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Conserved domains on  [gi|264681543|ref|NP_001074865|]
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TBC1 domain family member 31 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-336 6.17e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 6.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  48 VAFDGSGDSFIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFS--PDGKLLAsGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 126 ESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKY 204
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 205 QLPGPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQmpAKVRAVRHLEFLPDsfdagsNQVLGVLSQ 284
Cdd:COG2319  283 TLTGHSGGVNSV----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPD------GKTLASGSD 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 264681543 285 DGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQ 336
Cdd:COG2319  351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 684-941 6.10e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 76.32  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  684 IVDYQTREWERIRNDELDFL---RERQTVENMQAEVDEQRAKDEAwyqkqELLRRAEETRREILLQEEEKMAQQRQR--- 757
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMeqeRLRQEKEEKAREVERRRKLEEA-----EKARQAEMDRQAAIYAEQERMAMERERele 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  758 ---LAAVKRELE-------------IKEIH-LQ--------------DAARR-------RLLKLQQDQREMELRRLEDEI 799
Cdd:pfam17380 352 rirQEERKRELErirqeeiameisrMRELErLQmerqqknervrqelEAARKvkileeeRQRKIQQQKVEMEQIRAEQEE 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  800 ERKVQMRDQEiAATAKDLE-IRQLELEAQKRLyekDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRA 878
Cdd:pfam17380 432 ARQREVRRLE-EERAREMErVRLEEQERQQQV---ERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQA 507

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543  879 QRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQRQYMDSAylPQTSRL 941
Cdd:pfam17380 508 MIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKAT--EERSRL 568
RabGAP-TBC super family cl46302
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 461-605 2.33e-09

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


The actual alignment was detected with superfamily member pfam00566:

Pssm-ID: 480642  Cd Length: 178  Bit Score: 57.65  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  461 SLQKKYPIKSRKLLRVLQRTLSALAHWsaiFSDTPY---LPLLAFPFVkLFQNNQLICFEVVATLIINwcQHWFEYFPN- 536
Cdd:pfam00566  19 TFPHSFFFDNGPGQNSLRRILKAYSIY---NPDVGYcqgMNFIAAPLL-LVYLDEEDAFWCFVSLLEN--YLLRDFYTPd 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  537 -PPINILSMI-ENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIFSNHPSFLLM 605
Cdd:pfam00566  93 fPGLKRDLYVfEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF 163
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-336 6.17e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 6.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  48 VAFDGSGDSFIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFS--PDGKLLAsGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 126 ESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKY 204
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 205 QLPGPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQmpAKVRAVRHLEFLPDsfdagsNQVLGVLSQ 284
Cdd:COG2319  283 TLTGHSGGVNSV----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPD------GKTLASGSD 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 264681543 285 DGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQ 336
Cdd:COG2319  351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-334 9.31e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 9.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  39 HPKVLRFlnVAFDGSGDSFIAGDHQGNIYVFDLHGNRFNLVQR----TAQACTALAFNLRrkseFLVALADYSIKCFDTV 114
Cdd:cd00200    8 HTGGVTC--VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 115 TKELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIF 193
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDkTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 194 AWECDTLFCKYQLPGpPEGSnilykVFAVT--RDGRILAAGGKSNHLHLWclEATGLFRIIQMPAKVRAVRHLEFLPDsf 271
Cdd:cd00200  161 LWDLRTGKCVATLTG-HTGE-----VNSVAfsPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-- 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543 272 dagsNQVLGVLSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYS 334
Cdd:cd00200  231 ----GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 684-941 6.10e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 76.32  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  684 IVDYQTREWERIRNDELDFL---RERQTVENMQAEVDEQRAKDEAwyqkqELLRRAEETRREILLQEEEKMAQQRQR--- 757
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMeqeRLRQEKEEKAREVERRRKLEEA-----EKARQAEMDRQAAIYAEQERMAMERERele 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  758 ---LAAVKRELE-------------IKEIH-LQ--------------DAARR-------RLLKLQQDQREMELRRLEDEI 799
Cdd:pfam17380 352 rirQEERKRELErirqeeiameisrMRELErLQmerqqknervrqelEAARKvkileeeRQRKIQQQKVEMEQIRAEQEE 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  800 ERKVQMRDQEiAATAKDLE-IRQLELEAQKRLyekDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRA 878
Cdd:pfam17380 432 ARQREVRRLE-EERAREMErVRLEEQERQQQV---ERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQA 507

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543  879 QRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQRQYMDSAylPQTSRL 941
Cdd:pfam17380 508 MIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKAT--EERSRL 568
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 688-928 6.35e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.51  E-value: 6.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 688 QTREWE-RIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELL---RRAEETRREILLQEEEKMAQQRQRLAAVKR 763
Cdd:COG1196  261 ELAELEaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAELEEELEELEEELE 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 764 ELEIKEIHLQDAARRRLLKLQQ--DQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRL---------YE 832
Cdd:COG1196  341 ELEEELEEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEeallerlerLE 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 833 KDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEfHLQSAKKASALSDASRKWfLRQE 912
Cdd:COG1196  421 EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE-AALAELLEELAEAAARLL-LLLE 498

                        250
                 ....*....|....*.
gi 264681543 913 TSAALEHEEMPWLQRQ 928
Cdd:COG1196  499 AEADYEGFLEGVKAAL 514
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 461-605 2.33e-09

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 57.65  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  461 SLQKKYPIKSRKLLRVLQRTLSALAHWsaiFSDTPY---LPLLAFPFVkLFQNNQLICFEVVATLIINwcQHWFEYFPN- 536
Cdd:pfam00566  19 TFPHSFFFDNGPGQNSLRRILKAYSIY---NPDVGYcqgMNFIAAPLL-LVYLDEEDAFWCFVSLLEN--YLLRDFYTPd 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  537 -PPINILSMI-ENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIFSNHPSFLLM 605
Cdd:pfam00566  93 fPGLKRDLYVfEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF 163
PTZ00121 PTZ00121
MAEBL; Provisional
 691-888 2.40e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELDFLRE--RQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREilLQEEEKMAQQrqrlaaVKRELEIK 768
Cdd:PTZ00121 1657 EENKIKAAEEAKKAEedKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKK--EAEEKKKAEE------LKKAEEEN 1728

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  769 EIHLQDAARrrllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQ-------LELEAQKRLYEKDLTT---- 837
Cdd:PTZ00121 1729 KIKAEEAKK----EAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKeavieeeLDEEDEKRRMEVDKKIkdif 1804

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 264681543  838 -------------------SQEAVAKEIREDTDAH---RRKA-ALEEHMFQKLLENSQMGGRRAQRWKEAEEKE 888
Cdd:PTZ00121 1805 dnfaniieggkegnlvindSKEMEDSAIKEVADSKnmqLEEAdAFEKHKFNKNNENGEDGNKEADFNKEKDLKE 1878
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 699-898 1.79e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.45  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   699 ELDFLRER-QTVENMQAEVDEQRAKDEawyQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQD--- 774
Cdd:TIGR02168  303 QKQILRERlANLERQLEELEAQLEELE---SKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEElee 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   775 -----AARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAatakdlEIRQLEleaqKRLYEKDLTTSQEAVAKEIRED 849
Cdd:TIGR02168  380 qletlRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ------EIEELL----KKLEEAELKELQAELEELEEEL 449

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 264681543   850 TDAHRRKAALEEhmfqkLLENSQMGGRRAQRWKEAEEKEFHLQSAKKAS 898
Cdd:TIGR02168  450 EELQEELERLEE-----ALEELREELEEAEQALDAAERELAQLQARLDS 493
COG5210 COG5210
GTPase-activating protein [General function prediction only];
542-658 3.54e-05

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 47.49  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 542 LSMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIFSNHPSFLLMTVVAYSTCSRAPLLNC 621
Cdd:COG5210  350 LKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKL 429

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 264681543 622 TLKNDFEYFFHHRNNLDINVVIREVYHLMETTPADIH 658
Cdd:COG5210  430 DSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDIL 466
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-153 6.67e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.67e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 264681543   115 TKELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWD 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 501-609 1.37e-04

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 44.22  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   501 AFP-FVKLFQNNQLIcFEVVATLIINWCQHWFEYFpnppinilsmienvLAFHDKELLQHFIDRDITSQVYAWPLLETLF 579
Cdd:smart00164 112 AFWcLVKLMERYGPN-FYLPDMSGLQLDLLQLDRL--------------VKEYDPDLYKHLKDLGITPSLYALRWFLTLF 176

                           90       100       110
                   ....*....|....*....|....*....|
gi 264681543   580 SEVLTREEWLRLFDNIFSNHPSFLLMTVVA 609
Cdd:smart00164 177 ARELPLEIVLRIWDVLFAEGSDFLFRVALA 206
growth_prot_Scy NF041483
polarized growth protein Scy;
689-905 3.27e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.82  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  689 TREWERIRNDELdflrERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREI------LLQEEEKMAQQRQ------ 756
Cdd:NF041483  501 TAESERVRTEAI----ERATTLRRQAEETLERTRAEAERLRAEAEEQAEEVRAAAeraareLREETERAIAARQaeaaee 576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  757 ----------RLAAVKREL----------------EIKEIHLQDAARRRLLklqQDQREMELRRLEDEIERKVQMRDQEI 810
Cdd:NF041483  577 ltrlhteaeeRLTAAEEALadaraeaerirreaaeETERLRTEAAERIRTL---QAQAEQEAERLRTEAAADASAARAEG 653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  811 AATAKDL------EIRQLELEAQKrlyEKDLTTSQEAVAKEiREDTDAHRRKAALEEHMFQKLLENSQ-MGGRRA----Q 879
Cdd:NF041483  654 ENVAVRLrseaaaEAERLKSEAQE---SADRVRAEAAAAAE-RVGTEAAEALAAAQEEAARRRREAEEtLGSARAeadqE 729

                         250       260
                  ....*....|....*....|....*...
gi 264681543  880 RWKEAEEKEFHLQSAKK--ASALSDASR 905
Cdd:NF041483  730 RERAREQSEELLASARKrvEEAQAEAQR 757
growth_prot_Scy NF041483
polarized growth protein Scy;
714-933 9.51e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 43.28  E-value: 9.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  714 AEVDEQRAKDEAWYQKQELLRRAEETrreillQEEEKMAQQRQRLAAVKRELEIKeihlqdaarrrllklqqDQREMELR 793
Cdd:NF041483  500 ATAESERVRTEAIERATTLRRQAEET------LERTRAEAERLRAEAEEQAEEVR-----------------AAAERAAR 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  794 RLEDEIERKVQMRDQEIAAtakdlEIRQLELEAQKRlyekdLTTSQEAVAkEIREDTDAHRRKAALEEhmfQKLLENSQM 873
Cdd:NF041483  557 ELREETERAIAARQAEAAE-----ELTRLHTEAEER-----LTAAEEALA-DARAEAERIRREAAEET---ERLRTEAAE 622

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  874 GGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEmpwLQRQYMDSA 933
Cdd:NF041483  623 RIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAER---LKSEAQESA 679
WD40 pfam00400
WD domain, G-beta repeat;
116-153 1.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 264681543  116 KELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWD 153
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 702-848 9.97e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 9.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 702 FLRERQT-VENMQAEVDEQRAKDEAWyqkQELLRRAEETRREILlQEEEKMAQQRQRLAAVKRELEIKEihlqdaARRRL 780
Cdd:cd16269  147 YLEDREKlVEKYRQVPRKGVKAEEVL---QEFLQSKEAEAEAIL-QADQALTEKEKEIEAERAKAEAAE------QERKL 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543 781 LklQQDQREMElRRLEDE-------IERKVQMRDQEIAATAKDLE-IRQLELEAQKRLYEKDLTTSQEAVAKEIRE 848
Cdd:cd16269  217 L--EEQQRELE-QKLEDQersyeehLRQLKEKMEEERENLLKEQErALESKLKEQEALLEEGFKEQAELLQEEIRS 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-336 6.17e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 6.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  48 VAFDGSGDSFIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFS--PDGKLLAsGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 126 ESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKY 204
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 205 QLPGPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQmpAKVRAVRHLEFLPDsfdagsNQVLGVLSQ 284
Cdd:COG2319  283 TLTGHSGGVNSV----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPD------GKTLASGSD 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 264681543 285 DGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQ 336
Cdd:COG2319  351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
44-340 1.60e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  44 RFLNVAFDGSGDSFIAGDHQGNIYVFDL-HGNRFNLVQRTAQACTALAFNLRRKSeFLVALADYSIKCFDTVTKELVSWM 122
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGKLLRTL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 123 RGHESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLF 201
Cdd:COG2319  159 TGHSGAVTSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 202 CKYQLPGPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQMPAkvRAVRHLEFLPDSfdagsnQVLGV 281
Cdd:COG2319  238 LLRTLTGHSGSVRSV----AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDG------KLLAS 305

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543 282 LSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQALTQ 340
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-334 9.31e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 9.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  39 HPKVLRFlnVAFDGSGDSFIAGDHQGNIYVFDLHGNRFNLVQR----TAQACTALAFNLRrkseFLVALADYSIKCFDTV 114
Cdd:cd00200    8 HTGGVTC--VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 115 TKELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIF 193
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDkTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 194 AWECDTLFCKYQLPGpPEGSnilykVFAVT--RDGRILAAGGKSNHLHLWclEATGLFRIIQMPAKVRAVRHLEFLPDsf 271
Cdd:cd00200  161 LWDLRTGKCVATLTG-HTGE-----VNSVAfsPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-- 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543 272 dagsNQVLGVLSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYS 334
Cdd:cd00200  231 ----GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-336 1.97e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 1.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  39 HPKVLRFLNVAFDGSGDSFIAGDHQGNIYVFDLHGNRFNLVQRTAQAcTALAFNLRRKSeFLVALADYSIKCFDTVTKEL 118
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV-LSVAFSPDGRL-LASASADGTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 119 VSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNiRQSVGIQKVFFLPLSNTILSCFKDNSIFAWEC 197
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 198 DTLFCKYQLPGPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQMPAkvRAVRHLEFLPDSfdagsnQ 277
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSV----AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS--GSVRSVAFSPDG------R 259

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543 278 VLGVLSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQ 336
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
49-336 9.03e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 9.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  49 AFDGSGDSFIAGDHQGNIYVFDLHGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFDTVTKELVSWMRGHESS 128
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 129 VCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIRQSvGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKYQLP 207
Cdd:COG2319   81 VLSVAFSPDGRLLASASADgTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 208 GPPEGSNILykvfAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQmpAKVRAVRHLEFLPDSfdagsnQVLGVLSQDGI 287
Cdd:COG2319  160 GHSGAVTSV----AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDG------KLLASGSADGT 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 264681543 288 MRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQ 336
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-337 2.96e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 123 RGHESSVCSISVHASGRYAITTSSD-TAQLWDLDTFQRKRKLNIrQSVGIQKVFFLPLSNTILSCFKDNSIFAWECDTLF 201
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 202 CKYQLPGPPEGsnilykVFAV--TRDGRILAAGGKSNHLHLWCLEATGLfrIIQMPAKVRAVRHLEFLPDsfdagsNQVL 279
Cdd:cd00200   85 CVRTLTGHTSY------VSSVafSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRGHTDWVNSVAFSPD------GTFV 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543 280 GVLSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVYSVQA 337
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 684-941 6.10e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 76.32  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  684 IVDYQTREWERIRNDELDFL---RERQTVENMQAEVDEQRAKDEAwyqkqELLRRAEETRREILLQEEEKMAQQRQR--- 757
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMeqeRLRQEKEEKAREVERRRKLEEA-----EKARQAEMDRQAAIYAEQERMAMERERele 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  758 ---LAAVKRELE-------------IKEIH-LQ--------------DAARR-------RLLKLQQDQREMELRRLEDEI 799
Cdd:pfam17380 352 rirQEERKRELErirqeeiameisrMRELErLQmerqqknervrqelEAARKvkileeeRQRKIQQQKVEMEQIRAEQEE 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  800 ERKVQMRDQEiAATAKDLE-IRQLELEAQKRLyekDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRA 878
Cdd:pfam17380 432 ARQREVRRLE-EERAREMErVRLEEQERQQQV---ERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQA 507

