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Conserved domains on  [gi|157818193|ref|NP_001100007|]
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alpha-tocopherol transfer protein-like [Rattus norvegicus]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661176)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to phosphatidylinositol transfer proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
129-278 3.88e-43

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 146.33  E-value: 3.88e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 129 GFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGVVILADYKGVSLSKAShfGPFIARK 208
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 209 VIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLSSLHTSLPRNILPKEYGGT 278
Cdd:cd00170   87 LLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
57-103 5.37e-13

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 62.57  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157818193    57 RDVQALRDMVRKEYPYLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 103
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
129-278 3.88e-43

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 146.33  E-value: 3.88e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 129 GFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGVVILADYKGVSLSKAShfGPFIARK 208
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 209 VIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLSSLHTSLPRNILPKEYGGT 278
Cdd:cd00170   87 LLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
129-277 4.16e-36

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 127.76  E-value: 4.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193  129 GFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQS-EETQVNGVVILADYKGVSLSKASHFGPFIAR 207
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157818193  208 KVIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLH-GSDLSSLHTSLPRNILPKEYGG 277
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
137-278 8.03e-29

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 108.93  E-value: 8.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193   137 TDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQSE--ETQVNGVVILADYKGVSLSkasHFGPFIARKVIGILQ 214
Cdd:smart00516  15 YDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEEkkTGGIEGFTVIFDLKGLSMS---NPDLSVLRKILKILQ 91
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818193   215 DGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSD-LSSLHTSLPRNILPKEYGGT 278
Cdd:smart00516  92 DHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDsKEELLEYIDKEQLPEELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
57-103 5.37e-13

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 62.57  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157818193    57 RDVQALRDMVRKEYPYLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 103
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
78-102 5.88e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 45.73  E-value: 5.88e-07
                          10        20
                  ....*....|....*....|....*
gi 157818193   78 DDAFLLRFLRARKFDYDRALQLLVN 102
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
129-278 3.88e-43

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 146.33  E-value: 3.88e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 129 GFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGVVILADYKGVSLSKAShfGPFIARK 208
Cdd:cd00170    9 GGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLLKK 86
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193 209 VIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLSSLHTSLPRNILPKEYGGT 278
Cdd:cd00170   87 LLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
129-277 4.16e-36

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 127.76  E-value: 4.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193  129 GFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQS-EETQVNGVVILADYKGVSLSKASHFGPFIAR 207
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157818193  208 KVIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLH-GSDLSSLHTSLPRNILPKEYGG 277
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
137-278 8.03e-29

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 108.93  E-value: 8.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193   137 TDPRGCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLIQSE--ETQVNGVVILADYKGVSLSkasHFGPFIARKVIGILQ 214
Cdd:smart00516  15 YDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKILQEEkkTGGIEGFTVIFDLKGLSMS---NPDLSVLRKILKILQ 91
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818193   215 DGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSD-LSSLHTSLPRNILPKEYGGT 278
Cdd:smart00516  92 DHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDsKEELLEYIDKEQLPEELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
57-103 5.37e-13

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 62.57  E-value: 5.37e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157818193    57 RDVQALRDMVRKEYPYLSTSLDDAFLLRFLRARKFDYDRALQLLVNY 103
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
141-278 2.40e-10

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 58.11  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193  141 GCHVLCIRPDRWIPSNYPITENIRAIYLTLEKLiqSEETQVNGVVILADYKGVSlskaSHFGPFIA--RKVIGILQDGFP 218
Cdd:pfam13716   1 GRPVLVFISKLLPSRPASLDDLDRLLFYLLKTL--SEKLKGKPFVVVVDHTGVT----SENFPSLSflKKAYDLLPRAFK 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818193  219 IRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLSSLHTSLPRNILPKEYGGT 278
Cdd:pfam13716  75 KNLKAVYVVHPSTFLRTFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTELPGV 134
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
78-102 5.88e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 45.73  E-value: 5.88e-07
                          10        20
                  ....*....|....*....|....*
gi 157818193   78 DDAFLLRFLRARKFDYDRALQLLVN 102
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKMLED 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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