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Conserved domains on  [gi|108860686|ref|NP_001035844|]
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prolyl endopeptidase-like isoform 2 [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 1001746)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

EC:  3.4.21.-
Gene Ontology:  GO:0006508|GO:0004252
PubMed:  8439290

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtrB super family cl34357
Protease II [Amino acid transport and metabolism];
113-587 2.57e-85

Protease II [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1770:

Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 281.96  E-value: 2.57e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTN------------VGEPTE-------- 321
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNddapnfklvrapVDAPSRenwqelip 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 322 ------------FK-----------LP-----PW-------------ACGFIMDTNSDPkNCP---FQLCSPIRPPKYYT 357
Cdd:COG1770  317 hrpgvllegvdaFKdhlvvserengLPrirvrDLddgeeheiafdeeAYTAGLGGNPEF-DTDtlrYSYSSLTTPSSVYD 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 358 YKFAEGKLfeETGHEDPITK-------TSRvlRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRP 430
Cdd:COG1770  396 YDLATGER--TLLKQQEVPGgfdpadyVSE--RLWATARDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFST 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 431 ERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSN 510
Cdd:COG1770  472 SRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMA 551

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860686 511 PELVRAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 587
Cdd:COG1770  552 PELFAGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
113-587 2.57e-85

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 281.96  E-value: 2.57e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTN------------VGEPTE-------- 321
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNddapnfklvrapVDAPSRenwqelip 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 322 ------------FK-----------LP-----PW-------------ACGFIMDTNSDPkNCP---FQLCSPIRPPKYYT 357
Cdd:COG1770  317 hrpgvllegvdaFKdhlvvserengLPrirvrDLddgeeheiafdeeAYTAGLGGNPEF-DTDtlrYSYSSLTTPSSVYD 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 358 YKFAEGKLfeETGHEDPITK-------TSRvlRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRP 430
Cdd:COG1770  396 YDLATGER--TLLKQQEVPGgfdpadyVSE--RLWATARDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFST 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 431 ERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSN 510
Cdd:COG1770  472 SRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMA 551

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860686 511 PELVRAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 587
Cdd:COG1770  552 PELFAGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
PRK10115 PRK10115
protease 2; Provisional
 201-600 7.66e-47

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 176.23  E-value: 7.66e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 201 NVS-SFEWVKDEEdedVLFYTFQR--NLRCHDVYRATFGD-NKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSE 276
Cdd:PRK10115 172 NVEpSFVWANDSW---TFYYVRKHpvTLLPYQVWRHTIGTpASQDELVYEEKDDTFYVSLHKTTSKHYVVIHLASATTSE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 277 VWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNvGEPTEFKL---------------PPWAC----GFIMDTN- 336
Cdd:PRK10115 249 VLLLDAELADAEPFVFLPRRKDHEYSLDHYQHRFYLRSN-RHGKNFGLyrtrvrdeqqweeliPPRENimleGFTLFTDw 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 337 ----------------------------SDPKNCPFQLCSPIRPPKYYTYKFAE----GKLFE---ETGHEDPITKTS-- 379
Cdd:PRK10115 328 lvveerqrgltslrqinrktrevigiafDDPAYVTWIAYNPEPETSRLRYGYSSmttpDTLFEldmDTGERRVLKQTEvp 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 380 -------RVLRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGE 452
Cdd:PRK10115 408 gfdaanyRSEHLWITARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGE 487

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 453 LGLQWHADGRLTKKLNGLAD-LEACiKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMM 531
Cdd:PRK10115 488 LGQQWYEDGKFLKKKNTFNDyLDAC-DALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTML 566

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108860686 532 DTTLPLTLEELEEWGNPsSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKE 600
Cdd:PRK10115 567 DESIPLTTGEFEEWGNP-QDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRE 634
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
428-651 1.58e-21

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 93.45  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  428 FRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALC 507
Cdd:pfam00326   3 FSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  508 NSNPELVRAVTLEAPFLDVLnTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPqhYPSIHITAYENDERVP 587
Cdd:pfam00326  83 NQRPDLFKAAVAHVPVVDWL-AYMSDTSLPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKV--YPPLLLIHGLLDDRVP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860686  588 LKGIVSYTEKLKEAiaehakdtGEGYQtpniiLDIQPGGNHVI--EDSHKKITAQI-KFLYEELGLD 651
Cdd:pfam00326 160 PWQSLKLVAALQRK--------GVPFL-----LLIFPDEGHGIgkPRNKVEEYARElAFLLEYLGGT 213
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
113-587 2.57e-85

