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Conserved domains on  [gi|156523158|ref|NP_001095993|]
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major facilitator superfamily domain-containing protein 6-like [Bos taurus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
16-241 5.73e-33

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17479:

Pssm-ID: 452895 [Multi-domain]  Cd Length: 376  Bit Score: 124.73  E-value: 5.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  16 AKLFHLVCGVRDACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAGASL--- 92
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLlyh 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  93 ---FMVLV---------PPLDR-------------DPGDRRcnGSHS----LTAEGPPPGVELTVT-------------- 129
Cdd:cd17479   81 qifLLVLLviiiwellsAPLEKvaddslyeyldfvDATERY--GKLKvwsaLGAAFGPCGITLLVDnldcflppkisril 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 130 -----------------------VTLASEPASNSPAG------------------------------------------- 143
Cdd:cd17479  159 lhfytyggfmiltfllsffypipVPKKEEHSSKVVKGlrllggdgrailyaltvflvgfvgstvqnflfwlmqdkggsel 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 144 ------ALSLPGE-----------RSSGVAGT--LGFREGPGESAQEPFSYPPGS----------SVGSTQGTRNRSGVL 194
Cdd:cd17479  239 hmglsiALALLSEilmsffgnwllRKLGHAGCvvLGLLGLGAQLLYYSFLWTPWAvlpiellhafSNGALWWAVNSQVEF 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 156523158 195 LH-PGTERPLSAVFRAHVCGSGASLGSFVGGFVVMRFSLPVLYQACCV 241
Cdd:cd17479  319 LAsPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCV 366
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
16-241 5.73e-33

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 124.73  E-value: 5.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  16 AKLFHLVCGVRDACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAGASL--- 92
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLlyh 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  93 ---FMVLV---------PPLDR-------------DPGDRRcnGSHS----LTAEGPPPGVELTVT-------------- 129
Cdd:cd17479   81 qifLLVLLviiiwellsAPLEKvaddslyeyldfvDATERY--GKLKvwsaLGAAFGPCGITLLVDnldcflppkisril 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 130 -----------------------VTLASEPASNSPAG------------------------------------------- 143
Cdd:cd17479  159 lhfytyggfmiltfllsffypipVPKKEEHSSKVVKGlrllggdgrailyaltvflvgfvgstvqnflfwlmqdkggsel 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 144 ------ALSLPGE-----------RSSGVAGT--LGFREGPGESAQEPFSYPPGS----------SVGSTQGTRNRSGVL 194
Cdd:cd17479  239 hmglsiALALLSEilmsffgnwllRKLGHAGCvvLGLLGLGAQLLYYSFLWTPWAvlpiellhafSNGALWWAVNSQVEF 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 156523158 195 LH-PGTERPLSAVFRAHVCGSGASLGSFVGGFVVMRFSLPVLYQACCV 241
Cdd:cd17479  319 LAsPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCV 366
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
28-103 1.86e-04

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 42.62  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156523158   28 ACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAgASLFMVLVPPLDRD 103
Cdd:pfam12832  16 GCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAA-VLFLSVLFIPISLT 90
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
16-241 5.73e-33

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 124.73  E-value: 5.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  16 AKLFHLVCGVRDACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAGASL--- 92
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLlyh 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  93 ---FMVLV---------PPLDR-------------DPGDRRcnGSHS----LTAEGPPPGVELTVT-------------- 129
Cdd:cd17479   81 qifLLVLLviiiwellsAPLEKvaddslyeyldfvDATERY--GKLKvwsaLGAAFGPCGITLLVDnldcflppkisril 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 130 -----------------------VTLASEPASNSPAG------------------------------------------- 143
Cdd:cd17479  159 lhfytyggfmiltfllsffypipVPKKEEHSSKVVKGlrllggdgrailyaltvflvgfvgstvqnflfwlmqdkggsel 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158 144 ------ALSLPGE-----------RSSGVAGT--LGFREGPGESAQEPFSYPPGS----------SVGSTQGTRNRSGVL 194
Cdd:cd17479  239 hmglsiALALLSEilmsffgnwllRKLGHAGCvvLGLLGLGAQLLYYSFLWTPWAvlpiellhafSNGALWWAVNSQVEF 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 156523158 195 LH-PGTERPLSAVFRAHVCGSGASLGSFVGGFVVMRFSLPVLYQACCV 241
Cdd:cd17479  319 LAsPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCV 366
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
28-95 4.35e-07

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 50.66  E-value: 4.35e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  28 ACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSA--GASLFMV 95
Cdd:cd17335   14 GSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVlfFLSLFFV 83
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
16-100 5.58e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 5.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523158  16 AKLFHLVCGVRDACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAGASLFMV 95
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                 ....*
gi 156523158  96 LVPPL 100
Cdd:cd06174   81 APSFW 85
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
28-103 1.86e-04

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 42.62  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156523158   28 ACVTPFLTLYLRQLGLAAPWVGILMGTKHHIAASWAPFCAFLARSHQKRRVLMTASLLGSAgASLFMVLVPPLDRD 103
Cdd:pfam12832  16 GCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAA-VLFLSVLFIPISLT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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