|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
1-745 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 818.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 1 MAGSSAEQGKGRRVQPQWSPPA--GTEPCRLRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILR 78
Cdd:PTZ00399 10 LAGLNGTGQVSKSRLPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 79 RVLRDYFQYDVFYCMNITDIDDKIIRRARQNYLfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqns 158
Cdd:PTZ00399 90 RILEDYFGYDVFYVMNITDIDDKIIKRAREEKL----------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 159 vklatepleqavhsnpsgeevdsrvqvlleeakdllsdwldstggsevtdnSIFSKLPKFWEEEFHKDMEALNVLPPDVL 238
Cdd:PTZ00399 123 ---------------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVI 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 239 TRVSEYVPEIVNFVQKIVDNGYGYASNGSVYFDTAKFAASeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPN 318
Cdd:PTZ00399 152 TRVSEYVPEIVDFIQKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPN 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 319 DFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTG 398
Cdd:PTZ00399 228 DFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 399 HLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFMNEFFLNVKDILRAPVdiTG 478
Cdd:PTZ00399 308 HLHIKGLKMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LT 385
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 479 QFEKWEAEEVELNKNFYDKKTAVHEALCDNIDTRTVMEEMRALVSQCNLYMaarkAARRRPNRALLENIAMYLTHMLKIF 558
Cdd:PTZ00399 386 SPQKWTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYL----NSGEQPSAPLLRSVAQYVTKILSIF 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 559 GAIEEenplGFPVGGPGTNlNLESTVMPYLQVLSEFREGVRKIAR--------EKKVLEVLQLSDALRDDILPELGVRFE 630
Cdd:PTZ00399 462 GLVEG----SDGLGSQGQN-STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 631 DHEGLPTVVKLVDRDTLLKEKEEKKRAEEEKRRKKEEAARKKQEQEAAKLAKMKTPPSEMFRSETDKYSKFDENGLPTHD 710
Cdd:PTZ00399 537 DKPDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDETGLPTHD 616
|
730 740 750
....*....|....*....|....*....|....*
gi 157821465 711 TEGKELSKGQTKKLKKLFEAQEKVYKEYLQQLQNS 745
Cdd:PTZ00399 617 ADGEEISKKERKKLSKEYDKQAKLHEEYLAKGGKS 651
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-632 |
1.87e-162 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 477.29 E-value: 1.87e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQ 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 NylfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsGEEVdsrvqvlle 188
Cdd:COG0215 81 E------------------------------------------------------------------GESI--------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstggSEVTDnsifsklpkFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSV 268
Cdd:COG0215 86 ---------------WELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 269 YFDTAKFaasekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 345
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 346 IECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 425
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 426 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKFMNeFFLNVKDILRAPVDITGQFEKWEAEevelnknfydkktaVHEA 504
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN-ALRRLEEALGAADSSAEEIEELREE--------------FIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 505 LCDNIDTRTVMEEMRALVSQCNLYMAARKAARRrpnralLENIAMYLTHMLKIFGaIEEENPLGFpvGGPGTNLNLESTV 584
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREINKALDEGEDKAA------LAALAALLRALGGVLG-LLLLEPEAW--QGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 157821465 585 MPYLQvlsefregVRKIAREKKVLEvlqLSDALRDDILpELGVRFEDH 632
Cdd:COG0215 421 EALIE--------ERAEARKAKDFA---RADRIRDELA-ALGIVLEDT 456
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-457 |
4.12e-142 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 419.08 E-value: 4.12e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 42 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQNYLFEQyreqkps 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 122 aaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvlleeakdllsdwldst 201
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 202 ggsevtdnsifsKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY-ASNGSVYFDTAKFaasek 280
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYvSDNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 281 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLGASM 360
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 361 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 440
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 157821465 441 TLDYSsntmESALQYEK 457
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-631 |
6.36e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 419.48 E-value: 6.36e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 NYLFEQyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvlle 188
Cdd:TIGR00435 80 NGESVY-------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstggsEVTDNSIfsklpkfweEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYAS-NGS 267
Cdd:TIGR00435 86 ----------------EVSERFI---------EAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 268 VYFDTAKFaasekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 347
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 348 CSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 427
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 428 QLRLAFLMHSWKDTLDYSsntmESALQYEKFMNEFFLNVKDILRAPVDITGQFEKWEAEEVelnKNFYDkktAVHEALCD 507
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDTSLAYSGNQSLNKFPDE---KEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 508 NIDTR---TVMEEMralVSQCNLYMAArkaarrrpnralLENIAMYLTHMLKIFGAIEEenPLGFPVGGPGTNLN----- 579
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFVS------------KADAALLIEHLIFLESRLGL--LLGLPSKPVQAGSNddlge 419
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 157821465 580 LESTVMPylqvlsefregvRKIAREKKvleVLQLSDALRDDiLPELGVRFED 631
Cdd:TIGR00435 420 IEALIEE------------RSIARKEK---DFAKADEIRDE-LAKKGIVLED 455
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-445 |
1.13e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 334.55 E-value: 1.13e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 30 RLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDYFqYDVFYCMNITDIDDKIIRRARQN 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 110 YLFeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvllee 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 190 akdllsdwldstggsevtdnsiFSKLPKFWEEEFHKDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyasngsvy 269
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 270 fdtakfaasekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 349
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 350 AMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 429
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 157821465 430 RLAFLMHSWKDTLDYS 445
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
1-745 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 818.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 1 MAGSSAEQGKGRRVQPQWSPPA--GTEPCRLRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILR 78
Cdd:PTZ00399 10 LAGLNGTGQVSKSRLPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 79 RVLRDYFQYDVFYCMNITDIDDKIIRRARQNYLfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqns 158
Cdd:PTZ00399 90 RILEDYFGYDVFYVMNITDIDDKIIKRAREEKL----------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 159 vklatepleqavhsnpsgeevdsrvqvlleeakdllsdwldstggsevtdnSIFSKLPKFWEEEFHKDMEALNVLPPDVL 238
Cdd:PTZ00399 123 ---------------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVI 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 239 TRVSEYVPEIVNFVQKIVDNGYGYASNGSVYFDTAKFAASeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPN 318
Cdd:PTZ00399 152 TRVSEYVPEIVDFIQKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPN 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 319 DFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTG 398
Cdd:PTZ00399 228 DFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 399 HLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFMNEFFLNVKDILRAPVdiTG 478
Cdd:PTZ00399 308 HLHIKGLKMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LT 385
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 479 QFEKWEAEEVELNKNFYDKKTAVHEALCDNIDTRTVMEEMRALVSQCNLYMaarkAARRRPNRALLENIAMYLTHMLKIF 558
Cdd:PTZ00399 386 SPQKWTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYL----NSGEQPSAPLLRSVAQYVTKILSIF 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 559 GAIEEenplGFPVGGPGTNlNLESTVMPYLQVLSEFREGVRKIAR--------EKKVLEVLQLSDALRDDILPELGVRFE 630
Cdd:PTZ00399 462 GLVEG----SDGLGSQGQN-STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 631 DHEGLPTVVKLVDRDTLLKEKEEKKRAEEEKRRKKEEAARKKQEQEAAKLAKMKTPPSEMFRSETDKYSKFDENGLPTHD 710
Cdd:PTZ00399 537 DKPDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDETGLPTHD 616
|
730 740 750
....*....|....*....|....*....|....*
gi 157821465 711 TEGKELSKGQTKKLKKLFEAQEKVYKEYLQQLQNS 745
Cdd:PTZ00399 617 ADGEEISKKERKKLSKEYDKQAKLHEEYLAKGGKS 651
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-632 |
1.87e-162 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 477.29 E-value: 1.87e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQ 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 NylfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsGEEVdsrvqvlle 188
Cdd:COG0215 81 E------------------------------------------------------------------GESI--------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstggSEVTDnsifsklpkFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSV 268
Cdd:COG0215 86 ---------------WELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 269 YFDTAKFaasekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 345
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 346 IECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 425
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 426 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKFMNeFFLNVKDILRAPVDITGQFEKWEAEevelnknfydkktaVHEA 504
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN-ALRRLEEALGAADSSAEEIEELREE--------------FIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 505 LCDNIDTRTVMEEMRALVSQCNLYMAARKAARRrpnralLENIAMYLTHMLKIFGaIEEENPLGFpvGGPGTNLNLESTV 584
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREINKALDEGEDKAA------LAALAALLRALGGVLG-LLLLEPEAW--QGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 157821465 585 MPYLQvlsefregVRKIAREKKVLEvlqLSDALRDDILpELGVRFEDH 632
Cdd:COG0215 421 EALIE--------ERAEARKAKDFA---RADRIRDELA-ALGIVLEDT 456
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-457 |
4.12e-142 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 419.08 E-value: 4.12e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 42 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQNYLFEQyreqkps 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 122 aaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvlleeakdllsdwldst 201
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 202 ggsevtdnsifsKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY-ASNGSVYFDTAKFaasek 280
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYvSDNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 281 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLGASM 360
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 361 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 440
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 157821465 441 TLDYSsntmESALQYEK 457
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-631 |
6.36e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 419.48 E-value: 6.36e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 NYLFEQyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvlle 188
Cdd:TIGR00435 80 NGESVY-------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstggsEVTDNSIfsklpkfweEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYAS-NGS 267
Cdd:TIGR00435 86 ----------------EVSERFI---------EAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 268 VYFDTAKFaasekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 347
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 348 CSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 427
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 428 QLRLAFLMHSWKDTLDYSsntmESALQYEKFMNEFFLNVKDILRAPVDITGQFEKWEAEEVelnKNFYDkktAVHEALCD 507
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDTSLAYSGNQSLNKFPDE---KEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 508 NIDTR---TVMEEMralVSQCNLYMAArkaarrrpnralLENIAMYLTHMLKIFGAIEEenPLGFPVGGPGTNLN----- 579
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFVS------------KADAALLIEHLIFLESRLGL--LLGLPSKPVQAGSNddlge 419
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 157821465 580 LESTVMPylqvlsefregvRKIAREKKvleVLQLSDALRDDiLPELGVRFED 631
Cdd:TIGR00435 420 IEALIEE------------RSIARKEK---DFAKADEIRDE-LAKKGIVLED 455
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-445 |
1.13e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 334.55 E-value: 1.13e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 30 RLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDYFqYDVFYCMNITDIDDKIIRRARQN 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 110 YLFeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvllee 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 190 akdllsdwldstggsevtdnsiFSKLPKFWEEEFHKDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyasngsvy 269
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 270 fdtakfaasekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 349
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 350 AMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 429
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 157821465 430 RLAFLMHSWKDTLDYS 445
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
29-452 |
2.37e-91 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 296.46 E-value: 2.37e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIDDKIIRRARQ 108
Cdd:PLN02946 60 LHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKIIARANE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 nylfeqyreqkpsaaqLLKDvgdamkPFSvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsrvqvlle 188
Cdd:PLN02946 139 ----------------LGED------PIS--------------------------------------------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstggsevtdnsifskLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSV 268
Cdd:PLN02946 146 --------------------------LSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVDGDV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 269 YFDTAKFAasekhSYGKLVPEAVGDQKAlqeGEgdlSISADrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIEC 348
Cdd:PLN02946 200 YFSVDKFP-----EYGKLSGRKLEDNRA---GE---RVAVD--SRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIEC 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 349 SAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFEnDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQ 428
Cdd:PLN02946 267 SAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACC-DSNISYWIHNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLA 345
|
410 420
....*....|....*....|....
gi 157821465 429 LRLAFLMHSWKDTLDYSSNTMESA 452
Cdd:PLN02946 346 LRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
31-452 |
1.47e-67 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 236.15 E-value: 1.47e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 31 LYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDyFQYDVFYCMNITDIDDKIIRRARQNy 110
Cdd:PRK14535 230 IYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRE-CGYPLTYVRNITDIDDKIIARAAEN- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 111 lfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsGEEVdsrvqvlleea 190
Cdd:PRK14535 308 -----------------------------------------------------------------GETI----------- 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 191 kdllsdwldstggsevtdnsifSKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY-ASNGSVY 269
Cdd:PRK14535 312 ----------------------GELTARFIQAMHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYpAANGDVY 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 270 FDTAKFAAsekhsYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECS 349
Cdd:PRK14535 370 YAVREFAA-----YGQLSGKSLDDLRAGERVEVD--------GFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECS 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 350 AMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDC---------------WVRYFLHTGHLTIAGCKMSKSLKNF 414
Cdd:PRK14535 437 AMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGATGHTCghhhaqthhgqsiasHVKYWLHNGFIRVDGEKMSKSLGNF 516
|
410 420 430
....*....|....*....|....*....|....*...
gi 157821465 415 ITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESA 452
Cdd:PRK14535 517 FTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA 554
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
18-454 |
2.37e-63 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 217.29 E-value: 2.37e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 18 WSPPA-----GTEPcRLRLYNSLTRN-KDVfipQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDYfQYDVFY 91
Cdd:TIGR03447 3 WPAPAvpalpGTGP-PLRLFDTADGQvRPV---EPGPEAGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 92 CMNITDIDDKIIRRArqnylfeqyreqkpsaaqllkdvgdamkpfsvklsettdpdkrqmlERiqnsvklatepleqavh 171
Cdd:TIGR03447 78 VQNVTDVDDPLFERA----------------------------------------------ER----------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 172 snpSGEevdsrvqvlleeakdllsDWLDsTGGSEVtdnsifsklpkfweEEFHKDMEALNVLPPDVLTRVSEYVPEIVNF 251
Cdd:TIGR03447 95 ---DGV------------------DWRE-LGTSQI--------------DLFREDMEALRVLPPRDYIGAVESIDEVVEM 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 252 VQKIVDNGYGY----ASNGSVYFDTAkfaASEKHSYGKLVPEAVGDQKALQEGeGDlsisADRLSeKRSPNDFALWKASK 327
Cdd:TIGR03447 139 VEKLLASGAAYivegPEYPDVYFSID---ATEQFGYESGYDRATMLELFAERG-GD----PDRPG-KRDPLDALLWRAAR 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 328 PGEPSWPCPWGKGRPGWHIECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKM 407
Cdd:TIGR03447 210 EGEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKM 289
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 157821465 408 SKSLKNFITIKDaLKK--HSARQLRLAFLMHSWKDTLDYSSNTMESALQ 454
Cdd:TIGR03447 290 SKSLGNLVFVSK-LRAagVDPAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
47-454 |
2.71e-62 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 213.64 E-value: 2.71e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 47 GKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDYfQYDVFYCMNITDIDDKIIRRARqnylfeqyreqkpsaaqll 126
Cdd:PRK12418 7 GGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDDPLLERAA------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 127 kdvgdamkpfsvklsettdpdkrqmleriqnsvklatepleqavhsnpsgeevdsRVQVlleeakdllsDWLDsTGGSEV 206
Cdd:PRK12418 67 -------------------------------------------------------RDGV----------DWRD-LAEREI 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 207 tdnsifsklpkfweEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY----ASNGSVYFDTAkfAAsekhs 282
Cdd:PRK12418 81 --------------ALFREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYvvddEEYPDVYFSVD--AT----- 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 283 ygklvpEAVGDQKALQEGEGdLSISADRLSE-----KRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLG 357
Cdd:PRK12418 140 ------PQFGYESGYDRATM-LELFAERGGDpdrpgKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 358 ASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKdALKK--HSARQLRLAFLM 435
Cdd:PRK12418 213 SGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVFVS-RLRAagVDPAAIRLALLA 291
|
410
....*....|....*....
gi 157821465 436 HSWKDTLDYSSNTMESALQ 454
Cdd:PRK12418 292 GHYRADREWTDAVLAEAEA 310
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
29-527 |
7.64e-60 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 210.16 E-value: 7.64e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDiddkiirrarq 108
Cdd:PRK14536 3 LRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITD----------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 nylfeqyreqkpsaaqllkdVGDAmkpfsvklseTTDPDkrqmleriqnsvklatepleqavhsnpSGEevDSRVQVLLE 188
Cdd:PRK14536 71 --------------------VGHL----------TDDAD---------------------------SGE--DKMVKSAQE 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 EAKDLLsdwldstggsevtdnsifsKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSV 268
Cdd:PRK14536 92 HGKSVL-------------------EIAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCAGGNV 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 269 YFDTAKFAasekhSYGKLVPEAVGDqkaLQEGEgdlSISADrlSEKRSPNDFALWKASKPGEP---SWPCPWGKGRPGWH 345
Cdd:PRK14536 153 YFDIRTFP-----SYGSLASAAVED---LQAGA---RIEHD--TNKRNPHDFVLWFTRSKFENhalTWDSPWGRGYPGWH 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 346 IECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAyFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKK-H 424
Cdd:PRK14536 220 IECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEA-ATGKPWVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgF 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 425 SARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFMNEFFLNVKDILRAPVDIT-GQFEKWEAEEVELNKNFYDKK--TAV 501
Cdd:PRK14536 299 QPLDYRFFLLGGHYRSQLAFSWEALKTAKAARRSLVRRVARVVDAARATTGSVrGTLAECAAERVAESRASESELllTDF 378
|
490 500
....*....|....*....|....*.
gi 157821465 502 HEALCDNIDTRTVMEEMRALVSQCNL 527
Cdd:PRK14536 379 RAALEDDFSTPKALSELQKLVKDTSV 404
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
29-496 |
1.61e-43 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 164.25 E-value: 1.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 29 LRLYNslTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRdYFQYDVFYCMNITDIddkiirrarq 108
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDI---------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 109 nylfeqyreqkpsaAQLLKDVGDAmkpfsvklsettdPDKrqmleriqnSVKLATEPleqavhsnpsgeevdsrvqvlle 188
Cdd:PRK14534 70 --------------GHLTGDFDDG-------------EDK---------VVKAARER----------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 189 eakdllsdwldstgGSEVTDNSifsklpKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSV 268
Cdd:PRK14534 91 --------------GLTVYEIS------RFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTYFVNGNV 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 269 YFDTAKFaasekHSYGKLVPEAVGDQKALQEGEGDLSISadrlseKRSPNDFALWKAS---KPGEPSWPCPWGKGRPGWH 345
Cdd:PRK14534 151 YFDTSCF-----KSYGQMAGINLNDFKDMSVSRVEIDKS------KRNKSDFVLWFTNskfKDQEMKWDSPWGFGYPSWH 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 346 IECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKH- 424
Cdd:PRK14534 220 LECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAECYL-NKKWCDMFVHGEFLIMEYEKMSKSNNNFITIKDLEDQGf 298
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157821465 425 SARQLRLAFLMHSWKDTLDYSSNTME-SALQYEKFMNE--FFLNVKDilraPVDITGQFEKWEAEEVELNKNFYD 496
Cdd:PRK14534 299 SPLDFRYFCLTAHYRTQLKFTFNNLKaCKIARENMLNKltYFYSSLD----QFDLNLLNKDLENIEFSLEKEYYD 369
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
383-518 |
1.01e-07 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 55.64 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 383 AYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLaFLMHS---WKDtLDYSSNTMESAL-QYEKF 458
Cdd:PRK12300 554 AIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRL-YLTSSaelLQD-ADWREKEVESVRrQLERF 631
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 459 MnEFFLNVKDIlrAPVDITGQFEKWeaeeveLNKNFYDKKTAVHEALcDNIDTRTVMEEM 518
Cdd:PRK12300 632 Y-ELAKELIEI--GGEEELRFIDKW------LLSRLNRIIKETTEAM-ESFQTRDAVQEA 681
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
55-118 |
1.08e-07 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 51.71 E-value: 1.08e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157821465 55 CGPTVYDASHMGHARSYISFDILRRVLRDyFQYDVFYCMNITDIDDKIIRRARQNYL-FEQYREQ 118
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRK-LGYKVRCIALIDDAGGLIGDPANKKGEnAKAFVER 67
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
367-453 |
1.18e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 48.91 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 367 FDLRFPHHD---NELAQS----EAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRlaFLMHSWK 439
Cdd:PLN02959 672 FDLRVSGKDliqNHLTFAiynhTAIWAEEHWPRGFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATR--FALADAG 749
|
90
....*....|....*..
gi 157821465 440 DTLD---YSSNTMESAL 453
Cdd:PLN02959 750 DGVDdanFVFETANAAI 766
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
391-437 |
2.29e-04 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 44.06 E-value: 2.29e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 157821465 391 VRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 437
Cdd:cd00814 265 PTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
343-411 |
4.51e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 41.31 E-value: 4.51e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821465 343 GWHIECSAMAGSLLGASMDIHGGGFDLRFpHHDNELAQSEAYfeNDCWVRYFLHTGHLTIA-GCKMSKSL 411
Cdd:cd00802 77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKA--GGPARPFGLTFGRVMGAdGTKMSKSK 143
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
397-437 |
7.19e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 42.66 E-value: 7.19e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 157821465 397 TGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 437
Cdd:pfam09334 315 HGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNR 355
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
57-109 |
6.75e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 39.87 E-value: 6.75e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 157821465 57 PTVYDASHMGHARSYISFDILRRVLRdyfQ--YDVFYcmnITDIDD---KIIRRARQN 109
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKR---LrgYDVFF---LTGTDEhgqKIQRKAEEA 61
|
|
| |