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543  879 QRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQRQYMDSAylPQTSRL 941
Cdd:pfam17380 508 MIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKAT--EERSRL 568
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 688-928 6.35e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.51  E-value: 6.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 688 QTREWE-RIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELL---RRAEETRREILLQEEEKMAQQRQRLAAVKR 763
Cdd:COG1196  261 ELAELEaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAELEEELEELEEELE 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 764 ELEIKEIHLQDAARRRLLKLQQ--DQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRL---------YE 832
Cdd:COG1196  341 ELEEELEEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEeallerlerLE 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 833 KDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEfHLQSAKKASALSDASRKWfLRQE 912
Cdd:COG1196  421 EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE-AALAELLEELAEAAARLL-LLLE 498

                        250
                 ....*....|....*.
gi 264681543 913 TSAALEHEEMPWLQRQ 928
Cdd:COG1196  499 AEADYEGFLEGVKAAL 514
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 699-921 7.64e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 73.05  E-value: 7.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 699 ELDFLRERQtvENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKE---IHLQDA 775
Cdd:COG1196  233 KLRELEAEL--EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEqdiARLEER 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 776 ARRRLLKLQQDQREME--LRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRL--YEKDLTTSQEAVAKEIREDTD 851
Cdd:COG1196  311 RRELEERLEELEEELAelEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALleAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 852 AHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEfhlQSAKKASALSDASRKWFLRQETSAALEHEE 921
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELE---EALAELEEEEEEEEEALEEAAEEEAELEEE 457
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 693-921 3.45e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.74  E-value: 3.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRERQTVENMQAEVDEQRAK--------DEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRE 764
Cdd:COG1196  246 AELEELEAELEELEAELAELEAELEELRLEleelelelEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 765 LEIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRD------QEIAATAKDLEIRQLELEAQKRLYEKDLTTS 838
Cdd:COG1196  326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLeaeaelAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 839 QEAVAKEIREDTDAHRRKAALEEHMFQKLLEnsqmggRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALE 918
Cdd:COG1196  406 EEAEEALLERLERLEEELEELEEALAELEEE------EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479


                 ...
gi 264681543 919 HEE 921
Cdd:COG1196  480 AEL 482
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 688-865 5.20e-12

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 69.77  E-value: 5.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  688 QTREWERIRNDELDflrERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEE----KMAQQRQRLAAVKR 763
Cdd:pfam17380 444 RAREMERVRLEEQE---RQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEerkqAMIEEERKRKLLEK 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  764 ELEIKEIHLQDAARRRLLKLQQ-DQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAV 842
Cdd:pfam17380 521 EMEERQKAIYEEERRREAEEERrKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTI 600

                         170       180
                  ....*....|....*....|...
gi 264681543  843 AKEIREDTDAHrRKAALEEHMFQ 865
Cdd:pfam17380 601 KPIYRPRISEY-QPPDVESHMIR 622
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 689-927 5.41e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 5.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 689 TREWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAwyqkqellRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIK 768
Cdd:COG1196  294 LAELARLEQDIARLEERRRELEERLEELEEELAELEE--------ELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 769 EIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMrdQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIRE 848
Cdd:COG1196  366 ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL--EELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543 849 DTDAHRRKAALEEHMfQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQR 927
Cdd:COG1196  444 LEEAAEEEAELEEEE-EALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 687-921 6.17e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.50  E-value: 6.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 687 YQT-REWERIRNDELdFLRERQTVENMQAEVDEQRAkdeawyQKQELLRRAEETRREIllqeEEKMAQQRQRLAAVKREL 765
Cdd:COG1196  215 YRElKEELKELEAEL-LLLKLRELEAELEELEAELE------ELEAELEELEAELAEL----EAELEELRLELEELELEL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 766 EIKEIHLQdAARRRLLKLQQDQR--EMELRRLEDEIERKvQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVA 843
Cdd:COG1196  284 EEAQAEEY-ELLAELARLEQDIArlEERRRELEERLEEL-EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543 844 KEIREDTDAHRRKAALEEHMFQKLLENSqmggRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEE 921
Cdd:COG1196  362 EAEEALLEAEAELAEAEEELEELAEELL----EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 691-872 7.79e-10

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 62.66  E-value: 7.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELDFLRERQ----TVENMQAEVD--EQRAKDEAWYQKQellRRAEETRReillQEEEKMAQQRQRLAAVKRE 764
Cdd:pfam15709 349 EVERKRREQEEQRRLQQeqleRAEKMREELEleQQRRFEEIRLRKQ---RLEEERQR----QEEEERKQRLQLQAAQERA 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  765 leikeiHLQDAA-RRRLLKLQQDQREMELRRLEDEIERKVQMRDQeIAATAKDL-EIRQLE-LEAQKRLYEKDLTTSQEA 841
Cdd:pfam15709 422 ------RQQQEEfRRKLQELQRKKQQEEAERAEAEKQRQKELEMQ-LAEEQKRLmEMAEEErLEYQRQKQEAEEKARLEA 494

                         170       180       190
                  ....*....|....*....|....*....|.
gi 264681543  842 VAKEIREDTDAhrrKAALEEHMFQKLLENSQ 872
Cdd:pfam15709 495 EERRQKEEEAA---RLALEEAMKQAQEQARQ 522
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 713-922 8.47e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 8.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 713 QAEV---------DEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQdAARRRLLKL 783
Cdd:COG1196  208 QAEKaeryrelkeELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELE-ELELELEEA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 784 QQDQRE--MELRRLEDEIERKVQMRdqeiaataKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDTDAHRRKAALEE 861
Cdd:COG1196  287 QAEEYEllAELARLEQDIARLEERR--------RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543 862 HMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEM 922
Cdd:COG1196  359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419
WD40 COG2319
WD40 repeat [General function prediction only];
48-156 2.09e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  48 VAFDGSGDSFIAGDHQGNIYVFDLH-GNRFNLVQRTAQACTALAFNlrRKSEFLV-ALADYSIKCFDTVTKELVSWMRGH 125
Cdd:COG2319  294 VAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS--PDGKTLAsGSDDGTVRLWDLATGELLRTLTGH 371

                         90       100       110
                 ....*....|....*....|....*....|..
gi 264681543 126 ESSVCSISVHASGRYAITTSSD-TAQLWDLDT 156
Cdd:COG2319  372 TGAVTSVAFSPDGRTLASGSADgTVRLWDLAT 403
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 461-605 2.33e-09

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 57.65  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  461 SLQKKYPIKSRKLLRVLQRTLSALAHWsaiFSDTPY---LPLLAFPFVkLFQNNQLICFEVVATLIINwcQHWFEYFPN- 536
Cdd:pfam00566  19 TFPHSFFFDNGPGQNSLRRILKAYSIY---NPDVGYcqgMNFIAAPLL-LVYLDEEDAFWCFVSLLEN--YLLRDFYTPd 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  537 -PPINILSMI-ENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIFSNHPSFLLM 605
Cdd:pfam00566  93 fPGLKRDLYVfEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF 163
PTZ00121 PTZ00121
MAEBL; Provisional
 691-888 2.40e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELDFLRE--RQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREilLQEEEKMAQQrqrlaaVKRELEIK 768
Cdd:PTZ00121 1657 EENKIKAAEEAKKAEedKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKK--EAEEKKKAEE------LKKAEEEN 1728

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  769 EIHLQDAARrrllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQ-------LELEAQKRLYEKDLTT---- 837
Cdd:PTZ00121 1729 KIKAEEAKK----EAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKeavieeeLDEEDEKRRMEVDKKIkdif 1804

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 264681543  838 -------------------SQEAVAKEIREDTDAH---RRKA-ALEEHMFQKLLENSQMGGRRAQRWKEAEEKE 888
Cdd:PTZ00121 1805 dnfaniieggkegnlvindSKEMEDSAIKEVADSKnmqLEEAdAFEKHKFNKNNENGEDGNKEADFNKEKDLKE 1878
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 690-896 4.66e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 60.52  E-value: 4.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  690 REWERIRNdELDFLR-------ERQ-TVENMQAEVDEQRAKDEAwyQKQELLRRAEETR-REILLQEEEKMAQQRQrlaa 760
Cdd:pfam17380 389 QKNERVRQ-ELEAARkvkileeERQrKIQQQKVEMEQIRAEQEE--ARQREVRRLEEERaREMERVRLEEQERQQQ---- 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  761 vkreleiKEIHLQDAARRRLLKLQQDQREMELRRLEDE----IERKVQMRDQEIaatakdleirqLELEAQKRLYEKDLT 836
Cdd:pfam17380 462 -------VERLRQQEEERKRKKLELEKEKRDRKRAEEQrrkiLEKELEERKQAM-----------IEEERKRKLLEKEME 523

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  837 TSQEAVAKEiredtdaHRRKAALEEHMFQKLLENSQmggRRAQRWKEAEEKEFHLQSAKK 896
Cdd:pfam17380 524 ERQKAIYEE-------ERRREAEEERRKQQEMEERR---RIQEQMRKATEERSRLEAMER 573
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 733-921 7.73e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.95  E-value: 7.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 733 LRRAEE--TRREILLQEeekMAQQRQRLA----------AVKRELEIKEIHLQdAARRRLLKLQQDQREMELRRLEDEIE 800
Cdd:COG1196  181 LEATEEnlERLEDILGE---LERQLEPLErqaekaeryrELKEELKELEAELL-LLKLRELEAELEELEAELEELEAELE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 801 R-KVQMRDQEIAATAKDLEIRQLELE---AQKRLYE--KDLTTSQEAVAKEIREDTDAHRRKAALEEhmfQKLLENSQMG 874
Cdd:COG1196  257 ElEAELAELEAELEELRLELEELELEleeAQAEEYEllAELARLEQDIARLEERRRELEERLEELEE---ELAELEEELE 333

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 264681543 875 GRRAQRwKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEE 921
Cdd:COG1196  334 ELEEEL-EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
PTZ00121 PTZ00121
MAEBL; Provisional
 693-906 1.23e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.38  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRNDELdflreRQTVENMQAEVDEQRAKDEAwYQKQELLRRAEETRR--EILLQEEEKMAQQRQRLAAVKRELEIKei 770
Cdd:PTZ00121 1481 EAKKADEA-----KKKAEEAKKKADEAKKAAEA-KKKADEAKKAEEAKKadEAKKAEEAKKADEAKKAEEKKKADELK-- 1552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  771 hlqdaaRRRLLKLQQDQREMELRRLEDEiERKVQMRDQEIAATAKDLEIrqlelEAQKRLYEKDLTTSQEAVAKEIREDT 850
Cdd:PTZ00121 1553 ------KAEELKKAEEKKKAEEAKKAEE-DKNMALRKAEEAKKAEEARI-----EEVMKLYEEEKKMKAEEAKKAEEAKI 1620

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 264681543  851 DAHR-RKAALEEHMFQKLLENSQMGGRRAQRWKEAEEkEFHLQSAKKASALSDASRK 906
Cdd:PTZ00121 1621 KAEElKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE-ENKIKAAEEAKKAEEDKKK 1676
PTZ00121 PTZ00121
MAEBL; Provisional
 698-906 1.55e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  698 DELDFLRERQTVENMQAEvdEQRAKDEAwYQKQELLRRAEETRR--EILLQEEEKMAQQRQRLAAVKReleikeihLQDA 775
Cdd:PTZ00121 1095 EAFGKAEEAKKTETGKAE--EARKAEEA-KKKAEDARKAEEARKaeDARKAEEARKAEDAKRVEIARK--------AEDA 1163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  776 ARRRLLKLQQDQREMELRRLEDEIERKVQMRDQE----IAATAKDLEIRQLE----------LEAQKRLYEKDLTTSQEA 841
Cdd:PTZ00121 1164 RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEdarkAEAARKAEEERKAEearkaedakkAEAVKKAEEAKKDAEEAK 1243

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681543  842 VAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKefhlqsaKKASALSDASRK 906
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK-------KKADEAKKAEEK 1301
PTZ00121 PTZ00121
MAEBL; Provisional
 690-920 2.23e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.61  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  690 REWERIRNDELDFLRERQtvENMQAEvdeQRAKDEAWYQKQELLRRAEETRREILlQEEEKMAQQRQRLAAVKRELEIKE 769
Cdd:PTZ00121 1587 KKAEEARIEEVMKLYEEE--KKMKAE---EAKKAEEAKIKAEELKKAEEEKKKVE-QLKKKEAEEKKKAEELKKAEEENK 1660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  770 IHLQDAARrrllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLE-IRQLELEAQKRlyekdlttsqeavAKEIRE 848
Cdd:PTZ00121 1661 IKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEeLKKKEAEEKKK-------------AEELKK 1723

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 264681543  849 DTDAHRRKAaleehmfQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKasalSDASRKWFLRQETSAALEHE 920
Cdd:PTZ00121 1724 AEEENKIKA-------EEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK----EEEKKAEEIRKEKEAVIEEE 1784
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 693-887 2.24e-08

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 57.24  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRL---------AAVKR 763
Cdd:pfam13868 138 EQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelraklyqEEQER 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  764 ELEIKEIhlQDAARRR-----LLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKdlttS 838
Cdd:pfam13868 218 KERQKER--EEAEKKArqrqeLQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLE----H 291

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 264681543  839 QEAVAKEIREdtdAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEK 887
Cdd:pfam13868 292 RRELEKQIEE---REEQRAAEREEELEEGERLREEEAERRERIEEERQK 337
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 735-921 2.46e-08

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 57.65  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  735 RAEETRREILLQEEEKMAQQRQRL---AAVKRELEIKEIHLQDAARRRLlklQQDQREMElRRLEDEIERKVQMRDQEIA 811
Cdd:pfam15709 315 RSEEDPSKALLEKREQEKASRDRLraeRAEMRRLEVERKRREQEEQRRL---QQEQLERA-EKMREELELEQQRRFEEIR 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  812 ATAKDLE---IRQLELEAQKRLyekdlttsQEAVAKE-IREDTDAHRRKaaLEEHMFQKLLENSQMGGRRAQRWKEAEEK 887
Cdd:pfam15709 391 LRKQRLEeerQRQEEEERKQRL--------QLQAAQErARQQQEEFRRK--LQELQRKKQQEEAERAEAEKQRQKELEMQ 460

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 264681543  888 EFHLQsaKKASALSDASRKWFLRQ----ETSAALEHEE 921
Cdd:pfam15709 461 LAEEQ--KRLMEMAEEERLEYQRQkqeaEEKARLEAEE 496
PTZ00121 PTZ00121
MAEBL; Provisional
 690-900 2.83e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 2.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  690 REWERIRNDELdflreRQTVENMQAevDEQRAKDEAwyQKQELLRRAEETRR--EILLQEEEKMAQQRQRLAAVKRELEI 767
Cdd:PTZ00121 1505 AAEAKKKADEA-----KKAEEAKKA--DEAKKAEEA--KKADEAKKAEEKKKadELKKAEELKKAEEKKKAEEAKKAEED 1575

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  768 KEIHLQDAARRRllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIR 847
Cdd:PTZ00121 1576 KNMALRKAEEAK--KAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK 1653

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 264681543  848 EDTDAHRRKAAleehmfqKLLENSQMGGRRAQRWKEAEEKEfhlqsAKKASAL 900
Cdd:PTZ00121 1654 KAEEENKIKAA-------EEAKKAEEDKKKAEEAKKAEEDE-----KKAAEAL 1694
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
713-921 2.97e-08

