|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD4A |
cd17453 |
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily ... |
18-479 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4A (MFSD4A) belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341011 Cd Length: 415 Bit Score: 684.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 18 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLAQSLWALFTSTLVISLVFA 97
Cdd:cd17453 1 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLQQITWVFFSQQFCLLLGSTLGGVFKRTLAQSLFALFVSSLAISVVFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 98 VIPFCHDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDSAFFLQVLHFFVGLGALLSPLIADPFLSEANCfpanntan 177
Cdd:cd17453 81 IIPFCRNVGVLAFVMAVAGLAMGCIDTISNMQLVKIYQKDSAVFLQALHFFVGFGALLSPLIADPFLSDTNC-------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 178 atsrshgsrvlsqhhaaaqpwinqtiprlppkevtenhVSYAFWIMALINLPVPLAVLFLLSKERLLTC-AQRKPLLLSA 256
Cdd:cd17453 153 --------------------------------------VSYAFWIMAIINLPVPIAVFVLLYKERMVPCcSDPSRPLLSA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 257 DELALETRPAEKEDTSSlaPKFQPHSGQEDLFSCCQRKNFRGAPCSFFAIHITAALVLFMTDGMMGAYSAFVYSYAVEKP 336
Cdd:cd17453 195 DELAMEARPEEKLDEST--GKAHTSNGHADLFSCCQSKNFRGAPFSFFAIHVTGALVLFMTDGIVGEYSGFVYSYAVEPP 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 337 LSIGHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLLIFSYNVIFLFVGTASLGLFLSSTFPS 416
Cdd:cd17453 273 LNLPHKVAGYLPSLFWGFITLGRLISIPISYRMKPATMVFINLVGVIVTFLLLLIFSNSTVFLFVGTASLGLFLSSTFPS 352
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167900456 417 MLAYTEDILQYKGCATTVLVTGAGIGEMVLQMLVGLIFQAQGSYSFLVCGVIFGCLAFIFYIL 479
Cdd:cd17453 353 MLAYTEDILQYKGCATTVLVTGAGMGEMVLQMLVGSIMHSQGSYSFLVCGMIFGCLAFTFYTF 415
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
20-479 |
5.29e-142 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 413.07 E-value: 5.29e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 20 TYWSVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLAqSLWALFTSTLVISLVFAVI 99
Cdd:cd17395 1 TYWSVFFSFGLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLN-SLWALFTSSLLIALVLAVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 100 PFCHDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDSAFFLQVLHFFVGLGALLSPLIADPFLSeancfpanntanat 179
Cdd:cd17395 80 PFCKDVKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFLS-------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 180 srshgsrvlsqhhaaaqpwinqtiprlppkevtenhvsYAFWIMALINLPVPLAVLFLLSKERLLTCAqrkplllsadel 259
Cdd:cd17395 146 --------------------------------------YAYWIMALINLPVPMAVLMLLSKERLLTCC------------ 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 260 aletrpaekedtsslapkfqphsgqedlfSCCQRKNFRGAPCSFFAIHITAALVLFMTDGMMGAYSAFVYSYAVEKPLsI 339
Cdd:cd17395 176 -----------------------------SQRRRKNLRRAPYSFFAIHITGALFLFMYVGLEGAYGAFVYSYAVEKPG-V 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 340 GHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLLIFSYNVIFLFVGTASLGLFLSSTFPSMLA 419
Cdd:cd17395 226 GHKVAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVVTSLVLLLFSKSVVFLWIGTASLGLFLASTFPSMLS 305
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167900456 420 YTEDILQYKGCATTVLVTGAGIGEMVLQMLVGLI--FQAQGSYSFLVCGVIFGCLAFIFYIL 479
Cdd:cd17395 306 YTEDSLQYTGCSTTVLVTGAGLGEMVLPMLVGSIqpFQAQGSYSFLVCGVLFGCLAFTFYIL 367
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-479 |
8.74e-80 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 253.78 E-value: 8.74e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 21 YWSVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLaQSLWALFTSTLVISLVFAVIP 100
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRL-GRRRTLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 101 FCHDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDSAFFLQVLHFFVGLGALLSPLIADPFLSEancfpanntanats 180
Cdd:cd17333 80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTS-------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 181 rshgsrvlsqhhaaaqpwinqtiprlppkevtENHVSYAFWIMALINLPVPLAVLFLLSKERLLTCAQRkplllsadela 260
Cdd:cd17333 146 --------------------------------ELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQ----------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 261 letrpaekedtsslapkfqphsgqedlfSCCQRKNFRGAPCSFFAIHITAALVLFMTDGMMGAYSAFVYSYAVEKPlSIG 340
Cdd:cd17333 183 ----------------------------QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK-HVS 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 341 HKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLLIFsYNVIFLFVGTASLGLFLSSTFPSMLAY 420
Cdd:cd17333 234 DGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLA-PTLVVGLVATALLGLFMAALFPTILSL 312
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 421 TEDILQY-KGCATTVLVTGAGIGEMVLQMLVGLIFQAQGSYSFLVCGVIFGCLAFIFYIL 479
Cdd:cd17333 313 GISNLPYaKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_NaGLT1_MFSD4B |
cd17454 |
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily ... |
23-453 |
7.56e-25 |
|
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily domain-containing protein 4B; Sodium-dependent glucose transporter 1 (NaGLT1) is also called major facilitator superfamily domain-containing protein 4B (MFSD4B). NaGLT1 is a primary fructose transporter in rat renal brush-border membranes. It also facilitates sodium-independent urea uptake in assays performed on Xenopus oocytes. NaGLT1/MFSD4B belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341012 Cd Length: 369 Bit Score: 105.99 E-value: 7.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 23 SVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLAQSLwALFTSTLVISLVFAVIPFC 102
Cdd:cd17454 4 ASFLGLGMSIAVLGPTFQDLATNVNKNISNISYIFVGRSLGYLGGSVLGGILFDCMNHHL-LLGFSMLITAAGLFAIPWC 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 103 HDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDSAFFLQVLHFFVGLGALLSPLIADPFLSeancfpanntanatsrs 182
Cdd:cd17454 83 KKALLLTALMSLIGVSMGVLDTGGNVLILNTWGDQAGPHMQALHFSFALGAFVAPILAKLAFL----------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 183 hgsrvlsqhhaaaqpwinqtiprlppkevtenhvsYAFWIMALINLPVPLAVLFLLSKERlltcaqrkplllsadelale 262
Cdd:cd17454 146 -----------------------------------WAYIVIGTYVLLVSLFFFILYSKSS-------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 263 tRPAEKEDTSSLAPKFQPHSGqedlfsccqrknfrgapcsffAIHITAALVLFMTDGMMGAYSAFVYSYAVEKpLSIGHK 342
Cdd:cd17454 171 -SNREKSKASAQKTRFAKYHN---------------------ALIILLFLFFFFYVGAEVTYGSYIFTYAKTY-VHMEES 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 343 SAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLLIFSYNVIFLFVGTASLGLFLSSTFPSMLAYTE 422
Cdd:cd17454 228 EAAGLNSLFWGTFAACRGLAIFFAACLYPGTMILLSLIGSTVSSLFLVLFSKNPISLWVGTAVYGASMATTFPSGISWIE 307
|
410 420 430
....*....|....*....|....*....|.
