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Conserved domains on  [gi|153792772|ref|NP_001093249|]
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pyruvate kinase PKLR isoform 2 [Mus musculus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 788.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 453 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792772 533 YTNIMRVLTI 542
Cdd:cd00288  471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 788.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 453 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792772 533 YTNIMRVLTI 542
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 663.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772   55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  135 VLQGGPeseVEIVKGSQVLVTVDPKFRTrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  454 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 153792772  533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 630.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDE 294
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 375 GETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 454
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 455 RYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 153792772 534 TNIMRVLTI 542
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 597.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772   54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  134 GVLQGGPeSEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 153792772  373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 530.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGPeseVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 293
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSAQL 452
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792772 453 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAVWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 788.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 453 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 153792772 533 YTNIMRVLTI 542
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 663.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772   55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  135 VLQGGPeseVEIVKGSQVLVTVDPKFRTrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  454 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 153792772  533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 630.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDE 294
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 375 GETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 454
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 455 RYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 153792772 534 TNIMRVLTI 542
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 597.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772   54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  134 GVLQGGPeSEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 153792772  373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 530.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGPeseVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG-IKIISKIENHEGVKKFD 293
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSAQL 452
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792772 453 LSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAVWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 57-524 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 521.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfaTSPLSyrpvAIALDTKGPEIRTGVL 136
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN--TGILC----AVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 137 Q-GGPeseVEIVKGSQVLVTVDpkFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVT-EVEHGG 213
Cdd:PLN02461  97 KdGKP---VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEaGTVRcRCENSA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 214 FLGNRKGVNLPNAEVDLPGLSEQDLLD-LRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKF 292
Cdd:PLN02461 172 MLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNF 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 373 LSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 453 LSRYRPRAAVIAV------TRSAQ-------AARQVHLSRGVFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGD 519
Cdd:PLN02461 412 VAKYRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGD 491


                 ....*
gi 153792772 520 LVIVV 524
Cdd:PLN02461 492 SVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
55-539 7.87e-171

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 491.49  E-value: 7.87e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplSYRPVAIALDTKGPEIRTG 134
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSK------TGKKAAILLDTKGPEIRTM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGpeSEVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGF 214
Cdd:PRK09206  76 KLEGG--NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 215 LGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPE-GRGIKIISKIENHEGVKKFD 293
Cdd:PRK09206 152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRqlFEELRRAAPLsrDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSR--LESNNDNRKL--RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 454 SRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPpeavwaDDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 533
Cdd:PRK09206 388 RKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI------ASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGT 461


                 ....*.
gi 153792772 534 TNIMRV 539
Cdd:PRK09206 462 TNTASV 467
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 81-543 1.22e-168

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 485.32  E-value: 1.22e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  81 MNIARLNFSHGSHEYHAESIANIREAAESFATSplsyrpVAIALDTKGPEIRTGVLQGGpesEVEIVKGSQVLVTVDPKF 160
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 161 RTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPE-GLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLL 239
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 240 DLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVF 319
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 320 LAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEA 399
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 400 AVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSR 479
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 153792772 480 GVFPLLYrePPEAVWADD-VDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLTIS 543
Cdd:PTZ00300 392 GVESVFF--DAERLGHDEgKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PRK06354 PRK06354
pyruvate kinase; Provisional
 55-543 1.22e-168

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 490.21  E-value: 1.22e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLG------KTVGILQDLQGPKIRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 135 VLQGGPeseVEIVKGSQVLVTVDPKfrtRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEG--LVTEVEHG 212
Cdd:PRK06354  82 RFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 213 GFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPE-GRGIKIISKIENHEGVKK 291
Cdd:PRK06354 156 GVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCI 371
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 372 MLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplsrDPTEVTAIG-AV-EASFKCCAAAIIVLTKTGRS 449
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF-----TTTITNAISqAVsHIALQLDAAAIVTLTKSGAT 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 450 AQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAvwaddvDRRVQFGIESGKLRGFLRVGDLVIVVTGWRP 529
Cdd:PRK06354 391 ARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPST------DETFDAAINVAQESGLLKQGDLVVITAGTLV 464

                        490
                 ....*....|....*
gi 153792772 530 G-SGYTNIMRVLTIS 543
Cdd:PRK06354 465 GeSGSTDLMKVHVVG 479
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 32-542 2.01e-166

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 481.95  E-value: 2.01e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  32 AAMADTFLEHLCL-LDIDSEPVA-----ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIRE 105
Cdd:PTZ00066   9 SVMGCSLGKATNIsLDKILEPISdndlrQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 106 AAESfatsplsyRP---VAIALDTKGPEIRTGVLQGGpeSEVEIVKGSQVLVTVDPKFRtrGDAKTVWVDYHNITQVVAV 182
Cdd:PTZ00066  89 AAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 183 GGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLD-LRFGVEHNVDIIFASFVRKAS 261
Cdd:PTZ00066 157 GNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSAD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 262 DVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQ 341
Cdd:PTZ00066 237 DVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQ 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 342 MLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPT 421
Cdd:PTZ00066 317 MLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQ 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 422 EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRR 501
Cdd:PTZ00066 397 EAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS------FQGTDVV 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 153792772 502 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVLTI 542
Cdd:PTZ00066 471 IRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
PRK06247 PRK06247
pyruvate kinase; Provisional
 54-543 1.42e-136

