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Conserved domains on  [gi|115497052|ref|NP_001069130|]
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L-serine dehydratase/L-threonine deaminase [Bos taurus]

Protein Classification

serine/threonine dehydratase family protein( domain architecture ID 10157824)

serine/threonine dehydratase family protein such as L-serine dehydratase/L-threonine deaminase, a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catalyzes dehydration of L-Ser/Thr to yield pyruvate/ketobutyrate and ammonia

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
10-320 1.37e-139

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


:

Pssm-ID: 107209  Cd Length: 316  Bit Score: 397.44  E-value: 1.37e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERG---CEHFVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:cd06448    1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGlneCVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVGETL-DEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETM--TEKPGAI 163
Cdd:cd06448   81 VPESTKPRVVEKLRDEGATVVVHGKVWwEADNYLREELAENDPGPVYVHPFDDPLIWEGHSSMVDEIAQQLqsQEKVDAI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 164 VLAVGGGGLLCGVVQGLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFS 243
Cdd:cd06448  161 VCSVGGGGLLNGIVQGLERNGWGDIPVVAVETEGAHSLNASLKAGKLVTLPKITSVATSLGAKTVSSQALEYAQEHNIKS 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052 244 EVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgKLRTPLSSLVVIVCGGSNISLAQLVALKKQL 320
Cdd:cd06448  241 EVVSDRDAVQACLRFADDERILVEPACGAALAVVYSGKILDLQLE-VLLTPLDNVVVVVCGGSNITLEQLKEYKKQL 316
 
Name Accession Description Interval E-value
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
10-320 1.37e-139

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 397.44  E-value: 1.37e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERG---CEHFVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:cd06448    1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGlneCVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVGETL-DEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETM--TEKPGAI 163
Cdd:cd06448   81 VPESTKPRVVEKLRDEGATVVVHGKVWwEADNYLREELAENDPGPVYVHPFDDPLIWEGHSSMVDEIAQQLqsQEKVDAI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 164 VLAVGGGGLLCGVVQGLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFS 243
Cdd:cd06448  161 VCSVGGGGLLNGIVQGLERNGWGDIPVVAVETEGAHSLNASLKAGKLVTLPKITSVATSLGAKTVSSQALEYAQEHNIKS 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052 244 EVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgKLRTPLSSLVVIVCGGSNISLAQLVALKKQL 320
Cdd:cd06448  241 EVVSDRDAVQACLRFADDERILVEPACGAALAVVYSGKILDLQLE-VLLTPLDNVVVVVCGGSNITLEQLKEYKKQL 316
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
11-304 1.79e-52

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 425586 [Multi-domain]  Cd Length: 295  Bit Score: 174.42  E-value: 1.79e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCkMWAERGCE--HFVCSSAGNAGMAAAYAARKLGIPSTIVVP 88
Cdd:pfam00291   8 TPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLL-LRLKEGEGgkTVVEASSGNHGRALAAAAARLGLKVTIVVP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   89 STTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLAVG 168
Cdd:pfam00291  87 EDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGAYYINQYDNPLNIEGYGTIGLEILEQLGGDPDAVVVPVG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  169 GGGLLCGVVQGLAEvGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGV-TTVAAQAMKVYREHPIFSEVVS 247
Cdd:pfam00291 167 GGGLIAGIARGLKE-LGPDVRVIGVEPEGAPALARSLAAGRPVPVPVADTIADGLGVgFEPGALALDLLDEYVGEVVTVS 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052  248 DQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplSSLVVIVCG 304
Cdd:pfam00291 246 DEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-------DRVVVVLTG 295
IlvA COG1171
Threonine dehydratase [Amino acid transport and metabolism];
10-313 6.39e-47

Threonine dehydratase [Amino acid transport and metabolism];


Pssm-ID: 224092 [Multi-domain]  Cd Length: 347  Bit Score: 161.61  E-value: 6.39e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKmwAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:COG1171   25 PTPLQRSPSLSERLGAEIYLKRENLQPVGSFKIRGaynkLSSLSE--EEERAAGVIAASAGNHAQGVAYAAKRLGIKATI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVL 165
Cdd:COG1171  103 VMPETTPKIKVDATRGYGAEVILHGDNFDDAYAAAEELAEEE-GLTFVPPFDDPDVIAGQGTIALEILEQLPDLPDAVFV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 AVGGGGLLCGVVQGLAEVGWrDVPVITMETIGAESFHASTKAGKL-VTLPCITSVAKALGVTTVAAQAMKVYREHPIFSE 244
Cdd:COG1171  182 PVGGGGLISGIATALKALSP-EIKVIGVEPEGAPSMYASLKAGKIvVVLPDVGTIADGLAVKRPGDLTFEILRELVDDIV 260
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115497052 245 VVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplsSLVVIVCGGsNISLAQL 313
Cdd:COG1171  261 LVDEDEICAAMRDLFERTKIIAEPAGALALAALLAGKIEPLQGK--------TVVVILSGG-NIDFERL 320
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
11-310 2.49e-30

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 118.31  E-value: 2.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGalnkIANLSEDQRQRGV---VAASAGNHAQGVAYAAKKFGIKAVIV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   87 VPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELketMTEKP------ 160
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVILHGDDYDEAYAFATSLAEEE-GRVFVHPFDDEFVMAGQGTIGLEI---MEDIPdvdtvi 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  161 ------GAIVLAVGGGGLLCGvvqglaevgwrDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMK 234
Cdd:TIGR01127 154 vpvgggGLISGVASAAKQINP-----------NVKVIGVEAEGAPSMYESLREGKIKAVESVRTIADGIAVKKPGDLTFN 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497052  235 VYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSnviQKLQGEGKlrtplsSLVVIVCGGsNISL 310
Cdd:TIGR01127 223 IIKEYVDDVVTVDEEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGK------KIAVVLSGG-NIDL 288
PRK12483 PRK12483
threonine dehydratase; Reviewed
10-321 2.08e-26