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 281.96  E-value: 2.57e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTN------------VGEPTE-------- 321
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNddapnfklvrapVDAPSRenwqelip 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 322 ------------FK-----------LP-----PW-------------ACGFIMDTNSDPkNCP---FQLCSPIRPPKYYT 357
Cdd:COG1770  317 hrpgvllegvdaFKdhlvvserengLPrirvrDLddgeeheiafdeeAYTAGLGGNPEF-DTDtlrYSYSSLTTPSSVYD 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 358 YKFAEGKLfeETGHEDPITK-------TSRvlRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRP 430
Cdd:COG1770  396 YDLATGER--TLLKQQEVPGgfdpadyVSE--RLWATARDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFST 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 431 ERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSN 510
Cdd:COG1770  472 SRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMA 551

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860686 511 PELVRAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 587
Cdd:COG1770  552 PELFAGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
PRK10115 PRK10115
protease 2; Provisional
 201-600 7.66e-47

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 176.23  E-value: 7.66e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 201 NVS-SFEWVKDEEdedVLFYTFQR--NLRCHDVYRATFGD-NKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSE 276
Cdd:PRK10115 172 NVEpSFVWANDSW---TFYYVRKHpvTLLPYQVWRHTIGTpASQDELVYEEKDDTFYVSLHKTTSKHYVVIHLASATTSE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 277 VWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNvGEPTEFKL---------------PPWAC----GFIMDTN- 336
Cdd:PRK10115 249 VLLLDAELADAEPFVFLPRRKDHEYSLDHYQHRFYLRSN-RHGKNFGLyrtrvrdeqqweeliPPRENimleGFTLFTDw 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 337 ----------------------------SDPKNCPFQLCSPIRPPKYYTYKFAE----GKLFE---ETGHEDPITKTS-- 379
Cdd:PRK10115 328 lvveerqrgltslrqinrktrevigiafDDPAYVTWIAYNPEPETSRLRYGYSSmttpDTLFEldmDTGERRVLKQTEvp 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 380 -------RVLRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGE 452
Cdd:PRK10115 408 gfdaanyRSEHLWITARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGE 487

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 453 LGLQWHADGRLTKKLNGLAD-LEACiKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMM 531
Cdd:PRK10115 488 LGQQWYEDGKFLKKKNTFNDyLDAC-DALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTML 566

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108860686 532 DTTLPLTLEELEEWGNPsSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKE 600
Cdd:PRK10115 567 DESIPLTTGEFEEWGNP-QDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRE 634
PreP COG1505
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
78-586 2.52e-25

Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];


Pssm-ID: 441114 [Multi-domain]  Cd Length: 673  Bit Score: 111.37  E-value: 2.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  78 VKQENEKPLP--ENMDAFEKVRTKLEtqpqeeyEIINVE-----VKHGGFVYY------QE-GccLVRSKDeeADNDNYE 143
Cdd:COG1505   39 VKAQNAVTRAylAAIPRREALRARLL-------ELLNYDripapFKRGGRYYNfwndglQNqG--VLRVRD--GLDPEWE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 144 VLFNLEELKLDQP-FIDCIRVAPDEKYVAAKIRTEDSEASTCVIIKLSDQPVMEASFPNV--SSFEWVkdeeDEDVLFYT 220
Cdd:COG1505  108 VLLDPNALSEDGTwVLGAWSLSPDGRRLAYSLSEGGSDARVVRVFDVATGEFVEDGFEWEkkSGVAWL----DGTGFVYS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 221 -------------FQRNLRCH--------DVYraTFGDnkrnerfyTEKDPSYFVFLYLTKDSRFLTINIMNKT-TSEVW 278
Cdd:COG1505  184 rygepegsltdsgYPRKVYYHrrgtpqseDEL--VFEG--------PPDDPERYVGVSVSEDGRYLLISRALGFyRNELY 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 279 LID----GLSPWDPPVliqkrihGVLYYVEHRDDELYILTNVG-----------------EPTEF--------------- 322
Cdd:COG1505  254 LLDlpdgELVPLDLPF-------DADYSGVVNGGWLYLLTRLDaprgrlvaidlaapgprNWTEFipeaeavlegvswtg 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 323 ----------------------------KLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKL--------- 365
Cdd:COG1505  327 grlvlsylddvvsrvrvydldgklvrevPLPGLGSVSGFSGDDDGDELFYSFTSFLTPPTLYRYDLGTGESellkkppap 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 366 FEETGHEdpitktsrVLRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYC 445
Cdd:COG1505  407 FDASDYE--------VEQVFATSKDGTRVPYFIVHKKGLKLDGPNPTLLYGYGGFNISLTPSYSASGLAWLERGGVYAVA 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 446 HVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLD 525
Cdd:COG1505  479 NLRGGGEYGPAWHQAGLKENKQNVFDDFIAAAEDLIARGYTSPERLAIQGGSNGGLLVGAALTQRPELFGAVVCAVPLLD 558

