NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|209915547|ref|NP_001129595|]
View 

SMC5-SMC6 complex localization factor protein 2 isoform 2 [Homo sapiens]

Protein Classification

CANIN domain-containing protein( domain architecture ID 10632402)

CANIN domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
657-1031 0e+00

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


:

Pssm-ID: 464331  Cd Length: 375  Bit Score: 578.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   657 TGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIP 736
Cdd:pfam14816    1 VPSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSELESLEEDSDDEEVDLTPEHRMFVERFSVSSQAIP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   737 DHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSV 816
Cdd:pfam14816   81 DVHPGETVFNLSDSGKLFNQHPLDLRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVPCPVPLLRWLFQMMSV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   817 HTDCIVSVQILSTLMEITIRN-DTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGK 895
Cdd:pfam14816  161 HPEQIVSSQILSLLWDISLDNlFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFNERDLLSEAQLSENEQ 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   896 ESEDSSyKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDW 975
Cdd:pfam14816  241 QNAGSV-SPPFETLPEINLSNILKFLSLCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDW 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 209915547   976 NTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHE 1031
Cdd:pfam14816  320 PTKLPELCCALSDLSDHHHNLLALVQLFPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
335-624 9.63e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 9.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  335 KRKRNSVDSDLKSTRESM-------IPKARESFLEKRPDGPHQKEKFIKhialKTPGDVLRLEDISKEPSDETDGSSAGL 407
Cdd:PTZ00108 1112 EKKEKELEKLKNTTPKDMwledldkFEEALEEQEEVEEKEIAKEQRLKS----KTKGKASKLRKPKLKKKEKKKKKSSAD 1187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  408 APSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLV 487
Cdd:PTZ00108 1188 KSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSK 1267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  488 PLNAKNCALPVSKKDKERSSSKecsghsTESTKHKEHKAKTNkaDSNVSSGKISGGPLRSEYGTPTKSPPAAlevvpcip 567
Cdd:PTZ00108 1268 EGKPKNAPKRVSAVQYSPPPPS------KRPDGESNGGSKPS--SPTKKKVKKRLEGSLAALKKKKKSEKKT-------- 1331
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209915547  568 SPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSL 624
Cdd:PTZ00108 1332 ARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDEDDD 1388
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
657-1031 0e+00

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 578.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   657 TGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIP 736
Cdd:pfam14816    1 VPSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSELESLEEDSDDEEVDLTPEHRMFVERFSVSSQAIP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   737 DHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSV 816
Cdd:pfam14816   81 DVHPGETVFNLSDSGKLFNQHPLDLRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVPCPVPLLRWLFQMMSV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   817 HTDCIVSVQILSTLMEITIRN-DTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGK 895
Cdd:pfam14816  161 HPEQIVSSQILSLLWDISLDNlFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFNERDLLSEAQLSENEQ 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   896 ESEDSSyKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDW 975
Cdd:pfam14816  241 QNAGSV-SPPFETLPEINLSNILKFLSLCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDW 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 209915547   976 NTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHE 1031
Cdd:pfam14816  320 PTKLPELCCALSDLSDHHHNLLALVQLFPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
335-624 9.63e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 9.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  335 KRKRNSVDSDLKSTRESM-------IPKARESFLEKRPDGPHQKEKFIKhialKTPGDVLRLEDISKEPSDETDGSSAGL 407
Cdd:PTZ00108 1112 EKKEKELEKLKNTTPKDMwledldkFEEALEEQEEVEEKEIAKEQRLKS----KTKGKASKLRKPKLKKKEKKKKKSSAD 1187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  408 APSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLV 487
Cdd:PTZ00108 1188 KSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSK 1267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  488 PLNAKNCALPVSKKDKERSSSKecsghsTESTKHKEHKAKTNkaDSNVSSGKISGGPLRSEYGTPTKSPPAAlevvpcip 567
Cdd:PTZ00108 1268 EGKPKNAPKRVSAVQYSPPPPS------KRPDGESNGGSKPS--SPTKKKVKKRLEGSLAALKKKKKSEKKT-------- 1331
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209915547  568 SPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSL 624
Cdd:PTZ00108 1332 ARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDEDDD 1388
 
Name Accession Description Interval E-value
CANIN pfam14816
Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the ...
657-1031 0e+00

Coiled-coil and Nse Interacting (CANIN) domain; This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.


Pssm-ID: 464331  Cd Length: 375  Bit Score: 578.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   657 TGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIP 736
Cdd:pfam14816    1 VPSGGSVSYVNSLDYLLQEKREQARLQELEKLLLQDCRRGLLDLSELESLEEDSDDEEVDLTPEHRMFVERFSVSSQAIP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   737 DHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSV 816
Cdd:pfam14816   81 DVHPGETVFNLSDSGKLFNQHPLDLRSSHLKPQSALEKLLLSSPPAQQLSLLTSGLLSNAYLHVPCPVPLLRWLFQMMSV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   817 HTDCIVSVQILSTLMEITIRN-DTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGK 895
Cdd:pfam14816  161 HPEQIVSSQILSLLWDISLDNlFEQSDQDFHVWCPSLADVTEVFLNMGARFPSLFPLGPLQPSFNERDLLSEAQLSENEQ 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547   896 ESEDSSyKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDW 975
Cdd:pfam14816  241 QNAGSV-SPPFETLPEINLSNILKFLSLCTLAQPDAYTDEELLLLLELLCRIGLDVGLRLLPKTDFQQLLLLLLENIQDW 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 209915547   976 NTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHE 1031
Cdd:pfam14816  320 PTKLPELCCALSDLSDHHHNLLALVQLFPDVTSRGRQLRRHLSLVIIAKLLDQQET 375
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
335-624 9.63e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 9.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  335 KRKRNSVDSDLKSTRESM-------IPKARESFLEKRPDGPHQKEKFIKhialKTPGDVLRLEDISKEPSDETDGSSAGL 407
Cdd:PTZ00108 1112 EKKEKELEKLKNTTPKDMwledldkFEEALEEQEEVEEKEIAKEQRLKS----KTKGKASKLRKPKLKKKEKKKKKSSAD 1187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  408 APSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLV 487
Cdd:PTZ00108 1188 KSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSK 1267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915547  488 PLNAKNCALPVSKKDKERSSSKecsghsTESTKHKEHKAKTNkaDSNVSSGKISGGPLRSEYGTPTKSPPAAlevvpcip 567
Cdd:PTZ00108 1268 EGKPKNAPKRVSAVQYSPPPPS------KRPDGESNGGSKPS--SPTKKKVKKRLEGSLAALKKKKKSEKKT-------- 1331
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209915547  568 SPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSL 624
Cdd:PTZ00108 1332 ARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDEDDD 1388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH