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Conserved domains on  [gi|108860692|ref|NP_001035845|]
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prolyl endopeptidase-like isoform 3 [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 1001746)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

EC:  3.4.21.-
Gene Ontology:  GO:0006508|GO:0004252
PubMed:  8439290

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtrB super family cl34357
Protease II [Amino acid transport and metabolism];
113-583 5.35e-93

Protease II [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1770:

Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 302.00  E-value: 5.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPtEFKLMRTAADTPAIMNWDLFF 341
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNDDAP-NFKLVRAPVDAPSRENWQELI 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 342 TMKRNTKVIDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSL------------------------------------- 384
Cdd:COG1770  316 PHRPGVLLEGVDAFKDHLVVSERENGLPRIRVRDLDDGEEHEIafdeeaytaglggnpefdtdtlrysysslttpssvyd 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 385 ----------------------------------KDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRV 430
Cdd:COG1770  396 ydlatgertllkqqevpggfdpadyvserlwataRDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFSTSRLS 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 431 LVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELV 510
Cdd:COG1770  476 LLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELF 555

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 108860692 511 RAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 583
Cdd:COG1770  556 AGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
113-583 5.35e-93

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 302.00  E-value: 5.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPtEFKLMRTAADTPAIMNWDLFF 341
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNDDAP-NFKLVRAPVDAPSRENWQELI 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 342 TMKRNTKVIDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSL------------------------------------- 384
Cdd:COG1770  316 PHRPGVLLEGVDAFKDHLVVSERENGLPRIRVRDLDDGEEHEIafdeeaytaglggnpefdtdtlrysysslttpssvyd 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 385 ----------------------------------KDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRV 430
Cdd:COG1770  396 ydlatgertllkqqevpggfdpadyvserlwataRDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFSTSRLS 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 431 LVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELV 510
Cdd:COG1770  476 LLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELF 555

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 108860692 511 RAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 583
Cdd:COG1770  556 AGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
PRK10115 PRK10115
protease 2; Provisional
 201-596 2.53e-48

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 180.47  E-value: 2.53e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 201 NVS-SFEWVKDEEdedVLFYTFQR--NLRCHDVYRATFGD-NKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSE 276
Cdd:PRK10115 172 NVEpSFVWANDSW---TFYYVRKHpvTLLPYQVWRHTIGTpASQDELVYEEKDDTFYVSLHKTTSKHYVVIHLASATTSE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 277 VWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNvGEPTEFKLMRTAADTPAimNWDLFFTMKRNTKVIDLDMFK 356
Cdd:PRK10115 249 VLLLDAELADAEPFVFLPRRKDHEYSLDHYQHRFYLRSN-RHGKNFGLYRTRVRDEQ--QWEELIPPRENIMLEGFTLFT 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 357 DHCVL--------FLKHSNLLYVNVIGLA-DDSV---------------------------------------RSLK--- 385
Cdd:PRK10115 326 DWLVVeerqrgltSLRQINRKTREVIGIAfDDPAyvtwiaynpepetsrlrygyssmttpdtlfeldmdtgerRVLKqte 405

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 386 -------------------DGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGG 446
Cdd:PRK10115 406 vpgfdaanyrsehlwitarDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGG 485

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 447 GELGLQWHADGRLTKKLNGLAD-LEACiKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNT 525
Cdd:PRK10115 486 GELGQQWYEDGKFLKKKNTFNDyLDAC-DALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTT 564

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 108860692 526 MMDTTLPLTLEELEEWGNPsSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKE 596
Cdd:PRK10115 565 MLDESIPLTTGEFEEWGNP-QDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRE 634
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
424-647 1.60e-21

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 93.45  E-value: 1.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  424 FRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALC 503
Cdd:pfam00326   3 FSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  504 NSNPELVRAVTLEAPFLDVLnTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPqhYPSIHITAYENDERVP 583
Cdd:pfam00326  83 NQRPDLFKAAVAHVPVVDWL-AYMSDTSLPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKV--YPPLLLIHGLLDDRVP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860692  584 LKGIVSYTEKLKEAiaehakdtGEGYQtpniiLDIQPGGNHVI--EDSHKKITAQI-KFLYEELGLD 647
Cdd:pfam00326 160 PWQSLKLVAALQRK--------GVPFL-----LLIFPDEGHGIgkPRNKVEEYARElAFLLEYLGGT 213
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
113-583 5.35e-93

