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Conserved domains on  [gi|221307578|ref|NP_001138297|]
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RUN domain-containing protein 3A isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 30-185 3.77e-113

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


:

Pssm-ID: 439061  Cd Length: 151  Bit Score: 328.91  E-value: 3.77e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  30 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKacapaGPVSWFSSDGQRGFWDYIRLACSKVPNNCV 109
Cdd:cd17699    1 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 110 SSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 185
Cdd:cd17699   76 SSIENMENISTSRAKGRAWIRVALMEKRLSEYIATALRDTRTTRRFYDDGAIMLREESTVLTGMLIGLSAIDFSFC 151
CwlO1 super family cl25603
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 259-397 2.89e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


The actual alignment was detected with superfamily member COG3883:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 259 RIVYAQKGYLEELVRLREsQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLiPSDHAPLAQGSKELTT 338
Cdd:COG3883  126 KIADADADLLEELKADKA-ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL-SAEEAAAEAQLAELEA 203

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221307578 339 PLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWG 397
Cdd:COG3883  204 ELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSA 262
 
Name Accession Description Interval E-value
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 30-185 3.77e-113

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


Pssm-ID: 439061  Cd Length: 151  Bit Score: 328.91  E-value: 3.77e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  30 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKacapaGPVSWFSSDGQRGFWDYIRLACSKVPNNCV 109
Cdd:cd17699    1 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 110 SSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 185
Cdd:cd17699   76 SSIENMENISTSRAKGRAWIRVALMEKRLSEYIATALRDTRTTRRFYDDGAIMLREESTVLTGMLIGLSAIDFSFC 151
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 60-188 1.95e-38

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 135.87  E-value: 1.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578   60 NFAAILEQILSHRFKACAPAGpVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTA---RAKGRAWIRVALM 134
Cdd:pfam02759   1 QLCAALEALLSHGLKRSSLLI-LRAAGLLPERSFWALLERVGKLVPPaeELLSSVQELEQIHTPyspDGRGRAWIRLALN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221307578  135 EKRMSEYITTALRDTRTTRRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSFCLKG 188
Cdd:pfam02759  80 EKLLDQWLKLLLSNKELLSEYYEPWALLADPEfGEILLGLLVGLSALDFNLCLKL 134
RUN smart00593
domain involved in Ras-like GTPase signaling;
125-187 1.11e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 68.41  E-value: 1.11e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221307578   125 GRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSFCLK 187
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEeGEQLLGLLVGLSALDFNLPVD 64
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 259-397 2.89e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 259 RIVYAQKGYLEELVRLREsQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLiPSDHAPLAQGSKELTT 338
Cdd:COG3883  126 KIADADADLLEELKADKA-ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL-SAEEAAAEAQLAELEA 203

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221307578 339 PLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWG 397
Cdd:COG3883  204 ELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSA 262
bZIP_XBP1 cd14691
Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a ...
 264-304 4.32e-03

Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain; XBP1, a member of the Basic leucine zipper (bZIP) family, is the key transcription factor that orchestrates the unfolded protein response (UPR). It is the most conserved component of the UPR and is critical for cell fate determination in response to ER stress. The inositol-requiring enzyme 1 (IRE1)-XBP1 pathway is one of the three major sensors at the ER membrane that initiates the UPR upon activation. IRE1, a type I transmembrane protein kinase and endoribonuclease, oligomerizes upon ER stress leading to its increased activity. It splices the XBP1 mRNA, producing a variant that translocates to the nucleus and activates its target genes, which are involved in protein folding, degradation, and trafficking. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269839 [Multi-domain]  Cd Length: 58  Bit Score: 35.26  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 221307578 264 QKGYLEELvrlrESQLKDLEAENRRLQLQLEEAAAQNQREK 304
Cdd:cd14691   22 KKARMDEL----EERVRELEEENQKLRAENESLRARNEDLL 58
DUF3450 pfam11932
Protein of unknown function (DUF3450); This family of proteins are functionally ...
 245-331 6.63e-03

Protein of unknown function (DUF3450); This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.


