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Conserved domains on  [gi|206597470|ref|NP_001128649|]
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protein NEDD1 isoform c [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-210 3.48e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 3.48e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLK 80
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 YSLFKKSLLGSvSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT 160
Cdd:cd00200  143 FSPDGTFVASS-SQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHE 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206597470 161 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 210
Cdd:cd00200  220 nGVNSVAFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-210 3.48e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 3.48e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLK 80
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 YSLFKKSLLGSvSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT 160
Cdd:cd00200  143 FSPDGTFVASS-SQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHE 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206597470 161 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 210
Cdd:cd00200  220 nGVNSVAFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
2-210 3.73e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 3.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNqSVRHLKY 81
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  82 SLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 160
Cdd:COG2319  255 SP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTg 331

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 206597470 161 PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 210
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 84-220 1.99e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  84 FKKSLLGSVSDNGIVTLWDVnSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 163
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 206597470 164 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 220
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 19-58 2.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 206597470    19 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 58
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-210 3.48e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 3.48e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLK 80
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 YSLFKKSLLGSvSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT 160
Cdd:cd00200  143 FSPDGTFVASS-SQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHE 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206597470 161 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 210
Cdd:cd00200  220 nGVNSVAFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
2-210 3.73e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 3.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNqSVRHLKY 81
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  82 SLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 160
Cdd:COG2319  255 SP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTg 331

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 206597470 161 PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 210
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
2-210 8.97e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 8.97e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTT-NLSSTPFGHGSnqSVRHLK 80
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGHTG--AVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 YSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT 160
Cdd:COG2319  212 FSP-DGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLL-ASGSADGTVRLWDLATGELLRTLTGHS 288

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206597470 161 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 210
Cdd:COG2319  289 gGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
2-210 1.05e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTT-NLSSTPFGHGSnqSVRHLK 80
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGHSG--AVTSVA 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 YSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT 160
Cdd:COG2319  170 FSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATGKLLRTLTGHS 246

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206597470 161 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 210
Cdd:COG2319  247 gSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
2-189 5.70e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 5.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNqSVRHLKY 81
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  82 SLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 160
Cdd:COG2319  297 SPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLTGHTg 373

                        170       180
                 ....*....|....*....|....*....
gi 206597470 161 PLTAVDFMPDGATLAIGSSRGKIYQYDLR 189
Cdd:COG2319  374 AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-210 1.33e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  23 HRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTN-LSSTPFGHgsNQSVRHLKYSLFKKSLLgSVSDNGIVTLW 101
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGeLLRTLKGH--TGPVRDVAASADGTYLA-SGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470 102 DVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSR 180
Cdd:cd00200   79 DLETGECVRTLTG-HTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETGKCLTTLRGHTdWVNSVAFSPDGTFVASSSQD 156

                        170       180       190
                 ....*....|....*....|....*....|
gi 206597470 181 GKIYQYDLRMLKsPVKTISAHKTSVQCIAF 210
Cdd:cd00200  157 GTIKLWDLRTGK-CVATLTGHTGEVNSVAF 185
WD40 COG2319
WD40 repeat [General function prediction only];
3-210 9.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 9.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   3 LVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHGSnqSVRHLKY 81
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtGHTG--AVRSVAF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  82 SLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFdSVHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 160
Cdd:COG2319  129 SPDGKTLA-SGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTg 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 206597470 161 PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 210
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-187 3.40e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   1 MYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYnwndcyiasgslsgeiilhsvttnlsstpfgHGSNQSvrhlk 80
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF-------------------------------SPDGEK----- 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  81 yslfkkslLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVA-D 159
Cdd:cd00200  192 --------LLSSSSDGTIKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLSGhT 261

                        170       180
                 ....*....|....*....|....*...
gi 206597470 160 TPLTAVDFMPDGATLAIGSSRGKIYQYD 187
Cdd:cd00200  262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-105 4.60e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 4.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470   2 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTN-LSSTPFGHGSnqSVRHLK 80
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGeLLRTLTGHTG--AVTSVA 379

                         90       100
                 ....*....|....*....|....*
gi 206597470  81 YSLfKKSLLGSVSDNGIVTLWDVNS 105
Cdd:COG2319  380 FSP-DGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 84-220 1.99e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  84 FKKSLLGSVSDNGIVTLWDVnSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 163
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 206597470 164 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 220
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
36-199 6.05e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470  36 VTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDsV 115
Cdd:COG3391   30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-V 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597470 116 HKAPaSGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGK-----IYQYDLRM 190
Cdd:COG3391  109 GGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187


                 ....*....
gi 206597470 191 LKsPVKTIS 199
Cdd:COG3391  188 GK-VVATIP 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 19-58 2.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 206597470    19 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 58
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 121-190 6.91e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 6.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 206597470 121 SGICF-SPVNELLFVTIGLDKRIILYDTSSKK--LVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRM 190
Cdd:cd22857  182 TDLTFlSKDDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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