NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157786614|ref|NP_001099257|]
View 

major facilitator superfamily domain-containing protein 6-like [Rattus norvegicus]

Protein Classification

major facilitator superfamily domain-containing protein 6-like( domain architecture ID 13024730)

major facilitator superfamily domain-containing protein 6-like (MFSD6L)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-546 5.70e-122

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 365.09  E-value: 5.70e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  16 ARLFHLVCGVRDACVTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSLLGSAGASLLmv 95
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  96 lvppadrnlgnhfcngsskvattvlplvvtqtvtmtsaqgsvpnhwagapslpgsrhtraldtsgfpngsgktqertlrg 175
Cdd:cd17479      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 176 lqtylvgsvegvrttaqalnlvtsglrensqkgtsevsnanlsllpgsttlggpvnvsktqgdiqthnhtlkgSQWTVIL 255
Cdd:cd17479   79 -------------------------------------------------------------------------YHQIFLL 85

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 256 SFGFLVFWELLAAPLEQVADDSLYEYLDFVDAADRNKDLWVWRLLGISAGVCGIAALVEHLECFLVANGPQGVIYFYSYS 335
Cdd:cd17479   86 VLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPPKISRILLHFYTYG 165

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 336 LVSTLALAVSTAFPVPIDQQQRPSYKAIKALSLVRDDSRLILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVV 415
Cdd:cd17479  166 GFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIA 245

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 416 LGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRME 495
Cdd:cd17479  246 LALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGME 325

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157786614 496 RSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFL 546
Cdd:cd17479  326 RSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-546 5.70e-122

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 365.09  E-value: 5.70e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  16 ARLFHLVCGVRDACVTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSLLGSAGASLLmv 95
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  96 lvppadrnlgnhfcngsskvattvlplvvtqtvtmtsaqgsvpnhwagapslpgsrhtraldtsgfpngsgktqertlrg 175
Cdd:cd17479      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 176 lqtylvgsvegvrttaqalnlvtsglrensqkgtsevsnanlsllpgsttlggpvnvsktqgdiqthnhtlkgSQWTVIL 255
Cdd:cd17479   79 -------------------------------------------------------------------------YHQIFLL 85

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 256 SFGFLVFWELLAAPLEQVADDSLYEYLDFVDAADRNKDLWVWRLLGISAGVCGIAALVEHLECFLVANGPQGVIYFYSYS 335
Cdd:cd17479   86 VLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPPKISRILLHFYTYG 165

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 336 LVSTLALAVSTAFPVPIDQQQRPSYKAIKALSLVRDDSRLILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVV 415
Cdd:cd17479  166 GFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIA 245

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 416 LGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRME 495
Cdd:cd17479  246 LALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGME 325

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157786614 496 RSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFL 546
Cdd:cd17479  326 RSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 296-533 1.49e-15

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 78.44  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  296 VWRLLGISAGVCGIAALVEHLEcflVANGPqgVIYFYSYSLVSTLALAVSTAFPVPIDQQQRpsyKAIKALSLVRDDSRL 375
Cdd:pfam12832 132 LWGSVGFALSVFGLGALFDHYS---VGLLP--SVLFYLFAALMLLSLLLPLAPPEMEYESKG---GSKAVFWNLLKQPEV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  376 ILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYY 455
Cdd:pfam12832 204 IIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLY 283

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157786614  456 AFI-WSWWSVLPVQILSAISSGALWWAVGASIGDLASSRMERSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQA 533
Cdd:pfam12832 284 AFFvENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFRA 362
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
286-546 6.95e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 286 DAADRNKdLWVWRLLGISAGVCGIAALVEHLECFLVANGPQGV-IYFYSYSLVSTLALAVSTAF---PVPIDQQQRPSYK 361
Cdd:COG2211  141 DYEERTR-LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYrLTALIFAVLGLLAFLLTFFGtkeRPVPEEEKVSLKE 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 362 AIKALslVRDDSRLILLAFTVFWIGATTSTVQNFLFWhMKDH-GSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGV 440
Cdd:COG2211  220 SLKAL--LKNRPFLLLLLAYLLFFLALALVAALLLYY-FKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 441 LGLGLGCLALQMLYYAFI--WSWWSVLPVQILSAISSGALW---WAVGASIGDLASSRMER-------SLNTLFRGhlye 508
Cdd:COG2211  297 FIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILvlpWAMLADVVDYDEWKTGRrreglyfGIFTFAIK---- 372

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 157786614 509 SGCSLGSFVGGFVALRFG-VAVLYQACCVVLLLWLAVFL 546
Cdd:COG2211  373 LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFL 411
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-97 3.30e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 43.37  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614   1 MSPNPQwDVP----RALGVARLFHLVCGVRDACVTPFLTLYLRQLGVAAP-----WVGILMGTKHLIAACWTPFCAFLAR 71
Cdd:PRK09874   1 MSPCEN-DTPinwkRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHsalnmWSGLVFSITFLFSAIASPFWGGLAD 79

                         90       100
                 ....*....|....*....|....*.
gi 157786614  72 RYQKRRMFLTGSLlgsaGASLLMVLV 97
Cdd:PRK09874  80 RKGRKIMLLRSAL----GMGIVMVLM 101
 
Name Accession Description Interval E-value
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 16-546 5.70e-122

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 365.09  E-value: 5.70e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  16 ARLFHLVCGVRDACVTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSLLGSAGASLLmv 95
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  96 lvppadrnlgnhfcngsskvattvlplvvtqtvtmtsaqgsvpnhwagapslpgsrhtraldtsgfpngsgktqertlrg 175
Cdd:cd17479      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 176 lqtylvgsvegvrttaqalnlvtsglrensqkgtsevsnanlsllpgsttlggpvnvsktqgdiqthnhtlkgSQWTVIL 255
Cdd:cd17479   79 -------------------------------------------------------------------------YHQIFLL 85

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 256 SFGFLVFWELLAAPLEQVADDSLYEYLDFVDAADRNKDLWVWRLLGISAGVCGIAALVEHLECFLVANGPQGVIYFYSYS 335
Cdd:cd17479   86 VLLVIIIWELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNLDCFLPPKISRILLHFYTYG 165

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 336 LVSTLALAVSTAFPVPIDQQQRPSYKAIKALSLVRDDSRLILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVV 415
Cdd:cd17479  166 GFMILTFLLSFFYPIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIA 245

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 416 LGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRME 495
Cdd:cd17479  246 LALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGME 325

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157786614 496 RSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFL 546
Cdd:cd17479  326 RSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 328-549 5.96e-24

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 103.82  E-value: 5.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 328 VIYFYSYSLVSTLALAVSTAFPV-PIDQQQRPSYKAIKALSLvrdDSRLILLAFTVFWIGATTSTVQNFLFWHMKDHGSS 406
Cdd:cd17335  155 TIAFYVFAVLMLLALLLALKFPFrPKHPEPNENTGGLLALLR---NPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGS 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 407 DLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGASI 486
Cdd:cd17335  232 KTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYA 311

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157786614 487 GDLASSRMERSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFLSIQ 549
Cdd:cd17335  312 SAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 296-533 1.49e-15

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 78.44  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  296 VWRLLGISAGVCGIAALVEHLEcflVANGPqgVIYFYSYSLVSTLALAVSTAFPVPIDQQQRpsyKAIKALSLVRDDSRL 375
Cdd:pfam12832 132 LWGSVGFALSVFGLGALFDHYS---VGLLP--SVLFYLFAALMLLSLLLPLAPPEMEYESKG---GSKAVFWNLLKQPEV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  376 ILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYY 455
Cdd:pfam12832 204 IIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLY 283