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 109.12  E-value: 2.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK12483  37 ETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGaynkMARLPAEQLARGV---ITASAGNHAQGVALAAARLGVKAVI 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELketMTEKPGAIVL 165
Cdd:PRK12483 114 VMPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEE-GLTFVPPFDDPDVIAGQGTVAMEI---LRQHPGPLDA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 AVGGGGLLCGVVQGLAEVGW--RDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHpiFS 243
Cdd:PRK12483 190 IFVPVGGGGLIAGIAAYVKYvrPEIKVIGVEPDDSNCLQAALAAGERVVLGQVGLFADGVAVAQIGEHTFELCRHY--VD 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 244 EV--VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQK-LQGEgklrtplsSLVVIVcGGSNISLAQL--VALKK 318
Cdd:PRK12483 268 EVvtVSTDELCAAIKDIYDDTRSITEPAGALAVAGIKKYAEREgIEGQ--------TLVAID-SGANVNFDRLrhVAERA 338

                 ...
gi 115497052 319 QLG 321
Cdd:PRK12483 339 ELG 341
 
Name Accession Description Interval E-value
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
10-320 1.37e-139

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 397.44  E-value: 1.37e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERG---CEHFVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:cd06448    1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGlneCVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVGETL-DEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETM--TEKPGAI 163
Cdd:cd06448   81 VPESTKPRVVEKLRDEGATVVVHGKVWwEADNYLREELAENDPGPVYVHPFDDPLIWEGHSSMVDEIAQQLqsQEKVDAI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 164 VLAVGGGGLLCGVVQGLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFS 243
Cdd:cd06448  161 VCSVGGGGLLNGIVQGLERNGWGDIPVVAVETEGAHSLNASLKAGKLVTLPKITSVATSLGAKTVSSQALEYAQEHNIKS 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052 244 EVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgKLRTPLSSLVVIVCGGSNISLAQLVALKKQL 320
Cdd:cd06448  241 EVVSDRDAVQACLRFADDERILVEPACGAALAVVYSGKILDLQLE-VLLTPLDNVVVVVCGGSNITLEQLKEYKKQL 316
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
11-304 1.79e-52

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 425586 [Multi-domain]  Cd Length: 295  Bit Score: 174.42  E-value: 1.79e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCkMWAERGCE--HFVCSSAGNAGMAAAYAARKLGIPSTIVVP 88
Cdd:pfam00291   8 TPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLL-LRLKEGEGgkTVVEASSGNHGRALAAAAARLGLKVTIVVP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   89 STTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLAVG 168
Cdd:pfam00291  87 EDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGAYYINQYDNPLNIEGYGTIGLEILEQLGGDPDAVVVPVG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  169 GGGLLCGVVQGLAEvGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGV-TTVAAQAMKVYREHPIFSEVVS 247
Cdd:pfam00291 167 GGGLIAGIARGLKE-LGPDVRVIGVEPEGAPALARSLAAGRPVPVPVADTIADGLGVgFEPGALALDLLDEYVGEVVTVS 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052  248 DQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplSSLVVIVCG 304
Cdd:pfam00291 246 DEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-------DRVVVVLTG 295
IlvA COG1171
Threonine dehydratase [Amino acid transport and metabolism];
10-313 6.39e-47

Threonine dehydratase [Amino acid transport and metabolism];


Pssm-ID: 224092 [Multi-domain]  Cd Length: 347  Bit Score: 161.61  E-value: 6.39e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKmwAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:COG1171   25 PTPLQRSPSLSERLGAEIYLKRENLQPVGSFKIRGaynkLSSLSE--EEERAAGVIAASAGNHAQGVAYAAKRLGIKATI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVL 165
Cdd:COG1171  103 VMPETTPKIKVDATRGYGAEVILHGDNFDDAYAAAEELAEEE-GLTFVPPFDDPDVIAGQGTIALEILEQLPDLPDAVFV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 AVGGGGLLCGVVQGLAEVGWrDVPVITMETIGAESFHASTKAGKL-VTLPCITSVAKALGVTTVAAQAMKVYREHPIFSE 244
Cdd:COG1171  182 PVGGGGLISGIATALKALSP-EIKVIGVEPEGAPSMYASLKAGKIvVVLPDVGTIADGLAVKRPGDLTFEILRELVDDIV 260
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115497052 245 VVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplsSLVVIVCGGsNISLAQL 313
Cdd:COG1171  261 LVDEDEICAAMRDLFERTKIIAEPAGALALAALLAGKIEPLQGK--------TVVVILSGG-NIDFERL 320
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
10-308 5.71e-43

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 149.94  E-value: 5.71e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGcehFVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:cd01562   17 RTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGaynkLLSLSEEERAKG---VVAASAGNHAQGVAYAAKLLGIPATI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMtEKPGAIvl 165
Cdd:cd01562   94 VMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEE-GLTFIHPFDDPDVIAGQGTIGLEILEQV-PDLDAV-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 avggggllcgvvqgLAEVG---------------WRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAA 230
Cdd:cd01562  170 --------------FVPVGgggliagiatavkalSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVDTIADGLAVKRPGE 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 231 QAMKVYREHPifSEV--VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSnviQKLQGEGKlrtplsSLVVIVCGGsNI 308
Cdd:cd01562  236 LTFEIIRKLV--DDVvtVSEDEIAAAMLLLFEREKLVAEPAGALALAALLS---GKLDLKGK------KVVVVLSGG-NI 303
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
11-305 9.54e-43

