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Conserved domains on  [gi|201025393|ref|NP_001094226|]
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tetratricopeptide repeat protein 7A [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC7_N super family cl44857
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 5.17e-143

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


The actual alignment was detected with superfamily member pfam19440:

Pssm-ID: 466084  Cd Length: 386  Bit Score: 428.04  E-value: 5.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   11 LKVESEMERCRAEGQWDRMFQLVRHLqvlgisgggssnrrssPSGRfisLDTDDFGKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   91 pllEKTDSRLNEARDHLSSILNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVEDKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSL-SVDYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPpSQEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFM----SKEENSFITQTL 325
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLldepLKGTNTKNYTPS 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 201025393  326 RKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQEEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 308 RKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 3.64e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 95.83  E-value: 3.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLIL 789
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 790 SRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVL 849
Cdd:COG3914  157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 498-843 1.34e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 55.38  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  498 YSLQATDATLKSKQDELHRKALQTLERALELAPDDpqiIFYVSLQLA--LVRQISSAIERLQEALTVCRDDANALHLLAL 575
Cdd:TIGR00990 126 YAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDP---VYYSNRAAChnALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  576 LFSAQKHHQHAL----------DVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQALYNFSQLGGLEK 645
Cdd:TIGR00990 203 AYDGLGKYADALldltasciidGFRNEQSAQAVERLLKKFAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLED 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  646 DGSFEGLTVKKQNGIHLTLPDAhDADSGSRRASSIAASRLE-------EAMS-ELTITTSVLKQGP----------MQLW 707
Cdd:TIGR00990 283 SNELDEETGNGQLQLGLKSPES-KADESYEEAARAFEKALDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELD 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  708 TTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGL 787
Cdd:TIGR00990 362 PRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGV 441

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393  788 ILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:TIGR00990 442 TQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELE 497
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 378-473 5.68e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 5.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 378 QNASAiYDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAK 457
Cdd:COG4783   36 DNPEA-FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                         90
                 ....*....|....*.
gi 201025393 458 VCIGSLHWLEEAEHFA 473
Cdd:COG4783  115 AYRALGRPDEAIAALE 130
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 5.17e-143

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 428.04  E-value: 5.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   11 LKVESEMERCRAEGQWDRMFQLVRHLqvlgisgggssnrrssPSGRfisLDTDDFGKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   91 pllEKTDSRLNEARDHLSSILNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVEDKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSL-SVDYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPpSQEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFM----SKEENSFITQTL 325
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLldepLKGTNTKNYTPS 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 201025393  326 RKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQEEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 308 RKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 3.64e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 95.83  E-value: 3.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLIL 789
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 790 SRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVL 849
Cdd:COG3914  157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 498-843 1.34e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 55.38  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  498 YSLQATDATLKSKQDELHRKALQTLERALELAPDDpqiIFYVSLQLA--LVRQISSAIERLQEALTVCRDDANALHLLAL 575
Cdd:TIGR00990 126 YAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDP---VYYSNRAAChnALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  576 LFSAQKHHQHAL----------DVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQALYNFSQLGGLEK 645
Cdd:TIGR00990 203 AYDGLGKYADALldltasciidGFRNEQSAQAVERLLKKFAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLED 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  646 DGSFEGLTVKKQNGIHLTLPDAhDADSGSRRASSIAASRLE-------EAMS-ELTITTSVLKQGP----------MQLW 707
Cdd:TIGR00990 283 SNELDEETGNGQLQLGLKSPES-KADESYEEAARAFEKALDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELD 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  708 TTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGL 787
Cdd:TIGR00990 362 PRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGV 441

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393  788 ILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:TIGR00990 442 TQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELE 497
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 461-630 2.65e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 461 GSLHWLEEAEHFAMVVIGLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDelHRKALQTLERALELAPDDPQIIFYVS 540
Cdd:COG3914   42 GLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR--YEEALALYRRALALNPDNAEALFNLG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 541 LQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEA 620
Cdd:COG3914  120 NLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEA 199

                        170
                 ....*....|
gi 201025393 621 LVTCRQMLRL 630
Cdd:COG3914  200 IAAYRRALEL 209
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 715-840 3.43e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  715 LQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGH 794
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGE 242

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 201025393  795 KSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTAL 840
Cdd:TIGR02917 243 FEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDAL 288
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 378-473 5.68e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 5.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 378 QNASAiYDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAK 457
Cdd:COG4783   36 DNPEA-FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                         90
                 ....*....|....*.
gi 201025393 458 VCIGSLHWLEEAEHFA 473
Cdd:COG4783  115 AYRALGRPDEAIAALE 130
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 379-566 1.95e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 379 NASAIYDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVplmaakv 458
Cdd:COG3914  110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA------- 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 459 cigslhwleeaehfamvviglgeeageflpkgYLALGLTYSLQAtdatlkskqdeLHRKALQTLERALELAPDDPQIIFY 538
Cdd:COG3914  183 --------------------------------LNNLGNALQDLG-----------RLEEAIAAYRRALELDPDNADAHSN 219

                        170       180
                 ....*....|....*....|....*...
gi 201025393 539 VsLQLALVRQISSAIERLQEALTVCRDD 566
Cdd:COG3914  220 L-LFALRQACDWEVYDRFEELLAALARG 246
YPP1 cd23270
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
 485-554 4.61e-03

cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).


Pssm-ID: 438014 [Multi-domain]  Cd Length: 740  Bit Score: 40.72  E-value: 4.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 201025393 485 EFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERALELAPD-DPQIIFYVSLQLALVRQISSAIE 554
Cdd:cd23270  391 KILSKAWYALYEYYSYLLIYTSNESELELNSNDLLSYLKNSLIVNPTgNSDLLFQYAYTLAQQREIEPAIK 461
TPR_20 pfam14561
Tetratricopeptide repeat;
519-556 6.73e-03

Tetratricopeptide repeat;


Pssm-ID: 434039 [Multi-domain]  Cd Length: 90  Bit Score: 36.72  E-value: 6.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 201025393  519 LQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERL 556
Cdd:pfam14561   8 LAALEARLAADPDDLDARLDLALALHAAGRNEEALELL 45
TPR_11 pfam13414
TPR repeat;
758-793 7.33e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.14  E-value: 7.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 201025393  758 KGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLG 793
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 5.17e-143

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 428.04  E-value: 5.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   11 LKVESEMERCRAEGQWDRMFQLVRHLqvlgisgggssnrrssPSGRfisLDTDDFGKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393   91 pllEKTDSRLNEARDHLSSILNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVEDKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSL-SVDYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPpSQEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFM----SKEENSFITQTL 325
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLldepLKGTNTKNYTPS 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 201025393  326 RKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQEEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 308 RKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 3.64e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 95.83  E-value: 3.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLIL 789
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 790 SRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVL 849
Cdd:COG3914  157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-843 6.77e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.21  E-value: 6.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:COG0457   89 LGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 712-844 2.50e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 73.69  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEA 844
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-849 7.28e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.84  E-value: 7.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILS 790
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 201025393 791 RLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVL 849
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-847 2.31e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 73.87  E-value: 2.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLIL 789
Cdd:COG3914   43 LALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLL 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 201025393 790 SRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSP 847
Cdd:COG3914  123 LALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-844 2.62e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.42  E-value: 2.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG0457   43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEA 844
Cdd:COG0457  123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
740-847 7.01e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 7.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 740 LFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGL 819
Cdd:COG0457    3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                         90       100
                 ....*....|....*....|....*...
gi 201025393 820 GEVLQDQGHNEAAADCFLTALELEASSP 847
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPDDA 110
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 746-847 1.45e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 746 SVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQD 825
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100
                 ....*....|....*....|..
gi 201025393 826 QGHNEAAADCFLTALELEASSP 847
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHP 106
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-843 1.89e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.60  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILS 790
Cdd:COG2956   76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 201025393 791 RLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:COG2956  156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-841 1.05e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILS 790
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 201025393 791 RLGHKSLAQKVLRDAVERQSThHEAWQGLGEVLQDQGHNEAAADCFLTALE 841
Cdd:COG2956  224 KLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLR 273
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 729-842 6.32e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.79  E-value: 6.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 729 EAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVER 808
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 201025393 809 QSTHHEAWQGLGEVLQDQGHNEAAADCFLTALEL 842
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 758-843 1.19e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 60.74  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 758 KGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFL 837
Cdd:COG5010   67 LGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146