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 57.36  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 713 QAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELE--IKEIHLQDAARRRLLKLQQDQREM 790
Cdd:COG3064    1 AQEALEEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEeeAREAKAEAEQRAAELAAEAAKKLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 791 ELRRLEDEIERKVQMRDQEIAATA-KDLEIRQLELEAQKRLYEKdlttSQEAVAKEIREDTDAHRRKAALEEHMFQKLLE 869
Cdd:COG3064   81 EAEKAAAEAEKKAAAEKAKAAKEAeAAAAAEKAAAAAEKEKAEE----AKRKAEEEAKRKAEEERKAAEAEAAAKAEAEA 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 264681543 870 NSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEE 921
Cdd:COG3064  157 ARAAAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAA 208
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
686-861 4.61e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 4.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  686 DYQTREWERIRNDELDFLRERQTVENMQaevdeqrakdeawyQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKREL 765
Cdd:COG4913   260 LAERYAAARERLAELEYLRAALRLWFAQ--------------RRLELLEAELEELRAELARLEAELERLEARLDALREEL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  766 EIKEIHLQDAARRRLLKLQQdqremELRRLEDEIERKVQMRDQ----------EIAATAKDLEIRQLELEAQKRLYEKDL 835
Cdd:COG4913   326 DELEAQIRGNGGDRLEQLER-----EIERLERELEERERRRARleallaalglPLPASAEEFAALRAEAAALLEALEEEL 400

                         170       180
                  ....*....|....*....|....*.
gi 264681543  836 TTSQEAVAKEIREDTDAHRRKAALEE 861
Cdd:COG4913   401 EALEEALAEAEAALRDLRRELRELEA 426
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 696-921 6.31e-08

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 55.81  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  696 RNDELDFLRERQTVENMQAEvdEQRAKDEawyQKQELLRRaeETRREILLQEEEKMAQQRQRLAAVKRELE------IKE 769
Cdd:pfam15558  16 RHKEEQRMRELQQQAALAWE--ELRRRDQ---KRQETLER--ERRLLLQQSQEQWQAEKEQRKARLGREERrradrrEKQ 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  770 IHLQDAARRRLLKLQQDQRE--MELRRLEDEIERKVQ-------------MRDQEIAATAKDLEI----RQL-ELEAQKR 829
Cdd:pfam15558  89 VIEKESRWREQAEDQENQRQekLERARQEAEQRKQCQeqrlkekeeelqaLREQNSLQLQERLEEachkRQLkEREEQKK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  830 LYEKDLttsQEAVAKEIREDTDAHRRKAalEEHMFQKLLENS---------QMGGRRAQRWKE-AEEKEFHLQSAKKASA 899
Cdd:pfam15558 169 VQENNL---SELLNHQARKVLVDCQAKA--EELLRRLSLEQSlqrsqenyeQLVEERHRELREkAQKEEEQFQRAKWRAE 243

                         250       260
                  ....*....|....*....|....*
gi 264681543  900 LSDASRKWFLR---QETSAALEHEE 921
Cdd:pfam15558 244 EKEEERQEHKEalaELADRKIQQAR 268
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 699-898 1.79e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.45  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   699 ELDFLRER-QTVENMQAEVDEQRAKDEawyQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQD--- 774
Cdd:TIGR02168  303 QKQILRERlANLERQLEELEAQLEELE---SKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEElee 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   775 -----AARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAatakdlEIRQLEleaqKRLYEKDLTTSQEAVAKEIRED 849
Cdd:TIGR02168  380 qletlRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ------EIEELL----KKLEEAELKELQAELEELEEEL 449

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 264681543   850 TDAHRRKAALEEhmfqkLLENSQMGGRRAQRWKEAEEKEFHLQSAKKAS 898
Cdd:TIGR02168  450 EELQEELERLEE-----ALEELREELEEAEQALDAAERELAQLQARLDS 493
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 692-888 1.80e-07

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 54.15  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  692 WERIRNDELDFLRERQT-VENMQAEVDEQRAKDEAWYQKQ-----ELLRRAEETRREILLQEEEKMAQQRQRLAAVKREL 765
Cdd:pfam13868 107 VERIQEEDQAEAEEKLEkQRQLREEIDEFNEEQAEWKELEkeeerEEDERILEYLKEKAEREEEREAEREEIEEEKEREI 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  766 ---------EIKEIHLQDAARRRLL------KLQQDQREMELRRLEDEIERKvQMRDQEIAATAkdlEIRQLELEAQKRL 830
Cdd:pfam13868 187 arlraqqekAQDEKAERDELRAKLYqeeqerKERQKEREEAEKKARQRQELQ-QAREEQIELKE---RRLAEEAEREEEE 262

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543  831 YEKDLTTSQEAVAKEIREdtdAHRRKAALEEHmfQKLLENsQMGGRRAQRWKEAEEKE 888
Cdd:pfam13868 263 FERMLRKQAEDEEIEQEE---AEKRRMKRLEH--RRELEK-QIEEREEQRAAEREEEL 314
PRK12704 PRK12704
phosphodiesterase; Provisional
 682-832 2.62e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 54.40  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 682 KFIVDYQTREWERIRNDEL-----DFLRERQTVENmqaEVDEQRAKdeawYQKQEL-LRRAEET---RREILLQEEEKMA 752
Cdd:PRK12704  41 KRILEEAKKEAEAIKKEALleakeEIHKLRNEFEK---ELRERRNE----LQKLEKrLLQKEENldrKLELLEKREEELE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 753 QQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQ-------DQREMELRRLEDEIErkvqmrdQEIAATAKDLEiRQLELE 825
Cdd:PRK12704 114 KKEKELEQKQQELEKKEEELEELIEEQLQELERisgltaeEAKEILLEKVEEEAR-------HEAAVLIKEIE-EEAKEE 185


                 ....*..
gi 264681543 826 AQKRLYE 832
Cdd:PRK12704 186 ADKKAKE 192
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 683-907 3.62e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 54.59  E-value: 3.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   683 FIVDYQTREWE-RIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRR-EILLQEEEKMAQQRQRLAA 760
Cdd:pfam02463  168 KRKKKEALKKLiEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLyLDYLKLNEERIDLLQELLR 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   761 VKRELEIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRlyEKDLTTSQE 840
Cdd:pfam02463  248 DEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKL--KESEKEKKK 325

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543   841 AVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASA--LSDASRKW 907
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESErlSSAAKLKE 394
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 688-828 3.90e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 53.80  E-value: 3.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  688 QTREWE--RIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKREL 765
Cdd:pfam15709 382 QQRRFEeiRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQL 461

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 264681543  766 EIKEIHLQD-AARRRLLKLQQDQREMELRRLEDEIERKvqmRDQEIAATAKDLEIRQLELEAQK 828
Cdd:pfam15709 462 AEEQKRLMEmAEEERLEYQRQKQEAEEKARLEAEERRQ---KEEEAARLALEEAMKQAQEQARQ 522
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 690-922 4.03e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.30  E-value: 4.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   690 REWERIRNdELDFLRERqtVENMQAEVDE--------QRAKDEAwYQKQELLRRAEETRREILLQEEEKMAQQRQR---- 757
Cdd:TIGR02169  170 RKKEKALE-ELEEVEEN--IERLDLIIDEkrqqlerlRREREKA-ERYQALLKEKREYEGYELLKEKEALERQKEAierq 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   758 LAAVKRELEIKEIHLQDAARRrllklqQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTT 837
Cdd:TIGR02169  246 LASLEEELEKLTEEISELEKR------LEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELED 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   838 SQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALsdasrkwfLRQETSAAL 917
Cdd:TIGR02169  320 AEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE--------TRDELKDYR 391


                   ....*
gi 264681543   918 EHEEM 922
Cdd:TIGR02169  392 EKLEK 396
PTZ00121 PTZ00121
MAEBL; Provisional
 688-897 4.93e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 4.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  688 QTREWERIRNDEldflRERQTVENMQAEvDEQRA----KDEAWYQKQELLRRAEETR--REILLQEEEKMAQQRQRLAAV 761
Cdd:PTZ00121 1198 DARKAEAARKAE----EERKAEEARKAE-DAKKAeavkKAEEAKKDAEEAKKAEEERnnEEIRKFEEARMAHFARRQAAI 1272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  762 KRELEIKEIHLQDAARRRllKLQQDQREMELRRLeDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKdlttSQEA 841
Cdd:PTZ00121 1273 KAEEARKADELKKAEEKK--KADEAKKAEEKKKA-DEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA----KKAA 1345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543  842 VAKEIREDTDAHRRKAALEEHMFQKLlENSQMGGRRAQRWKEAEEKEFHLQSAKKA 897
Cdd:PTZ00121 1346 EAAKAEAEAAADEAEAAEEKAEAAEK-KKEEAKKKADAAKKKAEEKKKADEAKKKA 1400
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 703-867 6.14e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.79  E-value: 6.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 703 LRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLK 782
Cdd:COG1196  680 ELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEP 759

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 783 LQQDQREMELRRLEDEIER--KVQMR-DQEIAATAKDLEirqlELEAQKrlyeKDLTTSQEAVAKEIRE-DTDAHRR-KA 857
Cdd:COG1196  760 PDLEELERELERLEREIEAlgPVNLLaIEEYEELEERYD----FLSEQR----EDLEEARETLEEAIEEiDRETRERfLE 831

                        170
                 ....*....|....*.
gi 264681543 858 ALEE------HMFQKL 867
Cdd:COG1196  832 TFDAvnenfqELFPRL 847
PRK12704 PRK12704
phosphodiesterase; Provisional
 721-897 7.94e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 52.86  E-value: 7.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 721 AKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLaavKRELEIKEIHLQDAARRRLlklqqdQREMELRRLEDEIE 800
Cdd:PRK12704  36 AEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEF---EKELRERRNELQKLEKRLL------QKEENLDRKLELLE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 801 RkvqmRDQEIAATAKDLEIRQLELEAQKRLYEKdLTTSQEAVAKEIredtdahrrkAAL-EEHMFQKLLEN--SQMGGRR 877
Cdd:PRK12704 107 K----REEELEKKEKELEQKQQELEKKEEELEE-LIEEQLQELERI----------SGLtAEEAKEILLEKveEEARHEA 171

                        170       180
                 ....*....|....*....|
gi 264681543 878 AQRWKEAEEkEFHLQSAKKA 897
Cdd:PRK12704 172 AVLIKEIEE-EAKEEADKKA 190
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 712-920 1.05e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 51.84  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  712 MQAEVDEQRA-----KDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELeikEIHLQDAARRRLLKLQQD 786
Cdd:pfam13868  20 CNKERDAQIAekkriKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQEL---EEQIEEREQKRQEEYEEK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  787 QREMEL-----RRLEDEIERKVQMRDQEIAATAKDL--------EIRQLELEAQKRL------YEKDLTTSQEAVAKEIR 847
Cdd:pfam13868  97 LQEREQmdeivERIQEEDQAEAEEKLEKQRQLREEIdefneeqaEWKELEKEEEREEderileYLKEKAEREEEREAERE 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 264681543  848 EDTDAH-RRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQsakkasALSDASRKWFLRQETSAALEHE 920
Cdd:pfam13868 177 EIEEEKeREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKERQK------EREEAEKKARQRQELQQAREEQ 244
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 691-928 1.16e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 51.77  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELDFLR-ERQT---VENMQAEVDEQRAKDEAwyQKQELLRRAEEtrreillQEEEKMAQQRQRLAAVKR--E 764
Cdd:TIGR02794  51 QANRIQQQKKPAAKkEQERqkkLEQQAEEAEKQRAAEQA--RQKELEQRAAA-------EKAAKQAEQAAKQAEEKQkqA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  765 LEIKEIHLQDAArrrllklqqdqremelRRLEDEIERKVQmrdQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAK 844
Cdd:TIGR02794 122 EEAKAKQAAEAK----------------AKAEAEAERKAK---EEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  845 EiredtDAhRRKAALEEHMFQKLlensqmgGRRAQRWKEAEEKefhLQSAKKASALSDASRK-WFLRQETSAALEHEEMP 923
Cdd:TIGR02794 183 A-----EA-EAKAKAEEAKAKAE-------AAKAKAAAEAAAK---AEAEAAAAAAAEAERKaDEAELGDIFGLASGSNA 246


                  ....*
gi 264681543  924 WLQRQ 928
Cdd:TIGR02794 247 EKQGG 251
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
688-873 1.32e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.46  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 688 QTREWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREiLLQEEEKMAQQRQRLAAVKRelei 767
Cdd:COG4717   86 KEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAE-LAELPERLEELEERLEELRE---- 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 768 keihlqdaarrrlLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVaKEIR 847
Cdd:COG4717  161 -------------LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEEL-EELE 226

                        170       180
                 ....*....|....*....|....*.
gi 264681543 848 EDTDAHRRKAALEEhMFQKLLENSQM 873
Cdd:COG4717  227 EELEQLENELEAAA-LEERLKEARLL 251
PTZ00121 PTZ00121
MAEBL; Provisional
 691-855 1.74e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELDFLRE-RQTVENMQAEVDEQ--------RAKDEAWYQKQELLRRAEETRR--EILLQEEE---KMAQQRQ 756
Cdd:PTZ00121 1616 EEAKIKAEELKKAEEeKKKVEQLKKKEAEEkkkaeelkKAEEENKIKAAEEAKKAEEDKKkaEEAKKAEEdekKAAEALK 1695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  757 RLAAVKRELEikEIHLQDAARRRllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLE-----IRQLELEAQKRLY 831
Cdd:PTZ00121 1696 KEAEEAKKAE--ELKKKEAEEKK--KAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEeekkkIAHLKKEEEKKAE 1771

                         170       180
                  ....*....|....*....|....
gi 264681543  832 EkdLTTSQEAVAKEIREDTDAHRR 855
Cdd:PTZ00121 1772 E--IRKEKEAVIEEELDEEDEKRR 1793
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 684-888 2.18e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 51.07  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  684 IVDYQTREWERIR------NDELDFLRERQTVENMQAEVDEQRAKDEAWYQ-KQEL-----------LRRAEETRREILL 745
Cdd:pfam13868  23 ERDAQIAEKKRIKaeekeeERRLDEMMEEERERALEEEEEKEEERKEERKRyRQELeeqieereqkrQEEYEEKLQEREQ 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  746 --------QEEEKMAQQRQRlaavKRELEIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAAtakdl 817
Cdd:pfam13868 103 mdeiveriQEEDQAEAEEKL----EKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREA----- 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  818 eiRQLELEAQKRLYEKDLTTSQEAvAKEIREDTDAHRRKAALEEHmfqkllensqmggRRAQRWKEAEEKE 888
Cdd:pfam13868 174 --EREEIEEEKEREIARLRAQQEK-AQDEKAERDELRAKLYQEEQ-------------ERKERQKEREEAE 228
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 704-832 3.67e-06

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 47.73  E-value: 3.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  704 RERQTVENMQAEVDEQRAKDEAWYQ-KQELLRRAEETRREillQEEE--KMAQQRQRLAAVKRELEIKEIHLQDAARRRL 780
Cdd:pfam05672  19 KRRQAREQREREEQERLEKEEEERLrKEELRRRAEEERAR---REEEarRLEEERRREEEERQRKAEEEAEEREQREQEE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 264681543  781 LKLQQDQREMELRRLEDEIERKVQMRDQEIaatakdLEIRQLELEAQKRLYE 832
Cdd:pfam05672  96 QERLQKQKEEAEAKAREEAERQRQEREKIM------QQEEQERLERKKRIEE 141
PTZ00121 PTZ00121
MAEBL; Provisional
 688-900 3.87e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.30  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  688 QTREWERIRNDELdfLRERQTVENMQA--EVDEQRAKDEAwyQKQELLRRAEETRReilLQEEEKMAQQRQRLAAVKREL 765
Cdd:PTZ00121 1180 AARKAEEVRKAEE--LRKAEDARKAEAarKAEEERKAEEA--RKAEDAKKAEAVKK---AEEAKKDAEEAKKAEEERNNE 1252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  766 EIKEIhlqDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKdlEIRQLElEAQKRLYEKDLTTSQEAVAKE 845
Cdd:PTZ00121 1253 EIRKF---EEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEE 1326

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  846 IREDTDAHRRKAalEE-----HMFQKLLENSQMGGRRAQRWKEAEEKEFHlQSAKKASAL 900
Cdd:PTZ00121 1327 AKKKADAAKKKA--EEakkaaEAAKAEAEAAADEAEAAEEKAEAAEKKKE-EAKKKADAA 1383
mukB PRK04863
chromosome partition protein MukB;
707-897 4.05e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 51.11  E-value: 4.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  707 QTVENMQAEVDEQRAKDEAwyqkQELLRRAEETR--------REILLQEEEKMAQQRQRLAAVKRELEIK-EIHLQDAAr 777
Cdd:PRK04863  480 QLVRKIAGEVSRSEAWDVA----RELLRRLREQRhlaeqlqqLRMRLSELEQRLRQQQRAERLLAEFCKRlGKNLDDED- 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  778 rrLLKLQQDQREMELRRLEDE----IERKVQMRDQEIAATAkdlEIRQLELEAQKRLyekdltTSQEAVAK--EIREDTD 851
Cdd:PRK04863  555 --ELEQLQEELEARLESLSESvseaRERRMALRQQLEQLQA---RIQRLAARAPAWL------AAQDALARlrEQSGEEF 623

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 264681543  852 AHRrkAALEEHMfQKLLEnsqmggrraqRWKEAEEKEFHLQSAKKA 897
Cdd:PRK04863  624 EDS--QDVTEYM-QQLLE----------RERELTVERDELAARKQA 656
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 696-944 4.12e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.83  E-value: 4.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   696 RNDELDFLRERqtVENMQAEVDEQRAKDEAWYQKQE--------LLRRAEETRREI---------LLQEEEKMAQQRQRL 758
Cdd:TIGR02168  675 RRREIEELEEK--IEELEEKIAELEKALAELRKELEeleeeleqLRKELEELSRQIsalrkdlarLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   759 aavkrELEIKEIhlqdAARRRLLKLQQDQREMELRRLEDEIErKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTS 838
Cdd:TIGR02168  753 -----SKELTEL----EAEIEELEERLEEAEEELAEAEAEIE-ELEAQIEQLKEELKALREALDELRAELTLLNEEAANL 822

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   839 QEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALE 918
Cdd:TIGR02168  823 RERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEE 902

                          250       260
                   ....*....|....*....|....*.
gi 264681543   919 HEEMPwLQRQYMDSAYLPQTSRLHDV 944
Cdd:TIGR02168  903 LRELE-SKRSELRRELEELREKLAQL 927
PTZ00121 PTZ00121
MAEBL; Provisional
 693-896 4.62e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRNDELDFLRERQTVENMQaEVDEQRAKDEawyQKQELLRRAEETRreillQEEEKMAQQRQRLAAVKRELEIKEIHL 772
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEKK-KAEEAKKAEE---DKNMALRKAEEAK-----KAEEARIEEVMKLYEEEKKMKAEEAKK 1614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  773 QDAARrrlLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEA--VAKEIREDT 850
Cdd:PTZ00121 1615 AEEAK---IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAkkAEEDEKKAA 1691

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 264681543  851 DAHRRKAAlEEHMFQKLLENSQMGGRRAQRWKEAEE-KEFHLQSAKK 896
Cdd:PTZ00121 1692 EALKKEAE-EAKKAEELKKKEAEEKKKAEELKKAEEeNKIKAEEAKK 1737
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 706-861 4.66e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.21  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 706 RQTVENMQAEVDE-QRAKDEAWYQKQELLRRAEETRREILlQEEEKMAQQRQRLAAVKRELEIKEI------------HL 772
Cdd:COG3883   36 QAELDALQAELEElNEEYNELQAELEALQAEIDKLQAEIA-EAEAEIEERREELGERARALYRSGGsvsyldvllgseSF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 773 QDAARRRLL--KLQQDQREM--ELRRLEDEIERKvqmrDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIRE 848
Cdd:COG3883  115 SDFLDRLSAlsKIADADADLleELKADKAELEAK----KAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAE 190

                        170
                 ....*....|...
gi 264681543 849 DTDAHRRKAALEE 861
Cdd:COG3883  191 EAAAEAQLAELEA 203
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 691-808 5.03e-06

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 47.34  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRNDELdflRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMA-QQRQRLAAVKRELEike 769
Cdd:pfam05672  39 EEERLRKEEL---RRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQErLQKQKEEAEAKARE--- 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 264681543  770 ihlqDAARRRLLKLQQDQREMELR-----RLEdEIERKVQMRDQ 808
Cdd:pfam05672 113 ----EAERQRQEREKIMQQEEQERlerkkRIE-EIMKRTRKSDQ 151
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
714-861 5.20e-06

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 50.26  E-value: 5.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 714 AEVDEQRAKDEAwyqkqELLRRAEETRREILLQEEEKMAQQrqrlaavKRELEIKEIHLQDAARRRllKLQQDQREMELR 793
Cdd:COG2268  195 AEIIRDARIAEA-----EAERETEIAIAQANREAEEAELEQ-------EREIETARIAEAEAELAK--KKAEERREAETA 260

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543 794 RLEDEIERKVQmrdQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDTDAHRRKAALEE 861
Cdd:COG2268  261 RAEAEAAYEIA---EANAEREVQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAEA 325
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
686-937 1.01e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 686 DYQTREWERIRnDELDFLRErqtvenmqAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKREL 765
Cdd:COG4717  315 ELEEEELEELL-AALGLPPD--------LSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEE 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 766 EIKEIHLQDAARRRLLKlQQDQREMELRRLEDEIERKVQMRDQEiaatakDLEIRQLELEAQKRLYEKDLttsqeavake 845
Cdd:COG4717  386 ELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELLEALDEE------ELEEELEELEEELEELEEEL---------- 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 846 iredTDAHRRKAALEEHMfqKLLENSQmggrraqrwkEAEEKEFHLQSAKkaSALSDASRKWFLRQETSAALEHeempwL 925
Cdd:COG4717  449 ----EELREELAELEAEL--EQLEEDG----------ELAELLQELEELK--AELRELAEEWAALKLALELLEE-----A 505

                        250
                 ....*....|..
gi 264681543 926 QRQYMDSaYLPQ 937
Cdd:COG4717  506 REEYREE-RLPP 516
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 699-849 1.05e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.00  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 699 ELDFLRERQtvENMQAEVDEQRAKDEAWYQKQELLRRA-EETRREI------LLQEEEKMAQQRQRLAAVK--RELEI-- 767
Cdd:COG1579   18 ELDRLEHRL--KELPAELAELEDELAALEARLEAAKTElEDLEKEIkrleleIEEVEARIKKYEEQLGNVRnnKEYEAlq 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 768 KEIHLqdaarrrlLKLQQDQREMELRRLEDEIERKVQMRDQ---EIAATAKDLEIRQLELEAQKRLYEKD---LTTSQEA 841
Cdd:COG1579   96 KEIES--------LKRRISDLEDEILELMERIEELEEELAEleaELAELEAELEEKKAELDEELAELEAEleeLEAEREE 167


                 ....*...
gi 264681543 842 VAKEIRED 849
Cdd:COG1579  168 LAAKIPPE 175
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 719-886 1.24e-05

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 47.46  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  719 QRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLaaVKRELEIKEIHLQDAARRRLLKLQQDQrEMELRRLEDE 798
Cdd:pfam14988  17 QKKIEKLWNQYVQECEEIERRRQELASRYTQQTAELQTQL--LQKEKEQASLKKELQALRPFAKLKESQ-EREIQDLEEE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  799 IeRKVQmrdQEIAATAKDLEIRQLELEA--QKRLYEKDLTTSQEAVAKEIREDTDAHRRKA--ALEEHM----------- 863
Cdd:pfam14988  94 K-EKVR---AETAEKDREAHLQFLKEKAllEKQLQELRILELGERATRELKRKAQALKLAAkqALSEFCrsikrenrqlq 169

                         170       180       190
                  ....*....|....*....|....*....|..
gi 264681543  864 ---------FQKLLENSQMGGRRAQRWKEAEE 886
Cdd:pfam14988 170 kellqliqeTQALEAIKSKLENRKQRLKEEQW 201
RNase_Y_N pfam12072
RNase Y N-terminal region;
713-850 1.38e-05

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 47.19  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  713 QAEVDEQRAKDEAwyqKQEllrrAEETRREILLQEEEKMAQQRQRLaavkrELEIKEihlqdaaRRRLLKLQQD---QRE 789
Cdd:pfam12072  31 SAEELAKRIIEEA---KKE----AETKKKEALLEAKEEIHKLRAEA-----ERELKE-------RRNELQRQERrllQKE 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543  790 MEL-RRLE--DEIERKVQMRDQEIAATAKDLEIRQLELEA-----QKRLYEKDLTTSQEA-------VAKEIREDT 850
Cdd:pfam12072  92 ETLdRKDEslEKKEESLEKKEKELEAQQQQLEEKEEELEElieeqRQELERISGLTSEEAkeilldeVEEELRHEA 167
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
704-858 1.47e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  704 RERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREiLLQEEEKMAQQRQRLAAVKRELE--------IKEIHLQ-D 774
Cdd:COG4913   617 AELAELEEELAEAEERLEALEAELDALQERREALQRLAE-YSWDEIDVASAEREIAELEAELErldassddLAALEEQlE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  775 AARRRLLKLQQDQREM--ELRRLEDEIERKVQMRD--QEIAATAKDLEIRQLELEAQKRLYEkdltTSQEAVAKEIREDT 850
Cdd:COG4913   696 ELEAELEELEEELDELkgEIGRLEKELEQAEEELDelQDRLEAAEDLARLELRALLEERFAA----ALGDAVERELRENL 771


                  ....*...
gi 264681543  851 DAHRRKAA 858
Cdd:COG4913   772 EERIDALR 779
PTZ00121 PTZ00121
MAEBL; Provisional
 693-922 1.63e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRNDELdflreRQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQ---EEEKMAQQRQRLAAVKRELEIKE 769
Cdd:PTZ00121 1389 EKKKADEA-----KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKkkaEEAKKADEAKKKAEEAKKAEEAK 1463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  770 IHLQDAARRRLLKLQQDQREM--ELRRLEDEIERKVQMRDQEIAATAKDLEIRQLElEAQK----RLYEKDLTTSQEAVA 843
Cdd:PTZ00121 1464 KKAEEAKKADEAKKKAEEAKKadEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAE-EAKKadeaKKAEEAKKADEAKKA 1542

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  844 KEIREDTDAHR----RKAALEEHMFQ--KLLENSQMGGRRAQRWKEAEEKEfhLQSAKKASALSDASRKWFLRQETSAAL 917
Cdd:PTZ00121 1543 EEKKKADELKKaeelKKAEEKKKAEEakKAEEDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMKAEEAKKAEEAKI 1620


                  ....*
gi 264681543  918 EHEEM 922
Cdd:PTZ00121 1621 KAEEL 1625
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 689-922 1.74e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 48.26  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 689 TREWERIRNDELDFLR---ERQTVENMQAEvdEQRAKDEAWYQK-----------QELLRRAEETRREILLQEEEKMAQQ 754
Cdd:PRK09510  61 VEQYNRQQQQQKSAKRaeeQRKKKEQQQAE--ELQQKQAAEQERlkqlekerlaaQEQKKQAEEAAKQAALKQKQAEEAA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 755 RQRLAAVKRELEIKEIHLQDAArrrllklqqdqremelRRLEDEIERKvqmrdqEIAATAKdleirQLELEAQKRLYEKd 834
Cdd:PRK09510 139 AKAAAAAKAKAEAEAKRAAAAA----------------KKAAAEAKKK------AEAEAAK-----KAAAEAKKKAEAE- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 835 lttSQEAVAKEIREDTDAHRRKAALEEhmfqkllensqmggrrAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETS 914
Cdd:PRK09510 191 ---AAAKAAAEAKKKAEAEAKKKAAAE----------------AKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAA 251


                 ....*...
gi 264681543 915 AALEHEEM 922
Cdd:PRK09510 252 AAKAAAEV 259
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
697-869 2.65e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  697 NDELDFLRERQTVENMQAEVDEQ----RAKDEAWYQKQELLRRAEETRREIllqeeekmAQQRQRLAAVKRELeikeihl 772
Cdd:COG4913   637 EAELDALQERREALQRLAEYSWDeidvASAEREIAELEAELERLDASSDDL--------AALEEQLEELEAEL------- 701

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  773 qDAARRRLLKLQQDQR--EMELRRLEDEIERKvqmrdQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDT 850
Cdd:COG4913   702 -EELEEELDELKGEIGrlEKELEQAEEELDEL-----QDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERI 775

                         170
                  ....*....|....*....
gi 264681543  851 DAHRRKAALEEHMFQKLLE 869
Cdd:COG4913   776 DALRARLNRAEEELERAMR 794
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
693-925 2.73e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.59  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEAwyQKQELLRRAEETRREiLLQEEEKMAQQRQRLAAVKRELEIKEIHL 772
Cdd:COG4372    6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALF--ELDKLQEELEQLREE-LEQAREELEQLEEELEQARSELEQLEEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 773 QDAaRRRLLKLQQDQREM--ELRRLEDEIERKVQMRdQEIAATAKDLEIRQLELEAQKRLYEKDLTtSQEAVAKEIREDT 850
Cdd:COG4372   83 EEL-NEQLQAAQAELAQAqeELESLQEEAEELQEEL-EELQKERQDLEQQRKQLEAQIAELQSEIA-EREEELKELEEQL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681543 851 dahrrkAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWL 925
Cdd:COG4372  160 ------ESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLE 228
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 735-886 2.83e-05

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 45.42  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  735 RAEETRReiLLQEEEKMA-QQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQDQREmELRRLEDeiERKVQMRDQEIAAT 813
Cdd:pfam05672   8 DAEEAAR--ILAEKRRQArEQREREEQERLEKEEEERLRKEELRRRAEEERARREE-EARRLEE--ERRREEEERQRKAE 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543  814 AKDLEIRQLELEAQKRLYEKdlttSQEAVAKEiREdtDAHRRKAALEEHMFQKLLEnsqmggrRAQRWKEAEE 886
Cdd:pfam05672  83 EEAEEREQREQEEQERLQKQ----KEEAEAKA-RE--EAERQRQEREKIMQQEEQE-------RLERKKRIEE 141
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 707-886 3.34e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.02  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  707 QTVENMQAEVDeqraKDEAWYQKQELLRRAEETRreillqeeeKMAQQRQRLAAVKRELEiKEIHLQDAARRRL------ 780
Cdd:COG3096   479 ELVCKIAGEVE----RSQAWQTARELLRRYRSQQ---------ALAQRLQQLRAQLAELE-QRLRQQQNAERLLeefcqr 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  781 ----------LKLQQDQREMELRRLEDE----IERKVQMRDQEIAATAKDLEIRQLE---LEAQKRLyEKDLTTSQEAVA 843
Cdd:COG3096   545 igqqldaaeeLEELLAELEAQLEELEEQaaeaVEQRSELRQQLEQLRARIKELAARApawLAAQDAL-ERLREQSGEALA 623

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 264681543  844 KeiREDTDAHRRKAALEEHMFQklLENSQMGGRRAQRWKEAEE 886
Cdd:COG3096   624 D--SQEVTAAMQQLLEREREAT--VERDELAARKQALESQIER 662
COG5210 COG5210
GTPase-activating protein [General function prediction only];
542-658 3.54e-05

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 47.49  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 542 LSMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIFSNHPSFLLMTVVAYSTCSRAPLLNC 621
Cdd:COG5210  350 LKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKL 429

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 264681543 622 TLKNDFEYFFHHRNNLDINVVIREVYHLMETTPADIH 658
Cdd:COG5210  430 DSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDIL 466
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 684-897 3.64e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.76  E-value: 3.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   684 IVDYQTREWERIRN--DELDFL-RERQTVENMQAEVD---EQRAKDEAWYQKQ--ELLRRAEETRREILLQEEEKMAQQR 755
Cdd:TIGR02169  728 LEQEEEKLKERLEEleEDLSSLeQEIENVKSELKELEariEELEEDLHKLEEAlnDLEARLSHSRIPEIQAELSKLEEEV 807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   756 QRLAAVKRELEIKEihlqdaaRRRLLKLQQDQREM-ELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEaQKRLYEKD 834
Cdd:TIGR02169  808 SRIEARLREIEQKL-------NRLTLEKEYLEKEIqELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE-ELEAALRD 879

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681543   835 LTTSQEAVAKEiREDTDAHRRKA--ALEEHMFQKLLENSQMGGRRAQRwKEAEEKEFHLQSAKKA 897
Cdd:TIGR02169  880 LESRLGDLKKE-RDELEAQLRELerKIEELEAQIEKKRKRLSELKAKL-EALEEELSEIEDPKGE 942
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 704-887 4.26e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 47.17  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  704 RERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEetrREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLK- 782
Cdd:pfam08017 130 RQRDAENRSQGNVLERRQRDAENRSQGNVLERRQ---RDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNv 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  783 LQQDQREMELRRLEDEIERKvqMRDQEIAATAKDLEIRQLELEAQkrlyekdlttSQEAVAKEIREDTDAHRRKAALEEH 862
Cdd:pfam08017 207 LERRQRDAENRSQGNVLERR--QRDAENRSQGNVLERRQRDAENK----------SQGNVLERRQRDAENRSQGNVLERR 274

                         170       180
                  ....*....|....*....|....*
gi 264681543  863 mfQKLLENSQMGGRRAQRWKEAEEK 887
Cdd:pfam08017 275 --QRDAENRSQGNVLERRQRDAENK 297
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
696-896 4.64e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 696 RNDELDFLRERqtVENMQAEVDEQRAKDEAwyQKQELLRRAEETRReiLLQEEEKMAQQRQRLAAVKRELE--IKEIHLQ 773
Cdd:COG4372   71 ARSELEQLEEE--LEELNEQLQAAQAELAQ--AQEELESLQEEAEE--LQEELEELQKERQDLEQQRKQLEaqIAELQSE 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 774 DAARRRLLKlqqdQREMELRRLEDEIERkVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDTDAH 853
Cdd:COG4372  145 IAEREEELK----ELEEQLESLQEELAA-LEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEE 219

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 264681543 854 RRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKK 896
Cdd:COG4372  220 LLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEE 262
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 690-858 6.03e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 6.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 690 REWERIRNDELDFLRERQTVENMQAEVDEQRAKDEawyQKQELLRRAEETRREILLQEEEKMAQQRQRL-AAVKRELEIK 768
Cdd:COG1196  379 EELEELAEELLEALRAAAELAAQLEELEEAEEALL---ERLERLEEELEELEEALAELEEEEEEEEEALeEAAEEEAELE 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 769 EIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLE----IRQLELEAQKRL-------------- 830
Cdd:COG1196  456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGflegVKAALLLAGLRGlagavavligveaa 535

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 264681543 831 YEKDLTTS-----------QEAVAKEIREDTDAHRRKAA 858
Cdd:COG1196  536 YEAALEAAlaaalqnivveDDEVAAAAIEYLKAAKAGRA 574
PRK12705 PRK12705
hypothetical protein; Provisional
 713-847 6.04e-05

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 46.63  E-value: 6.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 713 QAEVDEQRAKDEAWYQKQELLRRAEET-------RREILLQEEEKMAQQRQRLAAVKRELEIKEIHLqdAARRRLLKLQQ 785
Cdd:PRK12705  41 EAQKEAEEKLEAALLEAKELLLRERNQqrqearrEREELQREEERLVQKEEQLDARAEKLDNLENQL--EEREKALSARE 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681543 786 DQREMELRRLEDEIERKVQMRDQEiaatAKDLEIRQL--ELEAQK-RLYEKDLTTSQEAVAKEIR 847
Cdd:PRK12705 119 LELEELEKQLDNELYRVAGLTPEQ----ARKLLLKLLdaELEEEKaQRVKKIEEEADLEAERKAQ 179
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-153 6.67e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.67e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 264681543   115 TKELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWD 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
693-905 6.71e-05

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 46.57  E-value: 6.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQE---LLRRAEETRREILLQEE--EKMAQQRQRLAAVKRELEI 767
Cdd:COG3064   16 ERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEeeaREAKAEAEQRAAELAAEaaKKLAEAEKAAAEAEKKAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 768 KEIHLQDAARRRlLKLQQDQREMELRRLEdEIERKVQmRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIR 847
Cdd:COG3064   96 EKAKAAKEAEAA-AAAEKAAAAAEKEKAE-EAKRKAE-EEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAAAAAAAAA 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543 848 EDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASR 905
Cdd:COG3064  173 RAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASR 230
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 703-870 7.80e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 7.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   703 LRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEE---TRREIL------------LQEEEKMAQQRQRLAAVKRELEI 767
Cdd:TIGR00618  327 LMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEvatSIREIScqqhtltqhihtLQQQKTTLTQKLQSLCKELDILQ 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   768 KEIHLQDAARRRLLKLQQDqremeLRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEK-DLTTSQEAVAKEI 846
Cdd:TIGR00618  407 REQATIDTRTSAFRDLQGQ-----LAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSlKEREQQLQTKEQI 481

                          170       180
                   ....*....|....*....|....
gi 264681543   847 redTDAHRRKAALEEHMFQKLLEN 870
Cdd:TIGR00618  482 ---HLQETRKKAVVLARLLELQEE 502
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
 689-873 9.76e-05

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 45.84  E-value: 9.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  689 TREWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRR-----AEETRREILLQEEEKMAQQRQRLaAVKR 763
Cdd:pfam12297 223 AAECNLETREKMEAQHQREMAEKEEAEELLKHADEQEALECSSLLDKlhkleQEHLQRSLLLRQEEDFAKAQRQL-AVFQ 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  764 ELEIKEI---HLQDAARRRLLKLQQDQREM-ELRRLEDEIERkvqMRDQEIAATAKDLEIR--QLE-----LEAQKRLYE 832
Cdd:pfam12297 302 RVELHKIfftQLKEATRKGELKPEAAKRLLqDYSKIQEQIEE---LMDFFQANQRYHLSERfaQREylvqsLQSLETRVS 378

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 264681543  833 KDLTTSQEAVAKEIREdtdaHRRKAALEEHMFQKLLENSQM 873
Cdd:pfam12297 379 GLLNTAATQLTSLIQK----MERAGYLDEEQMEMLLERAQK 415
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 691-931 9.81e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.04  E-value: 9.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  691 EWERIRND----------ELDFLRERQTvENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEE------------ 748
Cdd:pfam07888  70 QWERQRRElesrvaelkeELRQSREKHE-ELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEdiktltqrvler 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  749 -----------EKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLKLQ-----QDQREMELRRLEDEIERKVQMRDQeiaA 812
Cdd:pfam07888 149 etelermkeraKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQelrnsLAQRDTQVLQLQDTITTLTQKLTT---A 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  813 TAKDLEIRQleLEAQKRLYEKDLTTSQEAVA--KEIREDTDAHRRKAALEEHmfQKLLENSQMGGRRAQ---RWKE---- 883
Cdd:pfam07888 226 HRKEAENEA--LLEELRSLQERLNASERKVEglGEELSSMAAQRDRTQAELH--QARLQAAQLTLQLADaslALREgrar 301

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 264681543  884 -AEEKEFHLQSAKKasalsDASRKwflrQETSAALEHEEmPWLQRQYMD 931
Cdd:pfam07888 302 wAQERETLQQSAEA-----DKDRI----EKLSAELQRLE-ERLQEERME 340
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 727-906 9.82e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   727 YQKQELlrraEETRREILLQEEeKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQ-DQREMELRRLEDEIERKVQM 805
Cdd:TIGR02168  674 ERRREI----EELEEKIEELEE-KIAELEKALAELRKELEELEEELEQLRKELEELSRQiSALRKDLARLEAEVEQLEER 748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   806 RDQeiaatakdLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREdtdahrrKAALEEHMFQKLLENSQmgGRRAQRWKEAE 885
Cdd:TIGR02168  749 IAQ--------LSKELTELEAEIEELEERLEEAEEELAEAEAE-------IEELEAQIEQLKEELKA--LREALDELRAE 811

                          170       180
                   ....*....|....*....|.
gi 264681543   886 EKEFHLQSAKKASALSDASRK 906
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERR 832
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 693-907 1.08e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEAwyQKQELLRRAEETRREILlQEEEKMAQQRQRLAAVKRELEIKEIH- 771
Cdd:COG4942   44 AALKKEEKALLKQLAALERRIAALARRIRALEQ--ELAALEAELAELEKEIA-ELRAELEAQKEELAELLRALYRLGRQp 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 772 ----------LQDAARR-RLLKLQQDQREMELRRLEDEIERKVQMRdQEIAATAKDLEIRQLELEAQKRLYEKdLTTSQE 840
Cdd:COG4942  121 plalllspedFLDAVRRlQYLKYLAPARREQAEELRADLAELAALR-AELEAERAELEALLAELEEERAALEA-LKAERQ 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681543 841 AVAKEIREDTDAHRRKAAleehmfqKLLENSQmggRRAQRWKEAEEKEFHLQSAKKASALSDASRKW 907
Cdd:COG4942  199 KLLARLEKELAELAAELA-------ELQQEAE---ELEALIARLEAEAAAAAERTPAAGFAALKGKL 255
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 693-832 1.09e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 45.68  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRN--DELDFLRERQTVENMQAEvDEQRAKDEAwYQKQELLRRAEETRREILLQEEEKMAQQRQR-----LAAVKREL 765
Cdd:pfam13868 194 EKAQDekAERDELRAKLYQEEQERK-ERQKEREEA-EKKARQRQELQQAREEQIELKERRLAEEAEReeeefERMLRKQA 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  766 EIKEIHLQDAARRRL--LKLQQD-QREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYE 832
Cdd:pfam13868 272 EDEEIEQEEAEKRRMkrLEHRRElEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKKLKE 341
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 688-860 1.25e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   688 QTREWERIRND---ELDFLR-ERQTVENMQAEVDEQRAK-----DEAWYQKQELLRRAEETRREI--LLQEEEKMAQQRQ 756
Cdd:TIGR02169  813 RLREIEQKLNRltlEKEYLEkEIQELQEQRIDLKEQIKSiekeiENLNGKKEELEEELEELEAALrdLESRLGDLKKERD 892

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   757 RLAAVKRELEIK--EIHLQDAARRRLLKLQQDQREM---ELRRLEDEI------------ERKVQMRDQEIAATAKDLE- 818
Cdd:TIGR02169  893 ELEAQLRELERKieELEAQIEKKRKRLSELKAKLEAleeELSEIEDPKgedeeipeeelsLEDVQAELQRVEEEIRALEp 972

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 264681543   819 -----IRQLElEAQKRLyeKDLTTSQEAVAKEIR------EDTDAHRRKAALE 860
Cdd:TIGR02169  973 vnmlaIQEYE-EVLKRL--DELKEKRAKLEEERKaileriEEYEKKKREVFME 1022
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 719-809 1.34e-04

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 42.66  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  719 QRAKDEAWYQKQELLRRAEETRREillqeEEKMAQQRQRLAAVKREleikeihlqdaaRRRLLKLQQDQREMELRRLEDE 798
Cdd:pfam04696  19 QKFKKEESKQKEKEERRAEIEKRL-----EEKAKQEKEELEERKRE------------EREELFEERRAEQIELRALEEK 81

                          90
                  ....*....|.
gi 264681543  799 IERKVQMRDQE 809
Cdd:pfam04696  82 LELKELMETWH 92
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 501-609 1.37e-04

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 44.22  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   501 AFP-FVKLFQNNQLIcFEVVATLIINWCQHWFEYFpnppinilsmienvLAFHDKELLQHFIDRDITSQVYAWPLLETLF 579
Cdd:smart00164 112 AFWcLVKLMERYGPN-FYLPDMSGLQLDLLQLDRL--------------VKEYDPDLYKHLKDLGITPSLYALRWFLTLF 176

                           90       100       110
                   ....*....|....*....|....*....|
gi 264681543   580 SEVLTREEWLRLFDNIFSNHPSFLLMTVVA 609
Cdd:smart00164 177 ARELPLEIVLRIWDVLFAEGSDFLFRVALA 206
Caldesmon pfam02029
Caldesmon;
697-916 1.48e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 45.63  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  697 NDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAavKRELEIKEIHLQDAA 776
Cdd:pfam02029 211 NGEEEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQEKESEEFEKLRQKQQ--EAELELEELKKKREE 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  777 RRRLLKLQQDQREMElrrlEDEierkvqmrdqeiaatakdleiRQLELEAQKRlyekdlttsqeavakEIREDTDahRRK 856
Cdd:pfam02029 289 RRKLLEEEEQRRKQE----EAE---------------------RKLREEEEKR---------------RMKEEIE--RRR 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681543  857 AALEEHMfQKLLENSQMGGR--------RAQRWKEAEEKEFHLQSAKKASALSDASRKWF-------LRQETSAA 916
Cdd:pfam02029 327 AEAAEKR-QKLPEDSSSEGKkpfkcfspKGSSLKITERAEFLNKSLQKSSSVKKTHPPAVvskidsrLEQYTSAI 400
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 693-835 1.49e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEawyQKQELLRRAEEtrREILLQEEEKMAQQRQRLAavKRELEIKEIHl 772
Cdd:COG1579   48 EAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNVRNNKE--YEALQKEIESLKRRISDLE--DEILELMERI- 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543 773 qDAARRRLLKLQQdqremELRRLEDEIERKVQMRDQEIAATAKDLEirqlELEAQKRLYEKDL 835
Cdd:COG1579  120 -EELEEELAELEA-----ELAELEAELEEKKAELDEELAELEAELE----ELEAEREELAAKI 172
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
697-841 1.50e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 697 NDELDFLRER-QTVENMQAEVDEQRAKDEAWYQK-QELLRRAEETRREI------------LLQEEEKMAQQRQRL---- 758
Cdd:COG3206  211 SEEAKLLLQQlSELESQLAEARAELAEAEARLAAlRAQLGSGPDALPELlqspviqqlraqLAELEAELAELSARYtpnh 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 759 ---AAVKRELEIKEIHLQDAARRRLLKLQQD-----QREMELRRLEDEIERKVQmrdqEIAATAKDLEIRQLELEAQKRL 830
Cdd:COG3206  291 pdvIALRAQIAALRAQLQQEAQRILASLEAElealqAREASLQAQLAQLEARLA----ELPELEAELRRLEREVEVAREL 366

                        170
                 ....*....|.
gi 264681543 831 YEKDLTTSQEA 841
Cdd:COG3206  367 YESLLQRLEEA 377
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 717-941 1.51e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.98  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   717 DEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDAarRRLLKlqqdQREMELRRLE 796
Cdd:pfam12128  586 DLKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFA--RTALK----NARLDLRRLF 659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   797 DEiERKVQMRDQEIAATAKDLEIRQL-ELEAQKRLYEKDLTTSQEAVAKEIREDTDA--HRRKAALEEHMFQKLLENSQM 873
Cdd:pfam12128  660 DE-KQSEKDKKNKALAERKDSANERLnSLEAQLKQLDKKHQAWLEEQKEQKREARTEkqAYWQVVEGALDAQLALLKAAI 738

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543   874 GGRRAQRWKE--AEEKEFHLQSAKKA------SALSDASRKWFLRQETSAALEHEEMPWlqRQYMDSAYLPQTSRL 941
Cdd:pfam12128  739 AARRSGAKAElkALETWYKRDLASLGvdpdviAKLKREIRTLERKIERIAVRRQEVLRY--FDWYQETWLQRRPRL 812
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 702-810 1.59e-04

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 44.97  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  702 FLRERQTVENM-----QAEVDEQRAKdEAWYQKQELLRRAEETRREILLQEEEKMAQQRQR----LAAVKRELEIKEIHL 772
Cdd:pfam02841 181 FLQSKEAVEEAilqtdQALTAKEKAI-EAERAKAEAAEAEQELLREKQKEEEQMMEAQERSyqehVKQLIEKMEAEREQL 259

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 264681543  773 QDAARRRLLKLQQDQREMelrrLEDEIERKVQMRDQEI 810
Cdd:pfam02841 260 LAEQERMLEHKLQEQEEL----LKEGFKTEAESLQKEI 293
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
693-900 1.85e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDFLRER-QTVENMQAEVDEQRAKDEAWYQKQELLRRAEEtRREILLQEEEKMAQQRQRLAAVKRELEIKEIH 771
Cdd:COG4717   49 ERLEKEADELFKPQgRKPELNLKELKELEEELKEAEEKEEEYAELQE-ELEELEEELEELEAELEELREELEKLEKLLQL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 772 LQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQeiaatakdleIRQLELEAQK------RLYEKDLTTSQEAVAKE 845
Cdd:COG4717  128 LPLYQELEALEAELAELPERLEELEERLEELRELEEE----------LEELEAELAElqeeleELLEQLSLATEEELQDL 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 264681543 846 IREDTDAHRRKAALEEHmfqkLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASAL 900
Cdd:COG4717  198 AEELEELQQRLAELEEE----LEEAQEELEELEEELEQLENELEAAALEERLKEA 248
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 713-887 1.91e-04

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 44.86  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  713 QAEVDEQRAKDEAWYQKQELLRRAEetrREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLK-LQQDQREME 791
Cdd:pfam08017  27 QGNVLERRQRDAENRSQGNVLERRQ---RDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNvLERRQRDAE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  792 LRRLEDEIERKvqMRDQEIAATAKDLEIRQLELEAQkrlyekdlttSQEAVAKEIREDTDAHRRKAALEEHmfQKLLENS 871
Cdd:pfam08017 104 NRSQGNVLERR--QRDAENKSQGNVLERRQRDAENR----------SQGNVLERRQRDAENRSQGNVLERR--QRDAENR 169

                         170
                  ....*....|....*.
gi 264681543  872 QMGGRRAQRWKEAEEK 887
Cdd:pfam08017 170 SQGNVLERRQRDAENK 185
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
700-872 1.96e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 700 LDFLRERqtVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREI---------LLQEEEKMAQQRQRLAAVKRELEIKEI 770
Cdd:COG3206  177 LEFLEEQ--LPELRKELEEAEAALEEFRQKNGLVDLSEEAKLLLqqlselesqLAEARAELAEAEARLAALRAQLGSGPD 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 771 HLQDAA--------RRRLLKLQQDQREM---------ELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEK 833
Cdd:COG3206  255 ALPELLqspviqqlRAQLAELEAELAELsarytpnhpDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQA 334

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 264681543 834 DLTTSQEAVAK--EIREDTDAHRRKAALEEHMFQKLLENSQ 872
Cdd:COG3206  335 QLAQLEARLAElpELEAELRRLEREVEVARELYESLLQRLE 375
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 778-897 2.09e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.15  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 778 RRLLKLQQ-DQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLE---LEAQKRLYEKDLTTSQEAVA---------- 843
Cdd:COG1579    7 RALLDLQElDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTEledLEKEIKRLELEIEEVEARIKkyeeqlgnvr 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 844 --KEI----REDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKA 897
Cdd:COG1579   87 nnKEYealqKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE 146
DUF4200 pfam13863
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ...
 740-833 2.30e-04

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.


Pssm-ID: 464003 [Multi-domain]  Cd Length: 119  Bit Score: 41.78  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  740 RREI-LLQEE-----EKMAQQRQRLAAVKRELEIKEIHLQDAARR--RLLKLQQDQREMELRRLEDEIERKVQmRDQEIA 811
Cdd:pfam13863   5 KREMfLVQLAldakrEEIERLEELLKQREEELEKKEQELKEDLIKfdKFLKENDAKRRRALKKAEEETKLKKE-KEKEIK 83

                          90       100
                  ....*....|....*....|..
gi 264681543  812 ATAKDLEIRQLELEAQKRLYEK 833
Cdd:pfam13863  84 KLTAQIEELKSEISKLEEKLEE 105
PTZ00121 PTZ00121
MAEBL; Provisional
 693-897 2.53e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREillQEEEKMAQQrqrlaAVKRELEIKEIHL 772
Cdd:PTZ00121 1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKK---AEEAKKAAE-----AAKAEAEAAADEA 1359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  773 QDAARRrllKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDTDA 852
Cdd:PTZ00121 1360 EAAEEK---AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEA 1436

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 264681543  853 hRRKAalEEhmfqkllensqmgGRRAQRWKE-AEEKEFHLQSAKKA 897
Cdd:PTZ00121 1437 -KKKA--EE-------------AKKADEAKKkAEEAKKAEEAKKKA 1466
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 744-839 2.66e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 744 LLQEEEKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQ----DQREMELRRLEDEIERKVQMRDQEIAATAKDLEI 819
Cdd:COG4942   15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQlaalERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                         90       100
                 ....*....|....*....|
gi 264681543 820 RQLELEAQKRLYEKDLTTSQ 839
Cdd:COG4942   95 LRAELEAQKEELAELLRALY 114
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
696-928 2.73e-04

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 44.65  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 696 RNDELDFLRE-RQTVENMQAEVDEQRAKDEAwyQKQELLRRAEETRREI---LLQEEEKMAQQRQRLAAVKRELEI-KEI 770
Cdd:COG3064   43 RLAELEAKRQaEEEAREAKAEAEQRAAELAA--EAAKKLAEAEKAAAEAekkAAAEKAKAAKEAEAAAAAEKAAAAaEKE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 771 HLQDAARR--RLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIRE 848
Cdd:COG3064  121 KAEEAKRKaeEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 849 DTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQRQ 928
Cdd:COG3064  201 AALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVV 280
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 702-932 2.79e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.17  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   702 FLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEE---TRREILLQEEEKmaqQRQRLAAVKREL--EIKEIHLQDA- 775
Cdd:pfam01576  150 LSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEamiSDLEERLKKEEK---GRQELEKAKRKLegESTDLQEQIAe 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   776 --ARRRLLKLQQDQREMELR----RLEDEIERKVQ----MRDQE--IAATAKDLEI-RQLELEAQKRlyEKDLTTSQEAV 842
Cdd:pfam01576  227 lqAQIAELRAQLAKKEEELQaalaRLEEETAQKNNalkkIRELEaqISELQEDLESeRAARNKAEKQ--RRDLGEELEAL 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   843 AKEIRE--DTDAH----RRKAALEEHMFQKLLEN------SQMGGRRAQRWKEAEEKEFHLQSAKKASALSDASRkwflr 910
Cdd:pfam01576  305 KTELEDtlDTTAAqqelRSKREQEVTELKKALEEetrsheAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAK----- 379

                          250       260
                   ....*....|....*....|....*...
gi 264681543   911 qetsAALEHE------EMPWLQRQYMDS 932
Cdd:pfam01576  380 ----QALESEnaelqaELRTLQQAKQDS 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 717-894 2.82e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 717 DEQRAKDEAWYQKQELLRRAE---------------------ETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDA 775
Cdd:COG1196  555 DDEVAAAAIEYLKAAKAGRATflpldkiraraalaaalargaIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEA 634

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 776 ARRRLLKLQQDQREMELRRlEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAKEIREDTDAHRR 855
Cdd:COG1196  635 ALRRAVTLAGRLREVTLEG-EGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 264681543 856 KAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSA 894
Cdd:COG1196  714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA 752
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
693-895 3.17e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 3.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 693 ERIRNDELDF---LRERQTVENMQAEVDEQRAKDEAWYQKQELLR-RAEETRREILLQE------EEKMAQQRQRLAAVK 762
Cdd:PRK03918 193 ELIKEKEKELeevLREINEISSELPELREELEKLEKEVKELEELKeEIEELEKELESLEgskrklEEKIRELEERIEELK 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 763 REL--------EIKEIHLQDAARRRLLKLQQDQREmELRRLEDEIER------KVQMRDQEIAATAKDL-EIRQLELEAQ 827
Cdd:PRK03918 273 KEIeeleekvkELKELKEKAEEYIKLSEFYEEYLD-ELREIEKRLSRleeeinGIEERIKELEEKEERLeELKKKLKELE 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 828 KRL--YEKDLTTSQEAVAKE------------------IREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEk 887
Cdd:PRK03918 352 KRLeeLEERHELYEEAKAKKeelerlkkrltgltpeklEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEE- 430


                 ....*...
gi 264681543 888 efhLQSAK 895
Cdd:PRK03918 431 ---LKKAK 435
growth_prot_Scy NF041483
polarized growth protein Scy;
689-905 3.27e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.82  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  689 TREWERIRNDELdflrERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREI------LLQEEEKMAQQRQ------ 756
Cdd:NF041483  501 TAESERVRTEAI----ERATTLRRQAEETLERTRAEAERLRAEAEEQAEEVRAAAeraareLREETERAIAARQaeaaee 576

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  757 ----------RLAAVKREL----------------EIKEIHLQDAARRRLLklqQDQREMELRRLEDEIERKVQMRDQEI 810
Cdd:NF041483  577 ltrlhteaeeRLTAAEEALadaraeaerirreaaeETERLRTEAAERIRTL---QAQAEQEAERLRTEAAADASAARAEG 653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  811 AATAKDL------EIRQLELEAQKrlyEKDLTTSQEAVAKEiREDTDAHRRKAALEEHMFQKLLENSQ-MGGRRA----Q 879
Cdd:NF041483  654 ENVAVRLrseaaaEAERLKSEAQE---SADRVRAEAAAAAE-RVGTEAAEALAAAQEEAARRRREAEEtLGSARAeadqE 729

                         250       260
                  ....*....|....*....|....*...
gi 264681543  880 RWKEAEEKEFHLQSAKK--ASALSDASR 905
Cdd:NF041483  730 RERAREQSEELLASARKrvEEAQAEAQR 757
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
697-921 3.76e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.65  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 697 NDELDFLRER-QTVENMQAEVDEQRAKDEAWYQKQellRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDA 775
Cdd:PRK02224 341 NEEAESLREDaDDLEERAEELREEAAELESELEEA---REAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEEL 417

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 776 ARRR-LLKLQQDQREMELRRLEDEIERKVQMR-------------DQEIAATAKD-------LEIRQLELEAQKRLYEKD 834
Cdd:PRK02224 418 REERdELREREAELEATLRTARERVEEAEALLeagkcpecgqpveGSPHVETIEEdrerveeLEAELEDLEEEVEEVEER 497

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 835 LTTSQEAVAKEIREDTDAHRRKAALEehmfqkllensqmggRRAQRWKEAEEKEFHLQSAKK-ASALSDASRKWflrqET 913
Cdd:PRK02224 498 LERAEDLVEAEDRIERLEERREDLEE---------------LIAERRETIEEKRERAEELRErAAELEAEAEEK----RE 558


                 ....*...
gi 264681543 914 SAALEHEE 921
Cdd:PRK02224 559 AAAEAEEE 566
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
698-920 4.30e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 4.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 698 DELDFLR-ERQTVENMQAEVDEQR-----AKDEAwyqkQELLRRAEETRREILLQEEEkMAQQRQRLAAVKREleikeih 771
Cdd:PRK02224 206 ERLNGLEsELAELDEEIERYEEQReqareTRDEA----DEVLEEHEERREELETLEAE-IEDLRETIAETERE------- 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 772 lQDAARRRLlklqQDQREmELRRLEDEIERKVQMRDQEiAATAKDLEIRQLELEAQKRLYEKDLTTSQEAvAKEIREDTD 851
Cdd:PRK02224 274 -REELAEEV----RDLRE-RLEELEEERDDLLAEAGLD-DADAEAVEARREELEDRDEELRDRLEECRVA-AQAHNEEAE 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543 852 AHRRKAA-LEEhmfqkllensqmggrRAQRWKE-AEEKEFHLQSAKkaSALSDasrkwflRQETSAALEHE 920
Cdd:PRK02224 346 SLREDADdLEE---------------RAEELREeAAELESELEEAR--EAVED-------RREEIEELEEE 392
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 752-916 4.37e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 43.68  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  752 AQQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQDQR--EMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKR 829
Cdd:TIGR02794  49 AQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAaeQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQ 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  830 lyEKDLTTSQEAVAkEIREDTDAhRRKAALEehmfqKLLEnsqmggRRAQRWKEAEEKEFHLQSAKKASAlsDASRKwfL 909
Cdd:TIGR02794 129 --AAEAKAKAEAEA-ERKAKEEA-AKQAEEE-----AKAK------AAAEAKKKAEEAKKKAEAEAKAKA--EAEAK--A 189


                  ....*..
gi 264681543  910 RQETSAA 916
Cdd:TIGR02794 190 KAEEAKA 196
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 696-829 4.39e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 44.25  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  696 RNDELDFLRER-----QTVENMQAEVDE-----QRAKDEAWYQKQELLRRAEETRR-----EILLQEEEKMAQ-QR---- 755
Cdd:pfam05667 333 REEELEELQEQledleSSIQELEKEIKKlessiKQVEEELEELKEQNEELEKQYKVkkktlDLLPDAEENIAKlQAlvda 412

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681543  756 --QRLAAVKRELEIKEIHLQDAARRrlLKLQQDQREMELRRLEDEIER-KVQMRDQEIAATAKDLEIRQLELEAQKR 829
Cdd:pfam05667 413 saQRLVELAGQWEKHRVPLIEEYRA--LKEAKSNKEDESQRKLEEIKElREKIKEVAEEAKQKEELYKQLVAEYERL 487
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 684-829 4.66e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 684 IVDYQTREWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKmAQQRQRLAAVKR 763
Cdd:COG1196  623 LGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA-EEELELEEALLA 701

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543 764 ELEIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKR 829
Cdd:COG1196  702 EEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELER 767
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 704-922 4.75e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 4.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   704 RERQTVENMQAEVDEQRAKdEAWYQKQELLRRAEETRReiLLQEEEKMAQQRQRLAAVKRELEIK--EIHLQDA-ARRRL 780
Cdd:TIGR02168  207 RQAEKAERYKELKAELREL-ELALLVLRLEELREELEE--LQEELKEAEEELEELTAELQELEEKleELRLEVSeLEEEI 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   781 LKLQQDQREM--ELRRLEDEIERKVQmRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQE--AVAKEIREDTdahrrK 856
Cdd:TIGR02168  284 EELQKELYALanEISRLEQQKQILRE-RLANLERQLEELEAQLEELESKLDELAEELAELEEklEELKEELESL-----E 357

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543   857 AALEEhmFQKLLENSqmggrrAQRWKEAEEkefHLQSAKKASALsdasrkwFLRQETSAALEHEEM 922
Cdd:TIGR02168  358 AELEE--LEAELEEL------ESRLEELEE---QLETLRSKVAQ-------LELQIASLNNEIERL 405
PTZ00121 PTZ00121
MAEBL; Provisional
 688-896 4.90e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  688 QTREWERIRNDEldflrERQTVENMQAEVDEQRAKDE----AWYQKQELLRRAEETRREILLQEEEK-MAQQRQRLAAVK 762
Cdd:PTZ00121 1216 EARKAEDAKKAE-----AVKKAEEAKKDAEEAKKAEEernnEEIRKFEEARMAHFARRQAAIKAEEArKADELKKAEEKK 1290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  763 RELEIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAV 842
Cdd:PTZ00121 1291 KADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE 1370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543  843 AK--EIREDTDAHRRKAAlEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKK 896
Cdd:PTZ00121 1371 KKkeEAKKKADAAKKKAE-EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKK 1425
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 711-926 5.89e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.01  E-value: 5.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   711 NMQA-----EVDEQrAKDEAwyqkqellrrAEETRREILLQ----EEEKMAQQRQRLAAVkreleikeihlqdAARRRLl 781
Cdd:pfam01576  721 NMQAlkaqfERDLQ-ARDEQ----------GEEKRRQLVKQvrelEAELEDERKQRAQAV-------------AAKKKL- 775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   782 klqqdqrEMELRRLEDEIerkvqmrdqEIAATAKDLEIRQL-ELEAQKRLYEKDLTTSQEAVAKEIREDTDAHRRKAALE 860
Cdd:pfam01576  776 -------ELDLKELEAQI---------DAANKGREEAVKQLkKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLE 839

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543   861 EHMFQklLENSQMGGRRAQRWKEAEEKEFHLQ---SAKKASALSDASRkwflRQETSAALEHEEMPWLQ 926
Cdd:pfam01576  840 AELLQ--LQEDLAASERARRQAQQERDELADEiasGASGKSALQDEKR----RLEARIAQLEEELEEEQ 902
DegS pfam05384
Sensor protein DegS; This is small family of Bacillus DegS proteins. The DegS-DegU ...
 708-803 6.65e-04

Sensor protein DegS; This is small family of Bacillus DegS proteins. The DegS-DegU two-component regulatory system of Bacillus subtilis controls various processes that characterize the transition from the exponential to the stationary growth phase, including the induction of extracellular degradative enzymes, expression of late competence genes and down-regulation of the sigma D regulon. The family also contains one sequence Swiss:Q8R9D3 from Thermoanaerobacter tengcongensis which are described as sensory transduction histidine kinases.


