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Conserved domains on  [gi|145301607|ref|NP_001077422|]
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tRNA (32-2'-O)-methyltransferase regulator THADA isoform a [Homo sapiens]

Protein Classification

THADA/TRM732 family protein( domain architecture ID 10563587)

thyroid adenoma-associated protein (THADA)/TRM732 family protein is a DUF2428 domain-containing protein; similar to Homo sapiens thyroid adenoma-associated protein (THADA) and the tRNA -methyltransferase non-catalytic subunit TRM732

Gene Ontology:  GO:0030488
PubMed:  17889454

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
947-1248 1.70e-85

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


:

Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 280.40  E-value: 1.70e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607   947 PVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqmilneiqprdtndyfnqakilkehdsfdmkdlnasvv 1026
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1027 NIDTSTEIKGkevktcDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHLLQSRHR 1106
Cdd:pfam10350   41 STIDESEETE------GLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1107 GAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKI 1186
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1187 TMKELISLAGPTDDIQ--------STVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWA 1248
Cdd:pfam10350  191 AMKELLEIATSPVSSDeesesdetVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 super family cl47095
Uncharacterized conserved protein [Function unknown];
394-1484 8.00e-41

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG5543:

Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  394 EYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFvpDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  474 DKTIPSQILEVMGDQSLVPYASDLLETMFRN-HKSHLKSQTAESSwidQWHETWVSPLLFILCEGNLdQKSYVIdYYLPK 552
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEGEEV---MWMNLWCPKDLKYIHDKQP-ADPDSI-RAVKR 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  553 LLSYSPESLQYMVKILQTSIDAKtgqeqsfpslgscnsrgaLGALMACLRIARAHGHLqsatdtwENLVSD---ARIKQG 629
Cdd:COG5543   261 LFSSMPKASFRYSLRILKNKDER------------------FFVYLPDLKISTGYSIL-------RELLGKlspDRVRSI 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  630 LIHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKleQSKSK 709
Cdd:COG5543   316 IKIVGDEYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSMLKSLAR--YFRKF 393
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  710 REPENELTKQhpsvsLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIaevfhVPEGRIYTVYQLSHD------- 782
Cdd:COG5543   394 PDEQLWLKEK-----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSL-----IAEGIDKSTPQKFLIqnkrefp 463
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  783 ------IDVGRFQTLMECFTSTFEDVKILAFDLLMKLsKTAVHFQDSGKLQGLFQAALELSTSTKPYDC---VTASYLLN 853
Cdd:COG5543   464 fsaqllFDSDHERLMIDLLVSNYADIRKLSTKILLGL-ESMSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCV 542
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  854 FLIwqdalpsslsayltqqVACdngdRPAAVVErNTLMVIKCLMENLEeevsQAENSLLQAAAAFPMYGRvhcitgALQK 933
Cdd:COG5543   543 EFI----------------KSC----QSRSFVG-HTKSILDSHMKNFV----SGKKSMEEISIGPHFAAL------SLIL 591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  934 LSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqmilneiqprdtndyfnqakilkeh 1013
Cdd:COG5543   592 GLFNSEENHQDTSKILSELIEHDIITWVDIVYVCCFDSLSGVLP------------------------------------ 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1014 dsfdmkdlnasvvnidtsteikGKEvKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPmqpvpessdglLTVEQVKEIG 1093
Cdd:COG5543   636 ----------------------GQE-DDCGVPDQVILSVYWRNMKECSSLLCGMLLKYP-----------LTRGNLALSG 681
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1094 DYFKQHLLQSRHRGAFELAYTGFVkltEVLNRCpNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLA 1173
Cdd:COG5543   682 RLVQVLLSHIRHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRI----EKCKAITRRSGGIPLLFTSILR 753
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1174 SEPKKGRmDLLKITMKELISLAG---PTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVR 1250
Cdd:COG5543   754 AEVTKYP-SLLERTLKRLLELAEtpeSSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIR 832
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1251 NSSTLLFSALITRIFGVKRAK---DEHSKTNRMtgreFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFllLLVL 1327
Cdd:COG5543   833 NCSIMLFTNLVNRAFGRGPEGivgMAHAGSRKL----FFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIF--LVTE 906
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1328 ERLYASPMDGTSsalSMGPFVPFIMRCGHSPVYHSREMAARALVPfvMIDHIPNTIRtLLSTLPSCTDQcfrQNHIHGTL 1407
Cdd:COG5543   907 ALWRLSPRGGVT---GLKSFNICTKKCWKMPNWKARPRASMVLNP--LLSEGEVLLR-VLILLDSEAVE---QNGMHGSL 977
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1408 LQVFHLLQAYSDSKhgtnsdFQHELTDiTVCTKAKLWLAKrQNPCLVTRAVYIDI--LFLLTCCLNRS-AKDNQPVLESL 1484
Cdd:COG5543   978 LENVYGLSSYSSEY------LKHYTVQ-RICEIGYQEAAA-QRLRFYSLKIERSLscFFLESPSNEDSdLKHAISLMRMY 1049
 
Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
947-1248 1.70e-85

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 280.40  E-value: 1.70e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607   947 PVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqmilneiqprdtndyfnqakilkehdsfdmkdlnasvv 1026
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1027 NIDTSTEIKGkevktcDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHLLQSRHR 1106
Cdd:pfam10350   41 STIDESEETE------GLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1107 GAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKI 1186
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1187 TMKELISLAGPTDDIQ--------STVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWA 1248
Cdd:pfam10350  191 AMKELLEIATSPVSSDeesesdetVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 COG5543
Uncharacterized conserved protein [Function unknown];
394-1484 8.00e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  394 EYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFvpDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  474 DKTIPSQILEVMGDQSLVPYASDLLETMFRN-HKSHLKSQTAESSwidQWHETWVSPLLFILCEGNLdQKSYVIdYYLPK 552
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEGEEV---MWMNLWCPKDLKYIHDKQP-ADPDSI-RAVKR 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  553 LLSYSPESLQYMVKILQTSIDAKtgqeqsfpslgscnsrgaLGALMACLRIARAHGHLqsatdtwENLVSD---ARIKQG 629
Cdd:COG5543   261 LFSSMPKASFRYSLRILKNKDER------------------FFVYLPDLKISTGYSIL-------RELLGKlspDRVRSI 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  630 LIHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKleQSKSK 709
Cdd:COG5543   316 IKIVGDEYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSMLKSLAR--YFRKF 393
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  710 REPENELTKQhpsvsLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIaevfhVPEGRIYTVYQLSHD------- 782
Cdd:COG5543   394 PDEQLWLKEK-----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSL-----IAEGIDKSTPQKFLIqnkrefp 463
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  783 ------IDVGRFQTLMECFTSTFEDVKILAFDLLMKLsKTAVHFQDSGKLQGLFQAALELSTSTKPYDC---VTASYLLN 853
Cdd:COG5543   464 fsaqllFDSDHERLMIDLLVSNYADIRKLSTKILLGL-ESMSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCV 542
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  854 FLIwqdalpsslsayltqqVACdngdRPAAVVErNTLMVIKCLMENLEeevsQAENSLLQAAAAFPMYGRvhcitgALQK 933
Cdd:COG5543   543 EFI----------------KSC----QSRSFVG-HTKSILDSHMKNFV----SGKKSMEEISIGPHFAAL------SLIL 591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  934 LSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqmilneiqprdtndyfnqakilkeh 1013
Cdd:COG5543   592 GLFNSEENHQDTSKILSELIEHDIITWVDIVYVCCFDSLSGVLP------------------------------------ 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1014 dsfdmkdlnasvvnidtsteikGKEvKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPmqpvpessdglLTVEQVKEIG 1093
Cdd:COG5543   636 ----------------------GQE-DDCGVPDQVILSVYWRNMKECSSLLCGMLLKYP-----------LTRGNLALSG 681
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1094 DYFKQHLLQSRHRGAFELAYTGFVkltEVLNRCpNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLA 1173
Cdd:COG5543   682 RLVQVLLSHIRHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRI----EKCKAITRRSGGIPLLFTSILR 753
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1174 SEPKKGRmDLLKITMKELISLAG---PTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVR 1250
Cdd:COG5543   754 AEVTKYP-SLLERTLKRLLELAEtpeSSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIR 832
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1251 NSSTLLFSALITRIFGVKRAK---DEHSKTNRMtgreFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFllLLVL 1327
Cdd:COG5543   833 NCSIMLFTNLVNRAFGRGPEGivgMAHAGSRKL----FFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIF--LVTE 906
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1328 ERLYASPMDGTSsalSMGPFVPFIMRCGHSPVYHSREMAARALVPfvMIDHIPNTIRtLLSTLPSCTDQcfrQNHIHGTL 1407
Cdd:COG5543   907 ALWRLSPRGGVT---GLKSFNICTKKCWKMPNWKARPRASMVLNP--LLSEGEVLLR-VLILLDSEAVE---QNGMHGSL 977
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1408 LQVFHLLQAYSDSKhgtnsdFQHELTDiTVCTKAKLWLAKrQNPCLVTRAVYIDI--LFLLTCCLNRS-AKDNQPVLESL 1484
Cdd:COG5543   978 LENVYGLSSYSSEY------LKHYTVQ-RICEIGYQEAAA-QRLRFYSLKIERSLscFFLESPSNEDSdLKHAISLMRMY 1049
 
Name Accession Description Interval E-value
DUF2428 pfam10350
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
947-1248 1.70e-85

THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).


Pssm-ID: 463054 [Multi-domain]  Cd Length: 260  Bit Score: 280.40  E-value: 1.70e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607   947 PVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASrlqmilneiqprdtndyfnqakilkehdsfdmkdlnasvv 1026
Cdd:pfam10350    1 SLLERLLLLCERIWSIVLPVLCDDSPEGHLPEDLDDMDDD---------------------------------------- 40
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1027 NIDTSTEIKGkevktcDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHLLQSRHR 1106
Cdd:pfam10350   41 STIDESEETE------GLTHQILLSCSWRALKESSLLLGTIVKRVPLTTSPSNGDQLLTVEQLERIGELFFTQLLELRHR 114
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1107 GAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKI 1186
Cdd:pfam10350  115 GAFETVYVGFTALCRRLLSSDDPELKQLPEQWLQELLEAIK----SSSLSITRRSAGLPFLILAILSSEPNSGKRPLLHR 190
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  1187 TMKELISLAGPTDDIQ--------STVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWA 1248
Cdd:pfam10350  191 AMKELLEIATSPVSSDeesesdetVDLPQVHALNILRALFRDSLLGERVSPYVADGLILAIEGFSSPVWA 260
COG5543 COG5543
Uncharacterized conserved protein [Function unknown];
394-1484 8.00e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227830 [Multi-domain]  Cd Length: 1400  Bit Score: 165.95  E-value: 8.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  394 EYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFvpDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHILAI 473
Cdd:COG5543   108 EEVRDFGHLGRYKEEEAKTDFFSKLLELQLGRCPKEAV--KDVLFNWMNHLLLLLSGADVASQLIIFLMFYKLAVKYKVY 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  474 DKTIPSQILEVMGDQSLVPYASDLLETMFRN-HKSHLKSQTAESSwidQWHETWVSPLLFILCEGNLdQKSYVIdYYLPK 552
Cdd:COG5543   186 DPRFLHKSKTLLHLIHLARAVLKTIIAYLLNrVDLVFNEFEGEEV---MWMNLWCPKDLKYIHDKQP-ADPDSI-RAVKR 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  553 LLSYSPESLQYMVKILQTSIDAKtgqeqsfpslgscnsrgaLGALMACLRIARAHGHLqsatdtwENLVSD---ARIKQG 629
Cdd:COG5543   261 LFSSMPKASFRYSLRILKNKDER------------------FFVYLPDLKISTGYSIL-------RELLGKlspDRVRSI 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  630 LIHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKleQSKSK 709
Cdd:COG5543   316 IKIVGDEYKLQSFARLFLPLKMSDPQRFFTFRSVEVRIESLFHIDGVGLRRRFLESMQHFFIRSRSMLKSLAR--YFRKF 393
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  710 REPENELTKQhpsvsLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIaevfhVPEGRIYTVYQLSHD------- 782
Cdd:COG5543   394 PDEQLWLKEK-----VEEAHKFLTMYLEVIKPMLRPTNAYQRVLGSLYLMDSL-----IAEGIDKSTPQKFLIqnkrefp 463
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  783 ------IDVGRFQTLMECFTSTFEDVKILAFDLLMKLsKTAVHFQDSGKLQGLFQAALELSTSTKPYDC---VTASYLLN 853
Cdd:COG5543   464 fsaqllFDSDHERLMIDLLVSNYADIRKLSTKILLGL-ESMSESRGLFLDTLDANALKVKIESHQSHDVhgdAGATVYCV 542
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  854 FLIwqdalpsslsayltqqVACdngdRPAAVVErNTLMVIKCLMENLEeevsQAENSLLQAAAAFPMYGRvhcitgALQK 933
Cdd:COG5543   543 EFI----------------KSC----QSRSFVG-HTKSILDSHMKNFV----SGKKSMEEISIGPHFAAL------SLIL 591
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607  934 LSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPmdtdsesasrlqmilneiqprdtndyfnqakilkeh 1013
Cdd:COG5543   592 GLFNSEENHQDTSKILSELIEHDIITWVDIVYVCCFDSLSGVLP------------------------------------ 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1014 dsfdmkdlnasvvnidtsteikGKEvKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPmqpvpessdglLTVEQVKEIG 1093
Cdd:COG5543   636 ----------------------GQE-DDCGVPDQVILSVYWRNMKECSSLLCGMLLKYP-----------LTRGNLALSG 681
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1094 DYFKQHLLQSRHRGAFELAYTGFVkltEVLNRCpNVSLQKLPEQWLWSVLEEIKcsdpSSKLCATRRSAGIPFYIQALLA 1173
Cdd:COG5543   682 RLVQVLLSHIRHLGAFLQVSPYLN---MVCKRC-NMEFEEDELLELVKVSFNRI----EKCKAITRRSGGIPLLFTSILR 753
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1174 SEPKKGRmDLLKITMKELISLAG---PTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVR 1250
Cdd:COG5543   754 AEVTKYP-SLLERTLKRLLELAEtpeSSHQDEFDLPQVHALNILSRIFEEGCLSSKLPLQIEEAFGLAFKCFRSNLWAIR 832
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1251 NSSTLLFSALITRIFGVKRAK---DEHSKTNRMtgreFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFllLLVL 1327
Cdd:COG5543   833 NCSIMLFTNLVNRAFGRGPEGivgMAHAGSRKL----FFKKLSLLRDKLLDVLALSIAHLSGRMRESNGEESIF--LVTE 906
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1328 ERLYASPMDGTSsalSMGPFVPFIMRCGHSPVYHSREMAARALVPfvMIDHIPNTIRtLLSTLPSCTDQcfrQNHIHGTL 1407
Cdd:COG5543   907 ALWRLSPRGGVT---GLKSFNICTKKCWKMPNWKARPRASMVLNP--LLSEGEVLLR-VLILLDSEAVE---QNGMHGSL 977
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301607 1408 LQVFHLLQAYSDSKhgtnsdFQHELTDiTVCTKAKLWLAKrQNPCLVTRAVYIDI--LFLLTCCLNRS-AKDNQPVLESL 1484
Cdd:COG5543   978 LENVYGLSSYSSEY------LKHYTVQ-RICEIGYQEAAA-QRLRFYSLKIERSLscFFLESPSNEDSdLKHAISLMRMY 1049
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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