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 302.00  E-value: 5.35e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 113 VEVKHGGFVYYQ---EGC---CLVRSKDEEADNdnyEVLFNLEELKLDQPFIDC--IRVAPDEKYVAAKIRTEDSEASTC 184
Cdd:COG1770   83 VPYRDGGYWYYSrteEGKqypIYCRKPASGAGE---EVLLDGNALAEGHDFFSLggLSVSPDGRLLAYSVDTVGSERYTL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 185 VIIKLSDQPVMEASFPNVS-SFEWVkdeEDEDVLFYTFQR-NLRCHDVYRATFG-DNKRNERFYTEKDPSYFVFLYLTKD 261
Cdd:COG1770  160 RIKDLETGEDLPDVIENTSgGLVWA---ADNRTLFYTRVDeTLRPYQVWRHRLGtDPAEDVLVYEEKDERFFVGVGKTRS 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 262 SRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPtEFKLMRTAADTPAIMNWDLFF 341
Cdd:COG1770  237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSVEHAGDRFYILTNDDAP-NFKLVRAPVDAPSRENWQELI 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 342 TMKRNTKVIDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSL------------------------------------- 384
Cdd:COG1770  316 PHRPGVLLEGVDAFKDHLVVSERENGLPRIRVRDLDDGEEHEIafdeeaytaglggnpefdtdtlrysysslttpssvyd 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 385 ----------------------------------KDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRV 430
Cdd:COG1770  396 ydlatgertllkqqevpggfdpadyvserlwataRDGTKVPVSLVYRKDTKLDGSAPLLLYGYGSYGISIDPSFSTSRLS 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 431 LVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELV 510
Cdd:COG1770  476 LLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDFIACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELF 555

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 108860692 511 RAVTLEAPFLDVLNTMMDttlpltleeleeWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVP 583
Cdd:COG1770  556 AGVIAQVPFVDVLTTMLDpslplttgewdeWGNPLNDKEAYDYMKSYSPYDNVKAQAYPAILVTTGLNDSRVQ 628
PRK10115 PRK10115
protease 2; Provisional
 201-596 2.53e-48

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 180.47  E-value: 2.53e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 201 NVS-SFEWVKDEEdedVLFYTFQR--NLRCHDVYRATFGD-NKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSE 276
Cdd:PRK10115 172 NVEpSFVWANDSW---TFYYVRKHpvTLLPYQVWRHTIGTpASQDELVYEEKDDTFYVSLHKTTSKHYVVIHLASATTSE 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 277 VWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNvGEPTEFKLMRTAADTPAimNWDLFFTMKRNTKVIDLDMFK 356
Cdd:PRK10115 249 VLLLDAELADAEPFVFLPRRKDHEYSLDHYQHRFYLRSN-RHGKNFGLYRTRVRDEQ--QWEELIPPRENIMLEGFTLFT 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 357 DHCVL--------FLKHSNLLYVNVIGLA-DDSV---------------------------------------RSLK--- 385
Cdd:PRK10115 326 DWLVVeerqrgltSLRQINRKTREVIGIAfDDPAyvtwiaynpepetsrlrygyssmttpdtlfeldmdtgerRVLKqte 405

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 386 -------------------DGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGG 446
Cdd:PRK10115 406 vpgfdaanyrsehlwitarDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGG 485

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 447 GELGLQWHADGRLTKKLNGLAD-LEACiKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNT 525
Cdd:PRK10115 486 GELGQQWYEDGKFLKKKNTFNDyLDAC-DALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTT 564

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 108860692 526 MMDTTLPLTLEELEEWGNPsSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKE 596
Cdd:PRK10115 565 MLDESIPLTTGEFEEWGNP-QDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRE 634
PreP COG1505
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
78-582 2.23e-23

Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];


Pssm-ID: 441114 [Multi-domain]  Cd Length: 673  Bit Score: 105.21  E-value: 2.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  78 VKQENEKPLP--ENMDAFEKVRTKLEtqpqeeyEIINVE-----VKHGGFVYY------QE-GccLVRSKDeeADNDNYE 143
Cdd:COG1505   39 VKAQNAVTRAylAAIPRREALRARLL-------ELLNYDripapFKRGGRYYNfwndglQNqG--VLRVRD--GLDPEWE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 144 VLFNLEELKLDQP-FIDCIRVAPDEKYVAAKIRTEDSEASTCVIIKLSDQPVMEASFPNV--SSFEWVkdeeDEDVLFYT 220
Cdd:COG1505  108 VLLDPNALSEDGTwVLGAWSLSPDGRRLAYSLSEGGSDARVVRVFDVATGEFVEDGFEWEkkSGVAWL----DGTGFVYS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 221 -------------FQRNLRCH--------DVYraTFGDnkrnerfyTEKDPSYFVFLYLTKDSRFLTINIMNKT-TSEVW 278
Cdd:COG1505  184 rygepegsltdsgYPRKVYYHrrgtpqseDEL--VFEG--------PPDDPERYVGVSVSEDGRYLLISRALGFyRNELY 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 279 LID----GLSPWDPPVliqkrihGVLYYVEHRDDELYILTNVGEPTeFKLMRTAADTPAIMNWDLF----------FTMK 344
Cdd:COG1505  254 LLDlpdgELVPLDLPF-------DADYSGVVNGGWLYLLTRLDAPR-GRLVAIDLAAPGPRNWTEFipeaeavlegVSWT 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 345 RNT-------------KVIDLD----------------MF---KDHCVLFLKHSNLLYVNVIGLADDSVRSL-------- 384
Cdd:COG1505  326 GGRlvlsylddvvsrvRVYDLDgklvrevplpglgsvsGFsgdDDGDELFYSFTSFLTPPTLYRYDLGTGESellkkppa 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 385 ----------------KDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGE 448
Cdd:COG1505  406 pfdasdyeveqvfatsKDGTRVPYFIVHKKGLKLDGPNPTLLYGYGGFNISLTPSYSASGLAWLERGGVYAVANLRGGGE 485

