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Conserved domains on  [gi|148225671|ref|NP_001080556|]
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7-dehydrocholesterol reductase L homeolog [Xenopus laevis]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 97-340 3.65e-41

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 148.74  E-value: 3.65e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671   97 IYLAWVSFQVFLYMLVPDILHKFVPgyeggVQDGARTPaglinkYQVNGLQAWTIThLLWFANAYHFHWFSPTIIIDNWI 176
Cdd:pfam01222  73 VFLLWYFFQAVFYLTLPGKVVEGLP-----LSNGRKLP------YKINAFWSFLLT-LAAIGVLHYTQLFELTYLYDNFV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  177 PLLWCANLLGYSVATFALVKAYFFPTNASDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYA 254
Cdd:pfam01222 141 QIMSSAILFSFALAIYLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAAL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  255 AKQQELYGQVTNSMILVNVLQAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPIELS--- 331
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGwst 299


                  ....*....
gi 148225671  332 TTAAIGVLL 340
Cdd:pfam01222 300 YAVAIYALL 308
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
97-340 3.65e-41

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 148.74  E-value: 3.65e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671   97 IYLAWVSFQVFLYMLVPDILHKFVPgyeggVQDGARTPaglinkYQVNGLQAWTIThLLWFANAYHFHWFSPTIIIDNWI 176
Cdd:pfam01222  73 VFLLWYFFQAVFYLTLPGKVVEGLP-----LSNGRKLP------YKINAFWSFLLT-LAAIGVLHYTQLFELTYLYDNFV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  177 PLLWCANLLGYSVATFALVKAYFFPTNASDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYA 254
Cdd:pfam01222 141 QIMSSAILFSFALAIYLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAAL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  255 AKQQELYGQVTNSMILVNVLQAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPIELS--- 331
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGwst 299


                  ....*....
gi 148225671  332 TTAAIGVLL 340
Cdd:pfam01222 300 YAVAIYALL 308
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
97-340 3.65e-41

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 148.74  E-value: 3.65e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671   97 IYLAWVSFQVFLYMLVPDILHKFVPgyeggVQDGARTPaglinkYQVNGLQAWTIThLLWFANAYHFHWFSPTIIIDNWI 176
Cdd:pfam01222  73 VFLLWYFFQAVFYLTLPGKVVEGLP-----LSNGRKLP------YKINAFWSFLLT-LAAIGVLHYTQLFELTYLYDNFV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  177 PLLWCANLLGYSVATFALVKAYFFPTNASDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYA 254
Cdd:pfam01222 141 QIMSSAILFSFALAIYLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAAL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225671  255 AKQQELYGQVTNSMILVNVLQAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPIELS--- 331
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGwst 299


                  ....*....
gi 148225671  332 TTAAIGVLL 340
Cdd:pfam01222 300 YAVAIYALL 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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