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Conserved domains on  [gi|219273442|ref|NP_001136417|]
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zinc finger protein 68 isoform 2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 8.21e-09

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.82  E-value: 8.21e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 219273442     1 MLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-437 1.27e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 255 QKGYEFSQQSEVSLH--QKIRRGKKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQ 326
Cdd:COG5048  264 SLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 327 RVHTGERPYICFECR-------KAFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AE 395
Cdd:COG5048  344 LLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 219273442 396 CGKAFSTKSYLTVHQRTHTGEKPYECTVCRKSFICKSSFSHH 437
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-548 5.60e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219273442 475 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHTAKKASECKQSNKFFLSNTSQHQ 548
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 6.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.85e-03
                          10        20
                  ....*....|....*....|....*
gi 219273442  462 LTRHQRTHTGDKRYECQLCQKAFYC 486
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 8.21e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.82  E-value: 8.21e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 219273442     1 MLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-437 1.27e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 255 QKGYEFSQQSEVSLH--QKIRRGKKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQ 326
Cdd:COG5048  264 SLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 327 RVHTGERPYICFECR-------KAFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AE 395
Cdd:COG5048  344 LLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 219273442 396 CGKAFSTKSYLTVHQRTHTGEKPYECTVCRKSFICKSSFSHH 437
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-548 5.60e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219273442 475 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHTAKKASECKQSNKFFLSNTSQHQ 548
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-372 5.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.60e-04
                          10        20
                  ....*....|....*....|....
gi 219273442  349 ELTDHQRIHTGEKPYECKECGKAF 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-512 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....
gi 219273442  489 HLIVHQRTHTGEKPYECKECRKAF 512
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 6.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.85e-03
                          10        20
                  ....*....|....*....|....*
gi 219273442  462 LTRHQRTHTGDKRYECQLCQKAFYC 486
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 8.21e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.82  E-value: 8.21e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 219273442     1 MLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-437 1.27e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 255 QKGYEFSQQSEVSLH--QKIRRGKKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQ 326
Cdd:COG5048  264 SLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 327 RVHTGERPYICFECR-------KAFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AE 395
Cdd:COG5048  344 LLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 219273442 396 CGKAFSTKSYLTVHQRTHTGEKPYECTVCRKSFICKSSFSHH 437
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-548 5.60e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219273442 475 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHTAKKASECKQSNKFFLSNTSQHQ 548
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-547 1.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 361 KPYECKECGKAFCQKPQLTLHQR--IHTGE--KPYECAE--CGKAFSTKSYLTVHQRTHTGEKPYECtvcrKSFICKSSF 434
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE----KLLNSSSKF 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219273442 435 SHhwrthtgekpyeckqcmKTFYRKSGLTRHQRTHTGDKRYECQL--CQKAFYCTSHLIVHQRTHTGEKPYECK--ECRK 510
Cdd:COG5048  364 SP-----------------LLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 219273442 511 AFYDKSNLKRHQKIHTAKKASECKQSNKFFLSNTSQH 547
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-372 5.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.60e-04
                          10        20
                  ....*....|....*....|....
gi 219273442  349 ELTDHQRIHTGEKPYECKECGKAF 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-421 6.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.47e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219273442 361 KPYECKECGKAFCQKPQLTLHQRIHTGEKPYECA--ECGKAFSTKSYLTVHQRTHTGEKPYEC 421
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 9.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 219273442  405 YLTVHQRTHTGEKPYECTVCRKSFIC 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 219273442  378 LTLHQRIHTGEKPYECAECGKAFST 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-512 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....
gi 219273442  489 HLIVHQRTHTGEKPYECKECRKAF 512
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-365 1.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 219273442 305 KPYECTECSKAFCQKSHLTQHQRVHTGERPYICF--ECRKAFYRKSELTDHQRIHTGEKPYEC 365
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 391-413 3.43e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|...
gi 219273442  391 YECAECGKAFSTKSYLTVHQRTH 413
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-316 4.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.67e-03
                          10        20
                  ....*....|....*....|....
gi 219273442  293 SFNRHQSTHTGEKPYECTECSKAF 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 503-525 5.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|...
gi 219273442  503 YECKECRKAFYDKSNLKRHQKIH 525
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 6.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.85e-03
                          10        20
                  ....*....|....*....|....*
gi 219273442  462 LTRHQRTHTGDKRYECQLCQKAFYC 486
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 307-329 7.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.44e-03
                          10        20
                  ....*....|....*....|...
gi 219273442  307 YECTECSKAFCQKSHLTQHQRVH 329
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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