NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|189027115|ref|NP_001121072|]
View 

axin interactor, dorsalization-associated protein [Rattus norvegicus]

Protein Classification

Aida_N and Aida_C2 domain-containing protein( domain architecture ID 10556308)

Aida_N and Aida_C2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Aida_C2 pfam14186
Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of ...
 161-299 1.83e-81

Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points, thus it is combined with diverse domains related to cytoskeletal functions. This domain has predominantly a beta-strand globular fold composed of an antiparallel beta-sandwich with two beta-sheets, and three short alpha-helices to stabilize the conformation.


:

Pssm-ID: 464099  Cd Length: 140  Bit Score: 242.61  E-value: 1.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115  161 SEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFF 240
Cdd:pfam14186   1 REPGDTYLTVRIEKIGVKDASQMIDPYFTVSVKDGEGKDLEPPQDTPVGNRREGNYVHFNVTVELQTPLEKLPKGAAIFL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 189027115  241 EFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLH 299
Cdd:pfam14186  81 ELKHYKPKKKKTSTKCWSFMELDELKPGPAVLELYAKPTDFKRRKLKLLTSKPLYLHLS 139
Aida_N pfam08910
Aida N-terminus; This is the N-terminal domain of the axin interactor, ...
 9-112 6.65e-54

Aida N-terminus; This is the N-terminal domain of the axin interactor, dorsalization-associated protein family.


:

Pssm-ID: 462628  Cd Length: 103  Bit Score: 170.99  E-value: 6.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115    9 LQRWGASLRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQhnNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKL 88
Cdd:pfam08910   1 VAKWCASLKKATDFDSWGQLVEAIDEYQRLAKQLKKAAESQ--SSDFTEDQKKTLGKIATCLELRSKALQSGQGQDGITL 78

                          90       100
                  ....*....|....*....|....*
gi 189027115   89 EDLKKLEPILKNILTYN-KEFPFDV 112
Cdd:pfam08910  79 EDLKKLEEILKNILSDNvKEFPLDV 103
 
Name Accession Description Interval E-value
Aida_C2 pfam14186
Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of ...
 161-299 1.83e-81

Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points, thus it is combined with diverse domains related to cytoskeletal functions. This domain has predominantly a beta-strand globular fold composed of an antiparallel beta-sandwich with two beta-sheets, and three short alpha-helices to stabilize the conformation.


Pssm-ID: 464099  Cd Length: 140  Bit Score: 242.61  E-value: 1.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115  161 SEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFF 240
Cdd:pfam14186   1 REPGDTYLTVRIEKIGVKDASQMIDPYFTVSVKDGEGKDLEPPQDTPVGNRREGNYVHFNVTVELQTPLEKLPKGAAIFL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 189027115  241 EFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLH 299
Cdd:pfam14186  81 ELKHYKPKKKKTSTKCWSFMELDELKPGPAVLELYAKPTDFKRRKLKLLTSKPLYLHLS 139
Aida_N pfam08910
Aida N-terminus; This is the N-terminal domain of the axin interactor, ...
 9-112 6.65e-54

Aida N-terminus; This is the N-terminal domain of the axin interactor, dorsalization-associated protein family.


Pssm-ID: 462628  Cd Length: 103  Bit Score: 170.99  E-value: 6.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115    9 LQRWGASLRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQhnNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKL 88
Cdd:pfam08910   1 VAKWCASLKKATDFDSWGQLVEAIDEYQRLAKQLKKAAESQ--SSDFTEDQKKTLGKIATCLELRSKALQSGQGQDGITL 78

                          90       100
                  ....*....|....*....|....*
gi 189027115   89 EDLKKLEPILKNILTYN-KEFPFDV 112
Cdd:pfam08910  79 EDLKKLEEILKNILSDNvKEFPLDV 103
 
Name Accession Description Interval E-value
Aida_C2 pfam14186
Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of ...
 161-299 1.83e-81

Axin interactor dorsalization-associated protein, C-terminal; This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points, thus it is combined with diverse domains related to cytoskeletal functions. This domain has predominantly a beta-strand globular fold composed of an antiparallel beta-sandwich with two beta-sheets, and three short alpha-helices to stabilize the conformation.


Pssm-ID: 464099  Cd Length: 140  Bit Score: 242.61  E-value: 1.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115  161 SEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFF 240
Cdd:pfam14186   1 REPGDTYLTVRIEKIGVKDASQMIDPYFTVSVKDGEGKDLEPPQDTPVGNRREGNYVHFNVTVELQTPLEKLPKGAAIFL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 189027115  241 EFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLH 299
Cdd:pfam14186  81 ELKHYKPKKKKTSTKCWSFMELDELKPGPAVLELYAKPTDFKRRKLKLLTSKPLYLHLS 139
Aida_N pfam08910
Aida N-terminus; This is the N-terminal domain of the axin interactor, ...
 9-112 6.65e-54

Aida N-terminus; This is the N-terminal domain of the axin interactor, dorsalization-associated protein family.


Pssm-ID: 462628  Cd Length: 103  Bit Score: 170.99  E-value: 6.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189027115    9 LQRWGASLRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQhnNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKL 88
Cdd:pfam08910   1 VAKWCASLKKATDFDSWGQLVEAIDEYQRLAKQLKKAAESQ--SSDFTEDQKKTLGKIATCLELRSKALQSGQGQDGITL 78

                          90       100
                  ....*....|....*....|....*
gi 189027115   89 EDLKKLEPILKNILTYN-KEFPFDV 112
Cdd:pfam08910  79 EDLKKLEEILKNILSDNvKEFPLDV 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH