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Conserved domains on  [gi|127139202|ref|NP_001076012|]
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stefin-1 [Mus musculus]

Protein Classification

CY domain-containing protein (domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
4-91 7.36e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but members have not been included.


:

Pssm-ID: 394988  Cd Length: 92  Bit Score: 91.63  E-value: 7.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139202   4 GGVSEASRATPEIQMIANKVRPQLEAKT-NKKYEKFEAVEYKTQVVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80
                         90
                 ....*....|..
gi 127139202  80 ELHGYQTDKTMD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
4-91 7.36e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but members have not been included.


Pssm-ID: 394988  Cd Length: 92  Bit Score: 91.63  E-value: 7.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139202   4 GGVSEASRATPEIQMIANKVRPQLEAKT-NKKYEKFEAVEYKTQVVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80
                         90
                 ....*....|..
gi 127139202  80 ELHGYQTDKTMD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
1-62 2.10e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 68.22  E-value: 2.10e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127139202     1 MSLGGVSEASRATPEIQMIANKVRPQLEAKTNKKYE--KFEAVEYKTQVVAGENIFIKMDVGHG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
4-86 5.31e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002  Cd Length: 105  Bit Score: 54.02  E-value: 5.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139202   4 GGVSEASRATPEIQMIANKVRPQLEAKTNKKY-EKFEAVEYKTQVVAGENIFIKMDVGHGcfIHIKVFNGPTGKDNYELH 82
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDT--NCKKSSVPLDCPDCKLLE 78

                 ....
gi 127139202  83 GYQT 86
Cdd:cd00042   79 EGKK 82
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
4-91 7.36e-26

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but members have not been included.


Pssm-ID: 394988  Cd Length: 92  Bit Score: 91.63  E-value: 7.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139202   4 GGVSEASRATPEIQMIANKVRPQLEAKT-NKKYEKFEAVEYKTQVVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80
                         90
                 ....*....|..
gi 127139202  80 ELHGYQTDKTMD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
1-62 2.10e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 68.22  E-value: 2.10e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127139202     1 MSLGGVSEASRATPEIQMIANKVRPQLEAKTNKKYE--KFEAVEYKTQVVAGENIFIKMDVGHG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
4-86 5.31e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002  Cd Length: 105  Bit Score: 54.02  E-value: 5.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139202   4 GGVSEASRATPEIQMIANKVRPQLEAKTNKKY-EKFEAVEYKTQVVAGENIFIKMDVGHGcfIHIKVFNGPTGKDNYELH 82
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDT--NCKKSSVPLDCPDCKLLE 78

                 ....
gi 127139202  83 GYQT 86
Cdd:cd00042   79 EGKK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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