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Conserved domains on  [gi|186659506|ref|NP_001119516|]
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prostaglandin E2 receptor EP3 subtype isoform 4 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
49-358 0e+00

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15146:

Pssm-ID: 452889 [Multi-domain]  Cd Length: 308  Bit Score: 517.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGR 128
Cdd:cd15146    1 SVSVAFPITMMITGMVGNALAMLLVYRSYRKKENKRKRSFLLCIGSLALTDLFGQLLTSPIVISVYLSDRKWERVDPSGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd15146   81 LCPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTWC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTGRGgngtssshNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIM 288
Cdd:cd15146  161 FISTGDG--------EPGNNFFASTFASLGLFSLCVTFSCNLATIRALVSRCKTKAGASVSSKQWERITTETLIQLLGIM 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 289 CVLSVCWSPLLIMMLKMIFNQTSVEHCK------THTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFC 358
Cdd:cd15146  233 CVLSACWSPLLVLMLKMISNHTSSEHCKsatappQSTELQKDCNFFLTAVRLASLNQILDPWVYLLLRKILLRKFC 308
 
Name Accession Description Interval E-value
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
49-358 0e+00

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 517.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGR 128
Cdd:cd15146    1 SVSVAFPITMMITGMVGNALAMLLVYRSYRKKENKRKRSFLLCIGSLALTDLFGQLLTSPIVISVYLSDRKWERVDPSGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd15146   81 LCPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTWC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTGRGgngtssshNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIM 288
Cdd:cd15146  161 FISTGDG--------EPGNNFFASTFASLGLFSLCVTFSCNLATIRALVSRCKTKAGASVSSKQWERITTETLIQLLGIM 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 289 CVLSVCWSPLLIMMLKMIFNQTSVEHCK------THTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFC 358
Cdd:cd15146  233 CVLSACWSPLLVLMLKMISNHTSSEHCKsatappQSTELQKDCNFFLTAVRLASLNQILDPWVYLLLRKILLRKFC 308
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-346 6.50e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 115.87  E-value: 6.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506   65 GNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWehidPSGR-LCTFFGLTMTVFGLS 143
Cdd:pfam00001   1 GNLLVILVILRN-----KKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLHGDW----PFGSaLCKLVGALFYVNGYA 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  144 SLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTV-QWPGTWCFISTgrggngtsSS 222
Cdd:pfam00001  72 SILLLTAISIDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVpEGNVTVCFIDF--------PE 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  223 HNWGNLFFASAFAFLG-LLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIqlmgIMCVLSVCWSPLLIM 301
Cdd:pfam00001 144 VLSKPVSYTLLSSVLGfLLPLLVILVCYTRIIRTLRKSASKQKSEERTQRRERKALKTLAV----VVVVFILCWLPYHIV 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 186659506  302 MLKMIFNQTSVEHCKTHTekqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:pfam00001 220 NLLDSLALDCELSRLLDK-------ALSITLWLAYVNSCLNPIIY 257
 
Name Accession Description Interval E-value
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
49-358 0e+00

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 517.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGR 128
Cdd:cd15146    1 SVSVAFPITMMITGMVGNALAMLLVYRSYRKKENKRKRSFLLCIGSLALTDLFGQLLTSPIVISVYLSDRKWERVDPSGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd15146   81 LCPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTWC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTGRGgngtssshNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIM 288
Cdd:cd15146  161 FISTGDG--------EPGNNFFASTFASLGLFSLCVTFSCNLATIRALVSRCKTKAGASVSSKQWERITTETLIQLLGIM 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 289 CVLSVCWSPLLIMMLKMIFNQTSVEHCK------THTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFC 358
Cdd:cd15146  233 CVLSACWSPLLVLMLKMISNHTSSEHCKsatappQSTELQKDCNFFLTAVRLASLNQILDPWVYLLLRKILLRKFC 308
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
49-346 1.60e-109

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 322.66  E-value: 1.60e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRRReskRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWehiDPSGR 128
Cdd:cd14981    1 GESPAPPALMFVFGVLGNLLALIVLARSSKSH---KWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEW---DGGQP 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd14981   75 LCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLQYPGTWC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTGrggngtssSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKAT---ASQSSAQWGRITTETAIQLM 285
Cdd:cd14981  155 FLDFY--------SKNTGDAAYAYLYSILGLLILLVTLLCNLLVIITLLRMRRRKKRhrrSRRSARRQKRNEIQMVVLLL 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186659506 286 GIMCVLSVCWSPLLIMMLKMIFNQTSvehckthtekqKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd14981  227 AITVVFSVCWLPLMIRVLINATGDSE-----------KNGKTDLLAVRMASWNQILDPWVY 276
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
51-346 6.58e-64

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 206.16  E-value: 6.58e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  51 SVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHiDPSGRLC 130
Cdd:cd15144    3 SPAMPIFSMTLGALSNIVALVILAQSYARFRRRSKATFLLFASSLVLTDLAGHVIPGALVLRLYLSGQMPAE-EPRGALC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 131 TFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFI 210
Cdd:cd15144   82 QFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWCFI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 211 STGRGGngtssshNWGNLFFASAFAFLGLLALTVTFSCN-LATIKALVSRCRAKATASQSSAQWGRIttETAIQLMGIMC 289
Cdd:cd15144  162 KVQPPG-------SWADVAFALLFSLLGLASLLVSLVCNtISGLTLVRARLRKKCSCSNRRAKSHDI--EMVVQLVGIMV 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186659506 290 VLSVCWSPLLIMMLkmIFNQTSVEHCKTHTEKqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:cd15144  233 VSCICWSPLLIFVL--ISVSRSYERPKHQYEK-----LLFLGVRLASWNQILDPWVY 282
7tmA_FP cd15145
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...
50-346 1.25e-59

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.


Pssm-ID: 320273 [Multi-domain]  Cd Length: 290  Bit Score: 195.04  E-value: 1.25e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRL 129
Cdd:cd15145    2 LSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGTIAVFVYASDKDWIRFDQSNIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCF 209
Cdd:cd15145   82 CSVFGICMVFFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVALLPILGHRDYQIQASRTWCF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 IStgrggngTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLAT-IKALVSRCRakataSQSSAQWGRITTETAIQLMGIM 288
Cdd:cd15145  162 YK-------TEHIEDWEDRFYLLLFSFLGLLALAISFLCNAITgITLLRVKFR-----SQQHRQGRSHHFEMVIQLLAIM 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 289 CVLSVCWSPLLIMMLKMIFNQtsvehckthTEKQKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15145  230 CVSCICWSPFLVTMANIGING---------RDSLESCETILFALRMATWNQILDPWVY 278
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-346 7.32e-59

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 193.11  E-value: 7.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRL 129
Cdd:cd15143    2 TSVWFSTIFSAIGLASNLFAFIVLVKSSRKTKSRSRSSFLIFLCGLVVTDFLGLLVTGTIVISFHLTNFNWRVVDPDCYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCF 209
Cdd:cd15143   82 CNFMGLSMVFYGLCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLGRYTLQYPGSWCF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 ISTGrggngtsssHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRakataSQSSAQWGRIT-TETAIQLMGIM 288
Cdd:cd15143  162 LTLL---------FDSKDVAFGLLFSFLGILSVGLSFLLNTVSVVTLCRVYH-----DRESVQRRRDSeVEMMVQLLGIM 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 289 CVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKEcNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15143  228 VIASVCWLPLLVFIAQTVLQKPPAMLLAGQIPRLTE-KKLLIYLRFATWNQILDPWVY 284
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
51-346 2.03e-42

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 150.34  E-value: 2.03e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  51 SVAFPITMLLTGFVGNALAMLLVSRSyrRRESKRKKSFLLCIGwLALTDLVGQLLTTPVVIVVYLsKQRWEHIDPsgrLC 130
Cdd:cd15142    3 PPTIPAVMFIFGVVGNLIAIVVLCKS--RKEQKETTFYTLVCG-LAVTDLLGTCLASPVTIATYL-KGRWPGGQP---LC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 131 TFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFI 210
Cdd:cd15142   76 EYFSFILLFFSLSGLSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLGKSKLQYPKTWCFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 211 stgrggngtssshNW-GNLFFASAFAFL----GLLALTVTFSCNLATIKALVS------RCRAKATASQSSA----QWGR 275
Cdd:cd15142  156 -------------DWrTNVSVHAAYSYMyagfSSLLILVTVLCNVLVCGALIRmhrqfvRRTSLGTDQRLSDfrrrRSFR 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186659506 276 ITTETAIQ----LMGIMCVLSVCWSPLLIMMLKMIFNQTSVehckthtEKQKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15142  223 RMAGAEIQmvilLIATSVVVLICSIPLVVRVFVNQLYQPAV-------EKDLDKNPDLQAIRIASVNPILDPWIY 290
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
51-346 5.11e-39

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 141.45  E-value: 5.11e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  51 SVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLC 130
Cdd:cd15139    3 SPAISALMFSAGVLGNVLALVLLERRRRKEVGRRQSLFHVLVTSLVITDLLGTCLISPVVLASYSRNTTLVGMSPNRLVC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 131 TFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFI 210
Cdd:cd15139   83 GYFGFAMTFFSLATMLILLAMALERCLSIGHPYFYERYVSKRCGYVTIPLIYLLCALFCLFPFLGFGKYVQYCPGTWCFI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 211 STgrggNGTSSSHNwgnlFFASAFAFLGLLALTVTFSCNLATIKALV---SRCRAKATASQSSAQWGRITTETA-----I 282
Cdd:cd15139  163 DM----NPEASEHR----AYANLYATLLLLLIVAVVLCNASVIYHLVrmyRRRKRNRSSVGGRARSHRRRFSMAeevehL 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186659506 283 QLMGIMCVLSV-CWSPLLIMMLKMIFNQTSVEHCKthtekqkecnffLIAVRLASLNQILDPWVY 346
Cdd:cd15139  235 ILLVFMTIIFViCSLPLTIQVYMNTFSDSENHKWD------------LIALRFLSVNPIIDPWVF 287
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
49-346 1.01e-35

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 132.64  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSrsYRRRESKRKKS-FLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSG 127
Cdd:cd15141    1 DGHPATSTLMFAAGVVGNLLALGILG--VHRKERRTKSSaFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAGQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 128 RLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTW 207
Cdd:cd15141   79 PLCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 208 CFISTGRGGNGTSSShnwgnLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITT--------- 278
Cdd:cd15141  159 CFIRMTVPGHREPGS-----LAFSLLYASLMALLIAAIFLCNGSVTVSLCRMYRGQKARRGSLRRCGRLGWwlgqgeeev 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 279 ETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKthtekqkecnffLIAVRLASLNQILDPWVY 346
Cdd:cd15141  234 DHLILLALMTVIFVVCSLPLTIRAFLGAIAPDGNESGD------------LLAFRFSAFNPILDPWIF 289
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
52-346 3.74e-33

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 125.09  E-value: 3.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  52 VAFPITMLLTGFVGNALAMLLVSRSYRRReskrkKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWehidPSGRLCT 131
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLR-----TVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWW----FGDALCK 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 132 FFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFIs 211
Cdd:cd00637   73 LLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 tgrggngtSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTE--TAIQLMGIMC 289
Cdd:cd00637  152 --------WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRErkVTKTLLIVVV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186659506 290 VLSVCWSPLLIMMLKMIFNQTSVEHckthtekqkECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd00637  224 VFLLCWLPYFILLLLDVFGPDPSPL---------PRILYFLALLLAYLNSAINPIIY 271
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-346 6.50e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 115.87  E-value: 6.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506   65 GNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWehidPSGR-LCTFFGLTMTVFGLS 143
Cdd:pfam00001   1 GNLLVILVILRN-----KKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLHGDW----PFGSaLCKLVGALFYVNGYA 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  144 SLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTV-QWPGTWCFISTgrggngtsSS 222
Cdd:pfam00001  72 SILLLTAISIDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVpEGNVTVCFIDF--------PE 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  223 HNWGNLFFASAFAFLG-LLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIqlmgIMCVLSVCWSPLLIM 301
Cdd:pfam00001 144 VLSKPVSYTLLSSVLGfLLPLLVILVCYTRIIRTLRKSASKQKSEERTQRRERKALKTLAV----VVVVFILCWLPYHIV 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 186659506  302 MLKMIFNQTSVEHCKTHTekqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:pfam00001 220 NLLDSLALDCELSRLLDK-------ALSITLWLAYVNSCLNPIIY 257
7tmA_PGD2 cd15140
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
61-346 4.88e-27

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor (also called prostanoid DP receptor, DP1, or PGD2R1) is a G-protein coupled receptor whose endogenous ligand is prostaglandin D2 (PGD2). PGD2, the major cyclooxygenase metabolite of arachidonic acid produced by mast cells, mediates inflammatory reactions in response to allergen challenge and causes peripheral vasodilation. PGD2 exerts its biological effects by binding to two types of cell surface receptors: a DP1 receptor that belongs to the prostanoid receptor family and a chemoattractant receptor-homologous molecule expressed on the T-helper type 2 cells (CRTH2 or PD2R2).


Pssm-ID: 320268 [Multi-domain]  Cd Length: 312  Bit Score: 109.22  E-value: 4.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  61 TGFVGNALAMLLVSRSY-----RRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSG--RLCTFF 133
Cdd:cd15140   13 AGLLGNLLALGLLWLHKlhakkQRGGRPRTSVFYVLVTVLTVTDLLGKCLLSPVVLAAYAQNRSLVGLTPAGnlNLCQVF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 134 GLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTg 213
Cdd:cd15140   93 AFLMIFFGLASTFILLAMALECWLSLGHPFFYQRHINKRLGALVSLILYAFCLGFCALPFFGFGRYVQYCPGTWCFIQM- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 rGGNGTSSSHNWGNLFFASafaFLGLLALTVTFsCNLATIKAL--------------VSRCRAKATASQSSAQwgRITTE 279
Cdd:cd15140  172 -TAEESSTSALAYSVLYGS---LMGLLVLAIVL-CNLGIMRNLyqmyrrenekgipsTDLQGAAAFPRQQEPA--GMEEL 244
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 280 TAIQLMGIMCVL-SVCWSPLLIMMLKMIFNQTSVEHCKthtekqkecnffLIAVRLASLNQILDPWVY 346
Cdd:cd15140  245 EHLILLALMTVLfTACSLPVIARAYVGAFKGEKNEAAD------------LTALRFLSVNSIVDPWIF 300
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
49-312 1.24e-16

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 79.17  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  49 SVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRkksfLLCIGwLALTDLVGQLLTTPVVIVVYLSKqRWEHIDPsgr 128
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLN----LFLLN-LALADLLMSVVGYPLSFYSNLSG-RWSFGDP--- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd14969   72 GCVIYGFAVTFLGLVSISTLAALAFERYLVIVRP-LKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTgrggngtsSSHNWGNL-FFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGI 287
Cdd:cd14969  151 SVDW--------YSKDPNSLsYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVAKMVL 222
                        250       260
                 ....*....|....*....|....*..
gi 186659506 288 MCVLS--VCWSPLLIMMLKMIFNQTSV 312
Cdd:cd14969  223 VMIVAflIAWTPYAVVSLYVSFGGEST 249
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
52-346 9.14e-16

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 76.92  E-value: 9.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  52 VAFPITMLLT---GFVGNALAMLLVSRSYRrresKRKKSFLLCIGwLALTDLVgQLLTTPVVIVVYLSKQRWehidPSGR 128
Cdd:cd14982    1 TLFPIVYSLIfilGLLGNILALWVFLRKMK----KRSPTTIYMIN-LALADLL-FVLTLPFRIYYYLNGGWW----PFGD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 -LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTW 207
Cdd:cd14982   71 fLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 208 CFistgrggNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALvsrcrakatASQSSAQWGRITTETAIQL-MG 286
Cdd:cd14982  151 CF-------EFLSEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRAL---------RRRSKQSQKSVRKRKALRMiLI 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186659506 287 IMCVLSVCWSPL-LIMMLKMIFNQTSVEHCKTHTEKQKecnFFLIAVRLASLNQILDPWVY 346
Cdd:cd14982  215 VLAVFLVCFLPYhVTRILYLLVRLSFIADCSARNSLYK---AYRITLCLASLNSCLDPLIY 272
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
62-309 1.75e-12

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 67.30  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  62 GFVGNALAMLLvsrSYRRReSKRKKSFLLCIGwLALTDLVGQLLTTPVVIVVYLSkQRWEHIDPSgrlCTFFGLTMTVFG 141
Cdd:cd15074   14 STLGNGTVLFV---LYRRR-SKLKPAELLTVN-LAVSDLGISVFGYPLAIISAFA-HRWLFGDIG---CVFYGFCGFLFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHwYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFIstgrggNGTSS 221
Cdd:cd15074   85 CCSINTLTAISIYRYLKICHPP-YGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSI------DWTGA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 222 SHNWGNL-FFASAFAFLGLLALTVTFSCNLATIKALvsRCRAKATASQSSAQWGRITTETAIQLMGIMCVLS--VCWSPL 298
Cdd:cd15074  158 SASVGGMsYIISIFIFCYLLPVLIIVFSYVKIIRKV--KSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGflIAWTPY 235
                        250
                 ....*....|.
gi 186659506 299 LIMMLKMIFNQ 309
Cdd:cd15074  236 AVVSMWSAFGS 246
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-346 5.88e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 65.28  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRsYRRresKRKKSFLLcIGWLALTDLVGQLLTTPVVIVVYLskqrWEHIDPSGRL 129
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYR-NRR---LRTVTNYF-IVSLAVADLLVALLVMPFSAVYTL----LGYWPFGPVL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLG--VGQYTVQWPGTW 207
Cdd:cd14967   72 CRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGwrDETQPSVVDCEC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 208 CFIstgrggngtsssHNWGNLFFASAFAFlgLLALTVTFSCNLATIKALVSRCRAkatasqssaqwgrittetAIQLMGI 287
Cdd:cd14967  152 EFT------------PNKIYVLVSSVISF--FIPLLIMIVLYARIFRVARRELKA------------------AKTLAII 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 186659506 288 MCVLSVCWSPLLIMMLKMIFNQTsveHCKTHTekqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:cd14967  200 VGAFLLCWLPFFIIYLVSAFCPP---DCVPPI-------LYAVFFWLGYLNSALNPIIY 248
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
53-312 1.44e-11

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 64.66  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  53 AFPITMLLTGFVGNALAMLLVSRSyrrrESKRKKSFLLCIGwLALTDLVGQLLTTPVVIVVYLSKqRWehidPSGRL-CT 131
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRF----KSLRTPANYLIIN-LAISDFLMCILNCPLMVISSFSG-RW----IFGKTgCD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 132 FFGLTMTVFGLSSLFIASAMAVERALAIRAPH---WYASHmktRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC 208
Cdd:cd15083   75 MYGFSGGLFGIMSINTLAAIAVDRYLVITRPMkasVRISH---RRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 ---FISTgrggngtsSSHNWGNLFFASAFAFlgLLALTVTFSCNLATIKAlVSRCR-------AKATASQSSAQWGRITT 278
Cdd:cd15083  152 sfdYLSR--------DDANRSYVICLLIFGF--VLPLLIIIYCYSFIFRA-VRRHEkamkemaKRFSKSELSSPKARRQA 220
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 186659506 279 ETAIQLMGIMCVLSVC--WSPLLIMMLKMIFNQTSV 312
Cdd:cd15083  221 EVKTAKIALLLVLLFClaWTPYAVVALIGQFGYLEV 256
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
63-346 3.33e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 63.08  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  63 FVGNALAMLLVSRSYRRReskrKKSFLLcIGWLALTDLVGQLLTTPVVIVVYLSKQRwehIDPSGRLCTFFGLTMTvfGL 142
Cdd:cd14972   13 VVENSLVLAAIIKNRRLH----KPMYIL-IANLAAADLLAGIAFVFTFLSVLLVSLT---PSPATWLLRKGSLVLS--LL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 143 SSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGvgqytvqWPGTWCFIST-GRGGNGTSS 221
Cdd:cd14972   83 ASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLG-------WNCVLCDQEScSPLGPGLPK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 222 SHnwgnLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQwgRITTETAIQLMGIMCVLSVCWSPLLIM 301
Cdd:cd14972  156 SY----LVLILVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQP--STSRKLAKTVVIVLGVFLVCWLPLLIL 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 186659506 302 MLKMIfnqtsveHCKTHTEKQKECNFFLIavrLASLNQILDPWVY 346
Cdd:cd14972  230 LVLDV-------LCPSVCDIQAVFYYFLV---LALLNSAINPIIY 264
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
62-346 1.50e-09

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 58.22  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  62 GFVGNALAMLLVSRSYRrreskRKKSFLLCIGWLALTDLVGqLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFgltMTVFG 141
Cdd:cd15158   14 GLVGNGFALYVLIKTYR-----QKSAFHIYMLNLAVSDLLC-VCTLPLRVVYYVHKGQWLFGDFLCRISSYA---LYVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVlAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTS- 220
Cdd:cd15158   85 YCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFV-TLTSSPFLMSGSHDTETNKTKCFEPPQSNQQLTKl 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 221 SSHNWGNLFFASAFAFLgllaltVTFSCNLATIKALVSRcRAKATASQSSAQwgritteTAIQLMGI-MCVLSVCWSPLL 299
Cdd:cd15158  164 LVLNYISLVVGFIIPFL------VILICYAMIIRTLLKN-TMKARKQQSSRK-------KAIRMIIIvLLAFLVSFMPYH 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 186659506 300 I---MMLKMIFNQTSveHCKTHTEKQKECnffLIAVRLASLNQILDPWVY 346
Cdd:cd15158  230 IqrtIHLHFLSRKDS--TCEEVLYMQKSV---VITLCLAAANCCFDPLLY 274
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-315 2.16e-09

