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Conserved domains on  [gi|148612875|ref|NP_001091968|]
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small G protein signaling modulator 1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 20-196 1.21e-133

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


:

Pssm-ID: 439065  Cd Length: 177  Bit Score: 400.54  E-value: 1.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIE 99
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  100 SARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 179
Cdd:cd17703    81 NKRNQMQGLQENVRKMPKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 160

                         170
                  ....*....|....*..
gi 148612875  180 LEYTKMKTADHFWTDPS 196
Cdd:cd17703   161 LEYTKMKTADHFWTDPS 177
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 254-425 6.63e-102

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 316.97  E-value: 6.63e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  254 ATLLYGKNNVLVQPRDDMEAVPGYLSLHQTAD-VMTLKWTPNQLMNGSVGD-----LDYEKSVYWDYAMTIRLEEIVYLH 327
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGRgNLTLKWTPNQLMNGSSQAssaksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  328 CHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSaeSTSS 407
Cdd:cd15784    81 CHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTS--SKLS 158

                         170
                  ....*....|....*...
gi 148612875  408 DKDDDEATDYVFRIIYPG 425
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 820-989 2.22e-40

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 148.22  E-value: 2.22e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    820 LHRIEKDVQRCDRNYWYFT---PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQN 896
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    897 F--PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELVYDDVFLVWETIWAAKHvssaHYVL 974
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....*
gi 148612875    975 FIALALVEVYRDIIL 989
Cdd:smart00164  202 RVALALLKLHRDVLL 216
 
Name Accession Description Interval E-value
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 20-196 1.21e-133

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 400.54  E-value: 1.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIE 99
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  100 SARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 179
Cdd:cd17703    81 NKRNQMQGLQENVRKMPKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 160

                         170
                  ....*....|....*..
gi 148612875  180 LEYTKMKTADHFWTDPS 196
Cdd:cd17703   161 LEYTKMKTADHFWTDPS 177
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 254-425 6.63e-102

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 316.97  E-value: 6.63e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  254 ATLLYGKNNVLVQPRDDMEAVPGYLSLHQTAD-VMTLKWTPNQLMNGSVGD-----LDYEKSVYWDYAMTIRLEEIVYLH 327
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGRgNLTLKWTPNQLMNGSSQAssaksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  328 CHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSaeSTSS 407
Cdd:cd15784    81 CHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTS--SKLS 158

                         170
                  ....*....|....*...
gi 148612875  408 DKDDDEATDYVFRIIYPG 425
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 255-391 1.22e-53

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 183.87  E-value: 1.22e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   255 TLLYGKNNVLVQPRDDMEAVPGYLSLHQTADV-MTLKWTPNQLM----------NGSVGDLDYEKSVYWDYAMTIRLEEI 323
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQNDKGsVFLKWTPNQLMksssqpssasSDSEELQSPDGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148612875   324 VYLHCHQQ-VDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFP 391
Cdd:pfam12068   81 KYIHKHQPnEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 820-989 2.22e-40

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 148.22  E-value: 2.22e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    820 LHRIEKDVQRCDRNYWYFT---PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQN 896
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    897 F--PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELVYDDVFLVWETIWAAKHvssaHYVL 974
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....*
gi 148612875    975 FIALALVEVYRDIIL 989
Cdd:smart00164  202 RVALALLKLHRDVLL 216
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 44-188 1.40e-37

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 137.41  E-value: 1.40e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    44 SFCAAVEACVLHGLRR------RAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESArnqiqglqenvrklpk 117
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY---------------- 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148612875   118 lpnlSPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTA 188
Cdd:pfam02759   65 ----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 821-989 8.61e-32

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 122.36  E-value: 8.61e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   821 HRIEKDVQRCDRNYWYFT-PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR--MNQNF 897
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENylLRDFY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   898 PHGG-AMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHvssAHYVLFI 976
Cdd:pfam00566   90 TPDFpGLKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGE---KFVLFRV 165