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157786614  456 AFI-WSWWSVLPVQILSAISSGALWWAVGASIGDLASSRMERSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQA 533
Cdd:pfam12832 284 AFFvENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFRA 362
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 331-546 1.56e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 53.75  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 331 FYSYSLVSTLALAVST-----AFPVPIDQQQRPSYKAIKALSLVRDDSRLILL-AFTVFWIGATTSTVQNFLFWHMKDHG 404
Cdd:cd17489  146 HLGFAVLFIVAAVLALlalllVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPpALILFLASIAYGAISTFLPLYAAERG 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 405 SSDLVMGFSVVLGLLgeILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGA 484
Cdd:cd17489  226 ISNAGLFFTVYAIAL--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157786614 485 SIGDLA-SSRMERSLNTLFRGhlYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFL 546
Cdd:cd17489  304 LAVDLVpPHRRGAANGTFFIF--FDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 331-546 6.52e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 6.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 331 FYSYSLVSTLALAVSTAFP----VPIDQQQRPSYKAIKALSLVRDDSRLILLAFTVFWIGATTSTVQNFLFWHMKDH-GS 405
Cdd:cd17325  153 FLVCAALALLALVLALLLLpeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 406 SDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGAS 485
Cdd:cd17325  233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157786614 486 IGDLASSRMERSLNTLFRGhLYESGCSLGSFVGGFVALRFGVAVLYQACCVVLLLWLAVFL 546
Cdd:cd17325  313 LADIVPPEGRGTAMGLFNT-AFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 378-557 1.49e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.57  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 378 LAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAF 457
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 458 IWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRMERSLNTLFRGHLYeSGCSLGSFVGGFVALRFGVAVLYQACCVV 537
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIG-LGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170       180
                 ....*....|....*....|.
gi 157786614 538 LLL-WLAVFLSIQPRLPQEQR 557
Cdd:cd17325  160 ALLaLVLALLLLPEPRPPPNK 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-100 1.84e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  18 LFHLVCGVRDACVTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSLLGSAGASLLMVLV 97
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82


                 ...
gi 157786614  98 PPA 100
Cdd:cd06174   83 SFW 85
MFS_1 pfam07690
Major Facilitator Superfamily;
378-546 6.55e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 6.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  378 LAFTVFWIGATTSTVQNFLFWHM-KDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYA 456
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614  457 FIWSWWSVLPVQILSAISSGALWWAVGASIGDLAsSRMERSLNTLFRGHLYESGCSLGSFVGGFVALRFGVAVLYQACCV 536
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170
                  ....*....|
gi 157786614  537 VLLLWLAVFL 546
Cdd:pfam07690 160 LSLLAAVLLL 169
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
286-546 6.95e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 286 DAADRNKdLWVWRLLGISAGVCGIAALVEHLECFLVANGPQGV-IYFYSYSLVSTLALAVSTAF---PVPIDQQQRPSYK 361
Cdd:COG2211  141 DYEERTR-LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYrLTALIFAVLGLLAFLLTFFGtkeRPVPEEEKVSLKE 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 362 AIKALslVRDDSRLILLAFTVFWIGATTSTVQNFLFWhMKDH-GSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGV 440
Cdd:COG2211  220 SLKAL--LKNRPFLLLLLAYLLFFLALALVAALLLYY-FKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 441 LGLGLGCLALQMLYYAFI--WSWWSVLPVQILSAISSGALW---WAVGASIGDLASSRMER-------SLNTLFRGhlye 508
Cdd:COG2211  297 FIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILvlpWAMLADVVDYDEWKTGRrreglyfGIFTFAIK---- 372