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 57.81  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLtGFVGNALAMLLVSRSYRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYlSKQRWehidPSGR- 128
Cdd:cd15098    3 VPVVFGLIFCL-GVLGNSLVITVLARVKPGKRRSTTNVFILN---LSIADLFFLLFCVPFQATIY-SLPEW----VFGAf 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHwYASHMKTR--ATRAVLLgVWLAVLAFAlLPVLgvgQYTVQwpgt 206
Cdd:cd15098   74 MCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSR-TSSSLRTRrnALLGVLV-IWVLSLAMA-SPVA---VHQDL---- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 207 wcfISTGRGGNGTSSSHNWGN-----LFFASAFAFLGLLALTVTFSCNLATIKALvsRCRAKATASQSSaqwgRITTETA 281
Cdd:cd15098  144 ---VHHWTASNQTFCWENWPEkqqkpVYVVCTFVFGYLLPLLLITFCYAKVLNHL--HKKLKNMSKKSE----RSKKKTA 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 186659506 282 IQLMGIMCVLSVCWSPLLIMML-----KMIFNQTS-----VEHC 315
Cdd:cd15098  215 QTVLVVVVVFGISWLPHHIIHLwvefgDFPLTQASfvlriTAHC 258
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
60-307 1.14e-08

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 55.79  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  60 LTGFVGNALAMLLVSRSyrrrESKRKKSFLLCIGwLALTDLVGQLLTTPVVIVVYLSKQRWehidPSGRL-CTFFGLTMT 138
Cdd:cd15337   12 ILGVIGNLLVIYLFSKT----KSLRTPSNMFIIN-LAISDFGFSAVNGFPLKTISSFNKKW----IWGKVaCELYGFAGG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 139 VFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWC---FISTgrg 215
Cdd:cd15337   83 IFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCtfdYLSR--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 216 gngtssshNWGNLFFASAFAFLGLLA-LTVTFSCNLATIKALVSRCR------AKATASQSSAQWGRITTETAIQ--LMG 286
Cdd:cd15337  160 --------DLNNRLFILGLFIFGFLCpLLIIIFCYVNIIRAVRNHEKemtqtaKSGMGKDTEKNDARKKAEIRIAkvAII 231
                        250       260
                 ....*....|....*....|.
gi 186659506 287 IMCVLSVCWSPLLIMMLKMIF 307
Cdd:cd15337  232 LISLFLLSWTPYAVVALLGQF 252
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-309 1.26e-07

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 52.47  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLtGFVGNALAMLLVSRSYRRRESKRkksflLCIGWLALTDLVGQLLTTPVVIVVYlSKQRWEHIDpsgRL 129
Cdd:cd14971    3 VPLFFALIFLL-GLVGNSLVILVVARNKPMRSTTN-----LFILNLAVADLTFLLFCVPFTATIY-PLPGWVFGD---FM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhWYASHMKT-RATRAVLLGVWLAVLAFAlLPVLGVgqYTVQWPgtwc 208
Cdd:cd14971   73 CKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYP-LRSLHIRTpRNALAASGCIWVVSLAVA-APVLAL--HRLRNY---- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 fistgRGGNGTSSSHNWGN-----LFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIq 283
Cdd:cd14971  145 -----TPGNRTVCSEAWPSrahrrAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLV- 218
                        250       260
                 ....*....|....*....|....*.
gi 186659506 284 lmgIMCVLSVCWSPLLIMMLKMIFNQ 309
Cdd:cd14971  219 ---VVVLFAACWGPIHAILLLVALGP 241
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
50-318 1.42e-07

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 52.28  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLtGFVGNALAMLLVSRsYRRRESKrkKSFLLciGWLALTDLVgqllttpvVIVVYLSKQRWEHIDPSGRL 129
Cdd:cd15001    2 VIIVYVITFVL-GLIGNSLVIFVVAR-FRRMRSV--TNVFL--ASLATADLL--------LLVFCVPLKTAEYFSPTWSL 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSlFIAS-----AMAVERALAIRAPhwyashMKTRA------TRAVLLGVWLAVLAFALLPVLGVGQ 198
Cdd:cd15001   68 GAFLCKAVAYLQLLS-FICSvltltAISIERYYVILHP------MKAKSfctigrARKVALLIWILSAILASPVLFGQGL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 199 YTVQW----PGTWCFIstgrggngTSSSHNWGNLFFASAFAFLGLLALTVTfscnlatikalvsrcrakaTASQSSAQWG 274
Cdd:cd15001  141 VRYESengvTVYHCQK--------AWPSTLYSRLYVVYLAIVIFFIPLIVM-------------------TFAYARDTRK 193
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 186659506 275 RITTetaiQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTH 318
Cdd:cd15001  194 QVIK----MLISVVVLFAVCWGPLLIDNLLVSFDVISTLHTQAL 233
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
56-303 2.09e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 51.86  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSRSYRRRESkrkkSFLLCigWLALTDLVGQLLTTPVVIVVYLSKQ-RWEHIDPSGRLCTFFG 134
Cdd:cd14978    8 PVICIFGIIGNILNLVVLTRKSMRSST----NVYLA--ALAVSDILVLLSALPLFLLPYIADYsSSFLSYFYAYFLPYIY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 135 LTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAlLPVLGVGQYTVQW----PGTWCFI 210
Cdd:cd14978   82 PLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN-LPRFFEYEVVECEncnnNSYYYVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 211 STGRGGNGTSSS--HNWGNLFFasaFAFLGLLALTVtfsCNLATIKALV-SRCRAKATASQSSAQWGRITTETAIQLMGI 287
Cdd:cd14978  161 PTLLRQNETYLLkyYFWLYAIF---VVLLPFILLLI---LNILLIRALRkSKKRRRLLRRRRRLLSRSQRRERRTTIMLI 234
                        250
                 ....*....|....*...
gi 186659506 288 MCVLS--VCWSPLLIMML 303
Cdd:cd14978  235 AVVIVflICNLPAGILNI 252
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
95-196 2.19e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 51.87  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVGQLLTTPVVIVVYLSKQRWEHidpsgrLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRAT 174
Cdd:cd14968   42 LAVADILVGALAIPLAILISLGLPTNFH------GCLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRA 115
                         90       100
                 ....*....|....*....|..
gi 186659506 175 RAVLLGVWLAVLAFALLPVLGV 196
Cdd:cd14968  116 WGAIAVCWVLSFLVGLTPMFGW 137
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
51-314 2.48e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 51.83  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  51 SVAFPITMLLtGFVGNALAMLLVSRSYRRRESKRkkSFLLCigwLALTDLVGQLLTTPVVIVVYLSKQrWEHidpSGRLC 130
Cdd:cd14993    4 IVLYVVVFLL-ALVGNSLVIAVVLRNKHMRTVTN--YFLVN---LAVADLLVSLFCMPLTLLENVYRP-WVF---GEVLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 131 TFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWlaVLAFAL-LPVLGVgqYTVQwpgtwcf 209
Cdd:cd14993   74 KAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW--VIAIIImLPLLVV--YELE------- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 iSTGRGGNGTSSSH----NWGNLFFASAFAFLGLLAL------TVTFSCNLATIKaLVSRCRAKATASQSSAQWGRITTE 279
Cdd:cd14993  143 -EIISSEPGTITIYicteDWPSPELRKAYNVALFVVLyvlpllIISVAYSLIGRR-LWRRKPPGDRGSANSTSSRRILRS 220
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 186659506 280 --TAIQLMGIMCVL-SVCWSPLLIMMLKMIFNQTSVEH 314
Cdd:cd14993  221 kkKVARMLIVVVVLfALSWLPYYVLSILLDFGPLSSEE 258
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
60-297 4.61e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 50.87  E-value: 4.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  60 LTGFVGNALAMLLVSRSyrrrESKRKKSFLLCIGwLALTDLVGQLLTTPVVIVVYLSKqRWEHIDpsgRLCTFFGLTMTV 139
Cdd:cd15336   12 ITGMLGNALVIYAFCRS----KKLRTPANYFIIN-LAVSDFLMSLTQSPIFFVNSLHK-RWIFGE---KGCELYAFCGAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 140 FGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYT---VQWPGTWCFISTgrgg 216
Cdd:cd15336   83 FGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVpegLLTSCTWDYMTF---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 217 ngTSSSHNWGNLFFASAFaflgLLALTVTFSCNLATIKALVSRCRA-----KATASQSSAQWGRITTE---TAIQLMGIM 288
Cdd:cd15336  159 --TPSVRAYTMLLFCFVF----FIPLGIIIYCYLFIFLAIRSTGREvqklgSQDRKEKAKQYQRMKNEwkmAKIAFVVIL 232

                 ....*....
gi 186659506 289 cVLSVCWSP 297
Cdd:cd15336  233 -LFVLSWSP 240
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
58-200 5.71e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 50.92  E-value: 5.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  58 MLLTGFVGNALAMLLVSRSyrrRESKRKKSFLLCIgwLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLtm 137
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRD---RSLHRAPYYFLLD--LCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAV-- 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186659506 138 tVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYT 200
Cdd:cd15005   83 -LFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYT 144
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
95-342 3.40e-06

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 48.03  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIvvYLSKQRWEHidpsGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhwyashMKTRAT 174
Cdd:cd15164   42 LAVADCC-LLFSLPFVL--YFLKHSWPD----DELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYP------LKAKSL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 175 R-----AVLLGV-WLAVLAFALLPVLgvgqyTVQWPGTWCFIStgrggngTSSSHNWGNLFFASAFAFLGLLALTvtfSC 248
Cdd:cd15164  109 RsprkaALTCGLlWVLVIISVSLRLA-----WEEQEENFCFGK-------TSTRPSKRTLIFSLLGFFIPLIILS---FC 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 249 NLATIKALVsrcRAKATASQSsaqwgrittETAIQ-----LMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCkthTEKQK 323
Cdd:cd15164  174 SIQVIRSLK---KKKKTNPHE---------EKLIQkaiyiVSANLIVFIVCFLPLHIGLLVRFVMESNKASC---SLIQN 238
                        250
                 ....*....|....*....
gi 186659506 324 ECNFFLIAVRLASLNQILD 342
Cdd:cd15164  239 IRNFIYVASCLANANCCLD 257
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
129-196 9.95e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 46.81  E-value: 9.95e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHwYASHMKTRATRAVLLGVWLAVLAFALLPVLGV 196
Cdd:cd15137   79 LCTFAGFLATLSSEVSVLILTLITLDRFICIVFPF-SGRRLGLRRAIIVLACIWLIGLLLAVLPLLPW 145
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
50-249 1.07e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 46.49  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLsKQRWEHidpSGRL 129
Cdd:cd15210    2 FAAVWGIVFMVVGVPGNLLTVLALLRS-----KKLRTRTNAFIINLSISDLLFCAFNLPLAASTFL-HQAWIH---GETL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLG-VGQYTVQWPGTWC 208
Cdd:cd15210   73 CRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCSC 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 186659506 209 FISTGRGGngtsssHNWGNLFFASAFaFLGLLALTVTFSCN 249
Cdd:cd15210  153 SILRDKKG------RSPKTFLFVFGF-VLPCLVIIICYARR 186
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
59-210 1.22e-05

