALRELRLEGNRLNQLP--LTLLEPLHSLEALDLSGNELSALH 317
Cdd:cd21340 143 NLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
229-289 4.55e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 72.94  E-value: 4.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77404405   229 RSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-359 1.12e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 81.82  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   63 TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGN- 141
Cdd:PLN00113 144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNn 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  142 -------EIGRLSrgsfegleSLVKLRL-DGNVLGALPDAvFAPLGNLLYLHLEANRIRFLGKNAFTQLGKLRFLNLSAN 213
Cdd:PLN00113 224 lsgeipyEIGGLT--------SLNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  214 ELQ---PSLrhaatFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLN 290
Cdd:PLN00113 295 SLSgeiPEL-----VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT 369

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  291 -QLPLTLLEPLHsLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGN 359
Cdd:PLN00113 370 gEIPEGLCSSGN-LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438
LRR_8 pfam13855
Leucine rich repeat;
84-143 7.27e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 7.27e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405    84 QLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-344 8.62e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.65  E-value: 8.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNeigRLSRGSFEGL---ESLV 158
Cdd:PLN00113 283 LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN---KFSGEIPKNLgkhNNLT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  159 KLRLDGNVL-GALPDAVFAPlGNLLYLHLEAN-----------------RIRfLGKNA--------FTQLGKLRFLNLSA 212
Cdd:PLN00113 360 VLDLSTNNLtGEIPEGLCSS-GNLFKLILFSNslegeipkslgacrslrRVR-LQDNSfsgelpseFTKLPLVYFLDISN 437

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  213 NELQPSLRHAATFVPlrSLSTLILSANSLQHLGPRVFQHlPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQL 292
Cdd:PLN00113 438 NNLQGRINSRKWDMP--SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE 514

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 77404405  293 PLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNalsALSGDI 344
Cdd:PLN00113 515 IPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN---QLSGEI 563
LRR_8 pfam13855
Leucine rich repeat;
107-167 1.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77404405   107 SRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
156-215 6.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.42e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   156 SLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRIRFLGKNAFTQLGKLRFLNLSANEL 215
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
65-119 1.30e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.30e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 77404405    65 SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-295 6.99e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 6.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   83 GQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAplrKLRILY----ANGNEIGRLSRGSFEgLESLV 158
Cdd:PLN00113 380 GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFT---KLPLVYfldiSNNNLQGRINSRKWD-MPSLQ 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  159 KLRLDGN-VLGALPDAVFAPlgNLLYLHLEANRIRFLGKNAFTQLGKLRFLNLSANELQPSLrhAATFVPLRSLSTLILS 237
Cdd:PLN00113 456 MLSLARNkFFGGLPDSFGSK--RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLS 531

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 77404405  238 ANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLN-QLPLT 295
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHgSLPST 590
LRR_8 pfam13855
Leucine rich repeat;
204-265 1.55e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77404405   204 KLRFLNLSANELQpSLrHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQL 265
Cdd:pfam13855   2 NLRSLDLSNNRLT-SL-DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
302-359 1.61e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 77404405   302 SLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGN 359
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-338 1.91e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   98 LHPKTFeKLSRLEELYLGNNLLQALAPGTLAPL-RKLRIL-YANGNEIGRLSRGSFEGLESLvklRLDGNVL-GALPDAV 174
Cdd:PLN00113  85 ISSAIF-RLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLnLSNNNFTGSIPRGSIPNLETL---DLSNNMLsGEIPNDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  175 fAPLGNLLYLHLEANRIrfLGK--NAFTQLGKLRFLNLSANELQPSLRHAatFVPLRSLSTLILSAN------------- 239
Cdd:PLN00113 161 -GSFSSLKVLDLGGNVL--VGKipNSLTNLTSLEFLTLASNQLVGQIPRE--LGQMKSLKWIYLGYNnlsgeipyeiggl 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  240 -SLQHLG----------PRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDL 308
Cdd:PLN00113 236 tSLNHLDlvynnltgpiPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHL 315

                        250       260       270
                 ....*....|....*....|....*....|
gi 77404405  309 SGNELSALHPATFGHQGRLRELSLRDNALS 338
Cdd:PLN00113 316 FSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345
LRR_8 pfam13855
Leucine rich repeat;
279-337 1.95e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.95e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 77404405   279 LRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNAL 337
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 22-313 3.46e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  22 RAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFdFHRLGQlrrldlqynqirslhpk 101
Cdd:cd00116  14 RATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRG-LQSLLQ----------------- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 102 TFEKLSRLEELYLGNNLLQALAPGTLAPLRK---LRILYANGNEIGR-----LSRGSFEGLESLVKLRLDGNVLGALPDA 173
Cdd:cd00116  76 GLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCE 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 174 ----VFAPLGNLLYLHLEANRIRFLG----KNAFTQLGKLRFLNLSANELQP--SLRHAATFVPLRSLSTLILSANSL-- 241
Cdd:cd00116 156 alakALRANRDLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDegASALAETLASLKSLEVLNLGDNNLtd 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 242 ---QHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGL----EALRELRLEGNRLN-----QLPLTLLEPLHSLEALDLS 309
Cdd:cd00116 236 agaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGeegaqLLAESLLEPGNELESLWVK 315


                ....
gi 77404405 310 GNEL 313
Cdd:cd00116 316 DDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 229-364 4.53e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.82  E-value: 4.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 229 RSLSTLILSANSLQHLGPRV------FQHLPRLGLLSLSGNQLTHLAPEAFWGL---EALRELRLEGNRLNQLPL----- 294
Cdd:cd00116  51 PSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLrllak 130

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77404405 295 TLLEPLHSLEALDLSGNELSA--LHPA--TFGHQGRLRELSLRDNALS----ALSGDIFAASPALYRLDLDGNGWTCD 364
Cdd:cd00116 131 GLKDLPPALEKLVLGRNRLEGasCEALakALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDE 208
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 87-359 1.04e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 1.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  87 RLDLQYNQIRSLHPKT-FEKLSRLEELYL-GNNL----LQALAPgTLAPLRKLRILYANGNEIGRLSRG---SFEGLESL 157
Cdd:cd00116   2 QLSLKGELLKTERATElLPKLLCLQVLRLeGNTLgeeaAKALAS-ALRPQPSLKELCLSLNETGRIPRGlqsLLQGLTKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 158 VKLR-LDgnvlgaLPDAVFAPLGNLLYlhleanrirflgkNAFTQLGKLRFLNLSANELQPS-LRHAATFVPLRS--LST 233
Cdd:cd00116  81 CGLQeLD------LSDNALGPDGCGVL-------------ESLLRSSSLQELKLNNNGLGDRgLRLLAKGLKDLPpaLEK 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 234 LILSANSLQHLGPR----VFQHLPRLGLLSLSGNQL-----THLApEAFWGLEALRELRLEGNRLN-----QLPLTLLEp 299
Cdd:cd00116 142 LVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagiRALA-EGLKANCNLEVLDLNNNGLTdegasALAETLAS- 219

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 77404405 300 LHSLEALDLSGNEL-----SALHPATFGHQGRLRELSLRDNALSALSGDIFA----ASPALYRLDLDGN 359
Cdd:cd00116 220 LKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
131-191 2.03e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.03e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77404405   131 RKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRI 191
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 151-364 3.82e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 3.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 151 FEGLESLVKLRLDGNVLG-----ALPDAVFAPlGNLLYLHLEANRIRFLGKN------AFTQLGKLRFLNLSANELQPSL 219
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGeeaakALASALRPQ-PSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 220 RHA-ATFVPLRSLSTLILSANSLQHLGPRVFQ-----HLPRLGLLSLSGNQLTH-----LApEAFWGLEALRELRLEGNR 288
Cdd:cd00116  98 CGVlESLLRSSSLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEGasceaLA-KALRANRDLKELNLANNG 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 289 LNQLPLTLLEP----LHSLEALDLSGNEL-----SALhPATFGHQGRLRELSLRDNAL-----SALSGDIFAASPALYRL 354
Cdd:cd00116 177 IGDAGIRALAEglkaNCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTL 255

                       250
                ....*....|
gi 77404405 355 DLDGNGWTCD 364
Cdd:cd00116 256 SLSCNDITDD 265
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 11-194 4.65e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 4.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  11 LVVCGCLAFPPRAESVCPERCdcqhpqhlLCTNRGLRAVPKTssLPSPQDVLTYSLGGNfitNITAFDFHRLGQ------ 84
Cdd:cd00116 127 LLAKGLKDLPPALEKLVLGRN--------RLEGASCEALAKA--LRANRDLKELNLANN---GIGDAGIRALAEglkanc 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  85 -LRRLDLQYNQIRSLHPK----TFEKLSRLEELYLGNNLL-----QALAPGTLAPLRKLRILYANGNEIGRLSRGSF-EG 153
Cdd:cd00116 194 nLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLaEV 273

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 77404405 154 L---ESLVKLRLDGNVLGALPDAVFAPLgnllyLHLEANRIRFL 194
Cdd:cd00116 274 LaekESLLELDLRGNKFGEEGAQLLAES-----LLEPGNELESL 312
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 79-368 8.69e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 8.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  79 FHRLGQLRRLDLQYNQIR-----SLHPKTFEKLSRLEELYLGNNLLQALAPGTLA-PLRK---LRILYANGNEIGRLSRG 149
Cdd:COG5238 147 LKDPLGGNAVHLLGLAARlgllaAISMAKALQNNSVETVYLGCNQIGDEGIEELAeALTQnttVTTLWLKRNPIGDEGAE 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 150 SF----EGLESLVKLRLDGNVLGalpDAVFAPLGNllylHLEANRirflgknaftqlgKLRFLNLSANEL--QPSLRHAA 223
Cdd:COG5238 227 ILaealKGNKSLTTLDLSNNQIG---DEGVIALAE----ALKNNT-------------TVETLYLSGNQIgaEGAIALAK 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 224 TFVPLRSLSTLILSANSLQHLGPRVF----QHLPRLGLLSLSGNQLTHLAPEAFwgLEALRELRlegnrlnqlpltllep 299
Cdd:COG5238 287 ALQGNTTLTSLDLSVNRIGDEGAIALaeglQGNKTLHTLNLAYNGIGAQGAIAL--AKALQENT---------------- 348

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77404405 300 lhSLEALDLSGNELS-----ALHPATFGHQGrLRELSLRDNALSALSGDIFAAS---PALYRLDLDGNGWTCDCRLR 368
Cdd:COG5238 349 --TLHSLDLSDNQIGdegaiALAKYLEGNTT-LRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLIGAEAQQR 422
PLN03150 PLN03150
hypothetical protein; Provisional
 258-338 1.24e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405  258 LSLSGNQLTHLAPEAFWGLEALRELRLEGNRLN-QLPLTLlEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNA 336
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSL-GSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501


                 ..
gi 77404405  337 LS 338
Cdd:PLN03150 502 LS 503
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 84-124 1.73e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 77404405    84 QLRRLDLQYNQIRSLHPktFEKLSRLEELYL-GNNLLQALAP 124
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLsGNNKITDLSD 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-441 1.02e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405    332 LRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVfVQCRHPPALRGKYLdyLDDQLLQN 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPL--LGIPLLDS 78