                 ....*.
gi 201025393 838 TALELE 843
Cdd:COG5010  147 RALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 714-842 2.89e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 714 WLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLG 793
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 201025393 794 HKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALEL 842
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 712-855 7.92e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.32  E-value: 7.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG3914  113 EALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQD 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPVL-PFSIIA 855
Cdd:COG3914  193 LGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELsPFALLY 257
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
758-845 2.91e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 54.79  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 758 KGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKvLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFL 837
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                 ....*...
gi 201025393 838 TALELEAS 845
Cdd:COG3063   84 RALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 712-847 4.51e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG2956   43 EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQ 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSP 847
Cdd:COG2956  123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA 178
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 749-847 6.56e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 6.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 749 YMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGH 828
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                         90
                 ....*....|....*....
gi 201025393 829 NEAAADCFLTALELEASSP 847
Cdd:COG2956   92 LDRAEELLEKLLELDPDDA 110
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-815 4.95e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.01  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG0457   77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156

                         90       100
                 ....*....|....*....|....
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEA 815
Cdd:COG0457  157 LGRYEEALELLEKLEAAALAALLA 180
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 712-817 5.76e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 5.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSR 791
Cdd:COG4235   18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQ 97

                         90       100
                 ....*....|....*....|....*.
gi 201025393 792 LGHKSLAQKVLRDAVERQSTHHEAWQ 817
Cdd:COG4235   98 QGDYAEAIAAWQKLLALLPADAPARL 123
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 498-843 1.34e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 55.38  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  498 YSLQATDATLKSKQDELHRKALQTLERALELAPDDpqiIFYVSLQLA--LVRQISSAIERLQEALTVCRDDANALHLLAL 575
Cdd:TIGR00990 126 YAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDP---VYYSNRAAChnALGDWEKVVEDTTAALELDPDYSKALNRRAN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  576 LFSAQKHHQHAL----------DVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQALYNFSQLGGLEK 645
Cdd:TIGR00990 203 AYDGLGKYADALldltasciidGFRNEQSAQAVERLLKKFAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLED 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  646 DGSFEGLTVKKQNGIHLTLPDAhDADSGSRRASSIAASRLE-------EAMS-ELTITTSVLKQGP----------MQLW 707
Cdd:TIGR00990 283 SNELDEETGNGQLQLGLKSPES-KADESYEEAARAFEKALDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELD 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  708 TTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGL 787
Cdd:TIGR00990 362 PRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGV 441

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393  788 ILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:TIGR00990 442 TQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELE 497
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
720-814 6.65e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 6.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 720 LFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQlYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQ 799
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|....*
gi 201025393 800 KVLRDAVERQSTHHE 814
Cdd:COG3063   80 AYLERALELDPSALR 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
772-843 2.53e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 2.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 201025393 772 LTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD 72
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 461-630 2.65e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 461 GSLHWLEEAEHFAMVVIGLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDelHRKALQTLERALELAPDDPQIIFYVS 540
Cdd:COG3914   42 GLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR--YEEALALYRRALALNPDNAEALFNLG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 541 LQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEA 620
Cdd:COG3914  120 NLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEA 199

                        170
                 ....*....|
gi 201025393 621 LVTCRQMLRL 630
Cdd:COG3914  200 IAAYRRALEL 209
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 393-851 2.90e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  393 RRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAKVCIGSLHWLEeaehf 472
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDE----- 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  473 AMVVIGLGEEAGEFLPKGYLALGLTYsLQATDATlkskqdelhrKALQTLERALELAPDDPQiifyVSLQLALVR----Q 548
Cdd:TIGR02917 348 AIATLSPALGLDPDDPAALSLLGEAY-LALGDFE----------KAAEYLAKATELDPENAA----ARTQLGISKlsqgD 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  549 ISSAIERLQEALTVcrDDANALHLLALLFSAQKHHQ--HALDVINMAITEHPEN---FNLMFTKVKLEQVLKGPEEALvt 623
Cdd:TIGR02917 413 PSEAIADLETAAQL--DPELGRADLLLILSYLRSGQfdKALAAAKKLEKKQPDNaslHNLLGAIYLGKGDLAKAREAF-- 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  624 cRQMLRLWQAlyNFSQLGGLEKdgsfegLTVKKQNgihltLPDAHD-------ADSGSRRA----SSIAASRLEEAMSel 692
Cdd:TIGR02917 489 -EKALSIEPD--FFPAAANLAR------IDIQEGN-----PDDAIQrfekvltIDPKNLRAilalAGLYLRTGNEEEA-- 552

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  693 titTSVLKQgPMQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEAL 772
Cdd:TIGR02917 553 ---VAWLEK-AAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL 628

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 201025393  773 TVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAadcFLTALELEASSPVLPF 851
Cdd:TIGR02917 629 ALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA---KKIAKSLQKQHPKAAL 704
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 418-630 7.31e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 7.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 418 WYQVALSMVACGKSAYAVSLLRECMKLQPSNPtvplmAAKVCIGSLHW----LEEAEHFAMVVIGLGEEAgeflPKGYLA 493
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETV-----EAHLALGNLYRrrgeYDRAIRIHQKLLERDPDR----AEALLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 494 LGLTYSLQatdatlkskqdELHRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLL 573
Cdd:COG2956   82 LAQDYLKA-----------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCEL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 201025393 574 ALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL 630
Cdd:COG2956  151 AELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
705-841 7.45e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.99  E-value: 7.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 705 QLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHS 784
Cdd:COG4785   67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 201025393 785 LGLILSRLGHKSLAQKVLRDAVERQSTHHEA--WQGL------------------GEVLQDQGHNEAAADCFLTALE 841
Cdd:COG4785  147 RGIALYYLGRYELAIADLEKALELDPNDPERalWLYLaerkldpekalallledwATAYLLQGDTEEARELFKLALA 223
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 711-843 8.78e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.61  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPT---------SHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCI 781
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEaaalaaalgLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 201025393 782 MHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELE 843
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN 142
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 393-629 1.70e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 393 RRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAKVCIGSLHWlEEAEHF 472
Cdd:COG2956   54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-EKAIEV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 473 AMVVIGLGEEAGEFlpkgYLALGLTYslqatdatLKSKQDElhrKALQTLERALELAPDDPqiifYVSLQLALV----RQ 548
Cdd:COG2956  133 LERLLKLGPENAHA----YCELAELY--------LEQGDYD---EAIEALEKALKLDPDCA----RALLLLAELyleqGD 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 549 ISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITEHPENfNLMFTKVKLEQVLKGPEEALVTCRQML 628
Cdd:COG2956  194 YEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALLERQL 272


                 .
gi 201025393 629 R 629
Cdd:COG2956  273 R 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 715-840 3.43e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  715 LQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGH 794
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGE 242

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 201025393  795 KSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTAL 840
Cdd:TIGR02917 243 FEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDAL 288
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
748-858 3.76e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 748 LYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQG 827
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLG 155

                         90       100       110
                 ....*....|....*....|....*....|.
gi 201025393 828 HNEAAADCFLTALELeasSPVLPFSIIAREL 858
Cdd:COG4785  156 RYELAIADLEKALEL---DPNDPERALWLYL 183
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
491-626 5.34e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 491 YLALGLTYSLQatdatlkskqdELHRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANAL 570
Cdd:COG0457   45 LYNLGLAYLRL-----------GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393 571 HLLALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQ 626
Cdd:COG0457  114 YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 515-630 7.84e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 515 HRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAI 594
Cdd:COG4783   20 YDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKAL 99

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 201025393 595 TEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL 630
Cdd:COG4783  100 KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 763-847 1.49e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 763 EAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALEL 842
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                 ....*
gi 201025393 843 EASSP 847
Cdd:COG4235   81 DPDNP 85
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 515-598 2.56e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 515 HRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAI 594
Cdd:COG5010   70 FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRAL 149


                 ....
gi 201025393 595 TEHP 598
Cdd:COG5010  150 GTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
515-640 5.07e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 515 HRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAI 594
Cdd:COG0457   24 YEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKAL 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 201025393 595 TEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL----WQALYNFSQL 640
Cdd:COG0457  104 ELDPDDAEALYNLGLALLELGRYDEAIEAYERALELdpddADALYNLGIA 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 378-473 5.68e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 5.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 378 QNASAiYDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAK 457
Cdd:COG4783   36 DNPEA-FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                         90
                 ....*....|....*.
gi 201025393 458 VCIGSLHWLEEAEHFA 473
Cdd:COG4783  115 AYRALGRPDEAIAALE 130
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 721-808 7.37e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 721 FMEQRQLKEAGFCIQEAAGLFPTSH---SVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCI---MHSLGLILSRLGH 794
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGD 82

                         90
                 ....*....|....
gi 201025393 795 KSLAQKVLRDAVER 808
Cdd:COG1729   83 YDKARATLEELIKK 96
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 507-833 9.38e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 9.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  507 LKSKQDElhrKALQTLERALELAPDDPQIIFYVslqlALVR----QISSAIERLQEALTVCRDDANALHLLALLFSAQKH 582
Cdd:TIGR02917 238 IEAGEFE---EAEKHADALLKKAPNSPLAHYLK----ALVDfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  583 HQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQALYNFSQLGGLekdgsfegltvkkqngIHL 662
Cdd:TIGR02917 311 LEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGE----------------AYL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  663 TLPDAHDA----DSGSRRASSIAASRLEEAMSEL-----TITTSVLKQGpMQLWTTLEQIWLQAAELFMEQRQLKEAGFC 733
Cdd:TIGR02917 375 ALGDFEKAaeylAKATELDPENAAARTQLGISKLsqgdpSEAIADLETA-AQLDPELGRADLLLILSYLRSGQFDKALAA 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  734 IQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHH 813
Cdd:TIGR02917 454 AKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNL 533

                         330       340
                  ....*....|....*....|
gi 201025393  814 EAWQGLGEVLQDQGHNEAAA 833
Cdd:TIGR02917 534 RAILALAGLYLRTGNEEEAV 553
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
384-560 1.10e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 384 YDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVPLMAAKVCIgSL 463
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ-AL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 464 HWLEEAEHFAMVVIGLGEEagefLPKGYLALGLTYSLQatdatlkskqdELHRKALQTLERALELAPDDPQIIFYVSLQL 543
Cdd:COG0457   90 GRYEEALEDYDKALELDPD----DAEALYNLGLALLEL-----------GRYDEAIEAYERALELDPDDADALYNLGIAL 154

                        170
                 ....*....|....*..
gi 201025393 544 ALVRQISSAIERLQEAL 560
Cdd:COG0457  155 EKLGRYEEALELLEKLE 171
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 488-612 1.91e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 488 PKGYLALGLTYSLQatdatlkskqdELHRKALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDA 567
Cdd:COG4235   17 AEGWLLLGRAYLRL-----------GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNP 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 201025393 568 NALHLLALLFSAQKHHQHALDVINMAITEHPENFNLMFTKVKLEQ 612
Cdd:COG4235   86 EALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 379-566 1.95e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 379 NASAIYDLLSITLGRRGQYVMLSECLERAMKYAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSNPTVplmaakv 458
Cdd:COG3914  110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA------- 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 459 cigslhwleeaehfamvviglgeeageflpkgYLALGLTYSLQAtdatlkskqdeLHRKALQTLERALELAPDDPQIIFY 538
Cdd:COG3914  183 --------------------------------LNNLGNALQDLG-----------RLEEAIAAYRRALELDPDNADAHSN 219

                        170       180
                 ....*....|....*....|....*...
gi 201025393 539 VsLQLALVRQISSAIERLQEALTVCRDD 566
Cdd:COG3914  220 L-LFALRQACDWEVYDRFEELLAALARG 246
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 787-848 2.02e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 2.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 201025393 787 LILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPV 848
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPN 123
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 488-639 2.23e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 488 PKGYLALGLTYSLQatdatlkskqdELHRKALQTLERALELAPDDPQIifYVSLQLALVRQ--ISSAIERLQEALTVCRD 565
Cdd:COG3914  112 AEALFNLGNLLLAL-----------GRLEEALAALRRALALNPDFAEA--YLNLGEALRRLgrLEEAIAALRRALELDPD 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 566 DANALHLLALLFSAQKHHQHALDVINMAITEHPENF----NLMFTKVKLE--QVLKGPEEALVTCRQMLRLWQALYNFSQ 639
Cdd:COG3914  179 NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNAdahsNLLFALRQACdwEVYDRFEELLAALARGPSELSPFALLYL 258
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 517-848 2.91e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  517 KALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITE 596
Cdd:TIGR02917 449 KALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTI 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  597 HPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL-WQALYNFSQLGG-LEKDGSF---EGLTVKKQNG------------ 659
Cdd:TIGR02917 529 DPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELnPQEIEPALALAQyYLGKGQLkkaLAILNEAADAapdspeawlmlg 608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  660 -IHLTLPDAHDADSGSRRASSIA---------ASRLEEAMSELTITTSVLKQGpMQLWTTLEQIWLQAAELFMEQRQLKE 729
Cdd:TIGR02917 609 rAQLAAGDLNKAVSSFKKLLALQpdsalalllLADAYAVMKNYAKAITSLKRA-LELKPDNTEAQIGLAQLLLAAKRTES 687

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  730 AGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHsLGLILSRLGHKSLAQKVLRDAVERQ 809
Cdd:TIGR02917 688 AKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTH 766

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 201025393  810 STHHEAWQGLGEVLQDQGHNEAAADCFLTALELEASSPV 848
Cdd:TIGR02917 767 PNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAV 805
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 517-600 3.91e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 517 KALQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAITE 596
Cdd:COG4783   56 EAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                 ....
gi 201025393 597 HPEN 600
Cdd:COG4783  136 DPDD 139
YPP1 cd23270
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
 485-554 4.61e-03

cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).


Pssm-ID: 438014 [Multi-domain]  Cd Length: 740  Bit Score: 40.72  E-value: 4.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 201025393 485 EFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERALELAPD-DPQIIFYVSLQLALVRQISSAIE 554
Cdd:cd23270  391 KILSKAWYALYEYYSYLLIYTSNESELELNSNDLLSYLKNSLIVNPTgNSDLLFQYAYTLAQQREIEPAIK 461
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 712-777 5.06e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 5.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPD 777
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 747-842 5.10e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  747 VLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQ 826
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSL 206

                          90
                  ....*....|....*.
gi 201025393  827 GHNEAAADCFLTALEL 842
Cdd:TIGR02917 207 GNIELALAAYRKAIAL 222
TPR_20 pfam14561
Tetratricopeptide repeat;
519-556 6.73e-03

Tetratricopeptide repeat;


Pssm-ID: 434039 [Multi-domain]  Cd Length: 90  Bit Score: 36.72  E-value: 6.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 201025393  519 LQTLERALELAPDDPQIIFYVSLQLALVRQISSAIERL 556
Cdd:pfam14561   8 LAALEARLAADPDDLDARLDLALALHAAGRNEEALELL 45
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 517-833 6.87e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  517 KALQTLERALELAPDDPQIIFYV-SLQLALvRQISSAIERLQEALTVCRDDANALHLLALLFSAQKHHQHALDVINMAIT 595
Cdd:TIGR02917 585 KALAILNEAADAAPDSPEAWLMLgRAQLAA-GDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  596 EHPENFNLMFTKVKLEQVLKGPEEALVTCRQMlrlwQALYNFSQLGglekdGSFEGLTVKKQNGIHLTLPDAHDADsgSR 675
Cdd:TIGR02917 664 LKPDNTEAQIGLAQLLLAAKRTESAKKIAKSL----QKQHPKAALG-----FELEGDLYLRQKDYPAAIQAYRKAL--KR 732

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  676 RASSIAASRLEEAMSELTIT-------TSVLKQGPMQLWTTLEQiwlqaAELFMEQRQLKEAGFCIQEAAGLFPTSHSVL 748
Cdd:TIGR02917 733 APSSQNAIKLHRALLASGNTaeavktlEAWLKTHPNDAVLRTAL-----AELYLAQKDYDKAIKHYQTVVKKAPDNAVVL 807

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393  749 ymrGRLAEV--KGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLGHKSLAQKVLRDAVERQSTHHEAWQGLGEVLQDQ 826
Cdd:TIGR02917 808 ---NNLAWLylELKDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLAT 884


                  ....*...
gi 201025393  827 G-HNEAAA 833
Cdd:TIGR02917 885 GrKAEARK 892
TPR_11 pfam13414
TPR repeat;
758-793 7.33e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.14  E-value: 7.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 201025393  758 KGSFEEAKQLYKEALTVNPDGVCIMHSLGLILSRLG 793
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 758-847 8.45e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 8.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 201025393 758 KGSFEEAKQLYKEALTVNPDGVCI---MHSLGLILSRLGHKSLAQKVLRDAVERQSTHH---EAWQGLGEVLQDQGHNEA 831
Cdd:COG1729    6 AGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKLGLSYLELGDYDK 85

                         90
                 ....*....|....*.
gi 201025393 832 AADCFLTALELEASSP 847
Cdd:COG1729   86 ARATLEELIKKYPDSE 101
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
712-777 8.75e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 8.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 201025393 712 QIWLQAAELFMEQRQLKEAgFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPD 777
Cdd:COG3063   27 DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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