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Conserved domains on  [gi|189163493|ref|NP_001121168|]
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ataxin-3 isoform ad [Homo sapiens]

Protein Classification

ataxin-3 family protein( domain architecture ID 11128249)

ataxin-3 (ATXN3) family protein similar to Homo sapiens ataxin-3 and ataxin-3-like protein

Gene Ontology:  GO:0004843|GO:0016579
PubMed:  34813758

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
9-148 5.11e-73

Josephin;


:

Pssm-ID: 426599  Cd Length: 154  Bit Score: 222.87  E-value: 5.11e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189163493    9 QEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGvtSEDYRTFL----------------QVISNALKVW 72
Cdd:pfam02099   1 QELQLCAQHALNNLLQGPYFTAVDLADIARQLDEEERSLMAESP--SADYWTFLsfgsshnvddsgnfsiQVLEKALEVW 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189163493   73 GLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIF 148
Cdd:pfam02099  79 GLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKIGGQWYNLNSLLKAPELISDTYLSAFLDQLEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
248-314 2.36e-24

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


:

Pssm-ID: 435469  Cd Length: 60  Bit Score: 94.15  E-value: 2.36e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189163493  248 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 314
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQQ-------DQPGQSSHPHERPTTSSGALGSD 60
 
Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
9-148 5.11e-73

Josephin;


Pssm-ID: 426599  Cd Length: 154  Bit Score: 222.87  E-value: 5.11e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189163493    9 QEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGvtSEDYRTFL----------------QVISNALKVW 72
Cdd:pfam02099   1 QELQLCAQHALNNLLQGPYFTAVDLADIARQLDEEERSLMAESP--SADYWTFLsfgsshnvddsgnfsiQVLEKALEVW 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189163493   73 GLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIF 148
Cdd:pfam02099  79 GLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKIGGQWYNLNSLLKAPELISDTYLSAFLDQLEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
248-314 2.36e-24

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


Pssm-ID: 435469  Cd Length: 60  Bit Score: 94.15  E-value: 2.36e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189163493  248 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 314
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQQ-------DQPGQSSHPHERPTTSSGALGSD 60
 
Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
9-148 5.11e-73

Josephin;


Pssm-ID: 426599  Cd Length: 154  Bit Score: 222.87  E-value: 5.11e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189163493    9 QEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGvtSEDYRTFL----------------QVISNALKVW 72
Cdd:pfam02099   1 QELQLCAQHALNNLLQGPYFTAVDLADIARQLDEEERSLMAESP--SADYWTFLsfgsshnvddsgnfsiQVLEKALEVW 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189163493   73 GLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIF 148
Cdd:pfam02099  79 GLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKIGGQWYNLNSLLKAPELISDTYLSAFLDQLEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
248-314 2.36e-24

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


Pssm-ID: 435469  Cd Length: 60  Bit Score: 94.15  E-value: 2.36e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 189163493  248 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 314
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQQ-------DQPGQSSHPHERPTTSSGALGSD 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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