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 147.66  E-value: 9.54e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERG---CEHFVCSSAGNAGMAAAYAARKLGIPSTIVV 87
Cdd:cd00640    1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGklpKGVIIESTGGNTGIALAAAAARLGLKCTIVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  88 PSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTE-KPGAIVla 166
Cdd:cd00640   81 PEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQGTIGLEILEQLGGqKPDAVV-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 167 vggggllcgvvqglaevgwrdVPVITmetigaesfhASTkagklvtlpcITSVAKAL-----GVTTVAAQAmkvyrehpi 241
Cdd:cd00640  159 ---------------------VPVGG----------GGN----------IAGIARALkellpNVKVIGVEP--------- 188
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115497052 242 FSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplsSLVVIVCGG 305
Cdd:cd00640  189 EVVTVSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKLGKGK--------TVVVILTGG 244
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
11-310 2.49e-30

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 118.31  E-value: 2.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGalnkIANLSEDQRQRGV---VAASAGNHAQGVAYAAKKFGIKAVIV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   87 VPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELketMTEKP------ 160
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVILHGDDYDEAYAFATSLAEEE-GRVFVHPFDDEFVMAGQGTIGLEI---MEDIPdvdtvi 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  161 ------GAIVLAVGGGGLLCGvvqglaevgwrDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMK 234
Cdd:TIGR01127 154 vpvgggGLISGVASAAKQINP-----------NVKVIGVEAEGAPSMYESLREGKIKAVESVRTIADGIAVKKPGDLTFN 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497052  235 VYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSnviQKLQGEGKlrtplsSLVVIVCGGsNISL 310
Cdd:TIGR01127 223 IIKEYVDDVVTVDEEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGK------KIAVVLSGG-NIDL 288
PRK12483 PRK12483
threonine dehydratase; Reviewed
10-321 2.08e-26

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 109.12  E-value: 2.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK12483  37 ETPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGaynkMARLPAEQLARGV---ITASAGNHAQGVALAAARLGVKAVI 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELketMTEKPGAIVL 165
Cdd:PRK12483 114 VMPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEE-GLTFVPPFDDPDVIAGQGTVAMEI---LRQHPGPLDA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 AVGGGGLLCGVVQGLAEVGW--RDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHpiFS 243
Cdd:PRK12483 190 IFVPVGGGGLIAGIAAYVKYvrPEIKVIGVEPDDSNCLQAALAAGERVVLGQVGLFADGVAVAQIGEHTFELCRHY--VD 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 244 EV--VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQK-LQGEgklrtplsSLVVIVcGGSNISLAQL--VALKK 318
Cdd:PRK12483 268 EVvtVSTDELCAAIKDIYDDTRSITEPAGALAVAGIKKYAEREgIEGQ--------TLVAID-SGANVNFDRLrhVAERA 338

                 ...
gi 115497052 319 QLG 321
Cdd:PRK12483 339 ELG 341
ilvA_2Cterm TIGR01124
threonine ammonia-lyase, biosynthetic, long form; This model describes a form of threonine ...
10-321 2.67e-24

threonine ammonia-lyase, biosynthetic, long form; This model describes a form of threonine ammonia-lyase, a pyridoxal-phosphate dependent enzyme, with two copies of the threonine dehydratase C-terminal domain (pfam00585). Members with known function participate in isoleucine biosynthesis and are inhibited by isoleucine. Alternate name: threonine deaminase, threonine dehydratase. Forms scoring between the trusted and noise cutoff tend to branch with this subgroup of threonine ammonia-lyase phylogenetically but have only a single copy of the C-terminal domain. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130194 [Multi-domain]  Cd Length: 499  Bit Score: 102.89  E-value: 2.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGI-GHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVP 88
Cdd:TIGR01124  17 ETPLQKAAKLSERLGNRILIKREDLQPVFSFKLRGAyNKMAQLSPEQKARGVIAASAGNHAQGVAFSAARLGLKALIVMP 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   89 STTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLAVG 168
Cdd:TIGR01124  97 ETTPDIKVDAVRGFGGEVVLHGANFDDAKAKAIELSQEK-GLTFIHPFDDPLVIAGQGTLALEILRQVANPLDAVFVPVG 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  169 GGGLLCgvvqGLAEVGWRDVP---VITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFSEV 245
Cdd:TIGR01124 176 GGGLAA----GVAALIKQLMPeikVIGVEPTDSDCMKQALDAGEPVDLDQVGLFADGVAVKRVGDETFRLCQQYLDDIVT 251
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115497052  246 VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQK-LQGEgklrtplsSLVVIVCgGSNISLAQL--VALKKQLG 321
Cdd:TIGR01124 252 VDTDEVCAAIKDLFEDTRAVAEPAGALALAGLKKYVALHgIRGQ--------TLVAILS-GANMNFHRLryVSERCELG 321
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
10-304 1.11e-22

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 97.90  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK09224  20 ETPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGaynkMAQLTEEQLARGV---ITASAGNHAQGVALSAARLGIKAVI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIvl 165
Cdd:PRK09224  97 VMPVTTPDIKVDAVRAFGGEVVLHGDSFDEAYAHAIELAEEE-GLTFIHPFDDPDVIAGQGTIAMEILQQHPHPLDAV-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 avggggllcgvvqgLAEVG---------------WRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAA 230
Cdd:PRK09224 174 --------------FVPVGgggliagvaayikqlRPEIKVIGVEPEDSACLKAALEAGERVDLPQVGLFADGVAVKRIGE 239
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115497052 231 QAMKVYREHpiFSEV--VSDQEAVAALEKFVDDEKILVEPAcGA-ALAAVYSNVIQ-KLQGEgklrtplsSLVVIVCG 304
Cdd:PRK09224 240 ETFRLCQEY--VDDVitVDTDEICAAIKDVFEDTRSIAEPA-GAlALAGLKKYVAQhGIEGE--------TLVAILSG 306
PRK08246 PRK08246
serine/threonine dehydratase;
29-305 1.83e-22

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 95.41  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  29 LKLDSAQPSGSFKIRGIghLCKMWAER-GCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTPALTIQRLKNEGATVK 107
Cdd:PRK08246  41 LKLEHLQHTGSFKARGA--FNRLLAAPvPAAGVVAASGGNAGLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVV 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 108 VVGETLDEAIRVAKDLEKnNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKP---------GAIVlavggggllcgvvq 178
Cdd:PRK08246 119 VVGAEYADALEAAQAFAA-ETGALLCHAYDQPEVLAGAGTLGLEIEEQAPGVDtvlvavgggGLIA-------------- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 179 GLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFSEVVSDQEAVAALEKF 258
Cdd:PRK08246 184 GIAAWFEGRARVVAVEPEGAPTLHAALAAGEPVDVPVSGIAADSLGARRVGEIAFALARAHVVTSVLVSDEAIIAARRAL 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 115497052 259 VDDEKILVEPACGAALAAVYSNVIQKLQGEgklrtplsSLVVIVCGG 305
Cdd:PRK08246 264 WEELRLAVEPGAATALAALLSGAYVPAPGE--------RVAVVLCGA 302
PLN02970 PLN02970
serine racemase
11-316 4.17e-21

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 92.05  E-value: 4.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:PLN02970  28 TPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGacnaIFSLSDDQAEKGV---VTHSSGNHAAALALAAKLRGIPAYIV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLeKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLA 166
Cdd:PLN02970 105 VPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARV-QQETGAVLIHPYNDGRVISGQGTIALEFLEQVPELDVIIVPI 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 167 V--GGGGLLCGVVQGLAEvgwrDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGvTTVAAQAMKVYREhpIFSE 244
Cdd:PLN02970 184 SggGLISGIALAAKAIKP----SIKIIAAEPKGADDAAQSKAAGEIITLPVTNTIADGLR-ASLGDLTWPVVRD--LVDD 256
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115497052 245 V--VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQ-KLQGEGKLRtplssLVVIVCGGsNISLAQLVAL 316
Cdd:PLN02970 257 VitVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRsNPAWKGCKN-----VGIVLSGG-NVDLGVLWES 325
PRK08639 PRK08639
threonine dehydratase; Validated
10-307 5.62e-21

threonine dehydratase; Validated


Pssm-ID: 236318 [Multi-domain]  Cd Length: 420  Bit Score: 92.56  E-value: 5.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGcehFVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK08639  25 ETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGaynaISQLSDEELAAG---VVCASAGNHAQGVAYACRHLGIPGVI 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLK---NEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTE--KP 160
Cdd:PRK08639 102 FMPVTTPQQKIDQVRffgGEFVEIVLVGDTFDDSAAAAQEYAEET-GATFIPPFDDPDVIAGQGTVAVEILEQLEKegSP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 161 GAIVLAVGGGGLLCGVVQGLAEVGWRdVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHP 240
Cdd:PRK08639 181 DYVFVPVGGGGLISGVTTYLKERSPK-TKIIGVEPAGAASMKAALEAGKPVTLEKIDKFVDGAAVARVGDLTFEILKDVV 259
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 241 ifSEVVS-DQEAVAA--LEKFvDDEKILVEPAcGAALAAVYSNVIQKLQGegklrtplSSLVVIVCGGSN 307
Cdd:PRK08639 260 --DDVVLvPEGAVCTtiLELY-NKEGIVAEPA-GALSIAALELYKDEIKG--------KTVVCVISGGNN 317
PLN02550 PLN02550
threonine dehydratase
9-275 1.42e-20

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 92.29  E-value: 1.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   9 METPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGI-GHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVV 87
Cdd:PLN02550 108 IESPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAyNMMAKLPKEQLDKGVICSSAGNHAQGVALSAQRLGCDAVIAM 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  88 PSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKdLEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLAV 167
Cdd:PLN02550 188 PVTTPEIKWQSVERLGATVVLVGDSYDEAQAYAK-QRALEEGRTFIPPFDHPDVIAGQGTVGMEIVRQHQGPLHAIFVPV 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 168 GGGGLLCGVVQGLAEVGwRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFSEVVS 247
Cdd:PLN02550 267 GGGGLIAGIAAYVKRVR-PEVKIIGVEPSDANAMALSLHHGERVMLDQVGGFADGVAVKEVGEETFRLCRELVDGVVLVS 345
                        250       260
                 ....*....|....*....|....*...
gi 115497052 248 DQEAVAALEKFVDDEKILVEPACGAALA 275
Cdd:PLN02550 346 RDAICASIKDMFEEKRSILEPAGALALA 373
PRK07334 PRK07334
threonine dehydratase; Provisional
10-277 1.12e-19

threonine dehydratase; Provisional


Pssm-ID: 235994 [Multi-domain]  Cd Length: 403  Bit Score: 88.80  E-value: 1.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCehfVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK07334  23 RTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGalnkLLLLTEEERARGV---IAMSAGNHAQGVAYHAQRLGIPATI 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELketmtekpgaivl 165
Cdd:PRK07334 100 VMPRFTPTVKVERTRGFGAEVVLHGETLDEARAHARELAEEE-GLTFVHPYDDPAVIAGQGTVALEM------------- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 avggggllcgvvqgLAEVGWRDVPVIT--------------------METIG--AESFHASTKAGKLVTLPCITS-VAKA 222
Cdd:PRK07334 166 --------------LEDAPDLDTLVVPigggglisgmataakalkpdIEIIGvqTELYPSMYAAIKGVALPCGGStIAEG 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 115497052 223 LGVTTVAAQAMKVYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAV 277
Cdd:PRK07334 232 IAVKQPGQLTLEIVRRLVDDILLVSEADIEQAVSLLLEIEKTVVEGAGAAGLAAL 286
PRK06815 PRK06815
threonine/serine dehydratase;
5-313 1.73e-19