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 404.31  E-value: 1.42e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETG------RPIGILADLQGPKLRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 134 GVLQGGPeseVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGG 213
Cdd:PRK06247  78 GRFADGK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 214 FLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDAlgpEGRGIKIISKIENHEGVKKFD 293
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 374 SGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEelrraapLSRDPTEVTAIGAVEASFKCCA-----AAIIVLTKTGR 448
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLIH-------AQRPQPEATKRDAISYAARDIAerldlAALVAYTSSGD 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 449 SAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLyrePPEAVWADDVDRRVQfgiESGKLRGFLRVGDLVIVVTGWR 528
Cdd:PRK06247 382 TALRAARERPPLPILALTPNPETARRLALTWGVHCVV---VDDARDTDDMVRRAD---RIALAEGFYKRGDRVVIVAGVP 455

                        490
                 ....*....|....*.
gi 153792772 529 PG-SGYTNIMRVLTIS 543
Cdd:PRK06247 456 PGtPGSTNMLRIAYIG 471
PLN02765 PLN02765
pyruvate kinase
 57-523 9.63e-109

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 334.72  E-value: 9.63e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplSYRPVAIALDTKGPEIrtGVL 136
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPEL--QVI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 137 QGgPESEVEIVKGSQVLVTVDPKfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLIS--------LVVRKIGPEGLVTE 208
Cdd:PLN02765 102 NK-TEKPISLKAGNTVTLTPDQS--KEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 209 VEHGGFL-GNRKGVNLPNAEVDLPGLSEQDLLDLR-FGVEHNVDIIFASFVRKASDVVAVRDALGPEG-RGIKIISKIEN 285
Cdd:PLN02765 179 VKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIEN 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 286 HEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVcATQMLESMITKARPTRAETSDVANAVL 365
Cdd:PLN02765 259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVL 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 366 DGADCIMLSGETAKGSFPVEAVKMQHAIAREAEaAVYHRQLFeeLRRAAPLSRDP---TEVTAIGAVEASFKCCAAAIIV 442
Cdd:PLN02765 338 DGADAILLGAETLRGLYPVETISTVGRICAEAE-KVFNQDLY--FKKTVKYVGEPmshLESIASSAVRAAIKVKASVIIV 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 443 LTKTGRSAQLLSRYRPRAAVIAVT-------------RSAQAARQVHLSRGVFPLLY--REPPEAVWADDvDRRVQFGIE 507
Cdd:PLN02765 415 FTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLAdpRHSAESTSATN-ESVLKVALD 493

                        490
                 ....*....|....*.
gi 153792772 508 SGKLRGFLRVGDLVIV 523
Cdd:PLN02765 494 HGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 49-538 8.01e-98

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 308.01  E-value: 8.01e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  49 SEPVAARSTSIIATIGPASRSvdrlKEMI----KAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPlsyrpVAIAL 124
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNT----REMIwklaEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV-----IAIML 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 125 DTKGPEIRTGVLqggPESeVEIVKGSQVLVTVDpkfRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEG 204
Cdd:PLN02623 175 DTKGPEVRSGDL---PQP-IMLEEGQEFTFTIK---RGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDS 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 205 LVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIE 284
Cdd:PLN02623 248 VKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIE 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 285 NHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAV 364
Cdd:PLN02623 328 SADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAV 407

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 365 LDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAplsrdPTEVTAIGAVEASF--KCCAAAIIV 442
Cdd:PLN02623 408 REGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAF-----KNHMSEMFAFHATMmaNTLGTSIIV 482

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 443 LTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPlLYREppeavWADDVDRRVQFGIESGKLRGFLRVGDLVI 522
Cdd:PLN02623 483 FTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-----FSDDAEETFARALSLLLNKGMVKEGEEVA 556

                        490
                 ....*....|....*.
gi 153792772 523 VVTgwrpgSGYTNIMR 538
Cdd:PLN02623 557 LVQ-----SGRQPIWR 567
PRK06739 PRK06739
pyruvate kinase; Validated
 60-398 2.73e-92

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 286.46  E-value: 2.73e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  60 IATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESfatsplsyrpVAIALDTKGPEIRTGVLQGg 139
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 140 peSEVEIVKGSQVLVTVDPkfrTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRK 219
Cdd:PRK06739  75 --EQITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 220 GVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGR-GIKIISKIENHEGVKKFDEILEV 298
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKEtSPNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 299 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETA 378
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 153792772 379 KGSFPVEAVKMQHAIAREAE 398
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 54-543 1.26e-90

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 287.03  E-value: 1.26e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIRE--AAESFAtsplsyrpVAIALDTKGPEI 131
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA--------VAVMMDTEGSEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 132 RTGVLQGGPESEVEivKGSQVLVTVDpKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISL-VVRKIGPE------- 203
Cdd:PLN02762  96 HMGDLGGASSAKAE--DGEEWTFTVR-KFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPDvkckctd 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 204 -GLVTEVEHGGFLGNRKGVNLPNAEvdLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRG--IKII 280
Cdd:PLN02762 173 pGLLLPRANLTFWRDGSLVRERNAM--LPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVI 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 281 SKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV 360
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 361 ANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRR---AAPLSRDPTEVTAIGAVEASFKCCA 437
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGV 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 438 AAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYReppeavWADDVDRRVQFGIESGKLRGFLRV 517
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD------FSDDMESNLNKTFSLLKARGMIKS 484

                        490       500
                 ....*....|....*....|....*.
gi 153792772 518 GDLVIVVTGWRPGSGYTNImRVLTIS 543
Cdd:PLN02762 485 GDLVIAVSDLTPSSMLQSI-QVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 50-387 2.72e-55

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 193.69  E-value: 2.72e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  50 EPVAARSTSIIATI-GPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAEsfATSplsyRPVAIALDTKG 128
Cdd:PRK08187 128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAER--ATG----RRCKILMDLAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 129 PEIRTGVLqGGPESEVEIVKGSQVLVTVDPKF-RTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVT 207
Cdd:PRK08187 202 PKIRTGAV-AGPLGKTRLYTGDRLALVAQGPPrRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 208 EVEHGGFLGNR----KGVNLPNAEVDLPGLSEQDLLDLRFGVEHnVDIIFASFVRKASDVVAVRDAL---GPEGRG-IKI 279
Cdd:PRK08187 281 EVTHARPKGLKlkpeKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALaarRPDDWRkLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 280 ISKIENHEGVKKFDEILEVSDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTR 354
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350
                 ....*....|....*....|....*....|...
gi 153792772 355 AETSDVANAvlDGADCIMLSgetaKGSFPVEAV 387
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 26-412 7.76e-44

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 164.35  E-value: 7.76e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  26 QQQQLPAAMADTFLEHLCLLDIDSE-----PVAARSTSIIATIgPASRSVDR--LKEMIKAGMNIARLNFSHGSHEYHAE 98
Cdd:PRK14725 105 GPAYPPEDTAVTFEEGDELLDEHAEallgpPPSGRPTRIMVTL-PTEAADDPdlVRRLLAAGMDIARINCAHDDPEAWRA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  99 SIANIREAAESFAtsplsyRPVAIALDTKGPEIRTGVLQGGPE-----------------SEVEIVKGS---------QV 152
Cdd:PRK14725 184 MIANVRTAEEELG------RRCRIAMDLAGPKLRTGPIAPGPRviklrptrdalgrvltpARLWLTASEspppspppgPV 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 153 LVTVDPKF-------------RTRGDAK--------------------------TVWVDYHNITQV-------------- 179
Cdd:PRK14725 258 GLPVDPEWlarlepgdelrftDARGKKRkltvtevddegvlaegsqtaylangtLLRLGRHDSTRVgglppveqklrlkv 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 180 -----------------------------------VAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNR----KG 220
Cdd:PRK14725 338 gdrlvltrddapgdpaqgdapparisctlpeafraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKG 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 221 VNLPNAEVDLPGLSEQDLLDLRFGVEHnVDIIFASFVRKASDVVAVRDALGPEG-RGIKIISKIENHEGVKKFDEIL--- 296
Cdd:PRK14725 418 INLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGaDDLGVVLKIETRRAFENLPRILlea 496

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 297 --EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLdgADCIMLS 374
Cdd:PRK14725 497 mrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN 574

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 153792772 375 getaKGSFPVEAVKMQHAIAREAEAavYHRQLFEELRR 412
Cdd:PRK14725 575 ----KGPHIVEAVRVLDDILRRMEE--HQRKKRSLLRR 606
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
328-543 7.99e-40

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 147.35  E-value: 7.99e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 328 RCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRqlf 407
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYR--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772 408 eELRRAAPLSRDPTEVTAIG------AVEASfkccAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGV 481
Cdd:COG3848   78 -EQRVPRAKESSTTITDAIShavattAADLG----AAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153792772 482 FPLLYREPPEAVwaDDVDRRVQFGIESgklrGFLRVGDLVIVVTGWRPG-SGYTNIMRVLTIS 543
Cdd:COG3848  153 YPLLVEESASTD--EMFAVAVALALEA----GLVKDGDLVVITAGVPVGvSGTTNLLKVHVVG 209
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 422-540 7.41e-35

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 126.83  E-value: 7.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792772  422 EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeavwADDVDRR 501
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 153792772  502 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVL 540
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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