|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
41-1466 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1692.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 41 SKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 117
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 118 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 196
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 197 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG 275
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 276 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE 355
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 356 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 435
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 436 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 515
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 516 QIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFITPIV 594
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNpGFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 595 KASK-NKQELSFYSIPEFDEWKKHIeNQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKK 673
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 674 IDDRKEWLTNFMedrrqrrlhglPEQFLyGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRN 753
Cdd:PTZ00108 637 VEDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRN 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 754 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 833
Cdd:PTZ00108 705 LKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYI 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 834 FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKG 913
Cdd:PTZ00108 785 FPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 914 TIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEpmlNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKL 993
Cdd:PTZ00108 865 TIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLNDGVL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 994 AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE 1073
Cdd:PTZ00108 941 EQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKH 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1074 KIQGKITIENRSKKDLIQMLVQRGYES-DPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGP--DFNYILNMSLWSLT 1150
Cdd:PTZ00108 1021 VINGELVITNAKKKDLVKELKKLGYVRfKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAavSYDYLLSMPIWSLT 1100
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1151 KEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMP 1230
Cdd:PTZ00108 1101 KEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKK 1180
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1231 SpygrriipeiTAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGeealtpsvpINKGPKPKREKKEPGTRVR 1310
Cdd:PTZ00108 1181 K----------KKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSG---------SDQEDDEEQKTKPKKSSVK 1241
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1311 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKytfdfSEEEDDDADDDDDDNNDLEEL 1390
Cdd:PTZ00108 1242 RLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGE-----SNGGSKPSSPTKKKVKKRLEG 1316
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19913408 1391 KVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNlfSFPSYSQKSEDDSakfDSNEEDS 1466
Cdd:PTZ00108 1317 SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSED--DDDSEVDDSEDED---DEDDEDD 1387
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
96-685 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 807.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 96 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 175
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 176 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 255
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 256 TRRAYDLAGSCRGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 327
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 328 SFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 405
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 406 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 480
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 481 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQ 560
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFD----IEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 561 DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQ--ELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTA 637
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 19913408 638 KEAKEYFADMERHRILFRYAGPEDDA-AITLAFSKKKIDDRKEWLTNFM 685
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
727-1187 |
2.92e-172 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 525.59 E-value: 2.92e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 727 NERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSaYHHGEQALMMTIVNLAQNFvgSNNINLLQPI 803
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 804 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPN 882
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 883 YDAREIVNNVRRMLDGLDP-------HPMLPNYKNFkGTIQ---------ELGQNQYAVSGEIFVVD---RNTVEITELP 943
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEgragireayETGRGRYIIRGKYEIEDdegRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 944 VRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNsMVLFDHMG 1023
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1024 CLKKYeTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE--KIQGKITIENRSKKDLIQMLVQRGYESD 1101
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1102 pvkawkeaqekaaeedetqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS-----P 1176
Cdd:cd00187 390 -----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILaseerP 434
|
490
....*....|.
gi 19913408 1177 SDLWKEDLAAF 1187
Cdd:cd00187 435 KDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
729-1184 |
8.51e-152 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 470.49 E-value: 8.51e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFVGsnNINLLQPIGQ 805
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 806 FGTRLHGGKDAAsPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 884
Cdd:pfam00521 77 FGSRIDGDKDAA-MRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 885 AREIVNNVRRMLDGLDP-----HPMLPNYKNFKGTIQEL--------GQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY 951
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGgikeayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 952 KEQVLEPMLNGTDKtpaLISDYKEYhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETV 1031
Cdd:pfam00521 236 IEKIEELVKNGKIK---GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDG---GPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1032 QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN------NQARFILEKIQGKItIENRSKKDLIQMLvqrgyesdpvka 1105
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1106 wKEAQekaaeedetqnqhddsssdsgtpsgpdFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPS-----DLW 1180
Cdd:pfam00521 376 -SEIQ---------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLW 427
|
....
gi 19913408 1181 KEDL 1184
Cdd:pfam00521 428 IEEL 431
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
56-680 |
2.28e-41 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 162.89 E-value: 2.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 56 LEHILLRPDTYIGSVepltqfmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 127
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 128 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 205
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 206 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMFNGKKLPV----- 280
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 281 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 342
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 343 --DYVVDQvvGKLievvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 407
Cdd:COG0187 294 inDYARKN--GLL----KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 408 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 473
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 474 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTL 547
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFD----LEKL 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 548 RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK 625
Cdd:COG0187 489 RYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGKKKVE 566
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 19913408 626 IKYYKGLGTSTAKEAKEYFADMErHRILFRyAGPEDDAAITLAFSK---KKIDDRKEW 680
Cdd:COG0187 567 IQRYKGLGEMNPEQLWETTMDPE-TRTLLQ-VTIEDAAEADEIFSLlmgDKVEPRREF 622
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1503-1605 |
8.81e-23 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 94.44 E-value: 8.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1503 KRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGkgRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSdvdiFP 1582
Cdd:pfam08070 1 KAAPKAAKAADKSSSDSDSDAGASKKPAPPKG--RKARKRKPSSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDD----FS 74
|
90 100
....*....|....*....|...
