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Conserved domains on  [gi|148762978|ref|NP_001073951|]
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apical junction component 1 homolog [Homo sapiens]

Protein Classification

zinc finger MYND domain-containing protein( domain architecture ID 10484396)

zinc finger MYND (myeloid, Nervy, and DEAF-1) domain-containing protein may play important roles in development and could be associated with cancers, as well as mediate protein-protein interactions, mainly in the context of transcriptional regulation

Gene Ontology:  GO:0008270|GO:0005515
PubMed:  19925420

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
667-710 2.91e-06

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 44.72  E-value: 2.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148762978  667 NARCRRTETMFNAClyfKSCHSCYtyYCSRLCRREDWDAHKARC 710
Cdd:pfam01753   1 CAVCGKEALKLLRC---SRCKSVY--YCSKECQKADWPYHKKEC 39
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 247-655 6.43e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  247 ADPRAFYCDGPLPGPRdYAERRSLPFTT-----PPGPTQFFYTEEPQGFRGSFAASPGPTF---DAYYPRPYPSEELSGP 318
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTsrarrPDAPPQSARPRAPVDDRGDPRGPAPPSPlppDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  319 SPRRMGGYYAGEVRTFPIQEP-PSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYT-EDFGRYRERDVLARTYPHPR 396
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHAL 2715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  397 SSPAWADWGPRPYRTLQVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSwdnilAPGPRREDPLGRGRSYENLLGRE 476
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP-----APAPPAAPAAGPPRRLTRPAVAS 2790

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  477 VREPRGVSPEGRRPPVVVnlstsprryAALSLSETSLTEKGRAGEGLGRNWYVTPEITITDNDLRATERPSArAWELPGG 556
Cdd:PHA03247 2791 LSESRESLPSPWDPADPP---------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPGG 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  557 --RTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDS--RPTAGQASEPAADcLGPQLRRLLDSRPAGSGAPALAPPRSP 632
Cdd:PHA03247 2861 dvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfaLPPDQPERPPQPQ-APPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                         410       420
                  ....*....|....*....|...
gi 148762978  633 PASAGSAEEPAAPGEAADASPEP 655
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
667-710 2.91e-06

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 44.72  E-value: 2.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148762978  667 NARCRRTETMFNAClyfKSCHSCYtyYCSRLCRREDWDAHKARC 710
Cdd:pfam01753   1 CAVCGKEALKLLRC---SRCKSVY--YCSKECQKADWPYHKKEC 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 247-655 6.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  247 ADPRAFYCDGPLPGPRdYAERRSLPFTT-----PPGPTQFFYTEEPQGFRGSFAASPGPTF---DAYYPRPYPSEELSGP 318
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTsrarrPDAPPQSARPRAPVDDRGDPRGPAPPSPlppDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  319 SPRRMGGYYAGEVRTFPIQEP-PSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYT-EDFGRYRERDVLARTYPHPR 396
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHAL 2715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  397 SSPAWADWGPRPYRTLQVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSwdnilAPGPRREDPLGRGRSYENLLGRE 476
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP-----APAPPAAPAAGPPRRLTRPAVAS 2790

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  477 VREPRGVSPEGRRPPVVVnlstsprryAALSLSETSLTEKGRAGEGLGRNWYVTPEITITDNDLRATERPSArAWELPGG 556
Cdd:PHA03247 2791 LSESRESLPSPWDPADPP---------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPGG 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  557 --RTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDS--RPTAGQASEPAADcLGPQLRRLLDSRPAGSGAPALAPPRSP 632
Cdd:PHA03247 2861 dvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfaLPPDQPERPPQPQ-APPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                         410       420
                  ....*....|....*....|...
gi 148762978  633 PASAGSAEEPAAPGEAADASPEP 655
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
667-710 2.91e-06

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 44.72  E-value: 2.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148762978  667 NARCRRTETMFNAClyfKSCHSCYtyYCSRLCRREDWDAHKARC 710
Cdd:pfam01753   1 CAVCGKEALKLLRC---SRCKSVY--YCSKECQKADWPYHKKEC 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 247-655 6.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  247 ADPRAFYCDGPLPGPRdYAERRSLPFTT-----PPGPTQFFYTEEPQGFRGSFAASPGPTF---DAYYPRPYPSEELSGP 318
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPR-PAPRPSEPAVTsrarrPDAPPQSARPRAPVDDRGDPRGPAPPSPlppDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  319 SPRRMGGYYAGEVRTFPIQEP-PSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYT-EDFGRYRERDVLARTYPHPR 396
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPaPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHAL 2715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  397 SSPAWADWGPRPYRTLQVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSwdnilAPGPRREDPLGRGRSYENLLGRE 476
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP-----APAPPAAPAAGPPRRLTRPAVAS 2790

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  477 VREPRGVSPEGRRPPVVVnlstsprryAALSLSETSLTEKGRAGEGLGRNWYVTPEITITDNDLRATERPSArAWELPGG 556
Cdd:PHA03247 2791 LSESRESLPSPWDPADPP---------AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPGG 2860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  557 --RTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDS--RPTAGQASEPAADcLGPQLRRLLDSRPAGSGAPALAPPRSP 632
Cdd:PHA03247 2861 dvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfaLPPDQPERPPQPQ-APPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                         410       420
                  ....*....|....*....|...
gi 148762978  633 PASAGSAEEPAAPGEAADASPEP 655
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQP 2962
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 296-663 8.45e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  296 ASPGPTFDAYYPRPYPSEELSGPSPRRMGGYYAGEVRTFPIQEPPSRSYYGEAPrayGLPYGPRYVPEEPRAHSTARPFY 375
Cdd:PHA03307   73 PGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASP---PPSPAPDLSEMLRPVGSPGPPPA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  376 TEDFGRYRERDVLARTYPHPRSSPAWADWGPRPYRTlqVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSwdnilAP 455
Cdd:PHA03307  150 ASPPAAGASPAAVASDAASSRQAALPLSSPEETARA--PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSP-----AP 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  456 GPRREDPLGRGRSYENLLGREVREPrGVSPEGRRPPVVVNLSTSPRRYAALSLSETSLTEKGRAGEglgrnwyvtpeiti 535
Cdd:PHA03307  223 APGRSAADDAGASSSDSSSSESSGC-GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS-------------- 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762978  536 tdndlRATERPSARAWELPGGRTRPPPHAAPDGPTSGRQRSLEqldelitdlvIDSRPTAGQASEPAADCLGPQLRRLLD 615
Cdd:PHA03307  288 -----SSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS----------SSSTSSSSESSRGAAVSPGPSPSRSPS 352

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 148762978  616 SRPAGSGAPALAPPRSPPASAGSAEEPAAPGEAADASPEPSADEDDLM 663
Cdd:PHA03307  353 PSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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