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Conserved domains on  [gi|207029439|ref|NP_001128728|]
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histone-binding protein RBBP4 isoform c [Homo sapiens]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 13780222)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones, similar to human histone-binding proteins RBBP4 and RBBP7

Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433
SCOP:  4005630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-368 1.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439  87 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 162
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 163 DDHTICLWDISAVpkegkvvDAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 241
Cdd:cd00200  113 RDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 242 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 321
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029439 322 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 368
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 1-53 8.58e-19

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 79.55  E-value: 8.58e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 207029439    1 MTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 53
Cdd:pfam12265  18 HTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-368 1.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439  87 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 162
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 163 DDHTICLWDISAVpkegkvvDAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 241
Cdd:cd00200  113 RDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 242 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 321
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029439 322 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 368
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
137-370 1.20e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 1.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 137 RLRGHQKEGYGLSWNPNlsGHLL-SASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 215
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 216 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 295
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029439 296 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 370
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 1-53 8.58e-19

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 79.55  E-value: 8.58e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 207029439    1 MTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 53
Cdd:pfam12265  18 HTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-313 9.16e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 9.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 134 PDLRLRGHQKEGyGLSWNPNLSGHLLSASDDHTICLWDISavpKEGKVVDAKTiftgHTAVVEDVSWHLLHESLFGSVAD 213
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA---RSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 214 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 290
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 207029439 291 SphNETILASSGTDRRLNVWDLS 313
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-267 5.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 207029439   227 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
228-267 3.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 207029439  228 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-368 1.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439  87 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 162
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 163 DDHTICLWDISAVpkegkvvDAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 241
Cdd:cd00200  113 RDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 242 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 321
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029439 322 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 368
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
137-370 1.20e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 1.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 137 RLRGHQKEGYGLSWNPNlsGHLL-SASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 215
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 216 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 295
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029439 296 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 370
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-369 2.25e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 2.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439  88 HEGEVNRARYMPQNPcIIATKTPSSDVLVFDYTkhpskpdpsgECNPDLRLRGHQKEGYGLSWNPNlSGHLLSASDDHTI 167
Cdd:cd00200    8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 168 CLWDISAvpkeGKVVdakTIFTGHTAVVEDVSWHLLHESLFGSvADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFN 247
Cdd:cd00200   76 RLWDLET----GECV---RTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 248 PYSEFIlATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETILASSGtDRRLNVWDLSKigeeqspedaedg 327
Cdd:cd00200  145 PDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 207029439 328 pPELLFIHGGHTAKISDFSWNPNEPWvICSVSEDNIMQVWQM 369
Cdd:cd00200  209 -GKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
137-370 3.61e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 3.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 137 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 216
Cdd:COG2319  115 TLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDL----ATGKLL---RTLTGHSGAVTSVAFSPDGKLLA-SGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 217 LMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNET 296
Cdd:COG2319  186 VRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSP-DGR 259

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 207029439 297 ILASSGTDRRLNVWDLSkigeeqspedaedgPPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 370
Cdd:COG2319  260 LLASGSADGTVRLWDLA--------------TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-371 5.42e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 5.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 138 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDIsavpkegKVVDAKTIFTGHTAVVEDVSWHLLHESLFgSVADDQKL 217
Cdd:cd00200    5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDL-------ETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 218 MIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTI 297
Cdd:cd00200   76 RLWDL---ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDG-TF 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 207029439 298 LASSGTDRRLNVWDLSKIGEEQSpedaedgppellfiHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMAE 371
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVAT--------------LTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
137-313 6.71e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 6.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 137 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDISavpkEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 216
Cdd:COG2319  241 TLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLA----TGELL---RTLTGHSGGVNSVAFSPDGKLLA-SGSDDGT 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 217 LMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNET 296
Cdd:COG2319  312 VRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DGR 385