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 46.48  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  59 LLTGFVGNALAMLLVSRSYRRReskrkkSFLLCIGWLALTDlVGQLLTTPVVIVVYLSKQRWehidPSGRLCTFFGLTMT 138
Cdd:cd14973   11 SLCGLVGNGLVLWLLGFRIKRN------PFSVYILNLAAAD-FLFLSCQAIQSLEDLLGGSL----PGFALCRLLATLMF 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186659506 139 VFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFI 210
Cdd:cd14973   80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESACRT 151
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
95-346 1.34e-05

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 46.29  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCT-FFGLTMtvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRA 173
Cdd:cd15162   42 LAIADLL-LVIWLPFKIAYHIHGNNWIFGEALCRLVTvAFYGNM----YCSILLLTCISIDRYLAIVHPMGHRRLRARRY 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 174 TRAVLLGVWLAVLAfALLPVLGVGQyTVQWPG---TWCFISTgrggNGTSSSHNWGNlFFASAFAFLGLLALTVTFSCNL 250
Cdd:cd15162  117 ALGTCLAIWLLALL-VTLPLYLVKQ-TIFLPAldiTTCHDVL----PEQLLVGDWFY-YFLSLAIVGFLIPFILTASCYV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 251 ATIkalvsRCRAKATASQSSAQWGRITTETAIqlmgIMCVLSVCWSPL-LIMMLKMIFnqtsvehcKTHTEKQKECNFFL 329
Cdd:cd15162  190 ATI-----RTLAALEDENSEKKKKRAIKLAAT----VLAIFIICFAPSnLLLLAHYSL--------ISSSGTGHLYFAYL 252
                        250
                 ....*....|....*..
gi 186659506 330 IAVRLASLNQILDPWVY 346
Cdd:cd15162  253 LALCLSTLNSCIDPFIY 269
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
95-346 1.72e-05

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493  Cd Length: 274  Bit Score: 45.94  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCT-FFGLTMtvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRA 173
Cdd:cd15371   41 LAISDLL-FCITLPFKIVYHLNGNNWVFGETMCRIITiTFYGNM----YCSILLLTCISINRYLAIVHPFIYRSLPKKTY 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 174 TRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGtwcfISTGRGGNGTSSSHNWGNLFFASAFAFLG-LLALTVTFSCNLAT 252
Cdd:cd15371  116 AVLICALVWTIVFLYMLPFFILKQTYYLKELN----ITTCHDVLPECEQNSNFQFYYFISMAVFGfLIPLVITIFCYISI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 253 IKALvsrcrakataSQSSAQWGRITTETAIQLMgimcVLSVCWSPLLIMMLKMIFNQTsvehcktHTEKQKECNFFLIAV 332
Cdd:cd15371  192 IRTL----------NAYEHKWFWYVKITALVLI----IFTICFAPSNVILIIHHFNYY-------YFNNDNLYSIYLIAL 250
                        250
                 ....*....|....
gi 186659506 333 RLASLNQILDPWVY 346
Cdd:cd15371  251 CLGSLNSCLDPFLY 264
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
48-297 2.22e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 45.75  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  48 GSVSVAFpITMLLTGFVGNALAMLLVSRSYRRRESKrkKSFLLCigwLALTDLVGQLLTTPVVIVvYLSKQRWehidPSG 127
Cdd:cd15390    1 VLWSIVF-VVMVLVAIGGNLIVIWIVLAHKRMRTVT--NYFLVN---LAVADLLISAFNTVFNFT-YLLYNDW----PFG 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 128 R-LCTFFGLTMTVFGLSSLFIASAMAVERALAIRapHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPG- 205
Cdd:cd15390   70 LfYCKFSNFVAITTVAASVFTLMAISIDRYIAIV--HPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTg 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 206 ---TWCFISTGRGGNgtSSSHNWGNLFFASAFAFLGLLALTVTFScnlatikaLVSR--CRAKATASQSSAQWGRITTE- 279
Cdd:cd15390  148 serTVCFIAWPDGPN--SLQDFVYNIVLFVVTYFLPLIIMAVAYT--------RVGVelWGSKTIGENTPRQLESVRAKr 217
                        250
                 ....*....|....*....
gi 186659506 280 -TAIQLMGIMCVLSVCWSP 297
Cdd:cd15390  218 kVVKMMIVVVVIFAICWLP 236
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
95-346 2.36e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 45.69  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVGQLLTTPVVIVVYLSKQRWEHIdpsgrlCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRAT 174
Cdd:cd15069   42 LAAADVAVGLFAIPFAITISLGFCTDFHS------CLFLACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRA 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 175 RAVLLGVWLAVLAFALLPVLGvgqYTVQWPGTWCFISTGRGGNGTSSS------HNWGNLFFASAFAFLG-----LLALT 243
Cdd:cd15069  116 RGVIAVLWVLAFGIGLTPFLG---WNKAMSATNNSTNPADHGTNHSCClisclfENVVPMSYMVYFNFFGcvlppLLIML 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 244 VTFscnlatIKALVSRCRA--KATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSvehckthtEK 321
Cdd:cd15069  193 VIY------IKIFLVACRQlqRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEF--------SK 258
                        250       260
                 ....*....|....*....|....*
gi 186659506 322 QKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15069  259 SKPKWAMNVAILLSHANSVVNPIVY 283
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
50-346 2.67e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 45.53  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLtGFVGNALAMLLVSRsyrrRESKRKKSFLLCIGwLALTDLVgQLLTTPVVIVVYLSKQRWehiDPSGRL 129
Cdd:cd15368    3 LPVVYSLVALI-SIPGNLFSLWLLCF----HTKPKTPSIIFMIN-LSLTDLM-LACFLPFQIVYHIQRNHW---IFGKPL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLaFALLPVLGVG-QYTVQWPG-TW 207
Cdd:cd15368   73 CNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVL-TALSPLERTDlTYYVKELNiTT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 208 CFISTGRggNGTSSSHNWGNLFFaSAFAFLGLLALTVTFSCNLATIKALVsrcrakatasQSSAQWGRITTETAIQLMGI 287
Cdd:cd15368  152 CFDVLKW--TMLPNIAAWAAFLF-TLFILLFLIPFIITVYCYVLIILKLV----------QTSERYGREQKRRAIYLALI 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186659506 288 -MCVLSVCWSP----LLIMMLKMIFNQTSVEHckthtekqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:cd15368  219 vLLVFITCFAPnnfiLLAHMVSRLFYGKSLYH------------AYKLTLSLSCLNSCLDPFIY 270
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
54-206 2.96e-05

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 45.08  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  54 FPITMLLTGFVGNALAMLLVsrSYRRRESKRKKSFLLcigWLALTDLvGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTF- 132
Cdd:cd15161    6 FYILVFILAFPGNTLALWLF--IHDRKSGTPSNVFLM---HLAVADL-SYVLILPMRLVYHLSGNHWPFGEVPCRLAGFl 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 133 FGLTMtvfgLSSLFIASAMAVERALAIRAPHwyaSHMKTRATR--AVLLGVWLAVLAFALLPVLgVGQYTVQWPGT 206
Cdd:cd15161   80 FYLNM----YASLYFLACISVDRFLAIVHPV---KSMKIRKPLyaHVVCGFLWVIVTVAMAPLL-VSPQTVEVNNT 147
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-190 3.85e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 44.96  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGfVGNALAMLLVSRsYRRresKRKKSFLLcIGWLALTDLVGQLLTTPVVIVVYLSKQR-WEHidpSGR 128
Cdd:cd15204    3 LGVVYVLIMLVCG-VGNLLLIAVLAR-YKK---LRTLTNLL-IANLALSDFLVAVFCLPFEMDYYVVRQRsWTH---GDV 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 129 LCTFFGLTMTVfglsSLFIAS----AMAVERALAIRAPHWyaSHMKTRATRAVLLGVWLAVLAFAL 190
Cdd:cd15204   74 LCAVVNYLRTV----SLYVSTnallVIAIDRYLVIVHPLK--PRMKRRTACVVIALVWVVSLLLAI 133
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
56-346 4.77e-05

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 44.74  E-value: 4.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSrsYRRRESKRKKSFLLCigwLALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFfgl 135
Cdd:cd14991    8 ILEFVLGLPGNVVALWIFC--FHSRTWKANTVYLFN---LVLADFL-LLICLPFRIDYYLRGEHWIFGEAWCRVNLF--- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAlLPVLGVGQYTVQWPGTWC--FIStg 213
Cdd:cd14991   79 MLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLT-LPLLLSTLLTVNSNKSSChsFSS-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 rgGNGTSSSHNWGNLFFASAFaflgLLALTVTFSCNLATIKALVSRcrakatasQSSAQWGRITTETAIqLMGIMCVLSV 293
Cdd:cd14991  156 --YTKPSLSIRWHNALFLLEF----FLPLGLIVFCSVRIACNLRIR--------QSLGKQARVQRAIRL-VFLVVIVFVL 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 186659506 294 CWSPLLIM-MLKMIFNQTSVEHCKTHTEKqkecnFFLIAVRLASLNQILDPWVY 346
Cdd:cd14991  221 CFLPSIIAgLLALVFKNLGSCRCLNSVAQ-----LFHISLAFTYLNSALDPVIY 269
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
56-346 5.45e-05

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 44.28  E-value: 5.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVsrsYRRRESKRKKSFLLCIgwLALTDLVGQLLTTPVVIVVYLSkQRWEHIDpsgRLCTFFGL 135
Cdd:cd15213    8 ILMIFVGFLGNSIVCLIV---YQKPAMRSAINLLLAN--LAFSDIMLSLVCMPFAAVTIIT-GRWIFGD---IFCRISAM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAphwYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFIstgrg 215
Cdd:cd15213   79 LYWFFVLEGVAILLIISVDRYLIIVQ---RQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVL----- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 216 GNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRcrakatasqssaqwgritTETAIQLMGImcVLSVCW 295
Cdd:cd15213  151 GYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTR------------------AFTTILILFI--GFSVCW 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 186659506 296 SPLLIMMLKMIFNQTSVEHCKTHTekqkecnfflIAVRLASLNQILDPWVY 346
Cdd:cd15213  211 LPYTVYSLLSVFSRYSSSFYVIST----------CLLWLSYLKSAFNPVIY 251
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
130-346 7.53e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.16  E-value: 7.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGvgqytvqwpgtWCF 209
Cdd:cd15068   71 CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLG-----------WNN 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 ISTGRGGNGTSSSHNWGNL-----------------FFASAFAFLgLLALTVTFSCNLATIKALvSRCRAKATASQSSAQ 272
Cdd:cd15068  140 CGQPKEGKNHSQGCGEGQVaclfedvvpmnymvyfnFFACVLVPL-LLMLGVYLRIFLAARRQL-KQMESQPLPGERARS 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186659506 273 WGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFnqtsvehCkthtekqKECN-----FFLIAVRLASLNQILDPWVY 346
Cdd:cd15068  218 TLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF-------C-------PDCShaplwLMYLAIVLSHTNSVVNPFIY 282
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
95-346 7.64e-05

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 43.89  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFgLTMTVFGlsSLFIASAMAVERALAIRAPHWYASHMKTRAT 174
Cdd:cd15201   42 LAVADFL-LIICLPFRTDYYLRGKHWKFGDIPCRIVLFM-LAMNRAG--SIFFLTAVAVDRYFRVVHPHHRINSISVRKA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 175 RAVLLGVWLAVLAFALLpVLGVGQYTVQWPGTWC--FISTgrggNGTSSSHNWGNLFFASAFaflgLLALTVTFSCNLAT 252
Cdd:cd15201  118 AIIACGLWLLTIAMTVY-LLTKKHLFPRGNATQCesFNIC----TGTDSSSNWHEAMFLLEF----FLPLAIILYCSVRI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 253 IKALVSRcrakatasqSSAQWGRIttETAIQLMGIMCVL-SVCWSPLLIMMLKM-IFNQTSVEHCKTHTEKQkecNFFLI 330
Cdd:cd15201  189 IWQLRGR---------QLDRHAKI--KRAVQFIMVVAIVfIICFLPSNVTRIAIwILKHTSNEDCQYYRSVD---LAFYI 254
                        250
                 ....*....|....*.
gi 186659506 331 AVRLASLNQILDPWVY 346
Cdd:cd15201  255 TISFTYFNSMLDPVVY 270
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
64-300 9.55e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 43.86  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  64 VGNALAMLLVSRSyrRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSkQRWEHidpSGRLCTFFGLTMTVFGLS 143
Cdd:cd15051   16 IGNVLVCLAVAVN--RRLRNLTNYFIVS---LAVTDLLLGLLVLPFSAIYELR-GEWPL---GPVFCNIYISLDVMLCTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 144 SLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPV-LG--VGQYTVQ--WPGTWCFISTGRggng 218
Cdd:cd15051   87 SILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGwnTPDGRVQngDTPNQCRFELNP---- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 219 tssshNWGNLFFASAFaFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITT---ETAIQLMGIMCVLSVCW 295
Cdd:cd15051  163 -----PYVLLVAIGTF-YLPLLIMCGVYLRIFRIAREQAKRINALTPASTANSSKSAATArehKATVTLAAVLGAFIICW 236

                 ....*
gi 186659506 296 SPLLI 300
Cdd:cd15051  237 FPYFT 241
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
130-307 1.01e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 43.57  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYaSHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCF 209
Cdd:cd15073   73 CQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLG-RKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCT 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 ISTGRGGNGTSSshnwgnlFFASAFAFLGLLALTVTFSCNLATIKAlVSRCRAKATASQSSAQWgriTTETAIQLMGIMC 289
Cdd:cd15073  152 INWRKNDSSFVS-------YTMSVIVVNFIVPLAVMFYCYYNVSRF-VKKVLASDCLESVNIDW---TDQNDVTKMSVIM 220
                        170       180
                 ....*....|....*....|
gi 186659506 290 VLS--VCWSPLLIMMLKMIF 307
Cdd:cd15073  221 IVMflVAWSPYSIVCLWASF 240
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
59-346 1.05e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 43.46  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  59 LLTGFVGNALAMLLVSRSYRRRESKRKKSFLLcigwlALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCTF---FGL 135
Cdd:cd15168   11 FLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNL-----AVSDLL-YLLSLPFLIYYYANGDHWIFGDFMCKLVRFlfyFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 tmtvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAfALLPVLgvgqytvqwpgtwCFISTGRG 215
Cdd:cd15168   85 ------YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLL-QLLPIL-------------FFATTGRK 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 216 GNGTS----SSHNWGNLFFASAFAFLGL---LALTVTFSCNLATIKALVSRCRAKATASQSsaqwgrittETAIQLMGIM 288
Cdd:cd15168  145 NNRTTcydtTSPEELNDYVIYSMVLTGLgflLPLLIILACYGLIVRALIRKLGEGVTSALR---------RKSIRLVIIV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186659506 289 CVL-SVCWSPLLIM-MLKMIFNQTSVEHCKtHTEKQkeCNFFLIAVR-LASLNQILDPWVY 346
Cdd:cd15168  216 LALfAVCFLPFHVTrTINLAARLLSGTASC-ATLNG--IYVAYKVTRpLASLNSCLNPLLY 273
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
50-194 1.10e-04

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 43.65  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPItmlltGFVGNALamllVSRSYRRRESKRKKSFLLCIGwLALTDLVgQLLTTPVVIVvYLSKQRWEHIDPSGRL 129
Cdd:cd15121    7 LSLAFIL-----GFPGNLF----VVWSVLCRMKKRSVTCILVLN-LALADAA-VLLTAPFFLH-FLSGGGWEFGSVVCKL 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 130 CTFF-GLTMTVfglsSLFIASAMAVERALAIRAPhWYASHMKT-RATRAVLLGVWlaVLAFAL-LPVL 194
Cdd:cd15121   75 CHYVcGVSMYA----SIFLITLMSMDRCLAVAKP-FLSQKMRTkRSVRALLLAIW--IVAFLLsLPMP 135
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
56-303 1.41e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 43.21  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVgQLLTTPVVIVVYLSKQRWEHIDPsgrLCTFFGL 135
Cdd:cd15088    8 GCICVVGLVGNGIVLYVLVRC-----SKLRTAPDIFIFNLAVADLL-FMLGMPFLIHQFAIDGQWYFGEV---MCKIITA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLaFALLPVLgVGQYTVQWPG--TWCFISTG 213
Cdd:cd15088   79 LDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASF-LSILPVW-VYSSLIYFPDgtTFCYVSLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 RGGNGtssshNWGNLF-FASAFAFlgllALTVTFSCNLATIKALVsrcRAKATASQSSAQwgRITTETAIQLMGIMCVLS 292
Cdd:cd15088  157 SPDDL-----YWFTIYhFILGFAV----PLVVITVCYILILHRLA---RGVAPGNQSHGS--SRTKRVTKMVILIVVVFI 222
                        250
                 ....*....|.
gi 186659506 293 VCWSPLLIMML 303
Cdd:cd15088  223 VCWLPFHVVQL 233
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-205 1.60e-04

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 43.20  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  57 TMLLTGFVGNALAMLLVSRSYRRRESKRkksflLCIGWLALTDLVgQLLTTPVVIVVYLSKQrWEHIDPSGRLctFFG-- 134
Cdd:cd14999    8 LMCVVGVAGNVYTLVVMCLSMRPRASMY-----VYILNLALADLL-YLLTIPFYVSTYFLKK-WYFGDVGCRL--LFSld 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186659506 135 -LTMtvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRAtRAVLLGVWLAVLAFALLPVLGVGQYTVQWPG 205
Cdd:cd14999   79 fLTM----HASIFTLTVMSTERYLAVVKPLDTVKRSKSYR-KLLAGVIWLLSLLLTLPMAIMIRLVTVEDKS 145
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
59-189 1.98e-04

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 42.85  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  59 LLTGFVGNALAMLLVSRSYRRRESKrkksfLLCIGWLALTDLVgQLLTTPVVIVvYLSKQRWEHIDPSGRLCTFF-GLTM 137
Cdd:cd14975   11 FAIGLPGNSFVIWSILIKVKQRSVT-----MLLVLNLALADLA-VLLTLPVWIY-FLATGTWDFGLAACKGCVYVcAVSM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 186659506 138 tvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFA 189
Cdd:cd14975   84 ----YASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLA 131
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
57-346 2.10e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 42.75  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  57 TMLLTGFVGNALAMLLVSRsyRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVvYLSKQRWEHIDPSGRLCTFfglt 136
Cdd:cd14986    9 VLFVFTLVGNGLVILVLRR--KRKKRSRVNIFILN---LAIADLVVAFFTVLTQII-WEATGEWVAGDVLCRIVKY---- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 137 MTVFGL-SSLFIASAMAVERALAIRAPHWYASHmKTRATRAVLLGvWLAVLAFALLPVLGVGQYTVQWPGTWCFistgrg 215
Cdd:cd14986   79 LQVVGLfASTYILVSMSLDRYQAIVKPMSSLKP-RKRARLMIVVA-WVLSFLFSIPQLVIFVERELGDGVHQCW------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 216 gngTSSSHNWGNLFFASAFAFLGLLA-LTVTFSCNLATIKALVSRCRAKATASQS-------SAQWGRITTET------- 280
Cdd:cd14986  151 ---SSFYTPWQRKVYITWLATYVFVIpLIILSYCYGRILRTIWIRSRQKTDRPIAptamscrSVSCVSSRVSLisrakik 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186659506 281 AIQlMGIMCVLS--VCWSPLLIMMLKMIFNqtsvehckthTEKQKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd14986  228 TIK-MTLVIILAfiLCWTPYFIVQLLDVYA----------GMQQLENDAYVVSETLASLNSALNPLIY 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
56-297 2.13e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 42.48  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSRSYRRRESKRkksflLCIGWLALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGL 135
Cdd:cd15928    8 SVLMLVGASGNLLTVLVIGRSRDMRTTTN-----LYLSSLAVSDLL-IFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 TMTvfgLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWL--AVLAFALLPVLGVGQYTVQWP--GTWCFIS 211
Cdd:cd15928   82 TCT---YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAvaIVSAGPALVLVGVEHIQGQQTprGFECTVV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 TGRGGNGTSSshnwgnLFFASAFAFLGLLALTVTFSCnlaTIKALVSRCRAKATASQSSAQWGRitTETAIQLMGIMCVL 291
Cdd:cd15928  159 NVSSGLLSVM------LWVSTSFFFVPMVCLSLLYGL---IGRALWDRRQRSRTAGASRRDNNH--RQTVRMLAVIVLAF 227