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 87.06  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   5 RPLHMETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGcehFVCSSAGNAGMAAAYAARKLG 80
Cdd:PRK06815  15 RPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGasnkLRLLNEAQRQQG---VITASSGNHGQGVALAAKLAG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  81 IPSTIVVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKnNSGWVYVPPFDDPLIWEGHSSIVKELKETMtEKP 160
Cdd:PRK06815  92 IPVTVYAPEQASAIKLDAIRALGAEVRLYGGDALNAELAARRAAE-QQGKVYISPYNDPQVIAGQGTIGMELVEQQ-PDL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 161 GAIVLAVGGGGLLCGVVQGLAEVGwRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAK--ALGV-----TTVAAQAM 233
Cdd:PRK06815 170 DAVFVAVGGGGLISGIATYLKTLS-PKTEIIGCWPANSPSLYTSLEAGEIVEVAEQPTLSDgtAGGVepgaiTFPLCQQL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 234 ---KVyrehpifseVVSDQEAVAALEKFVDDEKILVEPACGAALAAvysnvIQKLQGEGKLRTplssLVVIVCgGSNISL 310
Cdd:PRK06815 249 idqKV---------LVSEEEIKEAMRLIAETDRWLIEGAAGVALAA-----ALKLAPRYQGKK----VAVVLC-GKNIVL 309

                 ...
gi 115497052 311 AQL 313
Cdd:PRK06815 310 EKY 312
eutB PRK07476
threonine dehydratase; Provisional
10-312 3.77e-19

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 86.17  E-value: 3.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEH-FVCSSAGNAGMAAAYAARKLGIPSTIVVP 88
Cdd:PRK07476  19 RTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSLSAQERARgVVTASTGNHGRALAYAARALGIRATICMS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  89 STTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMtekPGAIVLAVG 168
Cdd:PRK07476  99 RLVPANKVDAIRALGAEVRIVGRSQDDAQAEVERLVREE-GLTMVPPFDDPRIIAGQGTIGLEILEAL---PDVATVLVP 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 169 GGGLLCGVVQGLAEVGWR-DVPVI--TMETiGAeSFHASTKAGKLVTLPCITSVAKALG--------VTTVAAQAMkvyr 237
Cdd:PRK07476 175 LSGGGLASGVAAAVKAIRpAIRVIgvSMER-GA-AMHASLAAGRPVQVEEVPTLADSLGggigldnrYTFAMCRAL---- 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115497052 238 ehpiFSEVV--SDQEAVAALEKFVDDEKILVEPACGAALAAVYsnviqklqgEGKLRTPLSSLVVIVCGGsNISLAQ 312
Cdd:PRK07476 249 ----LDDVVllDEAEIAAGIRHAYREERLVVEGAGAVGIAALL---------AGKIAARDGPIVVVVSGA-NIDMEL 311
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
10-310 7.59e-18

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 82.86  E-value: 7.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGcehFVCSSAGNAGMAAAYAARKLGIPSTI 85
Cdd:PRK08638  27 KTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGafnkLSSLTDAEKRKG---VVACSAGNHAQGVALSCALLGIDGKV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  86 VVPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVL 165
Cdd:PRK08638 104 VMPKGAPKSKVAATCGYGAEVVLHGDNFNDTIAKVEEIVEEE-GRTFIPPYDDPKVIAGQGTIGLEILEDLWDVDTVIVP 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 AVGGGGLLcgvvqGLAEVGWRDVPVITMETIGAESFH---ASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREhpIF 242
Cdd:PRK08638 183 IGGGGLIA-----GIAVALKSINPTIHIIGVQSENVHgmaASFYAGEITTHRTTGTLADGCDVSRPGNLTYEIVRE--LV 255
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115497052 243 SEV--VSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQK-LQGEgklrtplsSLVVIVCGGsNISL 310
Cdd:PRK08638 256 DDIvlVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLSGKLDQyIQNK--------KVVAIISGG-NVDL 317
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
11-304 5.86e-17

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 79.94  E-value: 5.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAGT-TAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPS 89
Cdd:cd01563   23 TPLVRAPRLGERLGGkNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGVKAVACASTGNTSASLAAYAARAGIKCVVFLPA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  90 TTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsgWVYVPPFDDPLIWEGHSSIVKELKETM-TEKPGAIVLAVG 168
Cdd:cd01563  103 GKALGKLAQALAYGATVLAVEGNFDDALRLVRELAEEN--WIYLSNSLNPYRLEGQKTIAFEIAEQLgWEVPDYVVVPVG 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 169 GGGLLCGVVQG---LAEVGWRD-VP-VITMETIGAESFHASTKAGKLVTLP--CITSVAKALGVTTVA--AQAMKVYREH 239
Cdd:cd01563  181 NGGNITAIWKGfkeLKELGLIDrLPrMVGVQAEGAAPIVRAFKEGKDDIEPveNPETIATAIRIGNPAsgPKALRAVRES 260
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115497052 240 PIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVysnviQKLQGEGKLRTPlSSLVVIVCG 304
Cdd:cd01563  261 GGTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGL-----KKLREEGIIDKG-ERVVVVLTG 319
ectoine_eutB TIGR02991
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted ...
10-311 4.94e-14

ectoine utilization protein EutB; Members of this protein family are EutB, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida. Members of this family resemble threonine dehydratases.