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 157786614 509 SGCSLGSFVGGFVALRFG-VAVLYQACCVVLLLWLAVFL 546
Cdd:COG2211  373 LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFL 411
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-101 7.26e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 7.26e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157786614  28 ACVTPFLTLYLRQ-LGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSLLGSAGaSLLMVLVPPAD 101
Cdd:COG2211  245 ALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG-LLLLFFLGPGN 318
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
375-557 7.89e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 375 LILLAFTVFWIGATTSTVQNFLFWHMKDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLY 454
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 455 YAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRMERSLNTLFRGhLYESGCSLGSFVGGFVALRFGV-AVLYQA 533
Cdd:COG2814   92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGA-GLGLGPALGPLLGGLLADLFGWrWVFLVN 170

                        170       180
                 ....*....|....*....|....
gi 157786614 534 CCVVLLLWLAVFLSIQPRLPQEQR 557
Cdd:COG2814  171 AVLALLALLLLLRLLPESRPAARA 194
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 30-98 8.73e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 8.73e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157786614  30 VTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGsLLGSAGASLLMVLVP 98
Cdd:cd17325   15 IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG-LLLLAVSTLLFAFAT 82
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 375-559 2.35e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 375 LILLAFTVFWIGATTSTVQNFLfwhMKDHGSSDLVMGFSVVLGLLGEILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLY 454
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPAL---LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 455 YAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSRMERSLNTLFRGHLYESGcSLGSFVGGFVALR--FGVAVLYQ 532
Cdd:cd06174   78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGG-ILGPLLGGILASSlgFGWRAVFL 156

                        170       180
                 ....*....|....*....|....*..
gi 157786614 533 ACCVVLLLWLAVFLSIQPRLPQEQRIN 559
Cdd:cd06174  157 IAAALALLAAILLLLVVPDPPESARAK 183
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-97 3.30e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 43.37  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614   1 MSPNPQwDVP----RALGVARLFHLVCGVRDACVTPFLTLYLRQLGVAAP-----WVGILMGTKHLIAACWTPFCAFLAR 71
Cdd:PRK09874   1 MSPCEN-DTPinwkRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHsalnmWSGLVFSITFLFSAIASPFWGGLAD 79

                         90       100
                 ....*....|....*....|....*.
gi 157786614  72 RYQKRRMFLTGSLlgsaGASLLMVLV 97
Cdd:PRK09874  80 RKGRKIMLLRSAL----GMGIVMVLM 101
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 337-548 1.16e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 337 VSTLALAVSTAFPVP-IDQQQRPSYKAIKALSLVRDDSRLILLAFTVFWIGATTSTVQNFLFWHMKD--HGSSDLVMGFS 413
Cdd:cd17324  161 VLALLAALLLWRLLPsLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDvpGFSSSAIIGLL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614 414 VVLGLLGeILFHPFRTSLLRKLSRVGVLGLGLGCLALQMLYYAFIWSWWSVLPVQILSAISSGALWWAVGASIGDLASSR 493
Cdd:cd17324  241 LLFGVAG-VVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157786614 494 MER--SLNTLFrghlYESGCSLGSFVGGFVALRFGvavlYQACCVVLLLWLAVFLSI 548
Cdd:cd17324  320 RGLasSLYLAA----YNLGGALGAALGGLVLDHGG----WAGVGWVGAALLLLALLL 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-98 2.04e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786614   1 MSPNPQWDVPRALGVArLFHLVCGVRDACVTPFLTLYLRQLGVAAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFL 80
Cdd:COG2814    1 MPATPRRRWLALLALA-LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90
                 ....*....|....*...
gi 157786614  81 TGsLLGSAGASLLMVLVP 98
Cdd:COG2814   80 LG-LLLFALGSLLCALAP 96
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 30-98 8.85e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.78  E-value: 8.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157786614  30 VTPFLTLYLRQLGV-----AAPWVGILMGTKHLIAACWTPFCAFLARRYQKRRMFLTGSlLGSAGASLLMVLVP 98
Cdd:cd17391   15 IAPFLPLYIEQLGVtsgglVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRAS-LGMAIVIGLMAFVT 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH