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Conserved domains on  [gi|154354968|ref|NP_001093634|]
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phosphatase and actin regulator 2 isoform 1 [Homo sapiens]

Protein Classification

RPEL repeat-containing protein( domain architecture ID 10499653)

RPEL repeat-containing protein such as Phactrs 1-4, a family of protein phosphatase 1 and actin regulatory proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
527-551 8.26e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 8.26e-06
                           10        20
                   ....*....|....*....|....*
gi 154354968   527 KLVRRLSQRPTTEELEQRNILKQKN 551
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 73-94 1.59e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 38.79  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|..
gi 154354968   73 LERKISTRQSREELIRRGVLKE 94
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
564-589 2.00e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 38.61  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   564 RRLSRKLSLRPTVAELQARRILRFNE 589
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
488-513 3.97e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.97e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   488 DTLAIKLGNRPSKKELEDKNILQRTS 513
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
527-551 8.26e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 8.26e-06
                           10        20
                   ....*....|....*....|....*
gi 154354968   527 KLVRRLSQRPTTEELEQRNILKQKN 551
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 527-548 9.67e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 9.67e-05
                          10        20
                  ....*....|....*....|..
gi 154354968  527 KLVRRLSQRPTTEELEQRNILK 548
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 73-94 1.59e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 38.79  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|..
gi 154354968   73 LERKISTRQSREELIRRGVLKE 94
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
564-589 2.00e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 38.61  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   564 RRLSRKLSLRPTVAELQARRILRFNE 589
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
71-96 3.23e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 38.23  E-value: 3.23e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968    71 AVLERKISTRQSREELIRRGVLKELP 96
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
488-513 3.97e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.97e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   488 DTLAIKLGNRPSKKELEDKNILQRTS 513
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
527-551 8.26e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 8.26e-06
                           10        20
                   ....*....|....*....|....*
gi 154354968   527 KLVRRLSQRPTTEELEQRNILKQKN 551
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 527-548 9.67e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 9.67e-05
                          10        20
                  ....*....|....*....|..
gi 154354968  527 KLVRRLSQRPTTEELEQRNILK 548
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 73-94 1.59e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 38.79  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|..
gi 154354968   73 LERKISTRQSREELIRRGVLKE 94
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
564-589 2.00e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 38.61  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   564 RRLSRKLSLRPTVAELQARRILRFNE 589
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
71-96 3.23e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 38.23  E-value: 3.23e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968    71 AVLERKISTRQSREELIRRGVLKELP 96
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
488-513 3.97e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.97e-04
                           10        20
                   ....*....|....*....|....*.
gi 154354968   488 DTLAIKLGNRPSKKELEDKNILQRTS 513
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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