Pssm-ID: 428449 [Multi-domain]  Cd Length: 159  Bit Score: 41.31  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  708 TVENMQAEVDE--QRAKDEAWYQKQELlrraEETRREIL--------LQEEEKMAqqRQRLAAVKR------ELEIKEIH 771
Cdd:pfam05384  10 TIENSKEEIFEiaENARQEYERLKQEL----EELKEEVSetikevdkLEKKERRA--RQRLMEVSRdfnrysEEDIKEAY 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 264681543  772 LQ-DAARRRLLKLQQdqREMELRRLEDEIERKV 803
Cdd:pfam05384  84 EEaKDLQVELALLRE--REKQLRERRDELERRL 114
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 697-834 7.22e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   697 NDELDFlrerQTVENMQAEVDEQ-----------RAKDEAWYQKQELLRRAEETRREILL--QEEEKMAQQRQRLAAVKR 763
Cdd:pfam12128  190 SKEGKF----RDVKSMIVAILEDdgvvppksrlnRQQVEHWIRDIQAIAGIMKIRPEFTKlqQEFNTLESAELRLSHLHF 265

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 264681543   764 EleIKEIHLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEA---QKRLYEKD 834
Cdd:pfam12128  266 G--YKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAledQHGAFLDA 337
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 714-833 7.53e-04

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 43.05  E-value: 7.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  714 AEVDEQRAKDEAwyQKQELLRRAEETRREILLQEEEKMAQQrQRLAAVKRELEIKEihlqdAARRRLLKLQQDQremeLR 793
Cdd:pfam07767 205 VEAEKKRLKEEE--KLERVLEKIAESAATAEAREEKRKTKA-QRNKEKRRKEEERE-----AKEEKALKKKLAQ----LE 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 264681543  794 RLEdEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEK 833
Cdd:pfam07767 273 RLK-EIAKEIAEKEKEREEKAEARKREKRKKKKEEKKLRP 311
PRK12705 PRK12705
hypothetical protein; Provisional
 702-879 9.43e-04

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 42.77  E-value: 9.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 702 FLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREillqeeekMAQQRQRLAAVKRELEIKEihlqdaarRRLL 781
Cdd:PRK12705  24 LLKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRE--------RNQQRQEARREREELQREE--------ERLV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 782 KL--QQDQREMELRRLEDEIERkvqmRDQEIAATAKDLEIRQLELEAqkRLYEKDLTTSQEAVAKEIRE-DTDAHRRKAA 858
Cdd:PRK12705  88 QKeeQLDARAEKLDNLENQLEE----REKALSARELELEELEKQLDN--ELYRVAGLTPEQARKLLLKLlDAELEEEKAQ 161

                        170       180
                 ....*....|....*....|.
gi 264681543 859 LEEHMFQKLLENSQmggRRAQ 879
Cdd:PRK12705 162 RVKKIEEEADLEAE---RKAQ 179
growth_prot_Scy NF041483
polarized growth protein Scy;
714-933 9.51e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 43.28  E-value: 9.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  714 AEVDEQRAKDEAWYQKQELLRRAEETrreillQEEEKMAQQRQRLAAVKRELEIKeihlqdaarrrllklqqDQREMELR 793
Cdd:NF041483  500 ATAESERVRTEAIERATTLRRQAEET------LERTRAEAERLRAEAEEQAEEVR-----------------AAAERAAR 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  794 RLEDEIERKVQMRDQEIAAtakdlEIRQLELEAQKRlyekdLTTSQEAVAkEIREDTDAHRRKAALEEhmfQKLLENSQM 873
Cdd:NF041483  557 ELREETERAIAARQAEAAE-----ELTRLHTEAEER-----LTAAEEALA-DARAEAERIRREAAEET---ERLRTEAAE 622

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  874 GGRRAQRWKEAEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEmpwLQRQYMDSA 933
Cdd:NF041483  623 RIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAER---LKSEAQESA 679
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 703-899 9.77e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.40  E-value: 9.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  703 LRERQTVENMQAEVDEQRAKdeawyqkqelLRRAEETRREilLQEEEKMAQQRQRLAavkrELEIKEIHLQDAARRRLLK 782
Cdd:COG3096   343 LRQQEKIERYQEDLEELTER----------LEEQEEVVEE--AAEQLAEAEARLEAA----EEEVDSLKSQLADYQQALD 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  783 LQQD---QREMELRRLE--------DEI------ERKVQMRDQEIAATAKDLEIRQ-LEL-EAQKRLYEKDL-------- 835
Cdd:COG3096   407 VQQTraiQYQQAVQALEkaralcglPDLtpenaeDYLAAFRAKEQQATEEVLELEQkLSVaDAARRQFEKAYelvckiag 486

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543  836 -TTSQEA--VAKEIREDTDAHRRKAALEEHMFQKLLENSQmggrRAQRWKEAEE--KEFHLQSAKKASA 899
Cdd:COG3096   487 eVERSQAwqTARELLRRYRSQQALAQRLQQLRAQLAELEQ----RLRQQQNAERllEEFCQRIGQQLDA 551
WD40 pfam00400
WD domain, G-beta repeat;
116-153 1.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 264681543  116 KELVSWMRGHESSVCSISVHASGRYAITTSSD-TAQLWD 153
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 719-872 1.07e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.61  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  719 QRAKDEAWY--------QKQELLRRAEETRREillqeEEKMAQQRQRLAAVKRE--LEIKEihlQDAARRRLLKLQQDQR 788
Cdd:pfam13904  50 ERQPLEAYEnwlaakqrQRQKELQAQKEEREK-----EEQEAELRKRLAKEKYQewLQRKA---RQQTKKREESHKQKAA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  789 EMELRRLeDEIERKVQMRdqEIAATAKDLEIRQLELEAQKRLYEKDlttsqeavAKEIREDTDAHRRKAAleEHMFQKLL 868
Cdd:pfam13904 122 ESASKSL-AKPERKVSQE--EAKEVLQEWERKKLEQQQRKREEEQR--------EQLKKEEEEQERKQLA--EKAWQKWM 188


                  ....
gi 264681543  869 ENSQ 872
Cdd:pfam13904 189 KNVK 192
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 704-790 1.24e-03

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 41.83  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  704 RERQTVEnMQAEVDEQRAKDEAWYQKQELLRRAEETRREIlLQEEEKMAQQRQRlaavKREL--EIKEIHLQDAARRRLL 781
Cdd:pfam15991  22 RERKKQE-QEAKMEEERLRREREEREKEDRMTLEETKEQI-LKLEKKLADLKEE----KHQLflQLKKVLHEDETRKRQL 95


                  ....*....
gi 264681543  782 KLQQDQREM 790
Cdd:pfam15991  96 KEQSELFAL 104
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 706-828 1.25e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 39.52  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  706 RQTVENMQAEVdEQRAKdeawyQKQELLRRAEE-----TRREILLQEEEKMAQ-QRQRLAAVKRELE-----IKEIHLQD 774
Cdd:pfam20492   1 REEAEREKQEL-EERLK-----QYEEETKKAQEeleesEETAEELEEERRQAEeEAERLEQKRQEAEeekerLEESAEME 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 264681543  775 AARRRLLKLQQDQREMELRRLEDEIERkvqmrdqeiaataKDLEIRQLELEAQK 828
Cdd:pfam20492  75 AEEKEQLEAELAEAQEEIARLEEEVER-------------KEEEARRLQEELEE 115
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
707-848 1.30e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.54  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 707 QTVENMQAEVDEQRAKDEAwyQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEiKEIHLQDAARRRL---LKL 783
Cdd:COG2433  376 LSIEEALEELIEKELPEEE--PEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELE-AELEEKDERIERLereLSE 452

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543 784 QQDQREMELRRledeiERKVQMRDQEIAATAKDLE-----IRQLE--LEAQKRLYEKDLttSQEAVA-KEIRE 848
Cdd:COG2433  453 ARSEERREIRK-----DREISRLDREIERLERELEeererIEELKrkLERLKELWKLEH--SGELVPvKVVEK 518
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 700-845 1.62e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  700 LDFLRERQT---VENMQAEVDEQRAKDEAWYQKqelLRRAEETR---REILLQEEEKMAQQRQRLAAVKRELEIKEIHLQ 773
Cdd:COG3096   960 LSEVVQRRPhfsYEDAVGLLGENSDLNEKLRAR---LEQAEEARreaREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQ 1036

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  774 DAARR-RLLKLQQDQrEMELR-RLE-DEIERKVQMRDQEIAATAKDLEIRQLELE-AQKRL--YEKDLTTSQEAV--AKE 845
Cdd:COG3096  1037 ELEQElEELGVQADA-EAEERaRIRrDELHEELSQNRSRRSQLEKQLTRCEAEMDsLQKRLrkAERDYKQEREQVvqAKA 1115
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 728-908 1.86e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  728 QKQELLRRAEETRREiLLQEEEKMAQQRQRLAAVKRELEIK---EIHLQ---DAARRRLLKLQQDQREMElrrledeier 801
Cdd:COG3096   279 ERRELSERALELRRE-LFGARRQLAEEQYRLVEMARELEELsarESDLEqdyQAASDHLNLVQTALRQQE---------- 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  802 KVQMRDQEIAATAKDLEIRQLELEA---QKRLYEKDLTTSQEAVaKEIR-------EDTDAHRRKA--------ALEEHm 863
Cdd:COG3096   348 KIERYQEDLEELTERLEEQEEVVEEaaeQLAEAEARLEAAEEEV-DSLKsqladyqQALDVQQTRAiqyqqavqALEKA- 425

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 264681543  864 fQKLLENSQMGGRRAQRWKE---AEEKEFH--LQSAKKASALSDASRKWF 908
Cdd:COG3096   426 -RALCGLPDLTPENAEDYLAafrAKEQQATeeVLELEQKLSVADAARRQF 474
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 695-887 1.88e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 42.25  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 695 IRNDELDFLRERQTVENMQAEVD------EQRA--KDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELE 766
Cdd:COG5185  231 IEEALKGFQDPESELEDLAQTSDkleklvEQNTdlRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKA 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 767 IKEIHLQDAARRRLLKLQQDQRE--MELRRLEDEIERKVqmRDQEIAATAKDLEIRQLELEAQKRLYEKDL---TTSQEA 841
Cdd:COG5185  311 TESLEEQLAAAEAEQELEESKREteTGIQNLTAEIEQGQ--ESLTENLEAIKEEIENIVGEVELSKSSEELdsfKDTIES 388

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 264681543 842 VAKEIREDTDAHRRKA-----ALEEHMFQKLLENSQMGGRRAQRWKEAEEK 887
Cdd:COG5185  389 TKESLDEIPQNQRGYAqeilaTLEDTLKAADRQIEELQRQIEQATSSNEEV 439
PRK03963 PRK03963
V-type ATP synthase subunit E; Provisional
 730-849 2.03e-03

V-type ATP synthase subunit E; Provisional


Pssm-ID: 167649 [Multi-domain]  Cd Length: 198  Bit Score: 40.51  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 730 QELLRRAEETRREIlLQEEEKMAQQrqrlaavkreleIKEihlqdAARRRllklQQDQREMELRRLEDEIErkvqMRDQE 809
Cdd:PRK03963   9 QEINREAEQKIEYI-LEEAQKEAEK------------IKE-----EARKR----AESKAEWILRKAKTQAE----LEKQR 62

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 264681543 810 IAATAKdLEIRQLELEAQKRLYEKDLTTSQEAVAkEIRED 849
Cdd:PRK03963  63 IIANAK-LEVRRKRLAVQEELISEVLEAVRERLA-ELPED 100
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
690-861 2.06e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 690 REWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKE 769
Cdd:COG4372  101 EELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAE 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 770 I-----HLQDAARRRLLKLQQDqrEMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQEAVAK 844
Cdd:COG4372  181 AeqaldELLKEANRNAEKEEEL--AEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILK 258

                        170
                 ....*....|....*..
gi 264681543 845 EIREDTDAHRRKAALEE 861
Cdd:COG4372  259 EIEELELAILVEKDTEE 275
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 730-861 2.09e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 39.77  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 730 QELLRRAEETRREIllqeEEKMAQQRQRLAAVKRELEikEIhlQDAARRRLLKLQQDQREmelrRLEDEIERKVQMRDQE 809
Cdd:COG0711   37 ADGLAEAERAKEEA----EAALAEYEEKLAEARAEAA--EI--IAEARKEAEAIAEEAKA----EAEAEAERIIAQAEAE 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 264681543 810 IAAtAKDLEIRQLELEAQkrlyekdlTTSQEAVAKEIREDTDAHRRKAALEE 861
Cdd:COG0711  105 IEQ-ERAKALAELRAEVA--------DLAVAIAEKILGKELDAAAQAALVDR 147
DUF5384 pfam17358
Family of unknown function (DUF5384); This is a family of unknown function found in ...
 705-849 2.17e-03

Family of unknown function (DUF5384); This is a family of unknown function found in Proteobacteria.


Pssm-ID: 407453 [Multi-domain]  Cd Length: 145  Bit Score: 39.59  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  705 ERQTVENMQAEVDEQR---AKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEihlqdaarrrll 781
Cdd:pfam17358  12 ERQAAYEREWEEEQARaeaAAAAARRARAAAAAAAAAAAKERAKAEALADKKRDQSYEDELRALEIEE------------ 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  782 klqqdqREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYE--KDLTTSqEAVAKEIRED 849
Cdd:pfam17358  80 ------RKLALAAQKARAKRENDFIDQELKSQAAQTDVIQSEADANRNVSEgtKSLMES-EGKAREKKSS 142
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
690-918 2.48e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.97  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 690 REWERIRNDELDFLRERQTVENMQaEVDEQRAK------DEAWYQKQELLRRAEETRREI--LLQEEEKMAQQRQRLAAV 761
Cdd:PRK03918 483 RELEKVLKKESELIKLKELAEQLK-ELEEKLKKynleelEKKAEEYEKLKEKLIKLKGEIksLKKELEKLEELKKKLAEL 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 762 KREL-----EIKEIHLQ---------DAARRRLLKLQQDQREM--------ELRRLEDEI---ERKVQMRDQEIAATAKD 816
Cdd:PRK03918 562 EKKLdeleeELAELLKEleelgfesvEELEERLKELEPFYNEYlelkdaekELEREEKELkklEEELDKAFEELAETEKR 641

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 817 LEIRQLELEAQKRLYEKDlttSQEAVAKEIREDTDAHRRKAA----LEEHM--FQKLLENSQmggrraQRWKEAEEKEFH 890
Cdd:PRK03918 642 LEELRKELEELEKKYSEE---EYEELREEYLELSRELAGLRAeleeLEKRReeIKKTLEKLK------EELEEREKAKKE 712

                        250       260
                 ....*....|....*....|....*...
gi 264681543 891 LQSAKKASALSDASRKWFLRQETSAALE 918
Cdd:PRK03918 713 LEKLEKALERVEELREKVKKYKALLKER 740
Caldesmon pfam02029
Caldesmon;
693-796 2.48e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.39  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  693 ERIRndeldflRERQTVENMQAEVDEQRaKDEAWYQKQELLRRAEEtRREILLQEEEKMAQQRQrLAAVKRELEikeihl 772
Cdd:pfam02029 251 EELR-------RRRQEKESEEFEKLRQK-QQEAELELEELKKKREE-RRKLLEEEEQRRKQEEA-ERKLREEEE------ 314

                          90       100
                  ....*....|....*....|....
gi 264681543  773 qdaaRRRLlklqqdQREMELRRLE 796
Cdd:pfam02029 315 ----KRRM------KEEIERRRAE 328
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 749-904 2.74e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 41.53  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  749 EKMAQQRQRLAAVKREL-EIKEIHLQDAARR-RLLKLQQDQREMELRRLEDEIERKvqmrdQEIAATAKDlEIRQLELEA 826
Cdd:pfam05262 184 EALREDNEKGVNFRRDMtDLKERESQEDAKRaQQLKEELDKKQIDADKAQQKADFA-----QDNADKQRD-EVRQKQQEA 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543  827 QKRlyEKDLTTSQEAVAKEIREDTDAHRRKAALE-EHMFQKLLENSQMGGRRAQRWKEAEEKEFHLQSAKKASALSDAS 904
Cdd:pfam05262 258 KNL--PKPADTSSPKEDKQVAENQKREIEKAQIEiKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVA 334
YscO-like pfam16789
YscO-like protein; This family of proteins is similar to the type III secretion protein YscO. ...
 727-847 2.81e-03

YscO-like protein; This family of proteins is similar to the type III secretion protein YscO. The family includes Chlamydia trachomatis CT670 which is found in a type III secretion gene cluster. CT670 interacts with CT671, a putative YscP homolog and CT670 and CT671 may form a chaperone-effector pair.


