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Conserved domains on  [gi|116014334|ref|NP_001070648|]
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protein-L-histidine N-pros-methyltransferase isoform 2 precursor [Homo sapiens]

Protein Classification

methyltransferase-like protein 9( domain architecture ID 11155959)

methyltransferase-like protein 9 (METTL9) is a protein-histidine N-methyltransferase that specifically catalyzes the 1-methylhistidine (pros-methylhistidine) methylation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
56-316 3.32e-166

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


:

Pssm-ID: 253097  Cd Length: 265  Bit Score: 462.44  E-value: 3.32e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334   56 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQ 135
Cdd:pfam05219   1 WYCLNHE-LPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  136 RLLKI-----NPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLN 210
Cdd:pfam05219  80 KLLVIggfqpASGQEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  211 LLDRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVE-NGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAF 289
Cdd:pfam05219 160 LLDRCFDPFKLLEDIHLALAP-NGRVIVALVLPYMHYVEtNTGSHLPPRPLLENNGASFEEEVARFMEVFENAGFRVEAW 238
                         250       260
                  ....*....|....*....|....*..
gi 116014334  290 TRLPYLCEGDMYNDYYVLDDAVFVLKP 316
Cdd:pfam05219 239 TRLPYLCEGDMHNSFYWLIDAIFVLKP 265
 
Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
56-316 3.32e-166

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


Pssm-ID: 253097  Cd Length: 265  Bit Score: 462.44  E-value: 3.32e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334   56 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQ 135
Cdd:pfam05219   1 WYCLNHE-LPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  136 RLLKI-----NPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLN 210
Cdd:pfam05219  80 KLLVIggfqpASGQEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  211 LLDRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVE-NGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAF 289
Cdd:pfam05219 160 LLDRCFDPFKLLEDIHLALAP-NGRVIVALVLPYMHYVEtNTGSHLPPRPLLENNGASFEEEVARFMEVFENAGFRVEAW 238
                         250       260
                  ....*....|....*....|....*..
gi 116014334  290 TRLPYLCEGDMYNDYYVLDDAVFVLKP 316
Cdd:pfam05219 239 TRLPYLCEGDMHNSFYWLIDAIFVLKP 265
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
148-242 8.12e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334 148 RLLDLGAGDGEVT-KIMSPHFEEIYATELSETMIWQLQKKKYRVLG---------INEWQNTGF-QYD-VISCLNLLDRC 215
Cdd:cd02440    1 RVLDLGCGTGALAlALASGPGARVTGVDISPVALELARKAAAALLAdnvevlkgdAEELPPEADeSFDvIISDPPLHHLV 80
                         90       100
                 ....*....|....*....|....*..
gi 116014334 216 DQPLTLLKDIRSVLEPtRGRVILALVL 242
Cdd:cd02440   81 EDLARFLEEARRLLKP-GGVLVLTLVL 106
 
Name Accession Description Interval E-value
DREV pfam05219
DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. ...
56-316 3.32e-166

DREV methyltransferase; This family contains DREV protein homologs from several eukaryotes. The function of this protein is unknown. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).


Pssm-ID: 253097  Cd Length: 265  Bit Score: 462.44  E-value: 3.32e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334   56 WYVCNREkLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQ 135
Cdd:pfam05219   1 WYCLNHE-LPPRFQSKFVPSEPDATTQSFLENSKALSANIFTQLWHALARSILSFFMSQTDINGFLGRGSMFIFSEEQFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  136 RLLKI-----NPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLN 210
Cdd:pfam05219  80 KLLVIggfqpASGQEPVTLLDLGAGDGEITLRMAPTFEEVYATELSWTMRDRLKKKNYNVLTEIEWQETDVNLDLILCLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  211 LLDRCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVE-NGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAF 289
Cdd:pfam05219 160 LLDRCFDPFKLLEDIHLALAP-NGRVIVALVLPYMHYVEtNTGSHLPPRPLLENNGASFEEEVARFMEVFENAGFRVEAW 238
                         250       260
                  ....*....|....*....|....*..
gi 116014334  290 TRLPYLCEGDMYNDYYVLDDAVFVLKP 316
Cdd:pfam05219 239 TRLPYLCEGDMHNSFYWLIDAIFVLKP 265
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
135-288 2.24e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 55.51  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  135 QRLLKINPDWKthRLLDLGAGDGEVTKIMSPHFEEIYATELSETMI-WQLQKKKYRVLGINEWQNTGFQYDVISCLNLLD 213
Cdd:pfam13489  14 LRLLPKLPSPG--RVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIeRALLNVRFDQFDEQEAAVPAGKFDVIVAREVLE 91
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116014334  214 RCDQPLTLLKDIRSVLEPtRGRVILALVLPFHPYVENGGKWEKPSEILEiKGQNWEEQvnSLPEVFRKAGFVIEA 288
Cdd:pfam13489  92 HVPDPPALLRQIAALLKP-GGLLLLSTPLASDEADRLLLEWPYLRPRNG-HISLFSAR--SLKRLLEEAGFEVVS 162
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
150-231 6.82e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 52.37  E-value: 6.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  150 LDLGAGDGEVTKIMSPHFE--EIYATELSETMIWQLQKK----------KYRVLGINEWQNTGFQYDVISCLNLLDRCDQ 217
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPglEYTGLDISPAALEAARERlaalgllnavRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80
                          90
                  ....*....|....
gi 116014334  218 PLTLLKDIRSVLEP 231
Cdd:pfam08242  81 PRAVLRNIRRLLKP 94
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
150-238 1.42e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 429883 [Multi-domain]  Cd Length: 94  Bit Score: 48.43  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  150 LDLGAGDGEVTKIMSPHFEEIYATELSETMIwQLQKKKYRVLGINEWQNTGFQ-------YDVISCLNLLDRCDQPLTLL 222
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEML-ELAREKAPREGLTFVVGDAEDlpfpdnsFDLVLSSEVLHHVEDPERAL 79
                          90
                  ....*....|....*.
gi 116014334  223 KDIRSVLEPtRGRVIL 238
Cdd:pfam08241  80 REIARVLKP-GGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
150-231 3.01e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433377 [Multi-domain]  Cd Length: 97  Bit Score: 44.88  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334  150 LDLGAGDGEVTKIMSPHFE--EIYATELSETMIWQLQKK--------KYRVLGINEWQNTGFQYDVISC---LNLLDRCD 216
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGPnaRVTGVDLSPEMLERARERaaeaglnvEFVQGDAEDLPFPDGSFDLVVSsgvLHHLPDPD 81
                          90
                  ....*....|....*
gi 116014334  217 QPlTLLKDIRSVLEP 231
Cdd:pfam13649  82 LE-AALREIARVLKP 95
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
148-242 8.12e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116014334 148 RLLDLGAGDGEVT-KIMSPHFEEIYATELSETMIWQLQKKKYRVLG---------INEWQNTGF-QYD-VISCLNLLDRC 215
Cdd:cd02440    1 RVLDLGCGTGALAlALASGPGARVTGVDISPVALELARKAAAALLAdnvevlkgdAEELPPEADeSFDvIISDPPLHHLV 80
                         90       100
                 ....*....|....*....|....*..
gi 116014334 216 DQPLTLLKDIRSVLEPtRGRVILALVL 242
Cdd:cd02440   81 EDLARFLEEARRLLKP-GGVLVLTLVL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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