extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194474092  20 ALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNG 93
Cdd:cd23585    1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194474092  20 ALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNG 93
Cdd:cd23585    1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194474092  20 ALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNG 93
Cdd:cd23585    1 ALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNG 74

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194474092  20 ALECHVC--AYNGDNCFKPMRCPAMATYCMTTR-TYFTPYRMKVR--KSCVPSCFETVYDgYSKHASATSCCQYYLCN 92
Cdd:cd23543    2 SLYCYTCenQSSNWNCLKPTKCSDNDKYCVTTVaSGGTGSSSGVRitKKCSPKCPETNVN-IGIASVSTSCCQSSLCN 78

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474092  20 ALECHVC--AYNGDNCFKPMRCPAMATYCMTT--RTYFTPYRMKV-RKSCVPSCFETVYDGYSKHASaTSCCQYYLCNGA 94
Cdd:cd23575    2 SLKCYTCvsAHSNSDCLTETNCSSSDTYCKTLvaSASGGSGSLTTiTKWCASSCTPSTRTVEGTKVT-VSCCQTDLCNVS 80

                 .
gi 194474092  95 G 95
Cdd:cd23575   81 G 81

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474092  21 LECHVC-AYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASA---------TSCCQYYL 90
Cdd:cd23550    1 LTCHVCeVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVlekpmpflyIKCCRENL 80

                 ....*
gi 194474092  91 CNGAG 95
Cdd:cd23550   81 CNEEG 85

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194474092  21 LECHVCAYNGD--NCFKPMRCPAMATYCMTT---RTYFTPYR--MKVRKSCVPSCFETVYDGYSKhASATSCCQYYLCN 92
Cdd:cd23560    1 LRCYTCPEPTDssLCTTIVNCSPNETACKTTlysVDSGYPFFgnITVTRGCASECIPSDPDGIGE-THPISCCNTDLCN 78

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474092    21 LECHVCAYNGD-NCFKPMRCPAMATYCMTTRTYFTP--YRMKVRKSC--VPSC-FETVYDGYSKHASA-TSCCQYYLCNG 93
Cdd:smart00134   1 LQCYSCTGNPDsSCSSEEECRSPDDVCLTVVAEVISdsRGSVVYKGCatSPICpGSHGYEINLTIAFLkVSCCQTDLCNA 80

                   ..
gi 194474092    94 AG 95
Cdd:smart00134  81 AG 82