Pssm-ID: 435583 [Multi-domain]  Cd Length: 160  Bit Score: 39.43  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  727 YQKQELLR---RAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDaarrrllKLQQDQREME------------ 791
Cdd:pfam16789   3 YPLEQVLDikkKRVEEAEKVVKDKKRALEKEKEKLAELEAERDKVRKHKKA-------KMQQLRDEMDrgttsdkilqmk 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  792 --LRRLEDEI---ERKVQMRDQEIAATAKDLEIRQLELeAQKRLYEKDLTTSQEAVAKEIR 847
Cdd:pfam16789  76 ryIKVVKERLkqeEKKVQDQKEQVRTAARNLEIAREEL-KKKRQEVEKLEKHKKEWVKEMK 135
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 718-791 2.85e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 2.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   718 EQRAKDEAwyQKQELLRRAEETRREILLQ--EEEKMAQQRQ--------RLAAVKRELEIKEIHLQ--DAARRRLlklqq 785
Cdd:pfam01576  984 EQESRERQ--AANKLVRRTEKKLKEVLLQveDERRHADQYKdqaekgnsRMKQLKRQLEEAEEEASraNAARRKL----- 1056


                   ....*.
gi 264681543   786 dQREME 791
Cdd:pfam01576 1057 -QRELD 1061
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 738-928 2.97e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.49  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   738 ETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQdaaRRRLLKlQQDQREMELRRLEDEIERKVQMRDQE-----IAA 812
Cdd:TIGR00618  222 QVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLK---KQQLLK-QLRARIEELRAQEAVLEETQERINRArkaapLAA 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   813 TAKDL-EIRQ------LELEAQKRLYEKDLTTSQEAVAKE--IREDTDAHRRKAALEEHMFQkllENSQMGGRRAQRWKE 883
Cdd:TIGR00618  298 HIKAVtQIEQqaqrihTELQSKMRSRAKLLMKRAAHVKQQssIEEQRRLLQTLHSQEIHIRD---AHEVATSIREISCQQ 374

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 264681543   884 AEEKEFHLQSAKKASALSDASRKWFLRQETSAALEHEEMPWLQRQ 928
Cdd:TIGR00618  375 HTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAF 419
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 703-822 3.51e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.48  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  703 LRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREILLQE-----EEKMA--QQRQRLAAVKRELEIKE---IHL 772
Cdd:COG3096   528 LRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQaaeavEQRSElrQQLEQLRARIKELAARApawLAA 607

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 264681543  773 QDAARR-------RLLKLQQ--DQREMELRRledeiERKVQMRDQEIAATAKDLE--IRQL 822
Cdd:COG3096   608 QDALERlreqsgeALADSQEvtAAMQQLLER-----EREATVERDELAARKQALEsqIERL 663
DUF3375 pfam11855
Protein of unknown function (DUF3375); This family of proteins are functionally ...
 643-873 3.70e-03

Protein of unknown function (DUF3375); This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.


Pssm-ID: 463373  Cd Length: 469  Bit Score: 41.09  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  643 IREVYHLMETTPADIHpnSMLDAFVALTKGqypifnqypkfIVDyQTREWERIRNDELDF-LRERQTVenmqAEVDEQRA 721
Cdd:pfam11855 174 AREILQLARELPADFR--RVEDEFRQLDRE-----------LRE-RIIDWDGSRGEVLEElFDGYDAL----ADSDQGRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  722 KDEAWyqkqELLRRAEETR------REILLQEEEKM--AQQRQRLAAVKREL--EIKEIH--LQDAAR--RRLLKLQQDQ 787
Cdd:pfam11855 236 FEAFW----DLLMDPERQAeldellDTVLSRPFARGldADQRRFLRRLHRDLleAGEEVQrtRRRLSRslRRFVRSQAFL 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  788 REMELRRLEDEIERK-VQMRDQEIAATAKDLEI----RQLELEAQKRLY---EKDLTTSQEAVAKEIREDTDAHRR---- 855
Cdd:pfam11855 312 EDRRVDRLLREAEALaLALRDAPPADRRTGLELpltaPDIASPSERRLHdppALPVVDAPADDAGAGELDLEDLRAlggq 391

                         250       260
                  ....*....|....*....|..
gi 264681543  856 ----KAALEEHMFQKLLENSQM 873
Cdd:pfam11855 392 sevdRAELTEAVRAALAERGQV 413
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 696-892 3.97e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.31  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   696 RNDELDFLRERQT-VENMQAEVDEQRA-KDEAWYQKQELLRRAEETRREIL-LQEEEKMAQQRQRLAAVKRELEIKEIH- 771
Cdd:pfam01576  793 REEAVKQLKKLQAqMKDLQRELEEARAsRDEILAQSKESEKKLKNLEAELLqLQEDLAASERARRQAQQERDELADEIAs 872

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   772 -------LQDAARRRLLKLQQDQREME-----LRRLEDEIERKVQMRDQ---EIAA---TAKDLEIRQLELEAQKRLYEK 833
Cdd:pfam01576  873 gasgksaLQDEKRRLEARIAQLEEELEeeqsnTELLNDRLRKSTLQVEQlttELAAersTSQKSESARQQLERQNKELKA 952

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   834 DLTTSQEAVAKEIREDTDAHRRK-AALEEHMFQKLLENSQMGgrRAQRWKEAEEKEFHLQ 892
Cdd:pfam01576  953 KLQEMEGTVKSKFKSSIAALEAKiAQLEEQLEQESRERQAAN--KLVRRTEKKLKEVLLQ 1010
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
697-901 4.21e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.28  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 697 NDELDFLRE-RQTVENMQAEVDEQRakDEAWYQKQELLRRAEETR--REILLQEEEKMAQQRQRLAAVKREL--EIKEIH 771
Cdd:COG1340   21 REEIEELKEkRDELNEELKELAEKR--DELNAQVKELREEAQELRekRDELNEKVKELKEERDELNEKLNELreELDELR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 772 lQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEiaataKDL--EIRQLE--LEAQKRLYE--KDLTTSQEAVAKE 845
Cdd:COG1340   99 -KELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEE-----KELveKIKELEkeLEKAKKALEknEKLKELRAELKEL 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 264681543 846 IREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEE--KEFhLQSAKKASALS 901
Cdd:COG1340  173 RKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADElhKEI-VEAQEKADELH 229
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 763-888 4.34e-03

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 38.88  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  763 RELEIKEIhlQDAARRRLLKLQQDQREMELRRLEDEIERKVQMR-DQEIAATAKDLEI-----RQLELEAQKRLYE---K 833
Cdd:pfam15346   1 KEAESKLL--EEETARRVEEAVAKRVEEELEKRKDEIEAEVERRvEEARKIMEKQVLEelereREAELEEERRKEEeerK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 264681543  834 DLTTSQEAVAKEIREDTDAHRRKAalEEHmfQKLLENSQMGGRRAQRWKEAEEKE 888
Cdd:pfam15346  79 KREELERILEENNRKIEEAQRKEA--EER--LAMLEEQRRMKEERQRREKEEEER 129
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
717-861 4.56e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  717 DEQRAKDEAWY-------QKQELLRRAEETRREIllqeeEKMAQQRQRLAAVKRELEIKEIHLQDAARRRLLKLQQDQRE 789
Cdd:COG4913   593 DDRRRIRSRYVlgfdnraKLAALEAELAELEEEL-----AEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE 667

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 264681543  790 MELRRLEDEIERkvqmrdqeIAATAKDLEirqlELEAQKRLYEKDLTTSQEAVAKEIREDTDAHRRKAALEE 861
Cdd:COG4913   668 REIAELEAELER--------LDASSDDLA----ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE 727
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 642-769 4.83e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 642 VIREVYHLMETTPADI--HPNSMLDAFVALTKGQYpiFNQYPKFIVDYQTREWERIRNDELDFLRERQTVENMQAEVDEQ 719
Cdd:COG4942  109 LLRALYRLGRQPPLALllSPEDFLDAVRRLQYLKY--LAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEE 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 264681543 720 RAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKE 769
Cdd:COG4942  187 RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
 748-886 4.96e-03

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 39.21  E-value: 4.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 748 EEKMAQQRQRLAAVKRELEIKEIHLQDAARRRllklQQDQREMELRRLEDEIErkvQMRDQEIAaTAKdLEIRQLELEAQ 827
Cdd:PRK02292   8 EDIRDEARARASEIRAEADEEAEEIIAEAEAD----AEEILEDREAEAEREIE---QLREQELS-SAK-LEAKRERLNAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 264681543 828 KRLYEKdlttSQEAVAKEIReDTDAHRRKAALEehmfqKLLENSQMGGRRAQRWKEAEE 886
Cdd:PRK02292  79 KEVLED----VRNQVEDEIA-SLDGDKREELTK-----SLLDAADADGVRVYSRKDDED 127
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 714-891 5.30e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.93  E-value: 5.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   714 AEVDEQRAKDEAwyQKQEL--------LRRAEETRREILLQ-----------------EEEKMAQQRQRLAAVKRELEIK 768
Cdd:pfam01576   57 AEAEEMRARLAA--RKQELeeilheleSRLEEEEERSQQLQnekkkmqqhiqdleeqlDEEEAARQKLQLEKVTTEAKIK 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   769 EIH-----LQDAARrrllKLQQDQREMELRRLE-----DEIERKVQMRDQ---EIAATAKDLEIR-------QLELEAQK 828
Cdd:pfam01576  135 KLEedillLEDQNS----KLSKERKLLEERISEftsnlAEEEEKAKSLSKlknKHEAMISDLEERlkkeekgRQELEKAK 210

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 264681543   829 RLYEKDLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLLENSQMGGRRAQRWKEAEEKEFHL 891
Cdd:pfam01576  211 RKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQI 273
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 698-906 5.34e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.93  E-value: 5.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   698 DELDFLRER--QTVENMQAEVDEQRAKDEAWYQKQEllrraeetRREILLQEEE----KMAQQRQRLAAVKRELEIKEIH 771
Cdd:pfam01576  569 DKLEKTKNRlqQELDDLLVDLDHQRQLVSNLEKKQK--------KFDQMLAEEKaisaRYAEERDRAEAEAREKETRALS 640

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   772 LQdaarrRLLKLQQDQREmELRR----LEDEIERKVQMRDqeiaATAKDLEirqlELEAQKRLYEK---DLTTSQEAVAK 844
Cdd:pfam01576  641 LA-----RALEEALEAKE-ELERtnkqLRAEMEDLVSSKD----DVGKNVH----ELERSKRALEQqveEMKTQLEELED 706

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   845 EIREDTDAHRRkaaLEEHM------FQKLLENSQMGG--RRAQRWKEAEEKEFHLQSAKKASALSDASRK 906
Cdd:pfam01576  707 ELQATEDAKLR---LEVNMqalkaqFERDLQARDEQGeeKRRQLVKQVRELEAELEDERKQRAQAVAAKK 773
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 704-767 6.27e-03

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 38.49  E-value: 6.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  704 RERQTVENMQAEVDEQRAKDEAWYQKQELL--------RRAEETRR-----------EILLQEEEKMAQQRQRLAAVKRE 764
Cdd:pfam15346  54 VLEELEREREAELEEERRKEEEERKKREELerileennRKIEEAQRkeaeerlamleEQRRMKEERQRREKEEEEREKRE 133


                  ...
gi 264681543  765 LEI 767
Cdd:pfam15346 134 QQK 136
mukB PRK04863
chromosome partition protein MukB;
686-842 6.43e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.71  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  686 DYQTRE--WERIRN--DELDFLRERQTVENMQAEVDEQRAKDEAWYQKQELLRRAEETRREI---LLQEEEKMAQQRQRL 758
Cdd:PRK04863  943 DYQQAQqtQRDAKQqaFALTEVVQRRAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAreqLRQAQAQLAQYNQVL 1022

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  759 AAVKRELEIKEIHLQDAARR-RLLKLQQDQ-REMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELE-AQKRL--YEK 833
Cdd:PRK04863 1023 ASLKSSYDAKRQMLQELKQElQDLGVPADSgAEERARARRDELHARLSANRSRRNQLEKQLTFCEAEMDnLTKKLrkLER 1102


                  ....*....
gi 264681543  834 DLTTSQEAV 842
Cdd:PRK04863 1103 DYHEMREQV 1111
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 690-872 6.98e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   690 REWERIRNDELDFLRERQTVENMQAEVDEQRAKDEAW-----YQKQE----LLRRAEETRREILLQEEEKMAQQRQRLAA 760
Cdd:TIGR00618  615 HALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALqltltQERVRehalSIRVLPKELLASRQLALQKMQSEKEQLTY 694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543   761 VKRELEIKEIHLQdaarrrllklQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEKDLTTSQE 840
Cdd:TIGR00618  695 WKEMLAQCQTLLR----------ELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHF 764

                          170       180       190
                   ....*....|....*....|....*....|....
gi 264681543   841 AVAKE--IREDTDAHRRKAALEEHMFQKLLENSQ 872
Cdd:TIGR00618  765 NNNEEvtAALQTGAELSHLAAEIQFFNRLREEDT 798
PDCD7 pfam16021
Programmed cell death protein 7;
756-857 8.91e-03

Programmed cell death protein 7;


Pssm-ID: 464979 [Multi-domain]  Cd Length: 305  Bit Score: 39.32  E-value: 8.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  756 QRLAAVKRELEIKEIHLQDAARRRLLK--LQQDQREmELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQKRLYEK 833
Cdd:pfam16021  42 SRAAELKHELQEKLLLLEDPELLESLKrkLERRQKK-RLRRKRRKEERKEEKKEEQERRAEREAKIDKWRRKQIQEVEEK 120

                          90       100
                  ....*....|....*....|....
gi 264681543  834 DLTTSQEAVAKEIRedTDAHRRKA 857
Cdd:pfam16021 121 KRERELKLAADAVL--SEVRKKQA 142
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 779-872 9.96e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 39.72  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543  779 RLLKLQQD--QREMELRRLEDEIERKVqmrdqeiAATAKDLEI---RQLELEAQKRLYEKDLTTSQEAvakeIREDTDAH 853
Cdd:pfam05557  10 RLSQLQNEkkQMELEHKRARIELEKKA-------SALKRQLDResdRNQELQKRIRLLEKREAEAEEA----LREQAELN 78

                          90
                  ....*....|....*....
gi 264681543  854 RRKAALEEHMFQKLLENSQ 872
Cdd:pfam05557  79 RLKKKYLEALNKKLNEKES 97
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 702-848 9.97e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 9.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681543 702 FLRERQT-VENMQAEVDEQRAKDEAWyqkQELLRRAEETRREILlQEEEKMAQQRQRLAAVKRELEIKEihlqdaARRRL 780
Cdd:cd16269  147 YLEDREKlVEKYRQVPRKGVKAEEVL---QEFLQSKEAEAEAIL-QADQALTEKEKEIEAERAKAEAAE------QERKL 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 264681543 781 LklQQDQREMElRRLEDE-------IERKVQMRDQEIAATAKDLE-IRQLELEAQKRLYEKDLTTSQEAVAKEIRE 848
Cdd:cd16269  217 L--EEQQRELE-QKLEDQersyeehLRQLKEKMEEERENLLKEQErALESKLKEQEALLEEGFKEQAELLQEEIRS 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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