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 77404405    412 G------SCVDPSPSPTAGSR-QWPISTAPGEGMTPP 441
Cdd:TIGR00864   79 GcdeeyvACLKDNSSGGGAARsELVIFSAAHEGLFQP 115
LRR_9 pfam14580
Leucine-rich repeat;
228-307 1.04e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   228 LRSLSTLILSANSLQHLGPrvFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQlpLTLLEPLHSLEALD 307
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLDG--FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQE--LGDLDPLASLKKLT 116
PLN03150 PLN03150
hypothetical protein; Provisional
 78-146 1.15e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   78 DFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEI-GRL 146
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLsGRV 506
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-56 1.98e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 1.98e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 77404405     27 CPERCDCqHPQHLLCTNRGLRAVPktSSLP 56
Cdd:smart00013   2 CPAPCNC-SGTAVDCSGRGLTEVP--LDLP 28
PLN03150 PLN03150
hypothetical protein; Provisional
 228-301 2.26e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 2.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77404405  228 LRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLN-QLPLTL-LEPLH 301
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAALgGRLLH 516
fn3 pfam00041
Fibronectin type III domain;
589-667 2.69e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   589 NLTVEAVSANSASVRWavrehRSPRPQGGA--RFRLLF-DRFGQQPKFQRFVylPERSDSATLHELRGDTPYLVCVEGVL 665
Cdd:pfam00041   5 NLTVTDVTSTSLTVSW-----TPPPDGNGPitGYEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ..
gi 77404405   666 GG 667
Cdd:pfam00041  78 GG 79
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 78-230 2.82e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   78 DFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKlrilyangneigrlsrgsfeglesL 157
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKK------------------------L 525

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77404405  158 VKLRLDGNVL-GALPDAvFAPLGNLLYLHLEANRirfLGKNAFTQLGKLRFL---NLSANELQPSLRHAATFVPLRS 230
Cdd:PLN00113 526 VSLDLSHNQLsGQIPAS-FSEMPVLSQLDLSQNQ---LSGEIPKNLGNVESLvqvNISHNHLHGSLPSTGAFLAINA 598
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
208-376 3.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 3.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 208 LNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGN 287
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405 288 RLNQLPLTLLEPLHSLEALD-----------------LSGNELSALhPATFGHQGRLRELSLRDNALSALSGDIfAASPA 350
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDlsgneelsnltnlesldLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL-GNLTN 160

                       170       180
                ....*....|....*....|....*.
gi 77404405 351 LYRLDLDGNgwtcdcRLRGLKRWMGN 376
Cdd:COG4886 161 LKSLDLSNN------QLTDLPEELGN 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
359-406 5.00e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 5.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 77404405    359 NGWTCDCRLRGLKRW-MGNWHSQGRLLTVfvqCRHPPALRGKYLDYLDD 406
Cdd:smart00082   1 NPFICDCELRWLLRWlQANEHLQDPVDLR---CASPSSLRGPLLELLHS 46
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 589-661 5.15e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 5.15e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77404405    589 NLTVEAVSANSASVRWavrehRSPRPQGGARFRLLFDRFGQQPKFQ-RFVYLPERSDSATLHELRGDTPYLVCV 661
Cdd:smart00060   6 NLRVTDVTSTSVTLSW-----EPPPDDGITGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
LRR smart00370
Leucine-rich repeats, outliers;
82-104 6.47e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.47e-03
                           10        20
                   ....*....|....*....|...
gi 77404405     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
82-104 6.47e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.47e-03
                           10        20
                   ....*....|....*....|...
gi 77404405     82 LGQLRRLDLQYNQIRSLHPKTFE 104
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN03150 PLN03150
hypothetical protein; Provisional
 43-139 9.49e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 9.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404405   43 NRGLRA-VPktSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQA 121
Cdd:PLN03150 427 NQGLRGfIP--NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504

                         90       100
                 ....*....|....*....|
gi 77404405  122 LAPGTLA--PLRKLRILYAN 139
Cdd:PLN03150 505 RVPAALGgrLLHRASFNFTD 524
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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