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 449 LGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNT--- 525
Cdd:COG1505  486 YGPAWHQAGLKENKQNVFDDFIAAAEDLIARGYTSPERLAIQGGSNGGLLVGAALTQRPELFGAVVCAVPLLDMLRYhkf 565

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 108860692 526 ------MMDttlpltleeleeWGNPsSDEKHKNYIKRYCPYQNIKP-QHYPSIHITAYENDERV 582
Cdd:COG1505  566 tagaswIAE------------YGDP-DDPEEFAYLYAYSPYHNVKAgVAYPATLFTTADHDDRV 616
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
424-647 1.60e-21

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 93.45  E-value: 1.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  424 FRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALC 503
Cdd:pfam00326   3 FSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  504 NSNPELVRAVTLEAPFLDVLnTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPqhYPSIHITAYENDERVP 583
Cdd:pfam00326  83 NQRPDLFKAAVAHVPVVDWL-AYMSDTSLPFTERYMEWGNPWDNEEGYDYLSPYSPADNVKV--YPPLLLIHGLLDDRVP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108860692  584 LKGIVSYTEKLKEAiaehakdtGEGYQtpniiLDIQPGGNHVI--EDSHKKITAQI-KFLYEELGLD 647
Cdd:pfam00326 160 PWQSLKLVAALQRK--------GVPFL-----LLIFPDEGHGIgkPRNKVEEYARElAFLLEYLGGT 213
Peptidase_S9_N pfam02897
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
 108-337 6.70e-20

Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.


Pssm-ID: 397164 [Multi-domain]  Cd Length: 414  Bit Score: 92.76  E-value: 6.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  108 YEIINVEVKHGGFVYYQ--EGCC----LVRSKDEEADNDNYEVLFNLEELKLDQPF--IDCIRVAPDEKYVAAKIRTEDS 179
Cdd:pfam02897  68 YDDISAPFRKGGYYYYFrnDGGKnqsvLYRQDALPGEGKPEEVFLDPNTLSEDGTFtaLGGFAFSPDGRLLAYSLSLSGS 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  180 EASTCVIIKLSDQPVMEASFPNV--SSFEWVKDEedeDVLFYT----------FQRNLRcHDVYRATFGDNKRNER--FY 245
Cdd:pfam02897 148 DWYTIRFRDVETGEDLPDVLEGVkfSGIVWAPDG---KGFFYTrydkpdersdTGTNLN-QKVWRHRLGTPQSQDVlvFE 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692  246 TEKDPSYFVFLYLTKDSRFLTINIMNKT-TSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRD-DELYILTNVGEPTeFK 323
Cdd:pfam02897 224 FPKDPLWSLGAERSEDGKYLFISSASGTdTNELYYLDLTKETGDTLKLVDGRFDGEYDVEHNEgDRFYFLTNDGAPN-FR 302

                         250
                  ....*....|....
gi 108860692  324 LMRTAADTPAIMNW 337
Cdd:pfam02897 303 LVRVDLNDPSPSEW 316
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
386-645 1.82e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 61.57  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 386 DGKLVPMTVFHKTDSEdlqKKPLLVHVYGaYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADgrltkklnG 465
Cdd:COG1506    6 DGTTLPGWLYLPADGK---KYPVVVYVHG-GPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD--------E 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 466 LADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDvlntMMDTTLPLTLEELEEWGNPS 545
Cdd:COG1506   74 VDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSD----LRSYYGTTREYTERLMGGPW 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108860692 546 SDEKHknyikrycpYQNIKPQHY-PSIH----ITAYENDERVPlkgiVSYTEKLKEAIAEHAKDTGegyqtpniiLDIQP 620
Cdd:COG1506  150 EDPEA---------YAARSPLAYaDKLKtpllLIHGEADDRVP----PEQAERLYEALKKAGKPVE---------LLVYP 207

                        250       260
                 ....*....|....*....|....*..
gi 108860692 621 GGNHVIEDSHKK--ITAQIKFLYEELG 645
Cdd:COG1506  208 GEGHGFSGAGAPdyLERILDFLDRHLK 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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