                 ....*.
gi 186659506 292 SVCWSP 297
Cdd:cd15928  228 VLCWLP 233
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
62-303 2.25e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 42.41  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  62 GFVGNALAMLLVSRSYRRRESKRkksFLLCIgwLALTDLVGQLLttpVVIVVYLSKQRWEHIDPSGrLCTFFGLTMTVFG 141
Cdd:cd14964   12 GLLGNLLVLLSLVRLRKRPRSTR---LLLAS--LAACDLLASLV---VLVLFFLLGLTEASSRPQA-LCYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGvgqytvqwpgtWCFISTGRGGNGTSS 221
Cdd:cd14964   83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVG-----------KGAIPRYNTLTGSCY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 222 SHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVlsvCWSPLLIM 301
Cdd:cd14964  152 LICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLL---CWLPFSIV 228

                 ..
gi 186659506 302 ML 303
Cdd:cd14964  229 FI 230
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
63-255 2.48e-04

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 42.38  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  63 FVGNALAM-LLVSRSYRRRESKRKKSFLLcigwlALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFgltMTVFG 141
Cdd:cd15376   15 VLGNGLALwLFVTRERRPWHTGVVFSFNL-----AVSDLL-YALSLPLLAAYYYPPKNWRFGEAACKLERFL---FTCNL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAlLPVLGVGQytVQWPGTWCFISTGRGGNGTSS 221
Cdd:cd15376   86 YGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALS-APVLSFSH--LEVERHNKTECLGTAVDSRLP 162
                        170       180       190
                 ....*....|....*....|....*....|....
gi 186659506 222 SHNWGNLFFAsafAFLGLLALTVTFSCNLATIKA 255
Cdd:cd15376  163 TYLPYSLFLA---VVGCGLPFLLTLASYLAIVWA 193
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
53-194 2.59e-04

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 42.37  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  53 AFPITMLLTGFVGNALAMLLVsrsYRRRESKRKKS-FLLCigwLALTDLVgQLLTTPVVIVVYLSKQRWehidPSGR-LC 130
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVF---LFPRGPKRVADiFIAN---LAAADLV-FVLTLPLWATYTANQYDW----PFGAfLC 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186659506 131 TFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWlAVLAFALLPVL 194
Cdd:cd14985   74 KVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIW-VVACLLSLPTF 136
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
56-346 2.72e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 42.18  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSRSyrrrESKRKKSFLLCIGwLALTDLVgQLLTTPVVIV-VYLSKQRWEHIdpsgrLCTFFG 134
Cdd:cd15079    8 IFLGIVSLLGNGLVIYIFSTT----KSLRTPSNMLVVN-LAISDFL-MMIKMPIFIYnSFYEGWALGPL-----GCQIYA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 135 LTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATrAVLLGVWLAVLAFALLPVL-GVGQYTVQwpgtwcfistg 213
Cdd:cd15079   77 FLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKAL-LLILFIWLYALPWALLPLLfGWGRYVPE----------- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 rgGNGTSSS-----HNWGN-LFFASAFAFLGLLALTVTFSCNLATIKALVS-----RCRAK---ATASQSSAQWGRITTE 279
Cdd:cd15079  145 --GFLTSCSfdyltRDWNTrSFVATIFVFAYVIPLIIIIYCYSFIVKAVFAhekalREQAKkmnVVSLRSNADANKQSAE 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 280 TAIQLMGIMCVLS--VCWSPLLIMMLKMIF-NQTSVEHCKThtekqkecnffLIAVRLASLNQILDPWVY 346
Cdd:cd15079  223 IRIAKVALTNVFLwfIAWTPYAVVALIGAFgNQSLLTPLVS-----------MIPALFAKTAACYNPIVY 281
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
58-193 2.85e-04

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 42.07  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  58 MLLTGFVGNALAMLLVSRSYRRreskrKKSFLLCIGWLALTDLvGQLLTTPVVIVVYLSKQRWEHidpSGRLCTFFGLTM 137
Cdd:cd14988   10 IFVVGLVENVLVIWVNWHRWGS-----KNLVNLYILNMAIADL-GVVLTLPVWMLEVMLDYTWLW---GSFLCKFTHYFY 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 138 TVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPV 193
Cdd:cd14988   81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEV 136
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
95-346 2.93e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 42.37  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIVVYLSKQRWEHidpSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRAT 174
Cdd:cd15160   42 LSLSDLL-YILTLPLWIDYTANHHNWTF---GPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 175 RAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFistgrGGNGTSSSHNWGNLF-FASAFAF-LGLLALtvtfsCNLAT 252
Cdd:cd15160  118 LKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCY-----EKYPMEGWQASYNYArFLVGFLIpLSLILF-----FYRRV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 253 IKALVsrcRAKATASQSSAQWGRIttetaiqLMGIMCVLSVCWSPLLIMML-----KMIFNQTSVEHCKTHTEKQkecnf 327
Cdd:cd15160  188 LRAVR---QSPSLEREEKRKIIGL-------LLSIVVIFLLCFLPYHVVLLvrsviELVQNGLCGFEKRVFTAYQ----- 252
                        250
                 ....*....|....*....
gi 186659506 328 flIAVRLASLNQILDPWVY 346
Cdd:cd15160  253 --ISLCLTSLNCVADPILY 269
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
58-346 3.96e-04

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 41.91  E-value: 3.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  58 MLLTGFVGNaLAMLLVSRSYRRRESKRKKSFLLcigWLALTDLVGQLLTTPVVIVVYLSKQrWEHIDPSGRLCTFFgltm 137
Cdd:cd15382   10 LFLIAAVGN-LTVLLILLRNRRRKRSRVNILLM---HLAIADLLVTFIMMPLEIGWAATVA-WLAGDFLCRLMLFF---- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 138 TVFGLS-SLFIASAMAVERALAIRAPhWYASHMKTRAtRAVLLGVWlaVLAFAL-LP---VLGVGQY-TVQWpgtwcFIS 211
Cdd:cd15382   81 RAFGLYlSSFVLVCISLDRYFAILKP-LRLSDARRRG-RIMLAVAW--VISFLCsIPqsfIFHVESHpCVTW-----FSQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 TGRGGNGTSSSH-NWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQ--------WGRITTETAI 282
Cdd:cd15382  152 CVTFNFFPSHDHeLAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRlrrssvglLERARSRTLK 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186659506 283 QLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKqkecNFFLIAVrlasLNQILDPWVY 346
Cdd:cd15382  232 MTIVIVLVFIICWTPYFIMSLWYWFDRESASKVDPRIQK----GLFLFAV----SNSCMNPIVY 287
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
95-346 4.40e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 41.67  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVgQLLTTPVVIvvYLSKQRWEHIDPsgrLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhWYASHMKTRAT 174
Cdd:cd15923   42 LAVADLL-LLISLPFKM--HSYRRESAGLQK---LCNFVLSLYYINMYVSIFTITAISVDRYVAIRYP-LRARELRSPRK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 175 RAVLLGVwLAVLAFALLPVLGVGQYTVQwpGTWCFistgrggngTSSSHNWGNLFFAsAFAFLG-LLALTVTFSCNLATI 253
Cdd:cd15923  115 AAVVCAV-IWVLVVTISIPYFLLDSSNE--KTMCF---------QRTKQTESLKVFL-LLEIFGfLLPLIIMTFCSARVI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 254 KALVSRCRAKATASQssaqwgriTTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEhCKThteKQKECNFFLIAVR 333
Cdd:cd15923  182 HTLQKRLDDVGSRSE--------TKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSYS-CDS---KLIIHFFLQSAFC 249
                        250
                 ....*....|...
gi 186659506 334 LASLNQILDPWVY 346
Cdd:cd15923  250 LSDMNCCLDAFCY 262
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
56-309 4.67e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 41.44  E-value: 4.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSRsyRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSKQrWehidPSGR-LCTFFG 134
Cdd:cd15203    8 GLIIVLGVVGNLLVIYVVLR--NKSMQTVTNIFILN---LAVSDLLLCLVSLPFTLIYTLTKN-W----PFGSiLCKLVP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 135 LTMTVFGLSSLFIASAMAVERALAIRAPHwyASHMKTRATRAVLLGVWlaVLAFAL-LPvLGVGQYTVQWPgtwcfiSTG 213
Cdd:cd15203   78 SLQGVSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIW--ILSLLLsLP-LAIFQELSDVP------IEI 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 RGGNGTSSSHNWGN-----LFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTE----TAIQL 284
Cdd:cd15203  147 LPYCGYFCTESWPSsssrlIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELRrkrrTNRLL 226
                        250       260
                 ....*....|....*....|....*....
gi 186659506 285 MGIMCVLSVCWSPL----LIMMLKMIFNQ 309
Cdd:cd15203  227 IAMVVVFAVCWLPLnlfnLLRDFEPLPQI 255
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
50-195 5.05e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 41.28  E-value: 5.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSyrrrESKRKKSFL--LCIgwlalTDLVGQLLTTPVVIVVylSKQRWEHIDPSG 127
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVIAKT----PHLRKFAFVchLCV-----VDLLAALLLMPLGILS--SSPFFLGVVFGE 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186659506 128 RLCTFFgLTMTVFGLS-SLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLG 195
Cdd:cd15220   70 AECRVY-IFLSVCLVSaSILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLG 137
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
53-194 5.89e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 41.28  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  53 AFPITMLLTGFVGNALAMLLVSRsyRRRESKRKKSFLLCigwLALTDLVGqLLTTPVVIVVYLSKQRWEHidpSGRLCTF 132
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSK--RSTTKRLVDTFVLN---LAVADLVF-VLTLPFWAASTALGGQWLF---GEGLCKL 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186659506 133 FGLTMTVFGLSSLFIASAMAVERALAIRAPHwYASHMKT-RATRAVLLGVWLAVLAFALLPVL 194
Cdd:cd15193   76 SSFIIAVNRCSSILFLTGMSVDRYLAVVKLL-DSRPLRTrRCALITCCIIWAVSLVLGIPSLV 137
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
56-199 6.40e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 41.47  E-value: 6.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFV------GNALAMLLVSRSyrRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSKQRWEHidpSGRL 129
Cdd:cd15217    2 VKLVLLGLIicvslaGNLIVSLLVLKD--RALHKAPYYFLLD---LCLADTIRSAVCFPFVLVSIRNGSAWTY---SVLS 73
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQY 199
Cdd:cd15217   74 CKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTY 143
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
130-297 7.12e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 40.94  E-value: 7.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhwyASHMKTRATRAV--LLGVWLAVLAFALLPVLGVGQYTVQWPGTW 207
Cdd:cd15082   86 CVLEGFAVTFFGIVALWSLAVLAFERFFVICRP---LGNIRLQGKHAAlgLLFVWTFSFIWTIPPVLGWSSYTVSKIGTT 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 208 CfisTGRGGNGTSSSHNWGNLFFASAFaflgLLALTVTFSCNLATIKALvsrcrAKATASQSSAQWGRITTETAIQLMGI 287
Cdd:cd15082  163 C---EPNWYSGNMHDHTYIITFFTTCF----ILPLGVIFVSYGKLLQKL-----RKVSNTQGRLGNARKPERQVTRMVVV 230
                        170
                 ....*....|.
gi 186659506 288 MCV-LSVCWSP 297
Cdd:cd15082  231 MIVaFMVCWTP 241
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
135-313 1.05e-03

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 40.52  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 135 LTMTVFGL---SSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFIs 211
Cdd:cd15093   74 LVLSVDGInmfTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNM- 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 tgrggNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIkalvsrcrAKATASQSSAQWG-RITTETAIQLMGIMCV 290
Cdd:cd15093  153 -----QWPEPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIV--------IKVKSAGLRAGWQqRKRSERKVTRMVVMVV 219
                        170       180
                 ....*....|....*....|....*
gi 186659506 291 L--SVCWSPLLIMMLKMIFNQTSVE 313
Cdd:cd15093  220 VvfVICWLPFYVLQLVNVFVQLPET 244
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
50-303 1.18e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 40.36  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVgQLLTTPVVIVVYLSkQRWehidPSGR- 128
Cdd:cd14970    2 VIPAVYSVVCVVGLTGNSLVIYVILRY-----SKMKTVTNIYILNLAVADEL-FLLGLPFLATSYLL-GYW----PFGEv 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAlLPVL----------GVGQ 198
Cdd:cd14970   71 MCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLG-LPVIifartlqeegGTIS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 199 YTVQWPGtwcfistgrggngtsSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITT 278
Cdd:cd14970  150 CNLQWPD---------------PPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARRKVT 214
                        250       260
                 ....*....|....*....|....*
gi 186659506 279 ETAIQLMGimcVLSVCWSPLLIMML 303
Cdd:cd14970  215 RLVLVVVA---VFVVCWLPFHVFQI 236
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
95-308 1.20e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.22  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  95 LALTDLVGQLLTTPVVIVV------YLSKQrwehidpsgrLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPhWYASH 168
Cdd:cd15085   42 LSFSDLMMALCGTTIVTVTnyegyfYLGDA----------FCIFQGFAVNYFGIVSLWSLTLLAYERYNVVCKP-MGGLK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 169 MKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTgrggngtsSSHNWGN-----LFFASAFaFLGLLALT 243
Cdd:cd15085  111 LSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCSIGW--------EERSWSNysyliLYFLMCF-VIPVAIIG 181
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186659506 244 VTFSCNLATIKALvsrcrAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFN 308
Cdd:cd15085  182 FSYGNVLRSLHKL-----NKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVVN 241
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
135-346 1.51e-03

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 39.83  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 135 LTMTVFGL---SSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLaFALLPVLGVGQYTVQWPGTWCFIs 211
Cdd:cd15971   74 VVMTVDGInqfTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSL-LVILPIMIYAGVQTKHGRSSCTI- 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 tgrggNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATI-KALVSRCRAKATASQSSAQwgRITTETAIqlmgIMCV 290
Cdd:cd15971  152 -----IWPGESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIiKVKSSGIRVGSSKRKKSEK--KVTRMVSI----VVAV 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186659506 291 LSVCWSPLlimmlkMIFNQTSVEHCKTHTEKQKecNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15971  221 FVFCWLPF------YIFNVSSVSVSISPTPGLK--GMFDFVVVLSYANSCANPILY 268
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
56-190 1.72e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 39.94  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFvGNALAMLLVSrsYRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSKqrweHIDPSGRLCTFFGL 135
Cdd:cd15307    9 VLVLGTAA-GNILVCLAIA--WERRLQNVTNYFLMS---LAITDLMVAVLVMPLGILTLVKG----HFPLSSEHCLTWIC 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAL 190
Cdd:cd15307   79 LDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL 133
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
144-200 1.79e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 1.79e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186659506 144 SLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYT 200
Cdd:cd15136   94 SVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYS 150
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
57-320 2.30e-03

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 39.35  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  57 TMLLTGFVGNALAMLLVSRsyRRRESKRKKSFLLcigWLALTDLVgQLLTTPVVIVVylSKQRWEHidpSGRLCTFFGLT 136
Cdd:cd15181    9 LVFLLGVVGNGLVLTILLR--RRRSRRTTENYLL---HLALADLL-LLLTFPFSVVE--SIAGWVF---GTFLCKLVGAI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 137 MTVFGLSSLFIASAMAVERALAI-RAPHWYaSHMKTRATRAVLLGVWLAVLAFAL--LPVLGVGQYTvQWPGTWCFISTG 213
Cdd:cd15181   78 HKLNFYCSSLLLACISVDRYLAIvHAIHSY-RHRRLRSVHLTCGSIWLVCFLLSLpnLVFLEVETST-NANRTSCSFHQY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 rggnGTSSSHNWgnlfFASAFAF--LG-LLALTVTFSCNLATIKALVSRCRakatasqssaqwgRITTETAIQL-MGIMC 289
Cdd:cd15181  156 ----GIHESNWW----LTSRFLYhvVGfFLPLLIMGYCYATIVVTLCQSSR-------------RLQKQKAIRVaILVTL 214
                        250       260       270
                 ....*....|....*....|....*....|...
gi 186659506 290 VLSVCWSP--LLIMMLKMIFNQTSVEHCKTHTE 320
Cdd:cd15181  215 VFCLCWLPynIVIFLDTLDDLKAVVKNCKLNDL 247
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
62-186 2.65e-03

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 39.09  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  62 GFVGNALAMLLVsRSYRRRESKRKKSFLLCigwLALTDLvGQLLTTPVVIVVYLSKQRWehidPSGRLCTFFGLTMTVFG 141
Cdd:cd15925   14 GLLGNLAVMYLL-RNCARRAPPPIDVFVFN---LALADF-GFALTLPFWAVESALDFHW----PFGGAMCKMVLTATVLN 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 186659506 142 L-SSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVL 186
Cdd:cd15925   85 VyASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAAL 130
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
52-308 2.91e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 38.99  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  52 VAFPITMLLTGFVGNALAMLLVsrsyRRRESKRKKSFLLcIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHidpsgrLCT 131
Cdd:cd15070    4 ISIEILIGLCAVVGNVLVIWVV----KLNPSLRTTTFYF-IVSLALADIAVGVLVIPLAIVVSLGVTIHFY------SCL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 132 FFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGvgqytvqwpgtWCFIS 211
Cdd:cd15070   73 FMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFG-----------WNRKP 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 TGRGGNGTSSSHNWGN------LFFASAFAFLgLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLM 285
Cdd:cd15070  142 SLESVNTTPLQCQFTSvmrmdyMVYFSFFTWI-LIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLA 220
                        250       260
                 ....*....|....*....|...
gi 186659506 286 GIMCVLSVCWSPLLIMMLKMIFN 308
Cdd:cd15070  221 LVLFLFAVCWLPLSIINCVVYFN 243
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
60-199 3.05e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 39.12  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  60 LTGFVGNALAMLLVSRSYRRRESKRkksFLLCIgwLALTDL-VGQLLTTPVVIVVYLSKQRWEH-ID-PSGRLCTFFGLt 136
Cdd:cd15964   12 LLAILGNVFVLLILLTSHYKLTVPR---FLMCN--LAFADFcMGIYLLLIASVDLHTRSEYYNHaIDwQTGPGCNTAGF- 85
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186659506 137 MTVFglsslfiASAMAVERALAIRAPHWYASHMKTRATR--------AVLLGVWLAVLAFALLPVLGVGQY 199
Cdd:cd15964   86 FTVF-------ASELSVYTLTVITLERWYAITFAMRLDRkirlrhasAIMLGGWVFCFLLALLPLVGVSSY 149
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
60-346 3.37e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 38.88  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  60 LTGFVGNALAMLLVsrsyrRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTv 139
Cdd:cd14979   12 VVGIVGNLLTCIVI-----ARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEACT- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 140 fgLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAlLPVL---GVGQYTVQWPGT-----WCFIS 211
Cdd:cd14979   86 --YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-IPILflmGIQYLNGPLPGPvpdsaVCTLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 212 TGRGGNgtssshnwgNLFFASAFaflgllalTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQ-------- 283
Cdd:cd14979  163 VDRSTF---------KYVFQVST--------FIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVElslsqqar 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186659506 284 ------LMGIMCVLSVCWSP--LLIMMLKMIFNQTSVEHCKTHtekqkecNFFLIAVRLASLNQILDPWVY 346
Cdd:cd14979  226 rqvvkmLGAVVIAFFVCWLPfhAQRLMFSYASKEDTFLFDFYQ-------YLYPISGILFYLSSAINPILY 289
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
56-196 3.80e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 38.76  E-value: 3.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  56 ITMLLTGFVGNALAMLLVSrsYRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSKQRWEHidPSgRLCTFFGL 135
Cdd:cd15304    8 VIVIILTIAGNILVIMAVS--LEKKLQNATNYFLMS---LAIADMLLGFLVMPVSMLTILYGYRWPL--PS-KLCAVWIY 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFAL-LPVLGV 196
Cdd:cd15304   80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPVFGL 141
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
62-300 4.76e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 38.45  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  62 GFVGNALAMLLVSrsYRRRESKRKKSFLLCigwLALTDLVGQLLTTPVVIVVYLSKQRWehidPSGRLCTFFGLTMTV-F 140
Cdd:cd15052   14 TIGGNILVCLAIS--LEKRLQNVTNYFLMS---LAIADLLVGLLVMPLSILTELFGGVW----PLPLVLCLLWVTLDVlF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 141 GLSSLFIASAMAVERALAIRAPHWYaSHMKTRATRAV-LLGVWLAVLAFAL-LPVLGVGQYTVQWPGTWCFISTGRggng 218
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRT-RRNKSRTTVFLkIAIVWLISIGISSpIPVLGIIDTTNVLNNGTCVLFNPN---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 219 tssshnwgNLFFASAFAF-LGLLALTVTFScnlATIKALvsRCRAKATasqssaqwgrittetaiQLMGIM-CVLSVCWS 296
Cdd:cd15052  160 --------FVIYGSIVAFfIPLLIMVVTYA---LTIRLL--SNEQKAS-----------------KVLGIVfAVFVICWC 209