gi 167900456 423 DILQYKGCATTVLVTGAGIGEMVLQMLVGLI 453
Cdd:cd17454 308 QYTTITGKSAALFVVGAALGEMVIPAVVGYL 338
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-479 |
7.78e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.15 E-value: 7.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 12 RRNLQPTLTYWSVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVF------KRTLAqslwal 85
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLidrfgyKRGLL------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 86 fTSTLVISLVFAVIPFCHDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDSAFFLQVLHFFVGLGALLSPLIadpfls 165
Cdd:COG0738 78 -LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLL------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 166 eancfpanntanatsrshGSRVLSQHHAAAqpwinqtiprlppkevtenhVSYAFWIMALInlPVPLAVLFLLSKerllt 245
Cdd:COG0738 151 ------------------GGLLILLGLSLS--------------------WHLPYLILAVL--LLLLALLFLRSK----- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 246 caqrkpllLSADELALETRPAEKEDTSSLAPkfqphsgqedlfsccqRKNFrgapcsffaihITAALVLFMTDGMMGAYS 325
Cdd:COG0738 186 --------LPEIEEEEEEAAGSAASLKSLLK----------------NPRL-----------LLGGLAIFLYVGAEGAIG 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 326 AFVYSYAVEKpLSIGHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLmLLIFSYNVIFLFVGTAS 405
Cdd:COG0738 231 DWLPLYLKDV-LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL-LALLAPGPWLALIGLAL 308
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167900456 406 LGLFLSSTFPSMLAYTEDILQYKGCATT-VLVTGAGIGEMVLQMLVGLIFQAQG-SYSFLVCGVIFGCLAFIFYIL 479
Cdd:COG0738 309 VGLGLSLMFPTIFSLALDGLGKRTAAAVsAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALAL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
311-479 |
1.76e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 311 ALVLFMTDGMMGAYSAFVYSYAVEKpLSIGHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLL 390
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQ-FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 391 IFSYNVIFLFVGTASLGLFLSSTFPSMLAYTEDI--LQYKGCATTVLVTGAGIGEMVLQMLVGLIFQAQGSYS--FLVCG 466
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIfpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTaaFLVFA 369
|
170
....*....|...
gi 167900456 467 VIFGCLAFIFYIL 479
Cdd:COG2223 370 VLALVALVLTLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
308-481 |
7.56e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 7.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 308 ITAALVLFMTDGMMGAYSAFVYSYAVEKpLSIGHKSAGYLPSLFWGFITLGRFISIPVSSRM-RPATMVFINVVGVVVTF 386
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 387 LMLLIFSYNVIFLFVGTASLGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQMLVGLIFQAQGSYSFLV 464
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFpkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170
....*....|....*..
gi 167900456 465 CGVIFGCLAFIFYILLL 481
Cdd:COG2271 342 LLAALALLAALLALLLL 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-160 |
4.33e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 4.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 22 WSVFFSFGLCIAFLgPTLLDLRcqTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLAQSLWALFTSTLVISLVFAVIPF 101
Cdd:cd17474 208 FLYFFLYFAFLTYL-PFLLELL--YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGF 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 102 CHDVKVLASVIALAGLAMGCIDTVANMQLVRIYQKDS-AFFLQVLHFFVGLGALLSPLIA 160
Cdd:cd17474 285 VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLF 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
312-480 |
1.57e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 312 LVLFMTDGMMGAYSAFVYSYAVEKPLSIGHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFInVVGVVVTFLMLLI 391
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI-GLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 392 FSYNVIFLFVGTASLGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQMLVGLIFQAQG-SYSFLVCGVI 468
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFppEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwRAAFLILAIL 160
|
170
....*....|..