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 108860686 526 VLNT---------MMDttlpltleeleeWGNPsSDEKHKNYIKRYCPYQNIKP-QHYPSIHITAYENDERV 586
Cdd:COG1505  559 MLRYhkftagaswIAE------------YGDP-DDPEEFAYLYAYSPYHNVKAgVAYPATLFTTADHDDRV 616
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
428-651 1.58e-21

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 93.45  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  428 FRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALC 507
Cdd:pfam00326   3 FSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  508 NSNPELVRAVTLEAPFLDVLnTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPqhYPSIHITAYENDERVP 587
Cdd:pfam00326  83 NQRPDLFKAAVAHVPVVDWL-AYMSDTSLPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKV--YPPLLLIHGLLDDRVP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860686  588 LKGIVSYTEKLKEAiaehakdtGEGYQtpniiLDIQPGGNHVI--EDSHKKITAQI-KFLYEELGLD 651
Cdd:pfam00326 160 PWQSLKLVAALQRK--------GVPFL-----LLIFPDEGHGIgkPRNKVEEYARElAFLLEYLGGT 213
Peptidase_S9_N pfam02897
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
 108-319 1.65e-16

Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.


Pssm-ID: 397164 [Multi-domain]  Cd Length: 414  Bit Score: 82.36  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  108 YEIINVEVKHGGFVYYQ--EGCC----LVRSKDEEADNDNYEVLFNLEELKLDQPF--IDCIRVAPDEKYVAAKIRTEDS 179
Cdd:pfam02897  68 YDDISAPFRKGGYYYYFrnDGGKnqsvLYRQDALPGEGKPEEVFLDPNTLSEDGTFtaLGGFAFSPDGRLLAYSLSLSGS 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686  180 EASTCVIIKLSDQPVMEASFPNV--SSFEWVKDEedeDVLFYT----------FQRNLRcHDVYRATFGDNKRNER--FY 245
Cdd:pfam02897 148 DWYTIRFRDVETGEDLPDVLEGVkfSGIVWAPDG---KGFFYTrydkpdersdTGTNLN-QKVWRHRLGTPQSQDVlvFE 223

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 108860686  246 TEKDPSYFVFLYLTKDSRFLTINIMNKT-TSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRD-DELYILTNVGEP 319
Cdd:pfam02897 224 FPKDPLWSLGAERSEDGKYLFISSASGTdTNELYYLDLTKETGDTLKLVDGRFDGEYDVEHNEgDRFYFLTNDGAP 299
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
387-649 2.02e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 64.27  E-value: 2.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 387 KSKDGKLVPMTVFHKTDSEdlqKKPLLVHVYGaYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADgrltkk 466
Cdd:COG1506    3 KSADGTTLPGWLYLPADGK---KYPVVVYVHG-GPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD------ 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 467 lnGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDvlntMMDTTLPLTLEELEEWG 546
Cdd:COG1506   73 --EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSD----LRSYYGTTREYTERLMG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860686 547 NPSSDEKHknyikrycpYQNIKPQHY-PSIH----ITAYENDERVPlkgiVSYTEKLKEAIAEHAKDTGegyqtpniiLD 621
Cdd:COG1506  147 GPWEDPEA---------YAARSPLAYaDKLKtpllLIHGEADDRVP----PEQAERLYEALKKAGKPVE---------LL 204

                        250       260       270
                 ....*....|....*....|....*....|
gi 108860686 622 IQPGGNHVIEDSHKK--ITAQIKFLYEELG 649
Cdd:COG1506  205 VYPGEGHGFSGAGAPdyLERILDFLDRHLK 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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