                          170
                   ....*....|...
gi 148612875   977 ALALVEVYRDIIL 989
Cdd:pfam00566  166 ALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
820-1031 1.09e-18

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 90.63  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  820 LHRIEKDVQRCDRNYWYF---TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR---- 892
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNyglp 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  893 --MNQNFPhggAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELVYDDVFLVWETIWAakHVSSA 970
Cdd:COG5210   337 gyFLKNLS---GLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSM 410

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148612875  971 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIEN 1031
Cdd:COG5210   411 LFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN smart00593
domain involved in Ras-like GTPase signaling;
127-187 2.68e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 71.11  E-value: 2.68e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148612875    127 KHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKT 187
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
 
Name Accession Description Interval E-value
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 20-196 1.21e-133

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 400.54  E-value: 1.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIE 99
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  100 SARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 179
Cdd:cd17703    81 NKRNQMQGLQENVRKMPKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 160

                         170
                  ....*....|....*..
gi 148612875  180 LEYTKMKTADHFWTDPS 196
Cdd:cd17703   161 LEYTKMKTADHFWTDPS 177
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 254-425 6.63e-102

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 316.97  E-value: 6.63e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  254 ATLLYGKNNVLVQPRDDMEAVPGYLSLHQTAD-VMTLKWTPNQLMNGSVGD-----LDYEKSVYWDYAMTIRLEEIVYLH 327
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGRgNLTLKWTPNQLMNGSSQAssaksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  328 CHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSaeSTSS 407
Cdd:cd15784    81 CHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTS--SKLS 158

                         170
                  ....*....|....*...
gi 148612875  408 DKDDDEATDYVFRIIYPG 425
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 20-196 1.09e-97

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 305.70  E-value: 1.09e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIE 99
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  100 SaRNQIQGLQENVRKLP----KLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV 175
Cdd:cd17704    81 G-RKNTQSTQEELRRQSsttsKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLV 159

                         170       180
                  ....*....|....*....|.
gi 148612875  176 GPCALEYTKMKTADHFWTDPS 196
Cdd:cd17704   160 GPCALEYTKLKTADHYWTDPS 180
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 20-184 2.76e-87

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 277.25  E-value: 2.76e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIE 99
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  100 SARNQIQGlqenVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCA 179
Cdd:cd17687    81 NKRSSSSS----GSNSSNSHGNSSSNRKILWIRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLLVGPCA 156


                  ....*
gi 148612875  180 LEYTK 184
Cdd:cd17687   157 LDYTK 161
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 255-391 1.22e-53

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 183.87  E-value: 1.22e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   255 TLLYGKNNVLVQPRDDMEAVPGYLSLHQTADV-MTLKWTPNQLM----------NGSVGDLDYEKSVYWDYAMTIRLEEI 323
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQNDKGsVFLKWTPNQLMksssqpssasSDSEELQSPDGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148612875   324 VYLHCHQQ-VDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFP 391
Cdd:pfam12068   81 KYIHKHQPnEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 820-989 2.22e-40

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 148.22  E-value: 2.22e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    820 LHRIEKDVQRCDRNYWYFT---PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQN 896
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    897 F--PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELVYDDVFLVWETIWAAKHvssaHYVL 974
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201

                           170
                    ....*....|....*
gi 148612875    975 FIALALVEVYRDIIL 989
Cdd:smart00164  202 RVALALLKLHRDVLL 216
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 44-188 1.40e-37

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 137.41  E-value: 1.40e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875    44 SFCAAVEACVLHGLRR------RAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESArnqiqglqenvrklpk 117
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY---------------- 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148612875   118 lpnlSPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTA 188
Cdd:pfam02759   65 ----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 821-989 8.61e-32

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 122.36  E-value: 8.61e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   821 HRIEKDVQRCDRNYWYFT-PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR--MNQNF 897
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENylLRDFY 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   898 PHGG-AMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHvssAHYVLFI 976
Cdd:pfam00566   90 TPDFpGLKRDLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGE---KFVLFRV 165

                          170
                   ....*....|...
gi 148612875   977 ALALVEVYRDIIL 989
Cdd:pfam00566  166 ALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
820-1031 1.09e-18

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 90.63  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  820 LHRIEKDVQRCDRNYWYF---TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR---- 892
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNyglp 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  893 --MNQNFPhggAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELVYDDVFLVWETIWAakHVSSA 970
Cdd:COG5210   337 gyFLKNLS---GLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSM 410

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148612875  971 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIEN 1031
Cdd:COG5210   411 LFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 20-180 6.59e-16

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 75.92  E-value: 6.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   20 KEVKQIMEEAVTRK--------FVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNkiaalfmkvgknfppaedlsrkV 91
Cdd:cd17671     1 KAVKELLESFADNGeaddsaalTLTDDDPVVGRLCAALEAILSHGLKPKRFGGGKVS----------------------F 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   92 QDLEQLIESARNQIQGLQEnVRKLPKLPNLSPLAIK-HLWIRTALFEKVLDKIVHYLVENSS---KYYEKEALLMDPVDG 167
Cdd:cd17671    59 WDFLEALEKLLPAPSLKQA-IRDINSLSNVKTDDGRgRAWIRLALNEKSLESYLAALLSDQSllrKYYEPWALLRDPEEA 137

                         170
                  ....*....|...
gi 148612875  168 PILASLLVGPCAL 180
Cdd:cd17671   138 ELFLSLLVGLSSL 150
RUN smart00593
domain involved in Ras-like GTPase signaling;
127-187 2.68e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 71.11  E-value: 2.68e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148612875    127 KHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKT 187
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 11-176 1.60e-11

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 63.36  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   11 RQRLLRTVKKEVKQIMEEAV-TRKFVHEDSSHIISFCAAVEACVLHGLRRRAaGFLRSNKIAalfmkvgknFPPAEDLSR 89
Cdd:cd17681     2 RRNLLNLAKLSIKELIESALsFGRTLDSDHVPLQQFFVILEHVLRHGLKVKK-SFLGPNKSF---------WPVLEHVEK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   90 KVQDLEQLIESARNqiqglqenvrklpkLPNL-SPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPv 165
Cdd:cd17681    72 LVPEANEITASVRD--------------LPGIkTPLGRARAWLRLALMQKKLADYFRALIENKdllSEFYEPGALMMSE- 136

                         170
                  ....*....|.
gi 148612875  166 DGPILASLLVG 176
Cdd:cd17681   137 EAVVIAGLLVG 147
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 260-366 3.26e-11

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 60.49  E-value: 3.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875  260 KNNVLVQPRDDMEAVPGYLSLHQtadvMTLKWTPNQLMngsvgdldyeksvywDYAMTIRLEEIVYLHCHQQVDSGGTVV 339
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITS----DRLILRDKNDG---------------GLELSIPISDIVNVNVSPQGPSSRYLV 62

                          90       100
                  ....*....|....*....|....*..
gi 148612875  340 LVSQDGIQRPPFRFPKGGHLLQFLSCL 366
Cdd:cd00900    63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 11-176 3.38e-08

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 53.83  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   11 RQRLLRTVKKEVKQIMEEAVT-RKFVHEDSSHIISFCAAVEACVLHGLRRRAAgFLRSNK-IAALFMKVGKNFPPAEDLS 88
Cdd:cd17695     2 RANLLNMAKLSIKGLIESALSfGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKS-FLSYNKtIWGPLELVEKLCPEAEEIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   89 RKVQDLEqliesarnqiqGLQenvrklpklpnlSPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPv 165
Cdd:cd17695    81 ASVRDLP-----------GLK------------TPLGRARAWLRLALMQKKLADYLRCLIIRRdllSEFYEYHALMMEE- 136

                         170
                  ....*....|.
gi 148612875  166 DGPILASLLVG 176
Cdd:cd17695   137 EGAVIVGLLVG 147
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
 11-176 5.23e-06

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 47.68  E-value: 5.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   11 RQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAgFLRSNKiaalfmkvgKNFPPAEdlsr 89
Cdd:cd17696     2 RMNLMNMAKLSIKGLIESALNLgRTLDSDYAPLQQFFVVMEHCLKHGLKAKKT-FLGQNK---------SFWGPLE---- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   90 kvqdleqLIESARNQIQGLQENVRKLPKLPnlSPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPvD 166
Cdd:cd17696    68 -------LVEKLVPEAAEITASVKDLPGLK--TPVGRGRAWLRLALMQKKLSEYMKALINRKdllSEFYEPNALMMEE-E 137

                         170
                  ....*....|
gi 148612875  167 GPILASLLVG 176
Cdd:cd17696   138 GAIIAGLLVG 147
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 37-174 7.97e-06

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 46.84  E-value: 7.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   37 EDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNfppaedLSRKVQDLEQLIESARNQ--IQGLQENVRk 114
Cdd:cd17682    19 PDNPYLRPFCETLEKILRKGLKEKVSLGGRRKDYWDWLEELLKK------LNKIPKSLSDAVKFVKSCkkVKTNQGRGR- 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148612875  115 lpklpnlsplaikhLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLL 174
Cdd:cd17682    92 --------------LFIRYALNKKCLHDPVQQLVKNPkllSDYYSPDSILGNEILSEILLSLL 140
RUN_RUFY1 cd17694
RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; ...
 11-176 1.02e-05

RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439056  Cd Length: 156  Bit Score: 46.82  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   11 RQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAgFLRSNKiaalfmkvgKNFPPAEdlsr 89
Cdd:cd17694     2 RANLMNMMKLSIKVLIQSALSLgRTLDSDYPPLQQFFVVLEHCLKHGLKVKKS-FIGQNK---------SFFGPLE---- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   90 kvqdleqLIESARNQIQGLQENVRKLPKLPnlSPLAIKHLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPvD 166
Cdd:cd17694    68 -------LVEKLCPEASDIATSARNLPELK--TAVGRGRAWLHLALMQKKLADYLKVLIDRKdllSEFYEPGALMMEE-E 137

                         170
                  ....*....|
gi 148612875  167 GPILASLLVG 176
Cdd:cd17694   138 GAVIVGLLVG 147
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 37-176 7.19e-05

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 44.53  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   37 EDSSHIISFCAAVEACVLHGLRRraagflrSNKIAALFMKVGKNFPPAEDLSRKVQDL-------EQLIESARNQIQGLq 109
Cdd:cd17689    22 ESDSRVSCLCAQLEAVLQHGLKT-------SRSPNLVSSAVTQVSGLAGSLGSAETEPtfwpfvkEHLTKHELERFELL- 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148612875  110 envrklpklpnlsplaiKHL---------WIRTALFEKVLDKIVHYLVENSS---KYYEKEALLMDPVDGPILASLLVG 176
Cdd:cd17689    94 -----------------KNIwtdigrgraWLRSALNEHSLERYLHILLSNENllrQYYEDWAFLRDEERSSMLPNMAAG 155
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
 11-176 6.49e-04

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 41.81  E-value: 6.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   11 RQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHI-ISFCAAVEACVLHGLRrraagflrsnkiAALFMKVGKNFppaedlSR 89
Cdd:cd17679     1 KKSLTKELSSSVKELQLEYVSSDEVVTSSDDGaNTLCCVLEAIFLHGLK------------DKFISKVSSVF------SG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612875   90 KVQDLEQ-------LIESARNQIQglQenvrklpklpnlsplaIKHL------------WIRTALFEKVLDkivHYLV-- 148
Cdd:cd17679    63 DVDKLPEpnfwpllLKFSHRDVID--Q----------------IEHLsqittdvgrcraWIRLALNDGLLE---SYLEai 121

                         170       180       190
                  ....*....|....*....|....*....|..
gi 148612875  149 --ENS--SKYYEKEALLMDPVDGPILASLLVG 176
Cdd:cd17679   122 lkDKSalKSYYNPSAFLRDPEQLDILKSLLQG 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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