Pssm-ID: 132036 [Multi-domain]  Cd Length: 317  Bit Score: 71.42  E-value: 4.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG-IGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVP 88
Cdd:TIGR02991  19 ETPLVESPSLSELCGVPVHLKLEHRQTTGSFKLRGaTNAVLSLSDTQRAAGVVAASTGNHGRALAYAAAEEGVRATICMS 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   89 STTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMtekPGAIVLAVG 168
Cdd:TIGR02991  99 ELVPQNKVDEIRRLGAEVRIVGRSQDDAQEEVERLVADR-GLTMLPPFDHPDIVAGQGTLGLEVVEQM---PDLATVLVP 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  169 GGGLLCGVVQGLAEVGWR-DVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGVTTVAAQAMKVYREHPIFSEVV- 246
Cdd:TIGR02991 175 LSGGGLASGVAMAVKAARpDTRVIGVSMERGAAMKASLQAGRPVLVAELPTLADSLGGGIGLDNRVTFAMCKALLDEIVl 254
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115497052  247 -SDQEAVAALEKFVDDEKILVEPACGAALAAVysnviqkLQGEGKLRTPLSSLVvivcGGSNISLA 311
Cdd:TIGR02991 255 vSEAEIAAGIRHAYAEEREIVEGAGAVGIAAL-------LAGKIKNPGPCAVIV----SGRNIDMD 309
PRK08813 PRK08813
threonine dehydratase; Provisional
28-152 1.71e-12

threonine dehydratase; Provisional


Pssm-ID: 236339 [Multi-domain]  Cd Length: 349  Bit Score: 67.34  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  28 YLKLDSAQPSGSFKIRGIGHLCKMWAERGCEH-FVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTPALTIQRLKNEGATV 106
Cdd:PRK08813  51 WLKLENLQRTGSYKVRGALNALLAGLERGDERpVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATV 130
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 115497052 107 KVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKEL 152
Cdd:PRK08813 131 RQHGNSYDEAYAFARELADQN-GYRFLSAFDDPDVIAGQGTVGIEL 175
PRK06608 PRK06608
serine/threonine dehydratase;
10-309 1.79e-12

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 67.10  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRGI-GHLCKMwAERGC--EHFVCSSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:PRK06608  23 LTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVlNHLLEL-KEQGKlpDKIVAYSTGNHGQAVAYASKLFGIKTRIY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVgETLDEAIRVAKdlEKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKPGAIVLA 166
Cdd:PRK06608 102 LPLNTSKVKQQAALYYGGEVILT-NTRQEAEEKAK--EDEEQGFYYIHPSDSDSTIAGAGTLCYEALQQLGFSPDAIFAS 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 167 VGGGgllcgvvqGLAEVGWRDVPVI--TMETIGAESFHA-----STKAGKLVTLPCI-TSVAKALGVTTVAAQAMKVYRE 238
Cdd:PRK06608 179 CGGG--------GLISGTYLAKELIspTSLLIGSEPLNAndaylSLKNNKIYRLNYSpNTIADGLKTLSVSARTFEYLKK 250
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115497052 239 HPIFSEVVSDQEA--VAALEKFVddeKILVEPACGAALAAvysnVIQKLqgegKLRTPLSSLVVIVCGGsNIS 309
Cdd:PRK06608 251 LDDFYLVEEYEIYywTAWLTHLL---KVICEPSSAINMVA----VVNWL----KTQSKPQKLLVILSGG-NID 311
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
11-316 3.88e-11

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 63.11  E-value: 3.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKMWAERGCEHFvcsSAGNAGMAAAYAARKLGIPSTIV 86
Cdd:PRK07048  25 TPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGaynaLSQFSPEQRRAGVVTF---SSGNHAQAIALSARLLGIPATIV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  87 VPSTTPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKEtmtekpgaivla 166
Cdd:PRK07048 102 MPQDAPAAKVAATRGYGGEVVTYDRYTEDREEIGRRLAEER-GLTLIPPYDHPHVIAGQGTAAKELFE------------ 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 167 vggggllcgvvqglaEVGWRDVPVITM--------------------ETIGAE---------SFHAstkaGKLVTLPCIT 217
Cdd:PRK07048 169 ---------------EVGPLDALFVCLggggllsgcalaaralspgcKVYGVEpeagndgqqSFRS----GEIVHIDTPR 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 218 SVAKALGVTTVAAQAMKVYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVYSNVIQkLQGegklrtplSS 297
Cdd:PRK07048 230 TIADGAQTQHLGNYTFPIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALRGKVP-LKG--------KR 300
                        330
                 ....*....|....*....
gi 115497052 298 LVVIVCGGsNISLAQLVAL 316
Cdd:PRK07048 301 VGVIISGG-NVDLARFAAL 318
PRK05638 PRK05638
threonine synthase; Validated
11-305 3.27e-09

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 57.51  E-value: 3.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVaGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPST 90
Cdd:PRK05638  67 TPLIRARISEKL-GENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANGFIVASDGNAAASVAAYSARAGKEAFVVVPRK 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  91 TPALTIQRLKNEGATVKVVGETLDEAIRVAKDLEKNNsGWVYVPPFDDPLIWEGHSSIVKELKETMTekPGAIVLAVGGG 170
Cdd:PRK05638 146 VDKGKLIQMIAFGAKIIRYGESVDEAIEYAEELARLN-GLYNVTPEYNIIGLEGQKTIAFELWEEIN--PTHVIVPTGSG 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 171 GLLCGVVQGLAEVGWRDVPVITMETIGAESFHASTKAGKLVTLPCITSVAKALGV----TTVAAQAMKVYREHPIFSEVV 246
Cdd:PRK05638 223 SYLYSIYKGFKELLEIGVIEEIPKLIAVQTERCNPIASEILGNKTKCNETKALGLyvknPVMKEYVSEAIKESGGTAVVV 302
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115497052 247 SDQEAVAAlEKFVDDEKILVEPACGAALAAVYsnviqKLQGEGKLRTPLSSLVVIVCGG 305
Cdd:PRK05638 303 NEEEIMAG-EKLLAKEGIFAELSSAVVMPALL-----KLGEEGYIEKGDKVVLVVTGSG 355
PRK08197 PRK08197
threonine synthase; Validated
11-304 7.53e-09

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 56.55  E-value: 7.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAG-TTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPS 89
Cdd:PRK08197  80 TPLLPLPRLGKALGiGRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKHLAMPTNGNAGAAWAAYAARAGIRATIFMPA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  90 TTPALTIQRLKNEGATVKVVGETLDEAIR-VAKDLEKnnSGWVYVPPFDDPLIWEGHSSIVKELKETMT-EKPGAIVLAV 167
Cdd:PRK08197 160 DAPEITRLECALAGAELYLVDGLISDAGKiVAEAVAE--YGWFDVSTLKEPYRIEGKKTMGLELAEQLGwRLPDVILYPT 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 168 GGGGLLCGVVQGLAE---VGWRDVPVITMETIGAE-------SFHASTKAGKL----VTLPCITSVAKALGVTTVaaqaM 233
Cdd:PRK08197 238 GGGVGLIGIWKAFDEleaLGWIGGKRPRLVAVQAEgcapivkAWEEGKEESEFwedaHTVAFGIRVPKALGDFLV----L 313
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115497052 234 KVYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAVysnviQKLQGEGKLRtPLSSLVVIVCG 304
Cdd:PRK08197 314 DAVRETGGCAIAVSDDAILAAQRELAREEGLFACPEGAATFAAA-----RQLRESGWLK-GDERVVLFNTG 378
PRK06110 PRK06110
threonine dehydratase;
19-313 1.41e-06

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 49.22  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  19 LSKVAGTTAYLKLDSAQPSGSFKIRG----IGHLCKmwAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTpal 94
Cdd:PRK06110  30 LAERLGCEVWVKHENHTPTGAFKVRGglvyFDRLAR--RGPRVRGVISATRGNHGQSVAFAARRHGLAATIVVPHGN--- 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  95 tiQRLKNE-----GATVKVVGETLD----EAIRVAKDleknnSGWVYVPPFDDPLIwEGHSSIVKELketMTEKPGAivl 165
Cdd:PRK06110 105 --SVEKNAamralGAELIEHGEDFQaareEAARLAAE-----RGLHMVPSFHPDLV-RGVATYALEL---FRAVPDL--- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 166 avggGGLLCGVVQG---LAEVGWRDVPVITMETIGAESFHA-----STKAGKLVTLPCITSVAKALGVTTVAAQAMKVYR 237
Cdd:PRK06110 171 ----DVVYVPIGMGsgiCGAIAARDALGLKTRIVGVVSAHApayalSFEAGRVVTTPVATTLADGMACRTPDPEALEVIR 246
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115497052 238 EHpiFSEV--VSDQEAVAALEKFVDDEKILVEPACGAALAAVysnviqkLQGEGKLRtplSSLVVIVCGGSNISLAQL 313
Cdd:PRK06110 247 AG--ADRIvrVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAA-------LQERERLA---GKRVGLVLSGGNIDRAVF 312
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism];
21-276 2.31e-06

Threonine synthase [Amino acid transport and metabolism];


Pssm-ID: 223572 [Multi-domain]  Cd Length: 411  Bit Score: 48.86  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  21 KVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPST-TPALTIQRL 99
Cdd:COG0498   90 GVLNDNLYVKELGHNPTGSFKDRGMTVLVSLAKELGAKTILCASSGNTGASAAAYAARAGLKVFVLYPKGkVSPGKLAQM 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 100 KNEGATVKVVGETLDEAIRVAKDLeKNNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEK-------P----GAIVLAVG 168
Cdd:COG0498  170 LTLGAHVIAVDGNFDDAQELVKEA-ANREGLLSAVNSINPYRLEGQKTYAFEIAEQLGWKapdhvvvPvgngGNLLAIYK 248
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 169 GGGLlcgvvqgLAEVGW-----RDVPVitmETIGAESFHASTKAGKlvtlPCITSVAKAL--GVTTVAAQAMKVYREHPI 241
Cdd:COG0498  249 GFKE-------GLPIGKidkapNMNGV---QAEGFSPGVYAWKEGR----ETPETIAPAMdiGNPSNWERALFALRESGG 314
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 115497052 242 FSEVVSDQEAVAALEKFVDDEKILVEPACGAALAA 276
Cdd:COG0498  315 LAVAVSDEEILEAIKLLAEREGILIEPHSAVAVAA 349
PRK08329 PRK08329
threonine synthase; Validated
24-154 2.08e-05

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 45.59  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  24 GTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTPALTIQRLKNEG 103
Cdd:PRK08329  71 SIKVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGINEVVIDSSGNAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLG 150
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 115497052 104 ATVKVVG----ETLDEAIRVAKDleknnSGWVYVPPFDDPLIWEGHSSIVKELKE 154
Cdd:PRK08329 151 AELHFVEgdrmEVHEEAVKFSKR-----NNIPYVSHWLNPYFLEGTKTIAYEIYE 200
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
11-303 2.13e-05