                 ....
gi 186659506 297 PLLI 300
Cdd:cd15052  210 PFFI 213
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
63-312 4.83e-03

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 38.38  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  63 FVGNALAMLLVSRSYRrresKRKKSFLLCIGWLALTDLV--GQLLTTPVVIVVYLSK-----QRWEHidpsGRLCTFFGL 135
Cdd:cd14980   15 LIGNILVIIWHISSKK----KKKKVPKLLIINLAIADFLmgIYLLIIAIADQYYRGRyaqysEEWLR----SPPCLLACF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 136 TMTVFGLSSLFIASAMAVERALAIRAPhWYASHMKTRATRAVLLGVWLAVLAFALLPVLgvgqYTVQWPGTWCFISTgrg 215
Cdd:cd14980   87 LVSLSSLMSVLMMLLITLDRYICIVYP-FSNKRLSYKSAKIILILGWLFSIIFAAIPIL----YSINQPGDNRLYGY--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 216 gNGTSSSHNWGNLFFAS---AFAFLGLLALTVTFSCNLATIkALVSRCRAKATASQSSAQwGRIttetAIQLMGIMCVLS 292
Cdd:cd14980  159 -SSICMPSNVSNPYYRGwliAYLLLTFIAWIIICILYILIF-ISVRKSRKSARRSSSKRD-KRI----AIRLALILITDL 231
                        250       260
                 ....*....|....*....|
gi 186659506 293 VCWSPLLIMMLKMIFNQTSV 312
Cdd:cd14980  232 ICWLPYYIVIFSGLLTSTEI 251
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
54-209 4.87e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 38.25  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  54 FPITMLLT---GFVGNALAMLLVSRSYRRreskrKKSFLLCIGWLALTDLVgQLLTTPVVIVVYLSKQRWEHIDPSGRLC 130
Cdd:cd15921    3 YPTAYILIfilGLTGNSISVYVFLSQYRS-----QTPVSVLMVNLAISDLL-LVCTLPLRLTYYVLNSHWPFGDIACRII 76
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186659506 131 TFfglTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAfALLPVLGVGQYTVQWPGTWCF 209
Cdd:cd15921   77 LY---VLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGL-ASSPLLFAKSKQHDEGSTRCL 151
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
60-307 6.00e-03

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 37.97  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  60 LTGFVGNALAMLLVSRSyrrreSKRKKSFLLCIGWLALTDLVgQLLTTPVVIVVYLSKQrWehidPSGRLCTFFGLTMTV 139
Cdd:cd15970   12 LVGLCGNSMVIYVILRY-----AKMKTATNIYILNLAIADEL-LMLSVPFLVTSTLLRH-W----PFGSLLCRLVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 140 FGL-SSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLaFALLPVLgvgqytvqwpgtwCFISTGRGGNG 218
Cdd:cd15970   81 INMfTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSI-LVILPII-------------IFSNTAPNSDG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 219 TSS--------SHNWGNLFFASAFAFLGLLALTVTFSCNLATIkalvsrcrAKATASQSSAQW-GRITTETAIQLMGIMC 289
Cdd:cd15970  147 SVAcnmqmpepSQRWLAVFVVYTFLMGFLLPVIAICLCYILII--------VKMRVVALKAGWqQRKRSERKITLMVMMV 218
                        250       260
                 ....*....|....*....|
gi 186659506 290 --VLSVCWSPLLIMMLKMIF 307
Cdd:cd15970  219 vtVFVICWMPFYVVQLVSVF 238
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
63-346 7.19e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 37.80  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  63 FVGNALAMLLVSrSYRRRESKRKksflLCIGWLALTDLVGQLLTTPVViVVYLSKQRWEHIDPsgrLCTFFgLTMTVF-G 141
Cdd:cd15060   15 IVGNILVILSVF-TYRPLRIVQN----FFIVSLAVADLAVAIFVLPLN-VAYFLLGKWLFGIH---LCQMW-LTCDILcC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHWYAshmKTRATRAVLL---GVWLAVLAFALLPVLGVGqytvQWPG-----TWCFISTG 213
Cdd:cd15060   85 TASILNLCAIALDRYWAIHDPINYA---QKRTLKRVLLmivVVWALSALISVPPLIGWN----DWPEnftetTPCTLTEE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 214 RGgngtssshnwGNLFFASAFAFLGLLALTVTFscnlatIKALVsrcrakATASQSSAqwgrittetAIQLMGIMCVLSV 293
Cdd:cd15060  158 KG----------YVIYSSSGSFFIPLLIMTIVY------VKIFI------ATSKERRA---------ARTLGIIMGVFVV 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 186659506 294 CWSPLLIMMLKMIFnqtsvehCKTHTEKQKECNFFliaVRLASLNQILDPWVY 346
Cdd:cd15060  207 CWLPFFLMYVILPF-------CETCSPSAKVVNFI---TWLGYVNSALNPVIY 249
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
50-346 8.55e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 37.76  E-value: 8.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  50 VSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRkksflLCIGWLALTDLVGQLLTTPVVIVvYLSKQRWEHIDPSGRL 129
Cdd:cd15195    2 VRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQ-----ILIMHLALADLMVTFFNMPMDAV-WNYTVEWLAGDLMCRV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 130 CTFfgltMTVFGL-SSLFIASAMAVERALAIRAPhwYASHMKTRATRAVLLGVWLAVLAFALlPVLGVGQYTVQWPGTWC 208
Cdd:cd15195   76 MMF----LKQFGMyLSSFMLVVIALDRVFAILSP--LSANQARKRVKIMLTVAWVLSALCSI-PQSFIFSVLRKMPEQPG 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 FISTGRGGNGTSSSHNwgNLFFASAFAFLGLLALTVTFSCNLATIKALVSRC-RAKATASQSSAQWGRITTETA---IQL 284
Cdd:cd15195  149 FHQCVDFGSAPTKKQE--RLYYFFTMILSFVIPLIITVTCYLLILFEISKMAkRARDTPISNRRRSRTNSLERArmrTLR 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186659506 285 MGIMCVLS--VCWSPLLIMMLKMIFNQTSVEHCKTHTEKqkecnfflIAVRLASLNQILDPWVY 346
Cdd:cd15195  227 MTALIVLTfiVCWGPYYVLGLWYWFDKESIKNLPPALSH--------IMFLLGYLNPCLHPIIY 282
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
54-346 9.12e-03

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 37.72  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  54 FPITMLLTGFVGNALAMLLVSrsyrrreSKRKK--SFLLCIGWLALTDLvgqLLTT--PVVIVVYLSKQRWehidPSGR- 128
Cdd:cd15159    6 FYSLILVFGLLGNTLALHVIC-------QKRKKinSTTLYLINLAVSDI---LFTLalPGRIAYYALGFDW----PFGDw 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 129 LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAfALLPVLGVGqytvqwpgtwc 208
Cdd:cd15159   72 LCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFL-QTLPLLFMP----------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 209 fISTGRGGNGTSSSHNWGNLFFASAFAFLGllALTVTFSCNLATIKALVSR-----CRAkATASQSSAQWGRITTETAIQ 283
Cdd:cd15159  140 -MTKEMGGRITCMEYPNFEKIKRLPLILLG--ACVIGFGVPVGIILFCYSQitlklCRT-AKENPLTEKSGHHKKACNVI 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186659506 284 LMGIMCVLsVCWSP----LLIMMLKMIFNQTSvehCKthtEKQKECNFFLIAVRLASLNQILDPWVY 346
Cdd:cd15159  216 LLVLLVFV-VCFSPyhlnIIQFMIRKLLYQPS---CS---ELKAFKISLQITVCLMNLNCCLDPFIY 275
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-303 9.31e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 37.34  E-value: 9.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  52 VAFPITMLLTGFVGNALAMLLVSrsyrrrESKRKKSFLLC-IGWLALTDLVGQLLTTPVVIVVYLSKqRWehidPSGRLC 130
Cdd:cd15061    3 ISFLILAIIFTIFGNLLVILAVA------TTRRLRTITNCyIVSLATADLLVGVLVLPLAIIRQLLG-YW----PLGSHL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 131 TFFGLTMTVF-GLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGvgqytVQWPGTwcf 209
Cdd:cd15061   72 CDFWISLDVLlCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVG-----PSWHGR--- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 210 istgRGGNGTSSSHNWGNLFFASAFAFLGLLALtvtfscnLATIKALVSRCRAKatasqssaqwgriTTETAIQLMGIMC 289
Cdd:cd15061  144 ----RGLGSCYYTYDKGYRIYSSMGSFFLPLLL-------MLFVYLRIFRVIAK-------------ERKTAKTLAIVVG 199
                        250
                 ....*....|....
gi 186659506 290 VLSVCWSPLLIMML 303
Cdd:cd15061  200 CFIVCWLPFFIMYL 213
7tmA_GPR153_GPR162-like cd14998
orphan G protein-coupled receptors 153 and 162, member of the class A family of ...
63-195 9.52e-03

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320129  Cd Length: 301  Bit Score: 37.61  E-value: 9.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506  63 FVGNALAMLLVSRsyrRRESKRKKSFLLCigWLALTDLVGQLLTTPVVIVVYLSKQRWEHiDPSGRLCTFFGLTMTVFGL 142
Cdd:cd14998   15 LLANAWGILSISA---KQQKHKPLELLLC--FLAGTHMLMVAVPLTTYSVVQLRRQASDY-DWNEGLCKVFVSTFYTLTL 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 186659506 143 SSLFIASAMAVERALAIRAP-HWYASHMKTRATRAVlLGVWLAVLAFALLPVLG 195
Cdd:cd14998   89 ATCFTVTSLSYHRMWMVRWPvNYRLSNAKKQALHAV-MGIWMVSFILSTLPSIG 141
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
142-346 9.53e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 37.47  E-value: 9.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 142 LSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLgvgqYTVQWPGTWCFIStgrggngtss 221
Cdd:cd15103   91 LASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII----YSDSVPVIICLIS---------- 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186659506 222 shnwgnLFFASAFAFLGLLALTVTFSCnlATIKALVSRCRAKATASQSSAQwgritteTAIQLMGIMCVLSVCWSPLLIM 301
Cdd:cd15103  157 ------MFFAMLVLMASLYVHMFLLAR--SHVKKIAALPGQRSTRQRANMK-------GAVTLTILLGVFIFCWAPFFLH 221
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 186659506 302 MLKMIFNQTSvEHCKTHTekqKECNFFLIavrLASLNQILDPWVY 346
Cdd:cd15103  222 LTLMISCPSN-PYCACYM---SHFNVYLI---LIMCNSVIDPLIY 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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