                        170
                 ....*....|....*..
gi 207029439 297 ILASSGTDRRLNVWDLS 313
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
136-370 2.75e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 136 LRLRGHQKEGYGLSWNPnLSGHLLSASDDHTICLWDISAVPkegkvvdAKTIFTGHTAVVEDVSWHLLHESLfGSVADDQ 215
Cdd:COG2319   30 LLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 216 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 295
Cdd:COG2319  101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029439 296 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 370
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-370 5.78e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 5.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 230 PSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETiLASSGTDRRLNV 309
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207029439 310 WDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMA 370
Cdd:cd00200   78 WDLET--------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE 123
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 1-53 8.58e-19

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 79.55  E-value: 8.58e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 207029439    1 MTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 53
Cdd:pfam12265  18 HTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
WD40 COG2319
WD40 repeat [General function prediction only];
137-270 7.31e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 7.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 137 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDISavpkEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 216
Cdd:COG2319  283 TLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLA----TGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 207029439 217 LMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRN 270
Cdd:COG2319  354 VRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-313 9.16e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 9.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 134 PDLRLRGHQKEGyGLSWNPNLSGHLLSASDDHTICLWDISavpKEGKVVDAKTiftgHTAVVEDVSWHLLHESLFGSVAD 213
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA---RSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 214 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 290
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 207029439 291 SphNETILASSGTDRRLNVWDLS 313
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
 230-312 2.41e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 2.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 230 PSHSVDAHTAEVNCLSFNP-YSEfILATGSADKTVALWDLRN-------LKLKLHSFESHKDEIFQVQWSPHNETILASS 301
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcFSE-ILASGSEDLTIRVWEIPHndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|.
gi 207029439 302 GTDRRLNVWDL 312
Cdd:PTZ00420 145 GFDSFVNIWDI 155
PTZ00420 PTZ00420
coronin; Provisional
 126-272 4.36e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.96  E-value: 4.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 126 PDPSGECNPDLRLRGHQKEGYGLSwnpnlsghllsASDDHTICLWD------ISAVPKEGKVVDAKTI-FTGHTAVVEDV 198
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEveggglIGAIRLENQMRKPPVIkLKGHTSSILDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 207029439 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTS-----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 272
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00421 PTZ00421
coronin; Provisional
 133-323 1.49e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 133 NPDLRLrGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDIsavPKEG---KVVDAKTIFTGHTAVVEDVSWHLLHESLFG 209
Cdd:PTZ00421  67 NPPILL-GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 210 SVADDQKLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQ-V 288
Cdd:PTZ00421 143 SAGADMVVNVWDV---ERGKAVEVIKCHSDQITSLEWNLDGS-LLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQrC 217

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 207029439 289 QWSPHNETILA---SSGTDRRLNVWDLSKIGEEQSPED 323
Cdd:PTZ00421 218 LWAKRKDLIITlgcSKSQQRQIMLWDTRKMASPYSTVD 255
PTZ00420 PTZ00420
coronin; Provisional
 271-372 4.14e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.87  E-value: 4.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 271 LKLKlhsfeSHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKigEEQSPEDAEDGppelLFIHGGHTAKISDFSWNPN 350
Cdd:PTZ00420  68 IKLK-----GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKDP----QCILKGHKKKISIIDWNPM 136

                         90       100
                 ....*....|....*....|..
gi 207029439 351 EPWVICSVSEDNIMQVWQMaEN 372
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-267 5.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 207029439   227 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 179-311 1.41e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029439 179 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR----SNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 254
Cdd:PTZ00421  62 GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 207029439 255 ATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 311
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
228-267 3.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 207029439  228 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-171 7.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 207029439   138 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWD 171
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 275-311 9.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 207029439   275 LHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 311
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
275-311 7.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 207029439  275 LHSFESHKDEIFQVQWSPhNETILASSGTDRRLNVWD 311
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
138-171 1.41e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 207029439  138 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWD 171
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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