gi 167900456 469 FGCLAFIFYILL 480
Cdd:pfam07690 161 SLLAAVLLLLPR 172
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-477 |
4.16e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 21 YWSVFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVF-KRTLAQslWALFTSTLVISLVFAVI 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLaDRFGRR--PVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 100 PFCHDVKVLASVIALAGLAMGCIDTVANMQLVRIY-QKDSAFFLQVLHFFVGLGALLSPLIADPFLSEAncfpanntana 178
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILASSL----------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 179 tsrshgsrvlsqhhaaaqpwinqtiprlppkevtENHVSYAFWIMALINLPVPLAVLFLLSKErlltcaqrkplllsade 258
Cdd:cd06174 148 ----------------------------------GFGWRAVFLIAAALALLAAILLLLVVPDP----------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 259 laletrpaekedtsslapkfqPHSGQEDLFSCCQRKNFRGAPCSFFAIHITAALVLFMTdgMMGAYSAFVYSYAV--EKP 336
Cdd:cd06174 177 ---------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL--VNLAYYSFSTLLPLflLDL 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 337 LSIGHKSAGYLPSLFWGFITLGRFISIPVSSRMRPATMVFINVVGVVVTFLMLLIFSYNVIFLFVGTASLGLFLSSTFPS 416
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167900456 417 MLAYTEDI--LQYKGCATTVLVTGAGIGEMVLQMLVGLIFQAQGSYS--FLVCGVIFGCLAFIFY 477
Cdd:cd06174 314 SFALIAELfpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTgaFLVLAVLLLLAAILLL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
310-493 |
4.66e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 310 AALVLFMTDGMMGAYSAFVYSYAVEKPLSIGHksAGYLPSLFWGFITLGRFISIPVSSRM-RPATMVFINVVGVVVTFLM 388
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQ--LGLLFALFSLGYALLQPLAGLLADRFgRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 389 LLIFSYnvIFLFVGTASLGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGeMVLQMLVGLIFQAQGSYSFLVCG 466
Cdd:cd06174 79 AFAPSF--WLLLLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVG-GILGPLLGGILASSLGFGWRAVF 155
|
170 180
....*....|....*....|....*..
gi 167900456 467 VIFGCLAFIFYILLLFFHRIHPELSSV 493
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARA 182
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
116-477 |
5.34e-04 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 42.21 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 116 GLAMGCIDTVANMQLVRIYQKDSA-FFLQVLHFFVGLGALLSPLIADPFLSEAncfpANNTANATSRSHGSRVLSQHHAA 194
Cdd:cd17394 101 ASGLALLQTAANPYVTVLGPEETAaRRLNLAQAFNSLGSTIAPLFGSYLILSG----IPSTATALAAMSAAELQAYKTAE 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 195 AQPWInqtiprLPpkevtenhvsyaFWIMALINLPvpLAVLFLLSKerlltcaqrkplllsadelaletRPAEKEDTSSL 274
Cdd:cd17394 177 LASVQ------LP------------YLGIALVLLL--LAVLILLSK-----------------------LPEIEAAEAEA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 275 APKFqphsgqEDLFSCCQRKNFRGApcsffaihitaALVLFMTDGMMGAYSAFVYSYAVEKPLSIGHKSAGYLPSLFWGF 354
Cdd:cd17394 214 LGSK------GTLLRLLKNPHLRLG-----------VLAIFFYVGAEVAIWSFLINYLMEYIAGLTETSAATFVSYYWGG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 355 ITLGRFISIPVSSRMRPATMVFINVVGVVVtFLMLLIFSYNVIFLFVgTASLGLFLSSTFPSMLAYTEDIL-QYKGCATT 433
Cdd:cd17394 277 FMVGRFLGTALLKKISPKKLLAVFALLGLL-LLLGAIFTGGMVALYA-LVLVGFFNSIMFPTIFSLALKGLgKHTKTGSG 354
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 167900456 434 VLVTGAgIGEMVLQMLVGLIFQAQGSYSFLVCgVIFGCLAFIFY 477
Cdd:cd17394 355 LLVMAI-VGGAVVPLIQGAVADDAAGLRIAFL-VPLLCFAYILF 396
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
24-160 |
1.50e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.70 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167900456 24 VFFSFGLCIAFLGPTLLDLRCQTHSSLPQISWVFFSQQLCLLLGSALGGVFKRTLAqSLWALFTSTLVISLVFAVIPFCH 103
Cdd:cd17393 7 FFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFG-SRRVTRLGALLLLLALLLLGLAP 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 167900456 104 DVKVLASVIALAGLAMGCIDTVANMQLVRIyQKDSAF-FLQVLHFFVGLGALLSPLIA 160
Cdd:cd17393 86 SVPALALALFLFGAANGALDVAMNAQGVAV-ERAYGRpIMSSLHAMWSLGGLAGALLG 142
|
|
| |