Pssm-ID: 432198 [Multi-domain]  Cd Length: 238  Bit Score: 37.98  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  245 DSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAaaqnQREKRELEGVILELQEQLTGLIPS 324
Cdd:pfam11932  37 DKWDDEKQELLAEYRALKAELESLEVYNRQLERLVASQEQEIASLERQIEEI----ERTERELVPLMLKMLDRLEQFVAL 112


                  ....*..
gi 221307578  325 DHAPLAQ 331
Cdd:pfam11932 113 DLPFLLE 119
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
140-335 8.31e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.60  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 140 EYITTALRDTRTTRRfYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEE 219
Cdd:COG4717  230 EQLENELEAAALEER-LKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQ 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 220 RHSAESSTSEDNSPEHP---YLPLVTDEDSWYSKWHKMEQKFRivyaqkgYLEELVRLRES-QLKDLEAENRRLQLQ--- 292
Cdd:COG4717  309 ALPALEELEEEELEELLaalGLPPDLSPEELLELLDRIEELQE-------LLREAEELEEElQLEELEQEIAALLAEagv 381

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 221307578 293 --LEE--AAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKE 335
Cdd:COG4717  382 edEEElrAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE 428
 
Name Accession Description Interval E-value
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 30-185 3.77e-113

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


Pssm-ID: 439061  Cd Length: 151  Bit Score: 328.91  E-value: 3.77e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  30 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKacapaGPVSWFSSDGQRGFWDYIRLACSKVPNNCV 109
Cdd:cd17699    1 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 110 SSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 185
Cdd:cd17699   76 SSIENMENISTSRAKGRAWIRVALMEKRLSEYIATALRDTRTTRRFYDDGAIMLREESTVLTGMLIGLSAIDFSFC 151
RUN_RUNDC3 cd17684
RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 ...
 30-184 8.36e-95

RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 contains two isoforms, RUNDC3A and RUNDC3B. RUNDC3A, also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. RUNDC3B, also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. Both RUNDC3A and RUNDC3B contain a RUN domain.


Pssm-ID: 439046  Cd Length: 150  Bit Score: 281.98  E-value: 8.36e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  30 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPagpvsWFSSDGQRGFWDYIRLACSKVPNNCV 109
Cdd:cd17684    1 NLVTVCRLSVKSLIDKACLETIDDSSEELINFAAILEQILSHRLKPVKP-----WYGSEEPRTFWDYIRVACKKVPQNCI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221307578 110 SSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSF 184
Cdd:cd17684   76 ASIEQMENIKSPKAKGRAWIRVALMEKRLSEYLSTALKQTRLTRNFYQDGAIMLSEDATVLCGMLIGLNAIDFSF 150
RUN_RUNDC3B cd17700
RUN domain found in RUN domain-containing protein 3B (RUNDC3B) and similar proteins; RUN ...
 30-185 1.58e-85

RUN domain found in RUN domain-containing protein 3B (RUNDC3B) and similar proteins; RUN domain-containing protein 3B (RUNDC3B), also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. RUNDC3B contains a RUN domain.


Pssm-ID: 439062  Cd Length: 151  Bit Score: 258.36  E-value: 1.58e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  30 NLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKacapaGPVSWFSSDGQRGFWDYIRLACSKVPNNCV 109
Cdd:cd17700    1 NLITVCRFSVKTLIDRSCFETIDDSSPEFVNFAAILEQILSHRLK-----GQVTWFGYESPRSFWDYIRVACSKVPHNCI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 110 SSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFC 185
Cdd:cd17700   76 CSIENMENVSSSRAKGRAWIRVALMEKRLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFC 151
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 60-188 1.95e-38

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 135.87  E-value: 1.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578   60 NFAAILEQILSHRFKACAPAGpVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTA---RAKGRAWIRVALM 134
Cdd:pfam02759   1 QLCAALEALLSHGLKRSSLLI-LRAAGLLPERSFWALLERVGKLVPPaeELLSSVQELEQIHTPyspDGRGRAWIRLALN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221307578  135 EKRMSEYITTALRDTRTTRRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSFCLKG 188
Cdd:pfam02759  80 EKLLDQWLKLLLSNKELLSEYYEPWALLADPEfGEILLGLLVGLSALDFNLCLKL 134
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 27-184 9.63e-36

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 129.23  E-value: 9.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  27 ERKNLITVCRFSVKTLLEK--YTAEPIDDSSEEFVNFAAILEQILSHRFKAcapagPVSWFSSDgqRGFWDYIRLACSKV 104
Cdd:cd17681    1 ERRNLLNLAKLSIKELIESalSFGRTLDSDHVPLQQFFVILEHVLRHGLKV-----KKSFLGPN--KSFWPVLEHVEKLV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 105 P--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYItTALRDTRTTRR-FYDSGAIMLRDEATILTGMLIGLSAID 181
Cdd:cd17681   74 PeaNEITASVRDLPGIKTPLGRARAWLRLALMQKKLADYF-RALIENKDLLSeFYEPGALMMSEEAVVIAGLLVGLNVID 152


                 ...
gi 221307578 182 FSF 184
Cdd:cd17681  153 CNL 155
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 38-184 3.12e-30

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 114.44  E-value: 3.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  38 SVKTLLEKY---------TAEPIDDSSEEFVNFAAILEQILSHRFKAcapagpvSWFSSdGQRGFWDYIRLACSKVPNN- 107
Cdd:cd17671    2 AVKELLESFadngeaddsAALTLTDDDPVVGRLCAALEAILSHGLKP-------KRFGG-GKVSFWDFLEALEKLLPAPs 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 108 ---CVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIML-RDEATILTGMLIGLSAIDFS 183
Cdd:cd17671   74 lkqAIRDINSLSNVKTDDGRGRAWIRLALNEKSLESYLAALLSDQSLLRKYYEPWALLRdPEEAELFLSLLVGLSSLDFN 153


                 .
gi 221307578 184 F 184
Cdd:cd17671  154 L 154
RUN_RUFY1 cd17694
RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; ...
 27-185 5.82e-20

RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439056  Cd Length: 156  Bit Score: 86.11  E-value: 5.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKACApagpvswfSSDGQ-RGFWDYIRLACSK 103
Cdd:cd17694    1 ERANLMNMMKLSIKVLIQSALSlgRTLDSDYPPLQQFFVVLEHCLKHGLKVKK--------SFIGQnKSFFGPLELVEKL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 104 VP--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAID 181
Cdd:cd17694   73 CPeaSDIATSARNLPELKTAVGRGRAWLHLALMQKKLADYLKVLIDRKDLLSEFYEPGALMMEEEGAVIVGLLVGLNVID 152


                 ....
gi 221307578 182 FSFC 185
Cdd:cd17694  153 ANLC 156
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
 27-185 4.54e-19

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 83.89  E-value: 4.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  27 ERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACApagpvswfSSDGQ-RGFWDYIRLACSK 103
Cdd:cd17696    1 ERMNLMNMAKLSIKGLIESALnlGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK--------TFLGQnKSFWGPLELVEKL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 104 VPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAID 181
Cdd:cd17696   73 VPEaaEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINRKDLLSEFYEPNALMMEEEGAIIAGLLVGLNVID 152


                 ....
gi 221307578 182 FSFC 185
Cdd:cd17696  153 ANFC 156
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 27-185 4.79e-18

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 80.79  E-value: 4.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAcapagPVSWFSSDgqRGFWDYIRLACSKV 104
Cdd:cd17695    1 ERANLLNMAKLSIKGLIESALSfgRTLDSDYPPLQQFFVVMEHCLKHGLKV-----RKSFLSYN--KTIWGPLELVEKLC 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 105 PN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDF 182
Cdd:cd17695   74 PEaeEIAASVRDLPGLKTPLGRARAWLRLALMQKKLADYLRCLIIRRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDA 153


                 ...
gi 221307578 183 SFC 185
Cdd:cd17695  154 NLC 156
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
 38-191 1.86e-16

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 76.86  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  38 SVKTLLEKY--TAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRG----FWDYIRLACSKvpnNCVSS 111
Cdd:cd17679   11 SVKELQLEYvsSDEVVTSSDDGANTLCCVLEAIFLHGLKDKFISKVSSVFSGDVDKLpepnFWPLLLKFSHR---DVIDQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 112 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAImLRD--EATILTGMLIGLSAIDFSFCLKGE 189
Cdd:cd17679   88 IEHLSQITTDVGRCRAWIRLALNDGLLESYLEAILKDKSALKSYYNPSAF-LRDpeQLDILKSLLQGLESFQFELPYNSS 166


                 ..
gi 221307578 190 VL 191
Cdd:cd17679  167 LL 168
RUN smart00593
domain involved in Ras-like GTPase signaling;
125-187 1.11e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 68.41  E-value: 1.11e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221307578   125 GRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSFCLK 187
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEeGEQLLGLLVGLSALDFNLPVD 64
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 43-184 1.78e-14

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 70.33  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  43 LEKYTAEPIDDSSEEFVNFAAILEQILSHRFKAcapagPVSWFSsdGQRGFWDYIR-LA--CSKVP---NNCVSSIENME 116
Cdd:cd17682    9 LKSEFGEITDPDNPYLRPFCETLEKILRKGLKE-----KVSLGG--RRKDYWDWLEeLLkkLNKIPkslSDAVKFVKSCK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221307578 117 NISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDE-ATILTGMLIGLSAIDFSF 184
Cdd:cd17682   82 KVKTNQGRGRLFIRYALNKKCLHDPVQQLVKNPKLLSDYYSPDSILGNEIlSEILLSLLYQLNEINFDL 150
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 53-183 3.01e-13

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 67.26  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  53 DSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRG------------FWDYIRLACSKVPNNCvssIENMENIST 120
Cdd:cd17689   22 ESDSRVSCLCAQLEAVLQHGLKTSRSPNLVSSAVTQVSGLagslgsaeteptFWPFVKEHLTKHELER---FELLKNIWT 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221307578 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAiMLRDE--ATILTGMLIGLSAIDFS 183
Cdd:cd17689   99 DIGRGRAWLRSALNEHSLERYLHILLSNENLLRQYYEDWA-FLRDEerSSMLPNMAAGLGSILFA 162
RUN_PLEKHM2 cd17680
RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and ...
 65-184 2.43e-12

RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and similar proteins; PLEKHM2, also called PH domain-containing family M member 2, or Salmonella-induced filaments A (SifA) and Kinesin-Interacting Protein (SKIP), is the lysosome, melanosome and lytic granule cargo adaptor that controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. In addition to kinesin-1, it also interacts with several Rabs to affect endosomal trafficking. This model represents the RUN domain of PLEKHM2.


Pssm-ID: 439042  Cd Length: 145  Bit Score: 64.19  E-value: 2.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  65 LEQILSHRFKacapagpvswfssDGQRGFWDYIRLACSKvpnNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITT 144
Cdd:cd17680   41 LDHALLHGLR-------------RGNRGYWPFVKEFTHK---ETIKQIENLPNVTTDLGRGRAWLYLALNEGSLESYLRS 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 221307578 145 ALRDTRTTRRFYDSGAIMLRDEA-TILTGMLIGLSAIDFSF 184
Cdd:cd17680  105 FLENRKLVKKFYHKHALLRDSQRlELLLTLLSGLEFVQFDL 145
RUN_FYCO1 cd17698
RUN domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar ...
 47-182 1.43e-07

RUN domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins; FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and Phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. This model represents the RUN domain of FYCO1.


Pssm-ID: 439060  Cd Length: 158  Bit Score: 50.85  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  47 TAEPIDDSSEEFVNFAAILEQILSHRFKAcapagPVSWFSsdGQRGFWDYIR--LACSKVPNNCVSSIENMENISTARAK 124
Cdd:cd17698   25 TGEPITDDSTTLHKFCAKLEYLLQFDQKE-----KTTLLG--GRKDYWDYFCecLAKVKGLNDGIRFVKSLKEVRTSLGK 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221307578 125 GRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLR-DEATILTGMLIGLSAIDF 182
Cdd:cd17698   98 GRAFIRYSLVHQRLADTLQQCVMNGKVTSDWYYPRSVFLNhKYSSDIINSLYDLNEVQF 156
RUN1_DENND5 cd17677
RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 109-185 4.32e-06

RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.


Pssm-ID: 439039  Cd Length: 183  Bit Score: 47.01  E-value: 4.32e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221307578 109 VSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIML-RDEATILTGMLIGLSAIDFsFC 185
Cdd:cd17677  101 MKNVQNMKEIKTDVGYARAWIRLALEKKLLSKHLKTLLSNQDLLRSLYKRYAFLRcEDEREQFLYHLLSLNAVDY-FC 177
RUN1_DENND5B cd17691
RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, ...
 112-186 5.93e-06

RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5B.


Pssm-ID: 439053 [Multi-domain]  Cd Length: 206  Bit Score: 46.97  E-value: 5.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 112 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATILTGMLIGLSAIDFsFCL 186
Cdd:cd17691  127 IQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAFLrCEEEKEQFLYHLLSLNAVDY-FCF 201
RUN_RUFY4 cd17697
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins; ...
 50-182 6.80e-06

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins; RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. RUFY4 belongs to the FUFY protein family which is characterized by the presence of an N-terminal RUN domain and a C-terminal FYVE domain; this model represents the RUN domain of RUFY4.


Pssm-ID: 439059  Cd Length: 150  Bit Score: 45.94  E-value: 6.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  50 PIDDSSEEFVNFAAILEQILSHRFKAcapagPVSWFSSdgQRGFWDYIR--LACSKVPNNCVSSIENMENISTARAKGRA 127
Cdd:cd17697   20 PITDGSPELHRLCARLEYLLQFDQKE-----KKSFFGS--RKDYWDFLClcLNRHRGGTEGIHFVNSTDKLKTPLGKGRA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221307578 128 WIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDE--ATILtGMLIGLSAIDF 182
Cdd:cd17697   93 FIRYCLVQQQLAESLQLCLLNPELTGEWYYARSPFLSPElrSDIL-DSLYELNGVNF 148
RUN1_DENND5A cd17690
RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, ...
 112-186 5.84e-05

RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5A.


