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Conserved domains on  [gi|218505731|ref|NP_001136213|]
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protocadherin-15 isoform CD1-10 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECD super family cl39769
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 1.27e-46

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


The actual alignment was detected with superfamily member pfam18432:

Pssm-ID: 408229  Cd Length: 110  Bit Score: 162.95  E-value: 1.27e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 218505731   110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 1.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 1.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  700 PRNLSVVEEEA-NAFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREARDHYELVVVATDGAVH 775
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  776 PRHSTLTLYIKVLDIDDN 793
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 7.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 7.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  599 YSLEVSEAMRIGAILLNLQATDR---EGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPD 674
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505731  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 2.60e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  801 TYTVVVEENLPAGTSFLQIEAKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505731  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 3.47e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1023 VSELAARGTVVGVISA----AAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505731 1099 VPSKSNTAKVYIEIQDENDH 1118
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 1.41e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  491 SYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGD-FVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPP 569
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  570 aeRRHSICTVYIEVLPPN 587
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 2.56e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 2.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  908 IYKGMVAPDAVKGTPITTVYAEDADPPgmPASRVRYRVDDVQfpyPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505731  988 DDGEPVMSSSATVRILVL 1005
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 5.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 5.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  377 SYQGYILESAPVGATIseslnlttpLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTP-TGItryLTLLQPVDREEQQTY 455
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPsTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505731  456 TFLITAFDGVQE--SEPVVVNIRVMDANDN 483
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 4.63e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 4.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIqynpEDPTSNDTFEI-PLmlTGNVVLRKRLNYEDKTRYY 207
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSI----VSGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                          90
                  ....*....|.
gi 218505731  208 VIIQANDRAQN 218
Cdd:cd11304    70 LTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 1.60e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1127 YIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505731 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304    79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 9.21e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 9.21e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505731    363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 1.27e-46

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 162.95  E-value: 1.27e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 218505731   110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 1.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 1.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  700 PRNLSVVEEEA-NAFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREARDHYELVVVATDGAVH 775
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  776 PRHSTLTLYIKVLDIDDN 793
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 7.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 7.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  599 YSLEVSEAMRIGAILLNLQATDR---EGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPD 674
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505731  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 2.60e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  801 TYTVVVEENLPAGTSFLQIEAKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505731  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 3.47e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1023 VSELAARGTVVGVISA----AAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505731 1099 VPSKSNTAKVYIEIQDENDH 1118
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 718-795 9.80e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 9.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    718 RATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNS 794
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505731    795 P 795
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
706-788 1.13e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 1.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   706 VEEEA--NAFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHST 780
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 218505731   781 LTLYIKVL 788
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 617-693 5.45e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 5.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    617 QATDREGDP---ITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPDGTSTATVNIVVTDVNDNA 692
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505731    693 P 693
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 1.41e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  491 SYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGD-FVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPP 569
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  570 aeRRHSICTVYIEVLPPN 587
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1042-1120 7.48e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 7.48e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218505731   1042 NQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENDHPP 1120
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
599-686 4.12e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 4.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   599 YSLEVSEAMRIGAILLNLQATDREGDP---ITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPD 674
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 218505731   675 GTSTATVNIVVT 686
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 2.56e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 2.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  908 IYKGMVAPDAVKGTPITTVYAEDADPPgmPASRVRYRVDDVQfpyPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505731  988 DDGEPVMSSSATVRILVL 1005
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1023-1113 5.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 5.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  1023 VSELAARGTVVGVISA----AAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 218505731  1099 VPSKSNTAKVYIEIQ 1113
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
802-894 1.25e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   802 YTVVVEENLPAGTSFLQIEAKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 218505731   880 YGTMPPGIATVTVIV 894
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 821-902 3.30e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.30e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    821 AKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 218505731    899 DYPP 902
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 5.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 5.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  377 SYQGYILESAPVGATIseslnlttpLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTP-TGItryLTLLQPVDREEQQTY 455
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPsTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505731  456 TFLITAFDGVQE--SEPVVVNIRVMDANDN 483
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
916-1005 1.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 1.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   916 DAVKGTPITTVYAEDADPPgmPASRVRYRVddvQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 218505731   996 SSATVRILVL 1005
Cdd:pfam00028   83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 4.63e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 4.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIqynpEDPTSNDTFEI-PLmlTGNVVLRKRLNYEDKTRYY 207
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSI----VSGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                          90
                  ....*....|.
gi 218505731  208 VIIQANDRAQN 218
Cdd:cd11304    70 LTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
492-584 6.32e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 6.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   492 YDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGD-FVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPA 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 218505731   571 erRHSICTVYIEVL 584
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-591 1.57e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 1.57e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    510 TAVDADEGSNGEISYEILVGG-KGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPaeRRHSICTVYIEVLPPNN 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 218505731    589 QSP 591
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 1.60e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1127 YIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505731 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304    79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 928-1005 3.05e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 3.05e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218505731    928 AEDADPPgmPASRVRYRVDDvqfPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVL 1005
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 4.56e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 4.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    405 VALDKDIEDTKDPELHLFLNDYTSVFTVTP-TGItryLTLLQPVDREEQQTYTFLITAFDGVQE--SEPVVVNIRVMDAN 481
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPeTGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 218505731    482 DNTP 485
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 9.21e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 9.21e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505731    363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
130-217 7.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   130 YYATVNELTPVGTTIFTgfsgdNGATDIDDGPNGQIEYVIQYNPEDptsnDTFEI-PlmLTGNVVLRKRLNYEDKTRYYV 208
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-----VTATDPDLGPNGRIFYSILGGGPG----GNFRIdP--DTGDISTTKPLDRESIGEYEL 69


                   ....*....
gi 218505731   209 IIQANDRAQ 217
Cdd:pfam00028   70 TVEATDSGG 78
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-218 4.21e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 4.21e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218505731    154 ATDIDDGPNGQIEYVIQYNPEDptsnDTFEIpLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQN 218
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin pfam00028
Cadherin domain;
1131-1220 1.77e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  1131 VSEDARMFASVLRVKATDRDTGNySAMAYRLIIPPIKEGKegFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1210
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 218505731  1211 SGKADVLVSV 1220
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
378-477 2.56e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   378 YQGYILESAPVGatiseslnlTTPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTPtgITRYLTLLQPVDREEQQTYT 456
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 218505731   457 FLITAFDGVQE--SEPVVVNIRV 477
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1145-1225 2.51e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 2.51e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   1145 KATDRDTGNYSAMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 218505731   1225 D 1225
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 453-723 6.35e-05

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 48.11  E-value: 6.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  453 QTYTFLITAFDGVQESEPVVVNIRVmdANDNTPTFPEISYDVYVytdmSPGDSV-IQLTAVDADegsNGEISYE-ILVGG 530
Cdd:NF038112 1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  531 KGDFVINKTTGLVS-IAPGVELIVGQTYALTVqaSDNAPPAERrhsicTVYIEVLPPNnqsppRFPQLMYSLEVSEAMRi 609
Cdd:NF038112 1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTV--SDGTASATD-----TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  610 GAILLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSL-GKALDRESTDRYILIVTAsdgrpDGTSTATVNIVVTDV 688
Cdd:NF038112 1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 218505731  689 NDN-APVFDpylPRNLSVVEEEANAFVgQVRATDPD 723
Cdd:NF038112 1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
tand_rpt_95 NF012211
tandem-95 repeat; This 95-amino acid repeat occurs in tandem in proteins that may be several ...
 617-699 3.97e-03

tandem-95 repeat; This 95-amino acid repeat occurs in tandem in proteins that may be several thousand amino acids long.


Pssm-ID: 333740 [Multi-domain]  Cd Length: 98  Bit Score: 38.38  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  617 QATDREGDPITY------------AIENGDPQRVFNLSET-TGILSLGkaldrestdryiliVTASDGRPdGTSTATVNI 683
Cdd:NF012211   18 NASDVDGDDLTVsnvsysgptngtVTDNGDGTYTYTPNENfNGDDSFT--------------YTVSDGTG-ATATATVFV 82

                          90
                  ....*....|....*.
gi 218505731  684 VVTDVNDnAPVFDPYL 699
Cdd:NF012211   83 TVNPVND-APVAGNDA 97
 
Name Accession Description Interval E-value
ECD pfam18432
Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be ...
 30-118 1.27e-46

Extracellular Cadherin domain; This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them.


Pssm-ID: 408229  Cd Length: 110  Bit Score: 162.95  E-value: 1.27e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    30 DGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 109
Cdd:pfam18432   22 NGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYH 101


                   ....*....
gi 218505731   110 EVRIVVRDR 118
Cdd:pfam18432  102 EVRIVVRDR 110
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 700-793 1.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 1.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  700 PRNLSVVEEEA-NAFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREARDHYELVVVATDGAVH 775
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  776 PRHSTLTLYIKVLDIDDN 793
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 599-691 7.84e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 7.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  599 YSLEVSEAMRIGAILLNLQATDR---EGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPD 674
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                          90
                  ....*....|....*..
gi 218505731  675 GTSTATVNIVVTDVNDN 691
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 801-899 2.60e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  801 TYTVVVEENLPAGTSFLQIEAKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFD 878
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|.
gi 218505731  879 IYGTMPPGIATVTVIVKDMND 899
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1023-1118 3.47e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1023 VSELAARGTVVGVISA----AAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:cd11304     6 VPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA-------TDGG 78

                          90       100
                  ....*....|....*....|
gi 218505731 1099 VPSKSNTAKVYIEIQDENDH 1118
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 718-795 9.80e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 9.80e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    718 RATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNS 794
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505731    795 P 795
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
706-788 1.13e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 1.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   706 VEEEA--NAFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHST 780
Cdd:pfam00028    5 VPENApvGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 218505731   781 LTLYIKVL 788
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 617-693 5.45e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 5.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    617 QATDREGDP---ITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPDGTSTATVNIVVTDVNDNA 692
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 218505731    693 P 693
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-587 1.41e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  491 SYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGD-FVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPP 569
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 218505731  570 aeRRHSICTVYIEVLPPN 587
Cdd:cd11304    81 --PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1042-1120 7.48e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 7.48e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218505731   1042 NQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLRVPSKSNTAKVYIEIQDENDHPP 1120
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-------TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
599-686 4.12e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 4.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   599 YSLEVSEAMRIGAILLNLQATDREGDP---ITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASD-GRPD 674
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPP 80

                           90
                   ....*....|..
gi 218505731   675 GTSTATVNIVVT 686
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 908-1005 2.56e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 2.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  908 IYKGMVAPDAVKGTPITTVYAEDADPPgmPASRVRYRVDDVQfpyPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAF 987
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 218505731  988 DDGEPVMSSSATVRILVL 1005
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1023-1113 5.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 5.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  1023 VSELAARGTVVGVISA----AAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQAdslevvlANLR 1098
Cdd:pfam00028    5 VPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-------TDSG 77

                           90
                   ....*....|....*
gi 218505731  1099 VPSKSNTAKVYIEIQ 1113
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
802-894 1.25e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   802 YTVVVEENLPAGTSFLQIEAKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDI 879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE----SIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 218505731   880 YGTMPPGIATVTVIV 894
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 821-902 3.30e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.30e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    821 AKDVDLGAN--VSYRIRSPEVKHLFALHPFTGELSLLRSLDYEafpdQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Cdd:smart00112    2 ATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 218505731    899 DYPP 902
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-483 5.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 5.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  377 SYQGYILESAPVGATIseslnlttpLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTP-TGItryLTLLQPVDREEQQTY 455
Cdd:cd11304     1 SYEVSVPENAPPGTVV---------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPsTGE---ITTAKPLDREEQSSY 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 218505731  456 TFLITAFDGVQE--SEPVVVNIRVMDANDN 483
Cdd:cd11304    69 TLTVTATDGGGPplSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
916-1005 1.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 1.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   916 DAVKGTPITTVYAEDADPPgmPASRVRYRVddvQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMS 995
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 218505731   996 SSATVRILVL 1005
Cdd:pfam00028   83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-218 4.63e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 4.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  129 SYYATVNELTPVGTTIFTgFSgdngATDIDDGPNGQIEYVIqynpEDPTSNDTFEI-PLmlTGNVVLRKRLNYEDKTRYY 207
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT-VS----ATDPDSGENGEVTYSI----VSGNEDGLFSIdPS--TGEITTAKPLDREEQSSYT 69

                          90
                  ....*....|.
gi 218505731  208 VIIQANDRAQN 218
Cdd:cd11304    70 LTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
492-584 6.32e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 6.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   492 YDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGD-FVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPA 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 218505731   571 erRHSICTVYIEVL 584
Cdd:pfam00028   81 --LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-591 1.57e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 1.57e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    510 TAVDADEGSNGEISYEILVGG-KGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPaeRRHSICTVYIEVLPPNN 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVND 78


                    ...
gi 218505731    589 QSP 591
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1127-1221 1.60e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731 1127 YIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1206
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*
gi 218505731 1207 GKGLSGKADVLVSVV 1221
Cdd:cd11304    79 GPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 928-1005 3.05e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 3.05e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218505731    928 AEDADPPgmPASRVRYRVDDvqfPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVL 1005
Cdd:smart00112    2 ATDADSG--ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 4.56e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 4.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    405 VALDKDIEDTKDPELHLFLNDYTSVFTVTP-TGItryLTLLQPVDREEQQTYTFLITAFDGVQE--SEPVVVNIRVMDAN 481
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPeTGE---ITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVN 77


                    ....
gi 218505731    482 DNTP 485
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-371 9.21e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 9.21e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731    283 QAIDQDRNiqppsDRPGILYSILvgtPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIE 362
Cdd:smart00112    1 SATDADSG-----ENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 218505731    363 ILDENNQSP 371
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
130-217 7.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 7.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   130 YYATVNELTPVGTTIFTgfsgdNGATDIDDGPNGQIEYVIQYNPEDptsnDTFEI-PlmLTGNVVLRKRLNYEDKTRYYV 208
Cdd:pfam00028    1 YSASVPENAPVGTEVLT-----VTATDPDLGPNGRIFYSILGGGPG----GNFRIdP--DTGDISTTKPLDRESIGEYEL 69


                   ....*....
gi 218505731   209 IIQANDRAQ 217
Cdd:pfam00028   70 TVEATDSGG 78
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-218 4.21e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 4.21e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218505731    154 ATDIDDGPNGQIEYVIQYNPEDptsnDTFEIpLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQN 218
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin pfam00028
Cadherin domain;
1131-1220 1.77e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  1131 VSEDARMFASVLRVKATDRDTGNySAMAYRLIIPPIKEGKegFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1210
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 218505731  1211 SGKADVLVSV 1220
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
378-477 2.56e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   378 YQGYILESAPVGatiseslnlTTPLRIVALDKDIEDTKDPElHLFLNDYTS-VFTVTPtgITRYLTLLQPVDREEQQTYT 456
Cdd:pfam00028    1 YSASVPENAPVG---------TEVLTVTATDPDLGPNGRIF-YSILGGGPGgNFRIDP--DTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|...
gi 218505731   457 FLITAFDGVQE--SEPVVVNIRV 477
Cdd:pfam00028   69 LTVEATDSGGPplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1145-1225 2.51e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 2.51e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731   1145 KATDRDTGNYSAMAYRLIIPPikeGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Cdd:smart00112    1 SATDADSGENGKVTYSILSGN---DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    .
gi 218505731   1225 D 1225
Cdd:smart00112   78 D 78
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 453-723 6.35e-05

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 48.11  E-value: 6.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  453 QTYTFLITAFDGVQESEPVVVNIRVmdANDNTPTFPEISYDVYVytdmSPGDSV-IQLTAVDADegsNGEISYE-ILVGG 530
Cdd:NF038112 1252 TVLTFQLVVSDGTKTSAPDTVTVLV--RNVNRAPVAVAGAPATV----DERSTVtLDGSGTDAD---GDALTYAwTQTSG 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  531 KGDFVINKTTGLVS-IAPGVELIVGQTYALTVqaSDNAPPAERrhsicTVYIEVLPPNnqsppRFPQLMYSLEVSEAMRi 609
Cdd:NF038112 1323 PAVTLTGATTATATfTAPEVTADTQLTFTLTV--SDGTASATD-----TVTVTVRNVN-----RAPVANAGADQTVDER- 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  610 GAILLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSL-GKALDRESTDRYILIVTAsdgrpDGTSTATVNIVVTDV 688
Cdd:NF038112 1390 STVTLSGSATDPDGDALTYAWTQTAGPTVTLTGADTATASFtAPEVAADTELTFQLTVSA-----DGQASADVTVTVTVR 1464

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 218505731  689 NDN-APVFDpylPRNLSVVEEEANAFVgQVRATDPD 723
Cdd:NF038112 1465 NVNrAPVAH---AGESITVDEGSTVTL-DASATDPD 1496
tand_rpt_95 NF012211
tandem-95 repeat; This 95-amino acid repeat occurs in tandem in proteins that may be several ...
 617-699 3.97e-03

tandem-95 repeat; This 95-amino acid repeat occurs in tandem in proteins that may be several thousand amino acids long.


Pssm-ID: 333740 [Multi-domain]  Cd Length: 98  Bit Score: 38.38  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505731  617 QATDREGDPITY------------AIENGDPQRVFNLSET-TGILSLGkaldrestdryiliVTASDGRPdGTSTATVNI 683
Cdd:NF012211   18 NASDVDGDDLTVsnvsysgptngtVTDNGDGTYTYTPNENfNGDDSFT--------------YTVSDGTG-ATATATVFV 82

                          90
                  ....*....|....*.
gi 218505731  684 VVTDVNDnAPVFDPYL 699
Cdd:NF012211   83 TVNPVND-APVAGNDA 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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