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Conserved domains on  [gi|86355503|ref|NP_001034454|]
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myelin-associated oligodendrocyte basic protein isoform b [Mus musculus]

Protein Classification

PHD finger domain-containing protein( domain architecture ID 366290)

PHD (plant homeodomain) finger domain-containing protein

Gene Ontology:  GO:0008270|GO:0005515
PubMed:  16297627|21514168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 1-68 1.73e-15

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member pfam02318:

Pssm-ID: 473978  Cd Length: 118  Bit Score: 68.55  E-value: 1.73e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86355503     1 MSQKMAKEGPR---LSKNQKFSEHFSIHCCPPFTFL-NSKREIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 79-165 1.00e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503   79 KHQPAASPVVVRAPPAkPKSPLMPAKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKqparSSPLRGPGTS 158
Cdd:PTZ00449 566 EHKPSKIPTLSKKPEF-PKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESP----KSPKRPPPPQ 640


                 ....*..
gi 86355503  159 RGGSPTR 165
Cdd:PTZ00449 641 RPSSPER 647
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-68 1.73e-15

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 68.55  E-value: 1.73e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86355503     1 MSQKMAKEGPR---LSKNQKFSEHFSIHCCPPFTFL-NSKREIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-68 3.87e-10

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 52.79  E-value: 3.87e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 86355503  24 IHCCPPFTFL-NSKREIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:cd15753   3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQ 48
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 79-165 1.00e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503   79 KHQPAASPVVVRAPPAkPKSPLMPAKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKqparSSPLRGPGTS 158
Cdd:PTZ00449 566 EHKPSKIPTLSKKPEF-PKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESP----KSPKRPPPPQ 640


                 ....*..
gi 86355503  159 RGGSPTR 165
Cdd:PTZ00449 641 RPSSPER 647
 
Name Accession Description Interval E-value
FYVE_2 pfam02318
FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector ...
 1-68 1.73e-15

FYVE-type zinc finger; This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.


Pssm-ID: 426716  Cd Length: 118  Bit Score: 68.55  E-value: 1.73e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 86355503     1 MSQKMAKEGPR---LSKNQKFSEHFSIHCCPPFTFL-NSKREIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:pfam02318  32 LKGKLDKESSKrelLGNQAHLGETHCIRCLQPFGFLvNSKRQCLDCRKNVCKKCGVYNKPEQGWLCDPCSEA 103
FYVE_SlaC2-c cd15753
FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; ...
 24-68 3.87e-10

FYVE-related domain found in Slp homolog lacking C2 domains c (SlaC2-c) and similar proteins; SlaC2-c, also termed Rab effector MyRIP, or exophilin-8, or myosin-VIIa- and Rab-interacting protein, or synaptotagmin-like protein lacking C2 domains c, is a GTP-bound form of Rab27A-, myosin Va/VIIa-, and actin-binding protein mainly present on retinal melanosomes and secretory granules. It may play a role in insulin granule exocytosis. It is also involved in the control of isoproterenol (IPR)-induced amylase release from parotid acinar cells. SlaC2-c belongs to the Slp homolog lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of SlaC2-c are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-c has a middle myosin-binding domain and a C-terminal actin-binding domain.


Pssm-ID: 277292  Cd Length: 49  Bit Score: 52.79  E-value: 3.87e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 86355503  24 IHCCPPFTFL-NSKREIVDRKYSICKSGCFYQKKEEDWICCACQKT 68
Cdd:cd15753   3 MRCCSPFTFLfNRKRQCRDCKFNVCKSCASYDKKEKGWTCNVCQKQ 48
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 79-165 1.00e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503   79 KHQPAASPVVVRAPPAkPKSPLMPAKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKqparSSPLRGPGTS 158
Cdd:PTZ00449 566 EHKPSKIPTLSKKPEF-PKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESP----KSPKRPPPPQ 640


                 ....*..
gi 86355503  159 RGGSPTR 165
Cdd:PTZ00449 641 RPSSPER 647
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 67-117 4.93e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 4.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 86355503   67 KTSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSP 117
Cdd:PTZ00449 586 KHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRP 636
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 67-117 5.42e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 5.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503   67 KTSRRATSPQRPKHQPAAS-PVVVRAP--------PAKPKSPLMPAKPRSPPRPAKPRSP 117
Cdd:PTZ00449 595 KKPKRPRSAQRPTRPKSPKlPELLDIPkspkrpesPKSPKRPPPPQRPSSPERPEGPKII 654
PHA03247 PHA03247
large tegument protein UL36; Provisional
 66-154 2.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503    66 QKTSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQ 145
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948


                  ....*....
gi 86355503   146 PARSSPLRG 154
Cdd:PHA03247 2949 PAGAGEPSG 2957
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 72-117 3.37e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 37.20  E-value: 3.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 86355503   72 ATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSP 117
Cdd:PRK01297  19 PAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRE 64
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
64-119 6.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 36.39  E-value: 6.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 86355503   64 ACQKTSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSPSR 119
Cdd:PRK12323 436 ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 68-155 7.03e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 36.41  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86355503    68 TSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMPAKPRSPPRPAKPRSPsrterqprprpevRPPPAKQKPPQKSKQPA 147
Cdd:PRK12270   49 AAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAA-------------PPAAAAAAAPAAAAVED 115


                  ....*...
gi 86355503   148 RSSPLRGP 155
Cdd:PRK12270  116 EVTPLRGA 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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