leukocyte receptor cluster member 1 [Rattus norvegicus]
Protein Classification
CIR N-terminal domain-containing protein( domain architecture ID 10660961)
CIR N-terminal domain-containing protein such as CWC25 which is involved in pre-mRNA splicing as a component of the spliceosome, and CIR1 (corepressor interacting with RBPJ) which is a component of the Notch corepressor complex and the histone deacetylase complex, and plays a role in splicing regulation and in RBPJ-mediated repression of transcription
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Cir_N | smart01083 | N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ... |
8-44 | 5.73e-03 | ||
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex. : Pssm-ID: 198151 [Multi-domain] Cd Length: 37 Bit Score: 33.67 E-value: 5.73e-03
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| Name | Accession | Description | Interval | E-value | ||
| Cir_N | smart01083 | N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ... |
8-44 | 5.73e-03 | ||
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex. Pssm-ID: 198151 [Multi-domain] Cd Length: 37 Bit Score: 33.67 E-value: 5.73e-03
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| Name | Accession | Description | Interval | E-value | ||
| Cir_N | smart01083 | N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ... |
8-44 | 5.73e-03 | ||
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex. Pssm-ID: 198151 [Multi-domain] Cd Length: 37 Bit Score: 33.67 E-value: 5.73e-03
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