Pssm-ID: 439052 [Multi-domain]  Cd Length: 209  Bit Score: 44.23  E-value: 5.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221307578 112 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATILTGMLIGLSAIDFsFCL 186
Cdd:cd17690  130 IQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLrCDDEKEQFLYHLLSFNAVDY-FCF 204
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 64-180 1.33e-04

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


Pssm-ID: 439048  Cd Length: 151  Bit Score: 41.87  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  64 ILEQILSHRFKACApagpvswfSSDGQRGFWDYI----RLACSKVPNNCVSSIENMENISTaRAKGRAWIRVALMEKRMS 139
Cdd:cd17686   27 AVENILQHGLKEFQ--------GLNKEIDDWEFVqglrWLQPTLAPSIEQQSRSSPSESEV-SDKGRLWLRQSLQQHCLS 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 221307578 140 EYITTALRDTRTTRRFYDSGAImLRDEATIlTGMLIGLSAI 180
Cdd:cd17686   98 SQLQWLVSDKELLRKYYEDEAF-LRQEGYA-TALLICLTAV 136
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 128-183 9.00e-04

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 39.96  E-value: 9.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 128 WIRVALMEKRMS---EYITTalrdtrTTRRFYDSGAIML-RDEATILTGMLIGLSAIDFS 183
Cdd:cd17687  107 WIRIALFEKVLDkivDYLVE------NASKYYEKEALMAdPVDGPLLASLLVGPCALDYT 160
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 259-397 2.89e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 259 RIVYAQKGYLEELVRLREsQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLiPSDHAPLAQGSKELTT 338
Cdd:COG3883  126 KIADADADLLEELKADKA-ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL-SAEEAAAEAQLAELEA 203

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221307578 339 PLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWG 397
Cdd:COG3883  204 ELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSA 262
bZIP_XBP1 cd14691
Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a ...
 264-304 4.32e-03

Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain; XBP1, a member of the Basic leucine zipper (bZIP) family, is the key transcription factor that orchestrates the unfolded protein response (UPR). It is the most conserved component of the UPR and is critical for cell fate determination in response to ER stress. The inositol-requiring enzyme 1 (IRE1)-XBP1 pathway is one of the three major sensors at the ER membrane that initiates the UPR upon activation. IRE1, a type I transmembrane protein kinase and endoribonuclease, oligomerizes upon ER stress leading to its increased activity. It splices the XBP1 mRNA, producing a variant that translocates to the nucleus and activates its target genes, which are involved in protein folding, degradation, and trafficking. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269839 [Multi-domain]  Cd Length: 58  Bit Score: 35.26  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 221307578 264 QKGYLEELvrlrESQLKDLEAENRRLQLQLEEAAAQNQREK 304
Cdd:cd14691   22 KKARMDEL----EERVRELEEENQKLRAENESLRARNEDLL 58
DUF3450 pfam11932
Protein of unknown function (DUF3450); This family of proteins are functionally ...
 245-331 6.63e-03

Protein of unknown function (DUF3450); This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.


Pssm-ID: 432198 [Multi-domain]  Cd Length: 238  Bit Score: 37.98  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578  245 DSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAaaqnQREKRELEGVILELQEQLTGLIPS 324
Cdd:pfam11932  37 DKWDDEKQELLAEYRALKAELESLEVYNRQLERLVASQEQEIASLERQIEEI----ERTERELVPLMLKMLDRLEQFVAL 112


                  ....*..
gi 221307578  325 DHAPLAQ 331
Cdd:pfam11932 113 DLPFLLE 119
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
140-335 8.31e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.60  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 140 EYITTALRDTRTTRRfYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEE 219
Cdd:COG4717  230 EQLENELEAAALEER-LKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQ 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221307578 220 RHSAESSTSEDNSPEHP---YLPLVTDEDSWYSKWHKMEQKFRivyaqkgYLEELVRLRES-QLKDLEAENRRLQLQ--- 292
Cdd:COG4717  309 ALPALEELEEEELEELLaalGLPPDLSPEELLELLDRIEELQE-------LLREAEELEEElQLEELEQEIAALLAEagv 381

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 221307578 293 --LEE--AAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKE 335
Cdd:COG4717  382 edEEElrAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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