gi 19913408 1583 SDFPTEPPSLPRTGRARKEVKYF 1605
Cdd:pfam08070 75 VDLDSEVAPRARPGRAKKPVKYL 97
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
729-1050 |
8.64e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 89.68 E-value: 8.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 804
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 805 QFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPN 882
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 883 YDAREIVNNVRRMLDGLD----------PHPMLP-----NYKnfKGTIQ--ELGQNQYAVSGEIFV----VDRNTVEITE 941
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiiLGR--SGIRSayETGRGSIVIRARAEIeedsKGREAIIVTE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 942 LPVrtwtQVYKEQVLEPMLN-GTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1020
Cdd:TIGR01063 256 IPY----QVNKARLIEKIAElVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVK 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 19913408 1021 HmgcLKKYETVQDILKEFFDLRL------SYYGLRK 1050
Cdd:TIGR01063 332 G---LPKVLNLKELLEAFVEHRKdvitrrTIFELRK 364
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
41-1466 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1692.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 41 SKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 117
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 118 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 196
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 197 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG 275
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 276 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE 355
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 356 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 435
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 436 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 515
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 516 QIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFITPIV 594
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNpGFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 595 KASK-NKQELSFYSIPEFDEWKKHIeNQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKK 673
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 674 IDDRKEWLTNFMedrrqrrlhglPEQFLyGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRN 753
Cdd:PTZ00108 637 VEDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRN 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 754 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 833
Cdd:PTZ00108 705 LKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYI 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 834 FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKG 913
Cdd:PTZ00108 785 FPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 914 TIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEpmlNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKL 993
Cdd:PTZ00108 865 TIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLNDGVL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 994 AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE 1073
Cdd:PTZ00108 941 EQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKH 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1074 KIQGKITIENRSKKDLIQMLVQRGYES-DPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGP--DFNYILNMSLWSLT 1150
Cdd:PTZ00108 1021 VINGELVITNAKKKDLVKELKKLGYVRfKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAavSYDYLLSMPIWSLT 1100
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1151 KEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMP 1230
Cdd:PTZ00108 1101 KEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKK 1180
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1231 SpygrriipeiTAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGeealtpsvpINKGPKPKREKKEPGTRVR 1310
Cdd:PTZ00108 1181 K----------KKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSG---------SDQEDDEEQKTKPKKSSVK 1241
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1311 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKytfdfSEEEDDDADDDDDDNNDLEEL 1390
Cdd:PTZ00108 1242 RLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGE-----SNGGSKPSSPTKKKVKKRLEG 1316
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19913408 1391 KVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNlfSFPSYSQKSEDDSakfDSNEEDS 1466
Cdd:PTZ00108 1317 SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSED--DDDSEVDDSEDED---DEDDEDD 1387
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
45-1192 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1652.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYdEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVS 124
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 125 IDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 204
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 205 SFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG-SCRGVKVMFNGKKLPVNG 282
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 283 FRSYVDLYVKDKLDETGvaLKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNK 362
Cdd:PLN03128 241 FQDYVGLYLGPNSREDP--LPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 363 AGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLnKK 442
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 443 CSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAE 522
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 523 INNIIKIVGLQYKKSYDdAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKASKNKQ 601
Cdd:PLN03128 478 ITNIKQILGLQFGKTYD-EENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 602 ELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEW 680
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLEGEtKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 681 LTNFMEDrrqrrlhglpeQFLYGTATKhLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKV 760
Cdd:PLN03128 637 LNNYEPG-----------TFLDQTGNG-ISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 761 AQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN 840
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 841 LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQE--- 917
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEvst 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 918 LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAE 997
Cdd:PLN03128 865 SRSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 998 AAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQG 1077
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1078 KITIENRSKKDLIQMLVQRGYESDPVK-AWKEAQEKAAEEDETQNQHDDSSSDsgtpSGPDFNYILNMSLWSLTKEKVEE 1156
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFPKTaKISETNVVGDRDGEASEEEEASDNE----LAKSYDYLLGMPISSLTLEKVDE 1099
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 19913408 1157 LIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELD 1192
Cdd:PLN03128 1100 LRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
35-1364 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1475.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 35 ANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDvGMNCREVTFVPGLYKIFDEILVNAADNKQR 114
Cdd:PLN03237 17 AAPAASSGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETD-KMVQRSVTYVPGLYKIFDEILVNAADNKQR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 115 DKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFT 194
Cdd:PLN03237 96 DPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 195 VETACKEYKHSFKQTWMNNMMKTSEAKI-KHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGsCRG--VKV 271
Cdd:PLN03237 176 IETADGKRQKKYKQVFSNNMGKKSEPVItKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAG-CLGktVKV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 272 MFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVG 351
Cdd:PLN03237 255 ELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQIAN 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 352 KLIEVVKKKNKAGvSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWV 431
Cdd:PLN03237 335 HVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKSGIVENLLSWA 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 432 KFKAQTQLnKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVRE 511
Cdd:PLN03237 414 DFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLRGKLLNVRE 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 512 ASHKQIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFI 590
Cdd:PLN03237 493 ASHKQIMNNAEIENIKQILGLQHGKQY---ESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKvPSFLVEFI 569
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 591 TPIVKASK-NKQELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLA 668
Cdd:PLN03237 570 TPIVKATRrGKKVLSFYSMPEYEEWKESLGgNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAIELA 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 669 FSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYGTAtKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFT 748
Cdd:PLN03237 650 FSKKKIEARKNWLRQYE-----------PGTHLDQTQ-KDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFC 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 749 CFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLST 828
Cdd:PLN03237 718 SFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTRLSP 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 829 LARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNY 908
Cdd:PLN03237 798 ITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMHPWY 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 909 KNFKGTIQE----LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPA-LISDYKEYHTDTTVK 983
Cdd:PLN03237 878 RGFKGTIEKtaskEGGCTYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpFIKDVKAYNDDTTVH 956
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 984 FVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTK 1063
Cdd:PLN03237 957 FEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFELLK 1036
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1064 LNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDP--VKAWKEAQEKAAEEDETQNQHDDSSSDSGTPsGPDFNYI 1141
Cdd:PLN03237 1037 LENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPkkAKSVEAAVAGATDDAAEEEEEIDVSSSSGVR-GSDYDYL 1115
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1142 LNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKV--ESQEREDVLAGMSGKAIKGKVGKPK 1219
Cdd:PLN03237 1116 LSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLdkEDAKAEEAREKLQRAAARGESGAAK 1195
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1220 VKKLQLEETmPSPygrriipeitaMKADASKKLLKKKKGDLDTAAVKVEFDEEF----------SGAPVEGAGEEALTPS 1289
Cdd:PLN03237 1196 KVSRQAPKK-PAP-----------KKTTKKASESETTEETYGSSAMETENVAEVvkpkgragakKKAPAAAKEKEEEDEI 1263
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1290 VPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDE--SKSESDLEETEPVVIPRDSLLRR----AAAERP 1363
Cdd:PLN03237 1264 LDLKDRLAAYNLDSAPAQSAKMEETVKAVPARRAAARKKPLASVSviSDSDDDDDDFAVEVSLAERLKKKggrkPAAANK 1343
|
.
gi 19913408 1364 K 1364
Cdd:PLN03237 1344 K 1344
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
96-685 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 807.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 96 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 175
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 176 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 255
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 256 TRRAYDLAGSCRGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 327
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 328 SFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 405
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 406 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 480
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 481 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQ 560
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFD----IEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 561 DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQ--ELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTA 637
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 19913408 638 KEAKEYFADMERHRILFRYAGPEDDA-AITLAFSKKKIDDRKEWLTNFM 685
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
709-1182 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 564.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 709 LTYNDFINKELILFSNS-DNERSIPSLVDGFKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSAYH-HGEQALMMTIV 785
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 786 NLAQNFVgsNNINLLQPIGQFGTRLhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMV 864
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 865 LINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHP----MLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEIT 940
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 941 ELPVRTWTQVYKEQVLEPMLNGtdKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1020
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1021 HmGCLKKYETVQdILKEFFDLRLSYYGLRKEWLVGMLGAEsTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYES 1100
Cdd:smart00434 316 N-GRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1101 DpvkawkeaqekaaEEDETQnqhddsssdsgtpsgpdFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLW 1180
Cdd:smart00434 393 F-------------ELSEIQ-----------------ADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEW 442
|
..
gi 19913408 1181 KE 1182
Cdd:smart00434 443 LN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
727-1187 |
2.92e-172 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 525.59 E-value: 2.92e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 727 NERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSaYHHGEQALMMTIVNLAQNFvgSNNINLLQPI 803
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 804 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPN 882
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 883 YDAREIVNNVRRMLDGLDP-------HPMLPNYKNFkGTIQ---------ELGQNQYAVSGEIFVVD---RNTVEITELP 943
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEgragireayETGRGRYIIRGKYEIEDdegRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 944 VRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNsMVLFDHMG 1023
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1024 CLKKYeTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE--KIQGKITIENRSKKDLIQMLVQRGYESD 1101
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1102 pvkawkeaqekaaeedetqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS-----P 1176
Cdd:cd00187 390 -----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILaseerP 434
|
490
....*....|.
gi 19913408 1177 SDLWKEDLAAF 1187
Cdd:cd00187 435 KDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
729-1184 |
8.51e-152 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 470.49 E-value: 8.51e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFVGsnNINLLQPIGQ 805
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 806 FGTRLHGGKDAAsPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 884
Cdd:pfam00521 77 FGSRIDGDKDAA-MRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 885 AREIVNNVRRMLDGLDP-----HPMLPNYKNFKGTIQEL--------GQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY 951
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGgikeayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 952 KEQVLEPMLNGTDKtpaLISDYKEYhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETV 1031
Cdd:pfam00521 236 IEKIEELVKNGKIK---GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDG---GPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1032 QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN------NQARFILEKIQGKItIENRSKKDLIQMLvqrgyesdpvka 1105
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1106 wKEAQekaaeedetqnqhddsssdsgtpsgpdFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPS-----DLW 1180
Cdd:pfam00521 376 -SEIQ---------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLW 427
|
....
gi 19913408 1181 KEDL 1184
Cdd:pfam00521 428 IEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
93-238 |
1.70e-97 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 309.65 E-value: 1.70e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 93 FVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 172
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19913408 173 KVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHF-DGEDYTCITFQPD 238
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
57-642 |
3.98e-86 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 294.74 E-value: 3.98e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 57 EHILLRPDTYIGSV--EPLTQFMwvydedVGmNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISI 134
Cdd:PHA02569 11 EHILKRPGMYIGSVayEAHERFL------FG-KFTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 135 WNNGKGIP---VVEHKVEKVYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTwm 211
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCS-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 212 NNM----MKTSEAKIKHfdgedyTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNgFRSYV 287
Cdd:PHA02569 161 NGAenisWSTKPGKGKG------TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 288 DLYVKDKldetgvalkVIHElaNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSv 367
Cdd:PHA02569 234 KQFGDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHKIEVT- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 368 KPfQVKN--HIWVFINCLIeNPTFDSQTKENMTLQPKSFGSKCQLSEKFF--KAASNCGIVESILNWVKFK-------AQ 436
Cdd:PHA02569 302 KA-RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakQILKTEAIIMPIIEAALARklaaekaAE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 437 TQLNKKCSSVKYSK-IKgipklddANDAGgkHSLECTLILTEGDSAKSLAVSglgVIGRDRYGVFPLRGKILNVREASHK 515
Cdd:PHA02569 380 TKAAKKAKKAKVAKhIK-------ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYA 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 516 QIMENAEINNIIKIVGLQYKksyDDAESLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLLKHGFLEEFITPIV 594
Cdd:PHA02569 448 DILKNKELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGRIRFVKTPVI 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 19913408 595 KASKNKQELSFYSIPEFDEWKkhiENQKAWKIKYYKGLGTSTAKEAKE 642
Cdd:PHA02569 521 IAQVGKETKWFYSLDEFEKAK---DSLKKWSIRYIKGLGSLRKSEYRR 565
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
281-433 |
1.04e-85 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 276.48 E-value: 1.04e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 281 NGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK 360
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19913408 361 NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKF 433
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
471-591 |
4.14e-79 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 256.07 E-value: 4.14e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 471 CTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaESLKTLRYG 550
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDY--ESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 19913408 551 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFIT 591
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIpGFLVEFIT 120
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
713-1193 |
3.06e-77 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 263.46 E-value: 3.06e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 713 DFINKELILFSNSD-NERSIPSLVDGFKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSaYHHGEQALMMTIVNLA 788
Cdd:PHA02592 10 SIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQDAGALMA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 789 QNFvgSNNINLLQPIGQFGTRLhgGKDAASPRYIFTMLSTLARLLFPAVDdnlLKFLYDDNQRVEPEWYIPIIPMVLING 868
Cdd:PHA02592 89 NTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDED---LAPVHEDPEHIPPAFYLPIIPMVLLNG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 869 AEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWT 948
Cdd:PHA02592 162 VSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEIPVKYDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 949 QVYKEqVLEPMLNgtdktPALISDYKEYHTDtTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLfDHMGCLKKY 1028
Cdd:PHA02592 242 ETYVA-VLDPLEE-----KGKIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NENGKLKVY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1029 ETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLvqrgyesdpvKAWKE 1108
Cdd:PHA02592 314 ENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL----------SDNKD 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1109 AQEKAAEedetqnqhddsssdsgtpsgpdfnyILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLaafv 1188
Cdd:PHA02592 384 FGEYADK-------------------------LVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEYIKDL---- 434
|
....*
gi 19913408 1189 EELDK 1193
Cdd:PHA02592 435 EELKK 439
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
589-727 |
9.16e-74 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 241.27 E-value: 9.16e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 589 FITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLA 668
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 19913408 669 FSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYgTATKHLTYNDFINKELILFSNSDN 727
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
471-591 |
1.41e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 211.60 E-value: 1.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 471 CTLILTEGDSAKSLAVSGLGVIgrdRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYddaESLKTLRYG 550
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDD---FDLDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 19913408 551 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFIT 591
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
56-683 |
9.12e-59 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 215.35 E-value: 9.12e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 56 LEHILLRPDTYIGSvepltqfmwvYDEDvgmncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 128
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 129 sNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSF 206
Cdd:PRK05559 69 -GSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKrdGKVYRQRF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 207 KqtwmNNMMKTSEAKI-KHFDGEDYTCITFQPDLS-----KFKMEKLDKdivalMTRR-AYdLagsCRGVKVMFNGKKLP 279
Cdd:PRK05559 148 E----GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKifdspKFSPERLKE-----RLRSkAF-L---LPGLTITLNDERER 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 280 V-----NGFRSYVDLYVKDK--LDETGVAlKVIHELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHVDYVVDQVVG 351
Cdd:PRK05559 215 QtfhyeNGLKDYLAELNEGKetLPEEFVG-SFEGEAEGEAVEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 352 KLIEVVKKKN--KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENM-TLQPKSFGSKcQLSEKF-FKAASNCGIVESI 427
Cdd:PRK05559 294 AVREFAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRFVSG-VVKDAFdLWLNQNPELAEKL 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 428 LNWVKFKAQTQLNKKCSSVKYSKIKGI---PKLddaNDAGGKHSLECTLILTEGDSAkslavSGLGVIGRDRY--GVFPL 502
Cdd:PRK05559 373 AEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILPL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 503 RGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK 582
Cdd:PRK05559 445 RGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFD----LEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVE 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 583 HGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKA-WKIKYYKGLGTSTAKEAKEYFADmERHRILFRYAgP 659
Cdd:PRK05559 521 AGHV--YIalPPLYRVDKGKKKIYALDEEEKEELLKKLGKKGGkPEIQRFKGLGEMNPDQLWETTMD-PETRRLVRVT-I 596
|
650 660
....*....|....*....|....*..
gi 19913408 660 EDDAAITLAFSK---KKIDDRKEWLTN 683
Cdd:PRK05559 597 DDAEETEKLVDMlmgKKAEPRREWIEE 623
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
56-680 |
2.28e-41 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 162.89 E-value: 2.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 56 LEHILLRPDTYIGSVepltqfmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 127
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 128 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 205
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 206 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMFNGKKLPV----- 280
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 281 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 342
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 343 --DYVVDQvvGKLievvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 407
Cdd:COG0187 294 inDYARKN--GLL----KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 408 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 473
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 474 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTL 547
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFD----LEKL 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 548 RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK 625
Cdd:COG0187 489 RYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGKKKVE 566
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 19913408 626 IKYYKGLGTSTAKEAKEYFADMErHRILFRyAGPEDDAAITLAFSK---KKIDDRKEW 680
Cdd:COG0187 567 IQRYKGLGEMNPEQLWETTMDPE-TRTLLQ-VTIEDAAEADEIFSLlmgDKVEPRREF 622
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
56-633 |
6.79e-38 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 152.56 E-value: 6.79e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 56 LEHILLRPDTYIGSVEP--LTQFMW-VYDEDVgmncrevtfvpglykifDEILVNAADNkqrdknmtcIKVSIDPEsNII 132
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGErgLHHLVYeIVDNSI-----------------DEALAGYCDH---------IEVTINED-GSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 133 SIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSFKQ 208
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKrdGKIYYQEYER 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 209 TwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMF----NGKKLPV---- 280
Cdd:PRK05644 150 G-----VPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEEtfhy 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 281 -NGFRSYVDLYVKDKldetgvalKVIHE----LANERWDVCLtlsEKGFQQ--------ISFVNSIATTKGGRHV----- 342
Cdd:PRK05644 222 eGGIKEYVEYLNRNK--------EPLHEepiyFEGEKDGIEV---EVAMQYndgyseniLSFANNINTHEGGTHEegfkt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 343 -------DYVVDQvvGKLIEvvKKKNKAG----------VSVKpfqvknhiwvfinclIENPTFDSQTK------ENMTL 399
Cdd:PRK05644 291 altrvinDYARKN--KLLKE--KDDNLTGedvregltavISVK---------------HPEPQFEGQTKtklgnsEVRGI 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 400 QPKSFGSKcqLSEkFFKaaSNCGIVESILNWVKFKAQT--------QLNKKCSSVKYSkikGIP-KLDD--ANDAGgkhs 468
Cdd:PRK05644 352 VDSVVSEA--LSE-FLE--ENPNVAKKIVEKAILAARAreaarkarELTRRKSALESS---SLPgKLADcsSKDPE---- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 469 lECTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKT 546
Cdd:PRK05644 420 -ESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDFD----ISK 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 547 LRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFIT--PIVKASKNKQELsFYSIPEFDEWKKHIENQ--K 622
Cdd:PRK05644 490 LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKIKKGGKEY-AYSDEELDEILAELKLKgnP 566
|
650
....*....|.
gi 19913408 623 AWKIKYYKGLG 633
Cdd:PRK05644 567 KYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
282-442 |
4.94e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 120.80 E-value: 4.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 282 GFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTL---SEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVK 358
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 359 KKN---KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFK-AASNCGIVESILNWVKFK 434
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEfLEENPEIAKKILEKALQA 160
|
....*...
gi 19913408 435 AQTQLNKK 442
Cdd:pfam00204 161 AKARLAAR 168
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
471-586 |
1.28e-26 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 105.81 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 471 CTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLR 548
Cdd:cd03366 1 SELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|....*...
gi 19913408 549 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFL 586
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIENGHV 109
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
728-1089 |
2.28e-25 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 113.65 E-value: 2.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 728 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSAYH-HGEQALMMTIVNLAqnfvgsNNINLLQPIGQF 806
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 807 GTrLHGGKDAASPRYIFTMLSTLAR--LLFPAVDDNLLKFlydDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 884
Cdd:PRK09631 93 GN-LFTGDPASAARYIECRLTPLAKevLYNKEITEYEPSY---DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 885 AREIVNNVRRMLDGlDPHPMLPNYKNfkGTIQELgqNQYA-------VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLE 957
Cdd:PRK09631 169 FNEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYAdgngkvlVRAKIETKDEKTIVIREIPFGTTTESLIASIEK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 958 PMLNGTDKTPAlISDYkeyhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETVQDILKe 1037
Cdd:PRK09631 244 AARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK- 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 19913408 1038 ffdlrlsyygLRKEWLVGMLGAEstkLNNQARFILEKIQGK----ITIENRSKKDL 1089
Cdd:PRK09631 315 ----------FHAEHLQKVLKME---LELERAKLLEKIFAKtleqIFIEERIYKRI 357
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1503-1605 |
8.81e-23 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 94.44 E-value: 8.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 1503 KRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGkgRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSdvdiFP 1582
Cdd:pfam08070 1 KAAPKAAKAADKSSSDSDSDAGASKKPAPPKG--RKARKRKPSSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDD----FS 74
|
90 100
....*....|....*....|...
gi 19913408 1583 SDFPTEPPSLPRTGRARKEVKYF 1605
Cdd:pfam08070 75 VDLDSEVAPRARPGRAKKPVKYL 97
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
56-603 |
2.63e-20 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 97.86 E-value: 2.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 56 LEHILLRPDTYIGsvepltqfmwvyDEDVGMncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 128
Cdd:PRK14939 18 LDAVRKRPGMYIG------------DTDDGT---------GLHHMVYEVVDNAIDealaghcDD--------ITVTIHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 129 sNIISIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKH 204
Cdd:PRK14939 69 -GSVSVSDNGRGIPTDIHPEEGV--SAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLelTIRRDGKIHEQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 205 SFKQTWMNNMMKTSEAKIKHfdGedyTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMF----NGKKLP- 279
Cdd:PRK14939 146 EFEHGVPVAPLKVVGETDKT--G---TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLkderDGKEEEf 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 280 -----VNGFRSYVDlyvKDKldeTGVALKVIHeLANERWDVCLTLS---EKGFQQ--ISFVNSIATTKGGRHV---DYVV 346
Cdd:PRK14939 218 hyeggIKAFVEYLN---RNK---TPLHPNIFY-FSGEKDGIGVEVAlqwNDSYQEnvLCFTNNIPQRDGGTHLagfRAAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 347 DQVVGKLIEV--VKKKNK-------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKENMtlqpksfGSkcqlS 411
Cdd:PRK14939 291 TRTINNYIEKegLAKKAKvsltgddaregltAVLSVK---------------VPDPKFSSQTKDKL-------VS----S 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 412 E-KffkaasncGIVESILNwvkfkaqTQL------NKKCSSVKYSKI-------------------KGIpkLDDAN---- 461
Cdd:PRK14939 345 EvR--------PAVESLVN-------EKLsefleeNPNEAKIIVGKIidaarareaarkareltrrKGA--LDIAGlpgk 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 462 --DAGGKHSLECTLILTEGDSA----KSlavsglgviGRDRygVF----PLRGKILNVREASHKQIMENAEINNIIKI-- 529
Cdd:PRK14939 408 laDCQEKDPALSELYLVEGDSAggsaKQ---------GRDR--KFqailPLKGKILNVEKARFDKMLSSQEIGTLITAlg 476
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19913408 530 --VGlqyKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQEL 603
Cdd:PRK14939 477 cgIG---RDEFN----PDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaqPPLYKVKKGKQEQ 545
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
282-584 |
2.53e-18 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 91.48 E-value: 2.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 282 GFRSYVDLYVKDKL----DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTkGGRHVD---YVVDQVVGKLI 354
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDgfkYAITRCVNGNI 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 355 evvkKKNKA-GVSVKPFQ---VKNHIWVFINCLIENPTFDSQTKEnmtlqpksfgskcQLSEKFFKAasncgIVESILNW 430
Cdd:PTZ00109 455 ----KKNGYfKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 431 vKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAG-----------------GKHSlECT--------LILTEGDSAkslA 485
Cdd:PTZ00109 513 -QLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirqknnqyystilpGKLV-DCIsddierneLFIVEGESA---A 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 486 VSGLGVIGRDRYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGL----QYKKSYDDAESLK--------------- 545
Cdd:PTZ00109 588 GNAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLsvnpVTWRQYDLSHGTKaskdesvqnnnstlt 667
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 19913408 546 ---------TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHG 584
Cdd:PTZ00109 668 kkknslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHG 715
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
729-1050 |
8.64e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 89.68 E-value: 8.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 804
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 805 QFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPN 882
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 883 YDAREIVNNVRRMLDGLD----------PHPMLP-----NYKnfKGTIQ--ELGQNQYAVSGEIFV----VDRNTVEITE 941
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiiLGR--SGIRSayETGRGSIVIRARAEIeedsKGREAIIVTE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 942 LPVrtwtQVYKEQVLEPMLN-GTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1020
Cdd:TIGR01063 256 IPY----QVNKARLIEKIAElVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVK 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 19913408 1021 HmgcLKKYETVQDILKEFFDLRL------SYYGLRK 1050
Cdd:TIGR01063 332 G---LPKVLNLKELLEAFVEHRKdvitrrTIFELRK 364
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
728-1054 |
2.23e-16 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 84.18 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 728 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSAYHHGEQALMMTIVNLAqnfvgsNNINLLQPIGQFG 807
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 808 TRLHGGKDAASpRYIFTMLSTLAR-LLFpavDDNLLKF--LYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 884
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKeVLF---NTDLMTFhdSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 885 AREIVNNVRRMLDGlDPHPMLPNYknFKGTIQELGQNQ-----YAVSGEIFVVDRNTVEITELPVRTWTqvykEQVLEPM 959
Cdd:PRK09630 169 FCELLEAQIAILND-QPFTLLPDF--PSGGTMDASEYQdglgsITLRASIDIINDKTLLIKEICPSTTT----ETLIRSI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 960 LNGTDKTPALISDYKEYHTDTTvKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgclKKYET-VQDILKEF 1038
Cdd:PRK09630 242 ENAAKRGIIKIDSIQDFSTDLP-HIEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTAIYQN----KPVETsISEILRLH 316
|
330
....*....|....*.
gi 19913408 1039 FDLRLSYygLRKEWLV 1054
Cdd:PRK09630 317 TETLQGY--LKKELLI 330
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
97-274 |
1.12e-12 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 67.95 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 97 LYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDD 169
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLHED-NSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 170 DEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKHSFKqtwmnNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKL 247
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLevEVKRDGKIYRQEFS-----RGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEF 146
|
170 180
....*....|....*....|....*..
gi 19913408 248 DKDIVAlmtRRAYDLAGSCRGVKVMFN 274
Cdd:cd16928 147 DFDTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
728-903 |
3.03e-11 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 68.21 E-value: 3.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 728 ERSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 803
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 804 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 881
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180
....*....|....*....|..
gi 19913408 882 NYDAREIVNNVRRMLDgldpHP 903
Cdd:PRK05561 186 PHNLREVIDAAIHLID----NP 203
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
728-965 |
1.55e-10 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 66.18 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 728 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMsAYH-HGEQALMMTIVNLAQNFVgsnninLLQPIGQF 806
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHT--M-QYHpHGDASIGDALVQLGQKDL------LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 807 GTRLhGGKDAASPRYIFTMLSTLA-RLLF-PAVDDNLLKFlydDNQRVEPEwYIPI-IPMVLINGAEGIGTGWACKLPNY 883
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPH 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 884 DAREIVNNVRRMLDGlDPHPMLPNYKNfKGTIQELGQNQYAVSGEIFV------VDRNTVEITELPVRTWTqvykEQVLE 957
Cdd:PRK12758 187 NFNELIDASIAYLKG-KEFKLYPDFPT-GGIIDVSNYNDGERGGRVRVrakiekLDKKTLVITEIPYGTTT----SSLID 260
|
....*...
gi 19913408 958 PMLNGTDK 965
Cdd:PRK12758 261 SILKANDK 268
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
283-395 |
6.09e-10 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 58.04 E-value: 6.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 283 FRSYVDLYVKDKldetgVALKVIH---ELANERWDVCLTLSE----KGFQQISFVNSIATTKGGRHVDYVVDQVVGKLie 355
Cdd:cd00329 1 LKDRLAEILGDK-----VADKLIYvegESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 19913408 356 vvkkknkagvsvKPFQVKNHIWVFINCLIEN--PTFD-SQTKE 395
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
729-897 |
1.39e-09 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 63.12 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgsnniNLLQPI- 803
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 804 -GQ--FGTRlhGGKDAASPRYiftmlsTLARLLFPA-----------VD--DNllkflYDDNQRvEPEwYIPI-IPMVLI 866
Cdd:PRK05560 101 dGQgnFGSI--DGDPAAAMRY------TEARMSKIAhelladidketVDfvPN-----YDGSEQ-EPT-VLPArFPNLLV 165
|
170 180 190
....*....|....*....|....*....|.
gi 19913408 867 NGAEGIGTGWACKLPNYDAREIVNNVRRMLD 897
Cdd:PRK05560 166 NGSSGIAVGMATNIPPHNLGEVIDACLALID 196
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
729-897 |
6.86e-09 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 60.83 E-value: 6.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 729 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 804
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 805 QFGTRlhGGKDAASPRYiftmlsTLARLLFPA-----------VD--DNllkflYDDNQRvEPEwYIP-IIPMVLINGAE 870
Cdd:COG0188 110 NFGSI--DGDPAAAMRY------TEARLAKIAeelladidkdtVDfvPN-----YDGSEQ-EPT-VLPaRFPNLLVNGSS 174
|
170 180
....*....|....*....|....*..
gi 19913408 871 GIGTGWACKLPNYDAREIVNNVRRMLD 897
Cdd:COG0188 175 GIAVGMATNIPPHNLGEVIDACIALID 201
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
728-897 |
2.24e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 59.35 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 728 ERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 803
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 804 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 881
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170
....*....|....*.
gi 19913408 882 NYDAREIVNNVRRMLD 897
Cdd:PRK13979 189 PHNLKEVIDGTLAYID 204
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
96-193 |
1.48e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 48.52 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 96 GLYKIFDEILVNAADNKQrdkNMTCIKVSIDPESNI-ISIWNNGKGIPVVEHKvekvyvpaLIFGQLLTSSnydddekKV 174
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAA---KAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|....*....
gi 19913408 175 TGGRNGYGAKLCNIFSTKF 193
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELL 85
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
472-572 |
1.94e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.74 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 472 TLILTEGDS-AKSLAvsglGVIGRDRYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKsyddaeslktlryg 550
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 19913408 551 kIMIMTDQDQDGSHIKGLLINF 572
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
96-196 |
3.76e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 47.26 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 96 GLYKIFDEILVNAADNKQRDKNMTcIKVSIDPESNIISIWNNGKGIPvvEHKVEKVYVPaliFGQLltssnyddDEKKVT 175
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRIT-VTLERDGDHVEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRSRK 70
|
90 100
....*....|....*....|.
gi 19913408 176 GGRNGYGAKLCNIFSTKFTVE 196
Cdd:smart00387 71 IGGTGLGLSIVKKLVELHGGE 91
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
471-573 |
4.32e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.49 E-value: 4.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913408 471 CTLILTEGDS-AKSLAVsglgvIGRDRYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykksyddaeslktlRY 549
Cdd:cd00188 1 KKLIIVEGPSdALALAQ-----AGGYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100
....*....|....*....|....
gi 19913408 550 GKIMIMTDQDQDGSHIKGLLINFI 573
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELL 71
|
|
| |