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 45.20  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  11 TPVRDSMTLSKVAGTTAYLKLDSAQPSGSFKIR-----------------------------GIGhLCkmwaergcehFV 61
Cdd:cd01561    3 TPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRialymiedaekrgllkpgttiieptsgntGIG-LA----------MV 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  62 CssagnagmaaayaaRKLGIPSTIVVPSTTPALTIQRLKNEGATVKVVGETLDE----AIRVAKDLEKNNSGWVYVPPFD 137
Cdd:cd01561   72 A--------------AAKGYRFIIVMPETMSEEKRKLLRALGAEVILTPEAEADgmkgAIAKARELAAETPNAFWLNQFE 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 138 DPLIWEGHSsivkelKETMTEkpgaIvlavggggllcgvvqglaevgWRDVPvitmetigaesfhastkaGKLVTLPC-- 215
Cdd:cd01561  138 NPANPEAHY------ETTAPE----I---------------------WEQLD------------------GKVDAFVAgv 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 216 -----ITSVAKAL-----GVTTVAAQAM------------------------KVYREHPIfSEV--VSDQEAVAALEKFV 259
Cdd:cd01561  169 gtggtITGVARYLkeknpNVRIVGVDPVgsvlfsggppgphkiegigagfipENLDRSLI-DEVvrVSDEEAFAMARRLA 247
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 115497052 260 DDEKILVEPACGAALAAVYsNVIQKLqGEGKLrtplssLVVIVC 303
Cdd:cd01561  248 REEGLLVGGSSGAAVAAAL-KLAKRL-GPGKT------IVTILP 283
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
28-277 3.60e-05

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 44.68  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052   28 YLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTPAL--TIQRLkNEGAT 105
Cdd:TIGR00260  41 YVKELGHNPTLSFKDRGMAVALTKALELGNDTVLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKISLgkLAQAL-GYNAE 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  106 VKVVGETLDEAIRVAKDLEKNNSGWVYVPPFDDPLIWEGHSSIVKE-LKETMTEKPGAIVLAVGGGGLLCGVVQGLAE-- 182
Cdd:TIGR00260 120 VVAIDGNFDDAQRLVKQLFEDKPALGLNSANSIPYRLEGQKTYAFEaVEQLGWEAPDKVVVPVPNSGNFGAIWKGFKEkk 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  183 -VGWRDVPVitMETIGAESFH----ASTKAGKLVTLPCITSVAKAL--GVTTVAAQAMKVYREHPIFSEVVSDQEAVAAL 255
Cdd:TIGR00260 200 mLGLDSLPV--KRGIQAEGAAdivrAFLEGGQWEPIETPETLSTAMdiGNPANWPRALEAFRRSNGYAEDLSDEEILEAI 277
                         250       260
                  ....*....|....*....|..
gi 115497052  256 EKFVDDEKILVEPACGAALAAV 277
Cdd:TIGR00260 278 KLLAREEGYFVEPHSAVAVAAL 299
PRK06450 PRK06450
threonine synthase; Validated
10-160 1.64e-04

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 42.80  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  10 ETPVrdsmtlskVAGTTAYLKLDSAQPSGSFKIRGIGHLCKMWAERGCEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPS 89
Cdd:PRK06450  58 RTPL--------IKKGNIWFKLDFLNPTGSYKDRGSVTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPE 129
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115497052  90 TTPALTIQRLKNEGATVKVVGETLDEAIRVAKdleknNSGWVYVPPFDDPLIWEGHSSIVKELKETMTEKP 160
Cdd:PRK06450 130 TASGGKLKQIESYGAEVVRVRGSREDVAKAAE-----NSGYYYASHVLQPQFRDGIRTLAYEIAKDLDWKI 195
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism];
19-303 4.11e-03

Cysteine synthase [Amino acid transport and metabolism];


Pssm-ID: 223110 [Multi-domain]  Cd Length: 300  Bit Score: 38.29  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  19 LSKVAGTTAYLKLDSAQPSGSFKIRgIGH------LCKMWAERGcEHFVCSSAGNAGMAAAYAARKLGIPSTIVVPSTTP 92
Cdd:COG0031   20 LSPGTGVEIYAKLESFNPGGSVKDR-IALymiedaEKRGLLKPG-GTIVEATSGNTGIALAMVAAAKGYRLIIVMPETMS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052  93 ALTIQRLKNEGATVKVV---GETLDEAIRVAKDLEKNNSGWVYVPP-FDDPLIWEGHS-SIVKELKETMTEKPGAIvlav 167
Cdd:COG0031   98 QERRKLLRALGAEVILTpgaPGNMKGAIERAKELAAEIPGYAVWLNqFENPANPEAHYeTTGPEIWQQTDGKVDAF---- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 168 ggggllcgvvqgLAEVGwrdvpvitmeTIGaesfhasTkagklvtlpcITSVAKAL-----GVTTVAAQA---------- 232
Cdd:COG0031  174 ------------VAGVG----------TGG-------T----------ITGVARYLkernpNVRIVAVDPegsvllsgge 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115497052 233 --------------MKVYREHPIFSEVVSDQEAVAALEKFVDDEKILVEPACGAALAAvYSNVIQKLqGEGKlrtplsSL 298
Cdd:COG0031  215 gphkiegigagfvpENLDLDLIDEVIRVSDEEAIATARRLAREEGLLVGISSGAALAA-ALKLAKEL-PAGK------TI 286

                 ....*
gi 115497052 299 VVIVC 303
Cdd:COG0031  287 VTILP 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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