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Conserved domains on  [gi|157427673|ref|NP_001098720|]
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neurexin 3 isoform 3 precursor [Homo sapiens]

Protein Classification

LamG and Syndecan domain-containing protein( domain architecture ID 10059597)

LamG and Syndecan domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
86-265 1.88e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  86 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 165
Cdd:cd00110    1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673 166 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 245
Cdd:cd00110   75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                        170       180
                 ....*....|....*....|
gi 157427673 246 GGKDKGRLFQGQLSGLYYDG 265
Cdd:cd00110  124 GGLPEDLKSPGLPVSPGFVG 143
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
385-441 1.44e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157427673  385 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 441
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
86-265 1.88e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  86 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 165
Cdd:cd00110    1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673 166 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 245
Cdd:cd00110   75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                        170       180
                 ....*....|....*....|
gi 157427673 246 GGKDKGRLFQGQLSGLYYDG 265
Cdd:cd00110  124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
117-265 3.16e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 3.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  117 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 196
Cdd:pfam02210   1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157427673  197 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 265
Cdd:pfam02210  79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
112-265 1.29e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 84.70  E-value: 1.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673   112 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673   192 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 261
Cdd:smart00282  80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                   ....
gi 157427673   262 YYDG 265
Cdd:smart00282 128 KVNG 131
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
385-441 1.44e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157427673  385 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 441
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
4.1m smart00294
putative band 4.1 homologues' binding motif;
405-423 1.65e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 35.58  E-value: 1.65e-03
                           10
                   ....*....|....*....
gi 157427673   405 MYKYRNRDEGSYQVDETRN 423
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
86-265 1.88e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  86 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 165
Cdd:cd00110    1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673 166 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 245
Cdd:cd00110   75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                        170       180
                 ....*....|....*....|
gi 157427673 246 GGKDKGRLFQGQLSGLYYDG 265
Cdd:cd00110  124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
117-265 3.16e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 3.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  117 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 196
Cdd:pfam02210   1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157427673  197 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 265
Cdd:pfam02210  79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
112-265 1.29e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 84.70  E-value: 1.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673   112 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673   192 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 261
Cdd:smart00282  80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                   ....
gi 157427673   262 YYDG 265
Cdd:smart00282 128 KVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
117-203 2.88e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.24  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427673  117 FSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEErTPVNDGKYHVVRFTRNGGNATLQVD-NWPVN 195
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTLSVDgEARPT 78

                  ....*...
gi 157427673  196 EHYPTGNT 203
Cdd:pfam00054  79 GESPLGAT 86
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
385-441 1.44e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157427673  385 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 441
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
4.1m smart00294
putative band 4.1 homologues' binding motif;
405-423 1.65e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 35.58  E-value: 1.65e-03
                           10
                   ....*....|....*....
gi 157427673   405 MYKYRNRDEGSYQVDETRN 423
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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